Science 13 August 1993: Vol. 261. no. 5123, pp. 921 - 923 DOI: 10.1126/science.8346443

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Articles

Longitudinal Modeling of Age-Related Memory Decline and the APOE {epsilon}4 Effect.

R. J. Caselli, A. C. Dueck, D. Osborne, M. N. Sabbagh, D. J. Connor, G. L. Ahern, L. C. Baxter, S. Z. Rapcsak, J. Shi, B. K. Woodruff, et al. (2009)
N. Engl. J. Med. 361, 255-263
 |  Abstract »  |  Full Text »  |  PDF »

Ovariectomy and 17{beta}-Estradiol Replacement Do Not Alter {beta}-Amyloid Levels in Sheep Brain.

A. M. Barron, M. Cake, G. Verdile, and R. N. Martins (2009)
Endocrinology 150, 3228-3236
 |  Abstract »  |  Full Text »  |  PDF »

Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort.

J.C.S. Breitner, S. J.P.A. Haneuse, R. Walker, S. Dublin, P. K. Crane, S. L. Gray, and E. B. Larson (2009)
Neurology 72, 1899-1905
 |  Abstract »  |  Full Text »  |  PDF »

Advanced Lipoprotein Testing and Subfractionation Are Clinically Useful.

H. R. Superko (2009)
Circulation 119, 2383-2395
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Genetic architecture of quantitative traits in mice, flies, and humans.

J. Flint and T. F.C. Mackay (2009)
Genome Res. 19, 723-733
 |  Abstract »  |  Full Text »  |  PDF »

Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits.

J. A. Ronald, Y. Chen, L. Bernas, H. H. Kitzler, K. A. Rogers, R. A. Hegele, and B. K. Rutt (2009)
Brain 132, 1346-1354
 |  Abstract »  |  Full Text »  |  PDF »

Genetic association studies for complex traits: relevance for the sports medicine practitioner.

W. T Gibson (2009)
Br. J. Sports Med. 43, 314-316
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Complex Systems: From Chemistry to Systems Biology Special Feature: Modularity and interactions in the genetics of gene expression.

O. Litvin, H. C. Causton, B.-J. Chen, and D. Pe'er (2009)
PNAS 106, 6441-6446
 |  Abstract »  |  Full Text »  |  PDF »

Fibrillar amyloid-{beta} burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.

E. M. Reiman, K. Chen, X. Liu, D. Bandy, M. Yu, W. Lee, N. Ayutyanont, J. Keppler, S. A. Reeder, J. B. S. Langbaum, et al. (2009)
PNAS 106, 6820-6825
 |  Abstract »  |  Full Text »  |  PDF »

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review.

L. Minati, T. Edginton, M. Grazia Bruzzone, and G. Giaccone (2009)
American Journal of Alzheimer's Disease and Other Dementias 24, 95-121
 |  Abstract »  |  PDF »

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2009)
J. Lipid Res. 50, S183-S188
 |  Abstract »  |  Full Text »  |  PDF »

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure.

N. Zhong and K. H. Weisgraber (2009)
J. Biol. Chem. 284, 6027-6031
 |  Abstract »  |  Full Text »  |  PDF »

APOE genotype modulates the effect of serum calcium levels on cognitive function in old age.

P. van Vliet, A. M. Oleksik, S. P. Mooijaart, A.J.M. de Craen, and R. G.J. Westendorp (2009)
Neurology 72, 821-828
 |  Abstract »  |  Full Text »  |  PDF »

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection.

S. D. Buckingham, A. K. Jones, L. A. Brown, and D. B. Sattelle (2009)
Pharmacol. Rev. 61, 39-61
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Cognitive Status, Age, and APOE-4 Genetic Risk on Brain FDDNP Positron-Emission Tomography Imaging in Persons Without Dementia.

G. W. Small, P. Siddarth, A. C. Burggren, V. Kepe, L. M. Ercoli, K. J. Miller, H. Lavretsky, P. M. Thompson, G. M. Cole, S. C. Huang, et al. (2009)
Arch Gen Psychiatry 66, 81-87
 |  Abstract »  |  Full Text »  |  PDF »

APOE Genotype and Functional Outcome Following Aneurysmal Subarachnoid Hemorrhage.

M. J. Gallek, Y. P. Conley, P. R. Sherwood, M. B. Horowitz, A. Kassam, and S. A. Alexander (2009)
Biol Res Nurs 10, 205-212
 |  Abstract »  |  PDF »

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels.

D. R. Riddell, H. Zhou, K. Atchison, H. K. Warwick, P. J. Atkinson, J. Jefferson, L. Xu, S. Aschmies, Y. Kirksey, Y. Hu, et al. (2008)
J. Neurosci. 28, 11445-11453
 |  Abstract »  |  Full Text »  |  PDF »

Dementia of the Alzheimer Type.

J. J. Jalbert, L. A. Daiello, and K. L. Lapane (2008)
Epidemiol. Rev. 30, 15-34
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Genotype, Cortisol, and Cognitive Function in Community-Dwelling Older Adults.

B. K. Lee, T. A. Glass, G. S. Wand, M. J. McAtee, K. Bandeen-Roche, K. I. Bolla, and B. S. Schwartz (2008)
Am J Psychiatry 165, 1456-1464
 |  Abstract »  |  Full Text »  |  PDF »

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: Implication of Additional Loci.

J. H. Lee, R. Cheng, N. Graff-Radford, T. Foroud, R. Mayeux, and for the National Institute on Aging Late-Onset Alz (2008)
Arch Neurol 65, 1518-1526
 |  Abstract »  |  Full Text »  |  PDF »

Geographical Differences in the Occurrence of Alzheimer's Disease Mortality: United States Versus Puerto Rico.

R. Figueroa, K. Steenland, J. R. MacNeil, A. I. Levey, and I. E. Vega (2008)
American Journal of Alzheimer's Disease and Other Dementias 23, 462-469
 |  Abstract »  |  PDF »

Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series.

T. E. F. Webb, M. Poulter, J. Beck, J. Uphill, G. Adamson, T. Campbell, J. Linehan, C. Powell, S. Brandner, S. Pal, et al. (2008)
Brain 131, 2632-2646
 |  Abstract »  |  Full Text »  |  PDF »

The Brain Injury Biomarker VLP-1 Is Increased in the Cerebrospinal Fluid of Alzheimer Disease Patients.

J.-M. Lee, K. Blennow, N. Andreasen, O. Laterza, V. Modur, J. Olander, F. Gao, M. Ohlendorf, and J. H. Ladenson (2008)
Clin. Chem. 54, 1617-1623
 |  Abstract »  |  Full Text »  |  PDF »

Estrogens and Alzheimer's Disease: Is Cholesterol a Link?.

A. M. Etgen (2008)
Endocrinology 149, 4253-4255
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Correlating Cerebral Hypometabolism With Future Memory Decline in Subsequent Converters to Amnestic Pre-Mild Cognitive Impairment.

R. J. Caselli, K. Chen, W. Lee, G. E. Alexander, and E. M. Reiman (2008)
Arch Neurol 65, 1231-1236
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE {varepsilon}4/{varepsilon}4 genotype accelerates HIV disease progression.

T. D. Burt, B. K. Agan, V. C. Marconi, W. He, H. Kulkarni, J. E. Mold, M. Cavrois, Y. Huang, R. W. Mahley, M. J. Dolan, et al. (2008)
PNAS 105, 8718-8723
 |  Abstract »  |  Full Text »  |  PDF »

Review: Statins and stroke.

M. Rodriguez-Yanez, J. Agulla, R. Rodriguez-Gonzalez, T. Sobrino, and J. Castillo (2008)
Therapeutic Advances in Cardiovascular Disease 2, 157-166
 |  Abstract »  |  PDF »

Morphometric Changes in the Episodic Memory Network and Tau Pathologic Features Correlate with Memory Performance in Patients with Mild Cognitive Impairment.

A.M. Fjell, K.B. Walhovd, I. Amlien, A. Bjornerud, I. Reinvang, L. Gjerstad, T. Cappelen, F. Willoch, P. Due-Tonnessen, R. Grambaite, et al. (2008)
AJNR Am. J. Neuroradiol. 29, 1183-1189
 |  Abstract »  |  Full Text »  |  PDF »

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.

B. L. Burgess, P. F. Parkinson, M. M. Racke, V. Hirsch-Reinshagen, J. Fan, C. Wong, S. Stukas, L. Theroux, J. Y. Chan, J. Donkin, et al. (2008)
J. Lipid Res. 49, 1254-1267
 |  Abstract »  |  Full Text »  |  PDF »

Cognitive Dysfunction and Diabetes Mellitus.

C. T. Kodl and E. R. Seaquist (2008)
Endocr. Rev. 29, 494-511
 |  Abstract »  |  Full Text »  |  PDF »

Kernel-Based Association Test.

H.-C. Yang, H.-Y. Hsieh, and C. S. J. Fann (2008)
Genetics 179, 1057-1068
 |  Abstract »  |  Full Text »  |  PDF »

Human Apolipoprotein E Redistributes Fibrillar Amyloid Deposition in Tg-SwDI Mice.

F. Xu, M. P. Vitek, C. A. Colton, M. L. Previti, N. Gharkholonarehe, J. Davis, and W. E. Van Nostrand (2008)
J. Neurosci. 28, 5312-5320
 |  Abstract »  |  Full Text »  |  PDF »

APOE {varepsilon}4 allele predicts faster cognitive decline in mild Alzheimer disease.

S. Cosentino, N. Scarmeas, E. Helzner, M. M. Glymour, J. Brandt, M. Albert, D. Blacker, and Y. Stern (2008)
Neurology 70, 1842-1849
 |  Abstract »  |  Full Text »  |  PDF »

Increased CSF-BACE 1 activity is associated with ApoE-{varepsilon}4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.

M. Ewers, Z. Zhong, K. Burger, A. Wallin, K. Blennow, S. J. Teipel, Y. Shen, and H. Hampel (2008)
Brain 131, 1252-1258
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits.

H. Belinson, D. Lev, E. Masliah, and D. M. Michaelson (2008)
J. Neurosci. 28, 4690-4701
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E polymorphism, life stress and self-reported health among older adults.

F Zhang, M Lewis, G Yang, J Iriondo-Perez, Y Zeng, and J Liu (2008)
J Epidemiol Community Health 62, e3
 |  Abstract »  |  Full Text »  |  PDF »

The apolipoprotein-{varepsilon}4 gene: always harmful?.

T. W Teasdale (2008)
J. Neurol. Neurosurg. Psychiatry 79, 364-365
 |  Full Text »  |  PDF »

Human apolipoprotein C-I expression in mice impairs learning and memory functions.

K. Abildayeva, J. F. P. Berbee, A. Blokland, P. J. Jansen, F. J. Hoek, O. Meijer, D. Lutjohann, T. Gautier, T. Pillot, J. De Vente, et al. (2008)
J. Lipid Res. 49, 856-869
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}7 Nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease.

R Carson, D Craig, B McGuinness, J A Johnston, F A O'Neill, A P Passmore, and C W Ritchie (2008)
J. Med. Genet. 45, 244-248
 |  Abstract »  |  Full Text »  |  PDF »

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, K. Ramsey, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. (2008)
Physiol Genomics 33, 240-256
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.

W. S. Liang, E. M. Reiman, J. Valla, T. Dunckley, T. G. Beach, A. Grover, T. L. Niedzielko, L. E. Schneider, D. Mastroeni, R. Caselli, et al. (2008)
PNAS 105, 4441-4446
 |  Abstract »  |  Full Text »  |  PDF »

Toward a plasma marker for Alzheimer disease: Some progress, but still a long way to go.

H. A. Crystal and P. Davies (2008)
Neurology 70, 586-587
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Plasma amyloid {beta} protein is elevated in late-onset Alzheimer disease families.

N. Ertekin-Taner, L. H. Younkin, D. M. Yager, F. Parfitt, M. C. Baker, S. Asthana, M. L. Hutton, S. G. Younkin, and N. R. Graff-Radford (2008)
Neurology 70, 596-606
 |  Abstract »  |  Full Text »  |  PDF »

Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS.

Q. Xu, D. Walker, A. Bernardo, J. Brodbeck, M. E. Balestra, and Y. Huang (2008)
J. Neurosci. 28, 1452-1459
 |  Abstract »  |  Full Text »  |  PDF »

Translation of Genetic Discoveries into Clinical Therapies.

D. G. Hackam and A. S. Hackam (2008)
Ann Intern Med 148, 246-247
 |  Full Text »  |  PDF »

n-3 Fatty acid erythrocyte membrane content, APOE {varepsilon}4, and cognitive variation: an observational follow-up study in late adulthood.

L. J Whalley, I. J Deary, J. M Starr, K. W Wahle, K. A Rance, V. J Bourne, and H. C Fox (2008)
Am. J. Clinical Nutrition 87, 449-454
 |  Abstract »  |  Full Text »  |  PDF »

A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy.

M. Kinomura, H. Sugiyama, T. Saito, A. Matsunaga, K.-e. Sada, M. Kanzaki, Y. Takazawa, Y. Maeshima, H. Yanai, and H. Makino (2008)
Nephrol. Dial. Transplant. 23, 751-756
 |  Full Text »  |  PDF »

Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury.

V. Raymont, A. Greathouse, K. Reding, R. Lipsky, A. Salazar, and J. Grafman (2008)
Brain 131, 543-558
 |  Abstract »  |  Full Text »  |  PDF »

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

J. Brodbeck, M. E. Balestra, A. M. Saunders, A. D. Roses, R. W. Mahley, and Y. Huang (2008)
PNAS 105, 1343-1346
 |  Abstract »  |  Full Text »  |  PDF »

ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.

A. Ganguly, R.M. R. Feldman, and M. Guo (2008)
Hum. Mol. Genet. 17, 293-302
 |  Abstract »  |  Full Text »  |  PDF »

Greglist: a database listing potential G-quadruplex regulated genes.

R. Zhang, Y. Lin, and C.-T. Zhang (2008)
Nucleic Acids Res. 36, D372-D376
 |  Abstract »  |  Full Text »  |  PDF »

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function.

J. D. Cahoy, B. Emery, A. Kaushal, L. C. Foo, J. L. Zamanian, K. S. Christopherson, Y. Xing, J. L. Lubischer, P. A. Krieg, S. A. Krupenko, et al. (2008)
J. Neurosci. 28, 264-278
 |  Abstract »  |  Full Text »  |  PDF »

Geranylgeranyl pyrophosphate stimulates {gamma}-secretase to increase the generation of A and APP-CTF{gamma}.

Y. Zhou, A. Suram, C. Venugopal, A. Prakasam, S. Lin, Y. Su, B. Li, S. M. Paul, and K. Sambamurti (2008)
FASEB J 22, 47-54
 |  Abstract »  |  Full Text »  |  PDF »

Imaging Genetics of Brain Longevity and Mental Wellness: The Next Frontier?.

J. R. Petrella, V. S. Mattay, and P. M. Doraiswamy (2008)
Radiology 246, 20-32
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis for the Recognition and Cross-linking of Amyloid Fibrils by Human Apolipoprotein E.

M. J. Gunzburg, M. A. Perugini, and G. J. Howlett (2007)
J. Biol. Chem. 282, 35831-35841
 |  Abstract »  |  Full Text »  |  PDF »

Disease-modifying therapies for Alzheimer disease: Challenges to early intervention.

J. L. Cummings, R. Doody, and C. Clark (2007)
Neurology 69, 1622-1634
 |  Abstract »  |  Full Text »  |  PDF »

The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"?.

G. E. Stutzmann (2007)
Neuroscientist 13, 546-559
 |  Abstract »  |  PDF »

Tooth loss, dementia and neuropathology in the Nun Study.

P. S. Stein, M. Desrosiers, S. J. Donegan, J. F. Yepes, and R. J. Kryscio (2007)
J Am Dent Assoc 138, 1314-1322
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?.

S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi (2007)
J. Neurol. Neurosurg. Psychiatry 78, 1103-1108
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease.

O. Belbin, J. L. Dunn, Y. Ling, L. Morgan, S. Chappell, H. Beaumont, D. Warden, D. A. Smith, N. Kalsheker, and K. Morgan (2007)
Hum. Mol. Genet. 16, 2199-2208
 |  Abstract »  |  Full Text »  |  PDF »

Depressive Symptoms and Cognitive Change in Older Mexican Americans.

M. A. Raji, C. A. Reyes-Ortiz, Y.-F. Kuo, K. S. Markides, and K. J. Ottenbacher (2007)
J Geriatr Psychiatry Neurol 20, 145-152
 |  Abstract »  |  PDF »

Cognitive Domain Decline in Healthy Apolipoprotein E {varepsilon}4 Homozygotes Before the Diagnosis of Mild Cognitive Impairment.

R. J. Caselli, E. M. Reiman, D. E. C. Locke, M. L. Hutton, J. G. Hentz, C. Hoffman-Snyder, B. K. Woodruff, G. E. Alexander, and D. Osborne (2007)
Arch Neurol 64, 1306-1311
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease: Will Advances Made in the Past Turn the Tide?.

T. P Semla (2007)
Ann. Pharmacother. 41, 1494-1496
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Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease.

P. Bossu, A. Ciaramella, M. L. Moro, L. Bellincampi, S. Bernardini, G. Federici, A. Trequattrini, F. Macciardi, I. Spoletini, F. Di Iulio, et al. (2007)
J. Neurol. Neurosurg. Psychiatry 78, 807-811
 |  Abstract »  |  Full Text »  |  PDF »

Polymorphisms and Vascular Cognitive Impairment After Ischemic Stroke.

L. Baum, Xiangyan Chen, Wing Sze Cheung, C. K. A. Cheung, Lap Woon Cheung, K. F. P. Chiu, Hong Mei Wen, P. Poon, Kam Sang Woo, Ho Keung Ng, et al. (2007)
J Geriatr Psychiatry Neurol 20, 93-99
 |  Abstract »  |  PDF »

Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses.

H.-g. Lee, X. Zhu, R. J. Castellani, A. Nunomura, G. Perry, and M. A. Smith (2007)
J. Pharmacol. Exp. Ther. 321, 823-829
 |  Abstract »  |  Full Text »  |  PDF »

Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease.

G. V. De Ferrari, A. Papassotiropoulos, T. Biechele, F. Wavrant De-Vrieze, M. E. Avila, M. B. Major, A. Myers, K. Saez, J. P. Henriquez, A. Zhao, et al. (2007)
PNAS 104, 9434-9439
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Secretion of Apolipoprotein E2 from Macrophages.

D. Fan, S. Qiu, C. D. Overton, P. G. Yancey, L. L. Swift, W. G. Jerome, M. F. Linton, and S. Fazio (2007)
J. Biol. Chem. 282, 13746-13753
 |  Abstract »  |  Full Text »  |  PDF »

The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus.

A. Hellquist, M. Zucchelli, K. Kivinen, U. Saarialho-Kere, S. Koskenmies, E. Widen, H. Julkunen, A. Wong, M.-L. Karjalainen-Lindsberg, T. Skoog, et al. (2007)
J. Med. Genet. 44, 314-321
 |  Abstract »  |  Full Text »  |  PDF »

Serum {alpha}-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment.

J. E. Dunn, S. Weintraub, A. M. Stoddard, and S. Banks (2007)
Neurology 68, 670-676
 |  Abstract »  |  Full Text »  |  PDF »

Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-beta Peptide Generation.

W. S. Kim, A. S. Rahmanto, A. Kamili, K.-A. Rye, G. J. Guillemin, I. C. Gelissen, W. Jessup, A. F. Hill, and B. Garner (2007)
J. Biol. Chem. 282, 2851-2861
 |  Abstract »  |  Full Text »  |  PDF »

The Genetics of Alzheimer's Disease.

C. K. Chai (2007)
American Journal of Alzheimer's Disease and Other Dementias 22, 37-41
 |  Abstract »  |  PDF »

Rapid Dissection of the Genetic Risk of Age-Related Macular Degeneration: Achieving the Promise of the Genomic Era.

J. L. Haines and M. A. Pericak-Vance (2007)
JAMA 297, 401-402
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Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms.

B A Parmenter, D R Denney, S G Lynch, L S Middleton, and L M Harlan (2007)
Multiple Sclerosis 13, 25-32
 |  Abstract »  |  PDF »

Depressive Symptoms Associated With Hereditary Alzheimer's Disease: A Case Description.

M. Y. S. Contreras, P. A. O. Vargas, L. R. Ramos, and R. A. Velandia (2007)
American Journal of Alzheimer's Disease and Other Dementias 21, 411-415
 |  Abstract »  |  PDF »

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease.

R. Kimura, K. Kamino, M. Yamamoto, A. Nuripa, T. Kida, H. Kazui, R. Hashimoto, T. Tanaka, T. Kudo, H. Yamagata, et al. (2007)
Hum. Mol. Genet. 16, 15-23
 |  Abstract »  |  Full Text »  |  PDF »

A review of genome mutation and Alzheimer's disease.

P. Thomas and M. Fenech (2007)
Mutagenesis 22, 15-33
 |  Abstract »  |  Full Text »  |  PDF »

New Alzheimer's disease locus on chromosome 8.

V Giedraitis, M Hedlund, L Skoglund, E Blom, S Ingvast, R Brundin, L Lannfelt, and A Glaser (2006)
J. Med. Genet. 43, 931-935
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects..

J. R. Hodges (2006)
Brain 129, 2811-2822
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E {varepsilon}4 and Age at Onset of Sporadic and Familial Alzheimer Disease in Caribbean Hispanics.

L. Olarte, N. Schupf, J. H. Lee, M.-X. Tang, V. Santana, J. Williamson, P. Maramreddy, B. Tycko, and R. Mayeux (2006)
Arch Neurol 63, 1586-1590
 |  Abstract »  |  Full Text »  |  PDF »

Expanded Genomewide Scan Implicates a Novel Locus at 3q28 Among Caribbean Hispanics With Familial Alzheimer Disease.

J. H. Lee, R. Cheng, V. Santana, J. Williamson, R. Lantigua, M. Medrano, A. Arriaga, Y. Stern, B. Tycko, E. Rogaeva, et al. (2006)
Arch Neurol 63, 1591-1598
 |  Abstract »  |  Full Text »  |  PDF »

Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.

J. Padmanabhan, M. Levy, D. W. Dickson, and H. Potter (2006)
Brain 129, 3020-3034
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Abeta Secretion.

M. Hiltunen, A. Lu, A. V. Thomas, D. M. Romano, M. Kim, P. B. Jones, Z. Xie, M. Z. Kounnas, S. L. Wagner, O. Berezovska, et al. (2006)
J. Biol. Chem. 281, 32240-32253
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Mechanisms for cellular cholesterol transport: defects and human disease..

E. Ikonen (2006)
Physiol Rev 86, 1237-1261
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Quantitative MR Imaging in Alzheimer Disease.

A. Ramani, J. H. Jensen, and J. A. Helpern (2006)
Radiology 241, 26-44
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Neuroserpin Binds Abeta and Is a Neuroprotective Component of Amyloid Plaques in Alzheimer Disease.

K. J. Kinghorn, D. C. Crowther, L. K. Sharp, C. Nerelius, R. L. Davis, H. T. Chang, C. Green, D. C. Gubb, J. Johansson, and D. A. Lomas (2006)
J. Biol. Chem. 281, 29268-29277
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Associations between white matter lesions, cerebrovascular risk factors, and low CSF Abeta42..

V. Stenset, L. Johnsen, D. Kocot, A. Negaard, A. Skinningsrud, P. Gulbrandsen, A. Wallin, and T. Fladby (2006)
Neurology 67, 830-833
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Dementia--Epidemiological Considerations, Nomenclature, and a Tacit Consensus Definition.

J. C. S. Breitner (2006)
J Geriatr Psychiatry Neurol 19, 129-136
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Diagnostic Issues in Dementia: Neuroimaging as a Surrogate Marker of Disease.

G. W. Small (2006)
J Geriatr Psychiatry Neurol 19, 180-185
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Genetics and Dementia Nosology.

D. Blacker and S. Lovestone (2006)
J Geriatr Psychiatry Neurol 19, 186-191
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Apolipoprotein E-Derived Peptides Ameliorate Clinical Disability and Inflammatory Infiltrates into the Spinal Cord in a Murine Model of Multiple Sclerosis.

F.-Q. Li, G. D. Sempowski, S. E. McKenna, D. T. Laskowitz, C. A. Colton, and M. P. Vitek (2006)
J. Pharmacol. Exp. Ther. 318, 956-965
 |  Abstract »  |  Full Text »  |  PDF »

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