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Science 16 July 1993:
Vol. 261. no. 5119, pp. 361 - 364
DOI: 10.1126/science.8392750
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Articles

Science, Vol 261, Issue 5119, 361-364
Copyright © 1993 by American Association for the Advancement of Science

articles

Cellular mechanisms of a synchronized oscillation in the thalamus

M von Krosigk, T Bal, and DA McCormick

Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.

Spindle waves are a prototypical example of synchronized oscillations, a common feature of neuronal activity in thalamic and cortical systems in sleeping and waking animals. Spontaneous spindle waves recorded from slices of the ferret lateral geniculate nucleus were generated by rebound burst firing in relay cells. This rebound burst firing resulted from inhibitory postsynaptic potentials arriving from the perigeniculate nucleus, the cells of which were activated by burst firing in relay neurons. Reduction of gamma-aminobutyric acidA (GABAA) receptor-mediated inhibition markedly enhanced GABAB inhibitory postsynaptic potentials in relay cells and subsequently generated a slowed and rhythmic population activity resembling that which occurs during an absence seizure. Pharmacological block of GABAB receptors abolished this seizure-like activity but not normal spindle waves, suggesting that GABAB antagonists may be useful in the treatment of absence seizures.


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N. Hofle, T. Paus, D. Reutens, P. Fiset, J. Gotman, A. C. Evans, and B. E. Jones (1997)
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