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Science 6 August 1993:
Vol. 261. no. 5122, pp. 701 - 708
DOI: 10.1126/science.7688141
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Articles

Science, Vol 261, Issue 5122, 701-708
Copyright © 1993 by American Association for the Advancement of Science

articles

Metalloenzymes, structural motifs, and inorganic models

KD Karlin

Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218.

Metalloenzymes effect a variety of important chemical transformations, often involving small molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water. A diverse array of ions or metal clusters is observed at the active-site cores, but living systems use basic recurring structures that have been modified or tuned for specific purposes. Inorganic chemists are actively involved in the elucidation of the structure, spectroscopy, and mechanism of action of these biological catalysts, in part through a synthetic modeling approach involving biomimetic studies.


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