Science 30 July 1993: Vol. 261. no. 5121, pp. 609 - 612 DOI: 10.1126/science.7688139

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Articles

Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.

C Coquerelle, G Oldenhove, V Acolty, J Denoeud, G Vansanten, J-M Verdebout, A Mellor, J A Bluestone, and M Moser (2009)
Gut 58, 1363-1373
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles of CD28- and CD40 Ligand-Mediated Costimulation in the Development of Protective Immunity and Pathology during Chlamydia muridarum Urogenital Infection in Mice.

L. Chen, W. Cheng, P. Shivshankar, L. Lei, X. Zhang, Y. Wu, I-T. Yeh, and G. Zhong (2009)
Infect. Immun. 77, 3080-3089
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Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes.

F. Guimont-Desrochers, C. Beauchamp, G. Chabot-Roy, V. Dugas, E. E. Hillhouse, J. Dusseault, G. Langlois, P. Gautier-Ethier, J. Darwiche, M. Sarfati, et al. (2009)
Int. Immunol. 21, 167-177
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Transcriptional Regulation of Gata3 in T Helper Cells by the Integrated Activities of Transcription Factors Downstream of the Interleukin-4 Receptor and T Cell Receptor.

E. J. Scheinman and O. Avni (2009)
J. Biol. Chem. 284, 3037-3048
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Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice.

S. P. Vagvala, L. G. Thebeau, S. R. Wilson, and L. A. Morrison (2009)
J. Virol. 83, 953-960
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A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine.

Q. Chen, J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper (2008)
J. Immunol. 181, 8258-8266
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Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway.

J. A. Williams, J. M. Lumsden, X. Yu, L. Feigenbaum, J. Zhang, S. M. Steinberg, and R. J. Hodes (2008)
J. Immunol. 181, 907-917
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Spontaneous Development of a Pancreatic Exocrine Disease in CD28-Deficient NOD Mice.

C. Meagher, Q. Tang, B. T. Fife, H. Bour-Jordan, J. Wu, C. Pardoux, M. Bi, K. Melli, and J. A. Bluestone (2008)
J. Immunol. 180, 7793-7803
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A Critical Precursor Frequency of Donor-Reactive CD4+ T Cell Help Is Required for CD8+ T Cell-Mediated CD28/CD154-Independent Rejection.

M. L. Ford, M. E. Wagener, S. S. Hanna, T. C. Pearson, A. D. Kirk, and C. P. Larsen (2008)
J. Immunol. 180, 7203-7211
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Regulation of CD28 expression on CD8+ T cells by CTLA-4.

M. Berg and N. Zavazava (2008)
J. Leukoc. Biol. 83, 853-863
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Antitumor Immune Response by Homeostatic Proliferation and CD28 Signaling.

T. Suzuki, S. Ogawa, K. Tanabe, H. Tahara, R. Abe, and H. Kishimoto (2008)
J. Immunol. 180, 4596-4605
 |  Abstract »  |  Full Text »  |  PDF »

Kinetic and Mechanistic Requirements for Helping CD8 T Cells.

P. Agnellini, M. Wiesel, K. Schwarz, P. Wolint, M. F. Bachmann, and A. Oxenius (2008)
J. Immunol. 180, 1517-1525
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CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

F. Garcon, D. T. Patton, J. L. Emery, E. Hirsch, R. Rottapel, T. Sasaki, and K. Okkenhaug (2008)
Blood 111, 1464-1471
 |  Abstract »  |  Full Text »  |  PDF »

Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response.

S. Fuse, W. Zhang, and E. J. Usherwood (2008)
J. Immunol. 180, 1148-1157
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Deficiency Exacerbates Joint Inflammation upon Borrelia burgdorferi Infection, Resulting in the Development of Chronic Lyme Arthritis.

B. P. Iliopoulou, J. Alroy, and B. T. Huber (2007)
J. Immunol. 179, 8076-8082
 |  Abstract »  |  Full Text »  |  PDF »

B7 Costimulation Molecules Expressed from the Herpes Simplex Virus 2 Genome Rescue Immune Induction in B7-Deficient Mice.

L. G. Thebeau, S. P. Vagvala, Y. M. Wong, and L. A. Morrison (2007)
J. Virol. 81, 12200-12209
 |  Abstract »  |  Full Text »  |  PDF »

Memory CD8+ T Cells Require CD28 Costimulation.

A. B. Borowski, A. C. Boesteanu, Y. M. Mueller, C. Carafides, D. J. Topham, J. D. Altman, S. R. Jennings, and P. D. Katsikis (2007)
J. Immunol. 179, 6494-6503
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of Toxoplasma gondii Antigens via the Endogenous Major Histocompatibility Complex Class I Pathway in Nonprofessional and Professional Antigen-Presenting Cells.

F. Dzierszinski, M. Pepper, J. S. Stumhofer, D. F. LaRosa, E. H. Wilson, L. A. Turka, S. K. Halonen, C. A. Hunter, and D. S. Roos (2007)
Infect. Immun. 75, 5200-5209
 |  Abstract »  |  Full Text »  |  PDF »

Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8+ T Cells.

S. Ronchetti, G. Nocentini, R. Bianchini, L. T. Krausz, G. Migliorati, and C. Riccardi (2007)
J. Immunol. 179, 5916-5926
 |  Abstract »  |  Full Text »  |  PDF »

The B7 Family and Cancer Therapy: Costimulation and Coinhibition.

X. Zang and J. P. Allison (2007)
Clin. Cancer Res. 13, 5271-5279
 |  Abstract »  |  Full Text »  |  PDF »

Differential CD28 and Inducible Costimulatory Molecule Signaling Requirements for Protective CD4+ T-Cell-Mediated Immunity against Genital Tract Chlamydia trachomatis Infection.

E. Marks, M. Verolin, A. Stensson, and N. Lycke (2007)
Infect. Immun. 75, 4638-4647
 |  Abstract »  |  Full Text »  |  PDF »

Induction of autoimmune disease in CTLA-4 / mice depends on a specific CD28 motif that is required for in vivo costimulation.

X. Tai, F. Van Laethem, A. H. Sharpe, and A. Singer (2007)
PNAS 104, 13756-13761
 |  Abstract »  |  Full Text »  |  PDF »

CD86 Regulates IgG1 Production via a CD19-Dependent Mechanism.

N. W. Kin and V. M. Sanders (2007)
J. Immunol. 179, 1516-1523
 |  Abstract »  |  Full Text »  |  PDF »

A Costimulation-Initiated Signaling Pathway Regulates NFATc1 Transcription in T Lymphocytes.

R. I. Nurieva, S. Chuvpilo, E. D. Wieder, K. B. Elkon, R. Locksley, E. Serfling, and C. Dong (2007)
J. Immunol. 179, 1096-1103
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CD28-mediated regulation of multiple myeloma cell proliferation and survival.

N. J. Bahlis, A. M. King, D. Kolonias, L. M. Carlson, H. Y. Liu, M. A. Hussein, H. R. Terebelo, G. E. Byrne Jr, B. L. Levine, L. H. Boise, et al. (2007)
Blood 109, 5002-5010
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection.

H.-P. Raue and M. K. Slifka (2007)
J. Leukoc. Biol. 81, 1165-1175
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Dok-1 and Dok-2 are negative regulators of T cell receptor signaling.

T. Yasuda, K. Bundo, A. Hino, K. Honda, A. Inoue, M. Shirakata, M. Osawa, T. Tamura, H. Nariuchi, H. Oda, et al. (2007)
Int. Immunol. 19, 487-495
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.

A. Souabni, W. Jochum, and M. Busslinger (2007)
Blood 109, 281-289
 |  Abstract »  |  Full Text »  |  PDF »

Direct CD28 Costimulation Is Required for CD8+ T Cell-Mediated Resistance to an Acute Viral Disease in a Natural Host.

M. Fang and L. J. Sigal (2006)
J. Immunol. 177, 8027-8036
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study.

D.S. C. Graham, A.K. Wong, N.J. McHugh, J.C. Whittaker, and T. J. Vyse (2006)
Hum. Mol. Genet. 15, 3195-3205
 |  Abstract »  |  Full Text »  |  PDF »

TcR and TcR-CD28 Engagement of Protein Kinase B (PKB/AKT) and Glycogen Synthase Kinase-3 (GSK-3) Operates Independently of Guanine Nucleotide Exchange Factor VAV-1.

J. E. Wood, H. Schneider, and C. E. Rudd (2006)
J. Biol. Chem. 281, 32385-32394
 |  Abstract »  |  Full Text »  |  PDF »

A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.

L. D. Friend, D. D. Shah, C. Deppong, J. Lin, T. L. Bricker, T. I. Juehne, C. M. Rose, and J. M. Green (2006)
J. Exp. Med. 203, 2121-2133
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for CD70 in CD4+ Th Cell-Dependent and Innate Receptor-Mediated CD8+ T Cell Priming..

V. Y. Taraban, T. F. Rowley, D. F. Tough, and A. Al-Shamkhani (2006)
J. Immunol. 177, 2969-2975
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals.

M. Sun, K. T. Ames, I. Suzuki, and P. J. Fink (2006)
J. Immunol. 177, 1481-1491
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.

A. Nirula, M. Ho, H. Phee, J. Roose, and A. Weiss (2006)
J. Exp. Med. 203, 1733-1744
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Costimulation in the Development of Cardiac Allograft Vasculopathy: Potential Targets for Therapeutic Interventions.

M. Isobe, H. Kosuge, and J.-i. Suzuki (2006)
Arterioscler Thromb Vasc Biol 26, 1447-1456
 |  Abstract »  |  Full Text »  |  PDF »

BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation..

T. Nguyen, X. K. Liu, Y. Zhang, and C. Dong (2006)
J. Immunol. 176, 7354-7360
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28-stimulated CD4+ T cells--II.

S. M. L. Tamma, K. W. Chung, T. Patel, S. P. Balan, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 1339-1347
 |  Abstract »  |  Full Text »  |  PDF »

CD86 Stimulation on a B Cell Activates the Phosphatidylinositol 3-Kinase/Akt and Phospholipase C{gamma}2/Protein Kinase C{alpha}beta Signaling Pathways..

N. W. Kin and V. M. Sanders (2006)
J. Immunol. 176, 6727-6735
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Slc11a1 on the Outcome of Salmonella enterica Serovar Enteritidis Infection in Mice Is Associated with Th Polarization..

J. Caron, L. Lariviere, M. Nacache, M. Tam, M. M. Stevenson, C. McKerly, P. Gros, and D. Malo (2006)
Infect. Immun. 74, 2787-2802
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B-Inducing Kinase Is Involved in the Activation of the CD28 Responsive Element through Phosphorylation of c-Rel and Regulation of Its Transactivating Activity..

C. Sanchez-Valdepenas, A. G. Martin, P. Ramakrishnan, D. Wallach, and M. Fresno (2006)
J. Immunol. 176, 4666-4674
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin plus costimulation with anti-CD28 antibody induces phosphorylation of p38 MAPK and IL-4 synthesis-I.

S. M. L. Tamma, S. P. Balan, K. W. Chung, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 876-880
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: CD28 Controls Dominant Regulatory T Cell Activity during Active Immunization.

C. Lyddane, B. U. Gajewska, E. Santos, P. D. King, G. C. Furtado, and M. Sadelain (2006)
J. Immunol. 176, 3306-3310
 |  Abstract »  |  Full Text »  |  PDF »

Role for the CD28 Molecule in the Control of Coxiella burnetii Infection.

A. Honstettre, S. Meghari, J. A. Nunes, H. Lepidi, D. Raoult, D. Olive, and J.-L. Mege (2006)
Infect. Immun. 74, 1800-1808
 |  Abstract »  |  Full Text »  |  PDF »

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin..

S. Colombetti, V. Basso, D. L. Mueller, and A. Mondino (2006)
J. Immunol. 176, 2730-2738
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection..

K. E. Foulds and H. Shen (2006)
J. Immunol. 176, 3037-3043
 |  Abstract »  |  Full Text »  |  PDF »

Complete differentiation of CD8+ T cells activated locally within the transplanted liver.

I. Klein and I. N. Crispe (2006)
J. Exp. Med. 203, 437-447
 |  Abstract »  |  Full Text »  |  PDF »

Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma.

I. Tirapu, E. Huarte, C. Guiducci, A. Arina, M. Zaratiegui, O. Murillo, A. Gonzalez, C. Berasain, P. Berraondo, P. Fortes, et al. (2006)
Cancer Res. 66, 2442-2450
 |  Abstract »  |  Full Text »  |  PDF »

Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.

K Inagaki-Ohara, A Sasaki, G Matsuzaki, T Ikeda, M Hotokezaka, K Chijiiwa, M Kubo, H Yoshida, Y Nawa, and A Yoshimura (2006)
Gut 55, 212-219
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection.

C. C. Kemball, E. D. H. Lee, E. Szomolanyi-Tsuda, T. C. Pearson, C. P. Larsen, and A. E. Lukacher (2006)
J. Immunol. 176, 1814-1824
 |  Abstract »  |  Full Text »  |  PDF »

Cooperation between 4-1BB and ICOS in the Immune Response to Influenza Virus Revealed by Studies of CD28/ICOS-Deficient Mice.

M. Vidric, W.-K. Suh, U. Dianzani, T. W. Mak, and T. H. Watts (2005)
J. Immunol. 175, 7288-7296
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Is Required for Optimal Induction, but Not Maintenance, of Vaccine-Induced Immunity to Blastomyces dermatitidis.

M. Wuthrich, T. Warner, and B. S. Klein (2005)
Infect. Immun. 73, 7436-7441
 |  Abstract »  |  Full Text »  |  PDF »

Innate signals compensate for the absence of PKC-{theta} during in vivo CD8+ T cell effector and memory responses.

B. J. Marsland, C. Nembrini, N. Schmitz, B. Abel, S. Krautwald, M. F. Bachmann, and M. Kopf (2005)
PNAS 102, 14374-14379
 |  Abstract »  |  Full Text »  |  PDF »

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.

P. Loke, X. Zang, L. Hsuan, R. Waitz, R. M. Locksley, J. E. Allen, and J. P. Allison (2005)
PNAS 102, 9872-9877
 |  Abstract »  |  Full Text »  |  PDF »

ICOS Contributes to T Cell Expansion in CTLA-4 Deficient Mice.

M. E. A. T. van Berkel, E. H. R. Schrijver, F. M. A. Hofhuis, A. H. Sharpe, A. J. Coyle, C. P. Broeren, K. Tesselaar, and M. A. Oosterwegel (2005)
J. Immunol. 175, 182-188
 |  Abstract »  |  Full Text »  |  PDF »

The Antiapoptotic Protein Bcl-xL Is Dispensable for the Development of Effector and Memory T Lymphocytes.

N. Zhang and Y.-W. He (2005)
J. Immunol. 174, 6967-6973
 |  Abstract »  |  Full Text »  |  PDF »

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor.

I. Lee, L. Wang, A. D. Wells, M. E. Dorf, E. Ozkaynak, and W. W. Hancock (2005)
J. Exp. Med. 201, 1037-1044
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Intercellular Adhesion Molecule-1/LFA-1 Interactions in the Generation of Tumor-Specific CD8+ T Cell Responses.

S. R. Jenkinson, N. A. Williams, and D. J. Morgan (2005)
J. Immunol. 174, 3401-3407
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: p27Kip1 Deficiency Reduces the Requirement for CD28-Mediated Costimulation in Naive CD8+ but Not CD4+ T Lymphocytes.

L. A. Wolfraim and J. J. Letterio (2005)
J. Immunol. 174, 2481-2484
 |  Abstract »  |  Full Text »  |  PDF »

T Cells Modulate Neutrophil-Dependent Acute Renal Failure during Endotoxemia: Critical Role for CD28.

K. Singbartl, S. G.{b.}e Bockhorn, A. Zarbock, M. Schmolke, and H. Van Aken (2005)
J. Am. Soc. Nephrol. 16, 720-728
 |  Abstract »  |  Full Text »  |  PDF »

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b.

C. M. Krawczyk, R. G. Jones, A. Atfield, K. Bachmaier, S. Arya, B. Odermatt, P. S. Ohashi, and J. M. Penninger (2005)
J. Immunol. 174, 1472-1478
 |  Abstract »  |  Full Text »  |  PDF »

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator.

L. C. Gonzalez, K. M. Loyet, J. Calemine-Fenaux, V. Chauhan, B. Wranik, W. Ouyang, and D. L. Eaton (2005)
PNAS 102, 1116-1121
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 in Polyclonal and Specific T and B Cell Responses Required for Protection against Blood Stage Malaria.

R. M. Elias, L. R. Sardinha, K. R. B. Bastos, C. A. Zago, A. P. F. da Silva, J. M. Alvarez, and M. R. D. Lima (2005)
J. Immunol. 174, 790-799
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for CD28 May Not Be Absolute for Collagen-Induced Arthritis: Study with HLA-DQ8 Transgenic Mice.

V. Taneja, N. Taneja, M. Behrens, M. M. Griffiths, H. S. Luthra, and C. S. David (2005)
J. Immunol. 174, 1118-1125
 |  Abstract »  |  Full Text »  |  PDF »

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

J. L. Riley and C. H. June (2005)
Blood 105, 13-21
 |  Abstract »  |  Full Text »  |  PDF »

Bystander Activation of CD8+ T Lymphocytes during Experimental Mycobacterial Infection.

B. Gilbertson, S. Germano, P. Steele, S. Turner, B. F. de St. Groth, and C. Cheers (2004)
Infect. Immun. 72, 6884-6891
 |  Abstract »  |  Full Text »  |  PDF »

CD63 as an Activation-Linked T Cell Costimulatory Element.

K. Pfistershammer, O. Majdic, J. Stockl, G. Zlabinger, S. Kirchberger, P. Steinberger, and W. Knapp (2004)
J. Immunol. 173, 6000-6008
 |  Abstract »  |  Full Text »  |  PDF »

Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation.

A. C. Roden, M. T. Moser, S. D. Tri, M. Mercader, S. M. Kuntz, H. Dong, A. A. Hurwitz, D. J. McKean, E. Celis, B. C. Leibovich, et al. (2004)
J. Immunol. 173, 6098-6108
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Th2 and Th1 Lung Inflammatory Responses by Protein Kinase C{theta}.

S. Salek-Ardakani, T. So, B. S. Halteman, A. Altman, and M. Croft (2004)
J. Immunol. 173, 6440-6447
 |  Abstract »  |  Full Text »  |  PDF »

CD28 and Lipid Rafts Coordinate Recruitment of Lck to the Immunological Synapse of Human T Lymphocytes.

R. Tavano, G. Gri, B. Molon, B. Marinari, C. E. Rudd, L. Tuosto, and A. Viola (2004)
J. Immunol. 173, 5392-5397
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Is Required for the Expression of T-Cell-Dependent Cell-Mediated Immunity against Blood-Stage Plasmodium chabaudi Malaria Parasites.

T. Rummel, J. Batchelder, P. Flaherty, G. LaFleur, P. Nanavati, J. M. Burns, and W. P. Weidanz (2004)
Infect. Immun. 72, 5768-5774
 |  Abstract »  |  Full Text »  |  PDF »

B7-CD28 Interaction Promotes Proliferation and Survival but Suppresses Differentiation of CD4-CD8- T Cells in the Thymus.

X. Zheng, J.-X. Gao, X. Chang, Y. Wang, Y. Liu, J. Wen, H. Zhang, J. Zhang, Y. Liu, and P. Zheng (2004)
J. Immunol. 173, 2253-2261
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for CD28 in the Effector Phase of Allergic Airway Inflammation.

S. L. Kimzey, P. Liu, and J. M. Green (2004)
J. Immunol. 173, 632-640
 |  Abstract »  |  Full Text »  |  PDF »

CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation.

Y. Xiao, J. Hendriks, P. Langerak, H. Jacobs, and J. Borst (2004)
J. Immunol. 172, 7432-7441
 |  Abstract »  |  Full Text »  |  PDF »

CD28 disruption exacerbates inflammation in Tgf-{beta}1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-{beta}1.

M. Mamura, W. Lee, T. J. Sullivan, A. Felici, A. L. Sowers, J. P. Allison, and J. J. Letterio (2004)
Blood 103, 4594-4601
 |  Abstract »  |  Full Text »  |  PDF »

CD86 and {beta}2-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding to the 3'-IgH Enhancer in B Cells.

J. R. Podojil, N. W. Kin, and V. M. Sanders (2004)
J. Biol. Chem. 279, 23394-23404
 |  Abstract »  |  Full Text »  |  PDF »

The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28.

W.-K. Suh, A. Tafuri, N. N. Berg-Brown, A. Shahinian, S. Plyte, G. S. Duncan, H. Okada, A. Wakeham, B. Odermatt, P. S. Ohashi, et al. (2004)
J. Immunol. 172, 5917-5923
 |  Abstract »  |  Full Text »  |  PDF »

Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8+ T Cell Effector Function.

A. D. H. Doody, J. T. Kovalchin, M. A. Mihalyo, A. T. Hagymasi, C. G. Drake, and A. J. Adler (2004)
J. Immunol. 172, 6087-6092
 |  Abstract »  |  Full Text »  |  PDF »

Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells.

K. Tokoyoda, K. Tsujikawa, H. Matsushita, Y. Ono, T. Hayashi, Y. Harada, R. Abe, M. Kubo, and H. Yamamoto (2004)
Int. Immunol. 16, 643-653
 |  Abstract »  |  Full Text »  |  PDF »

NTB-A, a New Activating Receptor in T Cells That Regulates Autoimmune Disease.

P. A. Valdez, H. Wang, D. Seshasayee, M. van Lookeren Campagne, A. Gurney, W. P. Lee, and I. S. Grewal (2004)
J. Biol. Chem. 279, 18662-18669
 |  Abstract »  |  Full Text »  |  PDF »

CTLA-4 Blockage Increases Resistance to Infection with the Intracellular Protozoan Trypanosoma cruzi.

G. A. Martins, C. E. Tadokoro, R. B. Silva, J. S. Silva, and L. V. Rizzo (2004)
J. Immunol. 172, 4893-4901
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo.

L. A. Yi, S. Hajialiasgar, and E. Chuang (2004)
Int. Immunol. 16, 539-547
 |  Abstract »  |  Full Text »  |  PDF »

Akt Is a Neutral Amplifier for Th Cell Differentiation.

Y. Arimura, F. Shiroki, S. Kuwahara, H. Kato, U. Dianzani, T. Uchiyama, and J. Yagi (2004)
J. Biol. Chem. 279, 11408-11416
 |  Abstract »  |  Full Text »  |  PDF »

PKC{theta} Signals Activation versus Tolerance In Vivo.

N. N. Berg-Brown, M. A. Gronski, R. G. Jones, A. R. Elford, E. K. Deenick, B. Odermatt, D. R. Littman, and P. S. Ohashi (2004)
J. Exp. Med. 199, 743-752
 |  Abstract »  |  Full Text »  |  PDF »

Myeloid Differentiation Factor 88 Is Required for Cross-Priming In Vivo.

D. Palliser, H. Ploegh, and M. Boes (2004)
J. Immunol. 172, 3415-3421
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Single-Positive Thymocytes to Glucocorticoid-Induced Apoptosis Is Mediated by CD28 Signaling.

J. van den Brandt, D. Wang, and H. M. Reichardt (2004)
Mol. Endocrinol. 18, 687-695
 |  Abstract »  |  Full Text »  |  PDF »

Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.

Y. P. de Jong, S. T. Rietdijk, W. A. Faubion, A. C. Abadia-Molina, K. Clarke, E. Mizoguchi, J. Tian, T. Delaney, S. Manning, J.-C. Gutierrez-Ramos, et al. (2004)
Int. Immunol. 16, 205-213
 |  Abstract »  |  Full Text »  |  PDF »

CD7 and CD28 Are Required for Murine CD4+CD25+ Regulatory T Cell Homeostasis and Prevention of Thyroiditis.

G. D. Sempowski, S. J. Cross, C. S. Heinly, R. M. Scearce, and B. F. Haynes (2004)
J. Immunol. 172, 787-794
 |  Abstract »  |  Full Text »  |  PDF »

Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells.

K. Attanavanich and J. F. Kearney (2004)
J. Immunol. 172, 803-811
 |  Abstract »  |  Full Text »  |  PDF »

A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo.

E. M. Bertram, W. Dawicki, B. Sedgmen, J. L. Bramson, D. H. Lynch, and T. H. Watts (2004)
J. Immunol. 172, 981-988
 |  Abstract »  |  Full Text »  |  PDF »

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells.

J.-X. Gao, X. Liu, J. Wen, M. A. Caligiuri, I. Stroynowski, P. Zheng, and Y. Liu (2003)
Blood 102, 4456-4463
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Peripheral CD4+ T Cell Tolerance Induced by Deletion and TCR Revision.

M. Ali, M. Weinreich, S. Balcaitis, C. J. Cooper, and P. J. Fink (2003)
J. Immunol. 171, 6290-6296
 |  Abstract »  |  Full Text »  |  PDF »

B7h is required for T cell activation, differentiation, and effector function.

R. I. Nurieva, X. M. Mai, K. Forbush, M. J. Bevan, and C. Dong (2003)
PNAS 100, 14163-14168
 |  Abstract »  |  Full Text »  |  PDF »

CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool.

J. Hendriks, Y. Xiao, and J. Borst (2003)
J. Exp. Med. 198, 1369-1380
 |  Abstract »  |  Full Text »  |  PDF »

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