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Science 23 July 1993:
Vol. 261. no. 5120, pp. 472 - 475
DOI: 10.1126/science.8332913
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Articles

Science, Vol 261, Issue 5120, 472-475
Copyright © 1993 by American Association for the Advancement of Science

articles

Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

F Colotta, F Re, M Muzio, R Bertini, N Polentarutti, M Sironi, JG Giri, SK Dower, JE Sims, and A Mantovani

Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.


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Up-Regulation of CCR2 Chemokine Receptor Expression and Increased Susceptibility to the Multitropic HIV Strain 89.6 in Monocytes Exposed to Glucocorticoid Hormones.
G. Penton-Rol, M. Cota, N. Polentarutti, W. Luini, S. Bernasconi, A. Borsatti, A. Sica, G. J. LaRosa, S. Sozzani, G. Poli, et al. (1999)
J. Immunol. 163, 3524-3529
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Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.
H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly (1999)
PNAS 96, 10800-10805
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Interleukin 15 Induces Endothelial Hyaluronan Expression In Vitro and Promotes Activated T Cell Extravasation through a CD44-dependent Pathway In Vivo.
P. Estess, A. Nandi, M. Mohamadzadeh, and M. H. Siegelman (1999)
J. Exp. Med. 190, 9-20
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Ovarian Interleukin-1 Receptor Antagonist in Rats: Gene Expression, Cellular Localization, Cyclic Variation, and Hormonal Regulation of a Potential Determinant of Interleukin-1 Action.
S. Kol, B. W. Donesky, K. Ruutiainen-Altman, I. Ben-Shlomo, M. Irahara, M. Ando, R. M. Rohan, and E. Y. Adashi (1999)
Biol Reprod 61, 274-282
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Extracellular Regulation of Interleukin (IL)-1beta through Lung Epithelial Cells and Defective IL-1 Type II Receptor Expression.
K. R. Coulter, M. D. Wewers, M. P. Lowe, and D. L. Knoell (1999)
Am. J. Respir. Cell Mol. Biol. 20, 964-975
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Endotoxin-Stimulated Monocytes Release Multiple Forms of IL-1{beta}, Including a ProIL-1{beta} Form Whose Detection Is Affected by Export.
M. D. Wewers2, A. V. Winnard, and H. A. Dare (1999)
J. Immunol. 162, 4858-4863
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Middle Ear Fluid Cytokine and Inflammatory Cell Kinetics in the Chinchilla Otitis Media Model.
K. Sato, C. L. Liebeler, M. K. Quartey, C. T. Le, and G. S. Giebink (1999)
Infect. Immun. 67, 1943-1946
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