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Science 23 July 1993: Vol. 261. no. 5120, pp. 469 - 472 DOI: 10.1126/science.8332912
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Articles
Science, Vol 261, Issue 5120, 469-472
Copyright © 1993 by American Association for the Advancement of Science
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II
CH Warden,
CC Hedrick,
JH Qiao,
LW Castellani,
and
AJ Lusis
Department of Medicine, University of California, Los Angeles 90024.
Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.
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