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Science 30 July 1993:
Vol. 261. no. 5121, pp. 605 - 608
DOI: 10.1126/science.8342025
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Articles

Science, Vol 261, Issue 5121, 605-608
Copyright © 1993 by American Association for the Advancement of Science

articles

A detailed genetic map for the X chromosome of the malaria vector, Anopheles gambiae

L Zheng, FH Collins, V Kumar, and FC Kafatos

Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.

Anopheles gambiae, the primary vector of human malaria in Africa, is responsible for approximately a million deaths per year, mostly of children. Despite its significance in disease transmission, this mosquito has not been studied extensively by genetic or molecular techniques. To facilitate studies on this vector, a genetic map has been developed that covers the X chromosome at an average resolution of 2 centimorgans. This map has been integrated with the chromosome banding pattern and used to localize a recessive, sex-linked mutation (white eye) to within 1 centimorgan of flanking markers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Microsatellite Isolation and Linkage Group Identification in the Yellow Fever Mosquito Aedes aegypti.
E. W. Chambers, J. K. Meece, J. A. McGowan, D. D. Lovin, R. R. Hemme, D. D. Chadee, K. McAbee, S. E. Brown, D. L. Knudson, and D. W. Severson (2007)
J. Hered. 98, 202-210
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POPULATION STRUCTURE OF ANOPHELES ARABIENSIS ON LA REUNION ISLAND, INDIAN OCEAN.
I. MORLAIS, R. GIROD, R. HUNT, F. SIMARD, and D. FONTENILLE (2005)
Am J Trop Med Hyg 73, 1077-1082
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Sex-Linked Differentiation Between Incipient Species of Anopheles gambiae.
A. D. Stump, J. A. Shoener, C. Costantini, N. Sagnon, and N. J. Besansky (2005)
Genetics 169, 1509-1519
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A Comparative Genomic Analysis of Two Distant Diptera, the Fruit Fly, Drosophila melanogaster, and the Malaria Mosquito, Anopheles gambiae.
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SSCP Analysis of cDNA Markers Provides a Dense Linkage Map of the Aedes aegypti Genome.
R. E. Fulton, M. L. Salasek, N. M. DuTeau, and W. C. Black , IV (2001)
Genetics 158, 715-726
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Integration of the Aedes aegypti Mosquito Genetic Linkage and Physical Maps.
S. E. Brown, D. W. Severson, L. A. Smith, and D. L. Knudson (2001)
Genetics 157, 1299-1305
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The identification of markers segregating with resistance to Schistosoma mansoni infection in the snail Biomphalaria glabrata.
M. Knight, A. N. Miller, C. N. Patterson, C. G. Rowe, G. Michaels, D. Carr, C. S. Richards, and F. A. Lewis (1999)
PNAS 96, 1510-1515
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Complexities in the genetic structure of Anopheles gambiae populations in west Africa as revealed by microsatellite DNA analysis.
G. C. Lanzaro, Y. T. Toure, J. Carnahan, L. Zheng, G. Dolo, S. Traore, V. Petrarca, K. D. Vernick, and C. E. Taylor (1998)
PNAS 95, 14260-14265
   Abstract »    Full Text »    PDF »
Haldane's Rule in Taxa Lacking a Hemizygous X.
D. C. Presgraves and H. A. Orr (1998)
Science 282, 952-954
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Vector biology and the control of malaria in Africa.
F. Collins and N. Besansky (1994)
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