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Science 23 July 1993:
Vol. 261. no. 5120, pp. 469 - 472
DOI: 10.1126/science.8332912
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Articles

Science, Vol 261, Issue 5120, 469-472
Copyright © 1993 by American Association for the Advancement of Science

articles

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II

CH Warden, CC Hedrick, JH Qiao, LW Castellani, and AJ Lusis

Department of Medicine, University of California, Los Angeles 90024.

Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.


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Only the Two End Helixes of Eight Tandem Amphipathic Helical Domains of Human Apo A-I Have Significant Lipid Affinity : Implications for HDL Assembly.
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Cholesterol Efflux, Cholesterol Esterification, and Cholesteryl Ester Transfer by LpA-I and LpA-I/A-II in Native Plasma.
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Apolipoprotein A-II Production Rate Is a Major Factor Regulating the Distribution of Apolipoprotein A-I Among HDL Subclasses LpA-I and LpA-I:A-II in Normolipidemic Humans.
K. Ikewaki, L. A. Zech, M. Kindt, H. B. Brewer Jr, and D. J. Rader (1995)
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The Role of Lipoprotein A-I and Lipoprotein A-I/A-II in Predicting Coronary Artery Disease.
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Circulation 91, 521-531
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Apolipoprotein A-II Modulates the Binding and Selective Lipid Uptake of Reconstituted High Density Lipoprotein by Scavenger Receptor BI.
M. C. de Beer, D. M. Durbin, L. Cai, N. Mirocha, A. Jonas, N. R. Webb, F. C. de Beer, and D. R. van der Westhuyzen (2001)
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