Science 16 July 1993: Vol. 261. no. 5119, pp. 358 - 361 DOI: 10.1126/science.8332901

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Articles

Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge.

L. E. Cole, Y. Yang, K. L. Elkins, E. T. Fernandez, N. Qureshi, M. J. Shlomchik, L. A. Herzenberg, L. A. Herzenberg, and S. N. Vogel (2009)
PNAS 106, 4343-4348
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Mice Expressing Dominant-Negative Bright Exhibit Defects in B1 B Cells.

J. C. Nixon, S. Ferrell, C. Miner, A. L. Oldham, U. Hochgeschwender, and C. F. Webb (2008)
J. Immunol. 181, 6913-6922
 |  Abstract »  |  Full Text »  |  PDF »

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.

L. S. Westerberg, M. A. de la Fuente, F. Wermeling, H. D. Ochs, M. C. I. Karlsson, S. B. Snapper, and L. D. Notarangelo (2008)
Blood 112, 4139-4147
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-{kappa}B.

L. Yu, A. J. Mohamed, O. E. Simonson, L. Vargas, K. E. M. Blomberg, B. Bjorkstrand, H. J. Arteaga, B. F. Nore, and C. I. E. Smith (2008)
Blood 111, 4617-4626
 |  Abstract »  |  Full Text »  |  PDF »

The Tec Family Tyrosine Kinase Btk Regulates RANKL-induced Osteoclast Maturation.

S. H. Lee, T. Kim, D. Jeong, N. Kim, and Y. Choi (2008)
J. Biol. Chem. 283, 11526-11534
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor Basal Signaling Regulates Antigen-Induced Ig Light Chain Rearrangements.

B. R. Schram, L. E. Tze, L. B. Ramsey, J. Liu, L. Najera, A. L. Vegoe, R. R. Hardy, K. L. Hippen, M. A. Farrar, and T. W. Behrens (2008)
J. Immunol. 180, 4728-4741
 |  Abstract »  |  Full Text »  |  PDF »

CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleen.

J. C. Rodriguez-Alba, M. E. Moreno-Garcia, C. Sandoval-Montes, V. H. Rosales-Garcia, and L. Santos-Argumedo (2008)
Blood 111, 3644-3652
 |  Abstract »  |  Full Text »  |  PDF »

Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.

M.-F. Roy, N. Riendeau, C. Bedard, P. Helie, G. Min-Oo, K. Turcotte, P. Gros, F. Canonne-Hergaux, and D. Malo (2007)
J. Exp. Med. 204, 2949-2961
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Surrogate Light Chain Expression Induces Developmental Delay in Early B Cell Compartment.

D. A. Martin, L. Lu, M. Cascalho, and G. E. Wu (2007)
J. Immunol. 179, 4996-5005
 |  Abstract »  |  Full Text »  |  PDF »

A Population of CD19highCD45R /lowCD21low B Lymphocytes Poised for Spontaneous Secretion of IgG and IgA Antibodies.

B. de Andres, I. Cortegano, N. Serrano, B. del Rio, P. Martin, P. Gonzalo, M. A. R. Marcos, and M. L. Gaspar (2007)
J. Immunol. 179, 5326-5334
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Mediates NF-{kappa}B Activation and B Cell Survival by B Cell-Activating Factor Receptor of the TNF-R Family.

N. P. Shinners, G. Carlesso, I. Castro, K. L. Hoek, R. A. Corn, R. L. Woodland, M. L. Scott, D. Wang, and W. N. Khan (2007)
J. Immunol. 179, 3872-3880
 |  Abstract »  |  Full Text »  |  PDF »

Differential Association of Phosphatidylinositol 3-Kinase, SHIP-1, and PTEN with Forming Phagosomes.

L. A. Kamen, J. Levinsohn, and J. A. Swanson (2007)
Mol. Biol. Cell 18, 2463-2472
 |  Abstract »  |  Full Text »  |  PDF »

Activation Mechanism and Steady State Kinetics of Bruton's Tyrosine Kinase.

M. Dinh, D. Grunberger, H. Ho, S. Y. Tsing, D. Shaw, S. Lee, J. Barnett, R. J. Hill, D. C. Swinney, and J. M. Bradshaw (2007)
J. Biol. Chem. 282, 8768-8776
 |  Abstract »  |  Full Text »  |  PDF »

Transitional B Cell Fate Is Associated with Developmental Stage-Specific Regulation of Diacylglycerol and Calcium Signaling upon B Cell Receptor Engagement.

K. L. Hoek, P. Antony, J. Lowe, N. Shinners, B. Sarmah, S. R. Wente, D. Wang, R. M. Gerstein, and W. N. Khan (2006)
J. Immunol. 177, 5405-5413
 |  Abstract »  |  Full Text »  |  PDF »

Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.

J. Liu, M. E. Fitzgerald, M. C. Berndt, C. W. Jackson, and T. K. Gartner (2006)
Blood 108, 2596-2603
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1.

L. Yu, A. J. Mohamed, L. Vargas, A. Berglof, G. Finn, K. P. Lu, and C. I. E. Smith (2006)
J. Biol. Chem. 281, 18201-18207
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Immunoglobulin Heavy-Chain Transcription through the Transcription Factor Bright Requires TFII-I.

J. Rajaiya, J. C. Nixon, N. Ayers, Z. P. Desgranges, A. L. Roy, and C. F. Webb (2006)
Mol. Cell. Biol. 26, 4758-4768
 |  Abstract »  |  Full Text »  |  PDF »

MyD88 Adapter-like (Mal) Is Phosphorylated by Bruton's Tyrosine Kinase during TLR2 and TLR4 Signal Transduction.

P. Gray, A. Dunne, C. Brikos, C. A. Jefferies, S. L. Doyle, and L. A. J. O'Neill (2006)
J. Biol. Chem. 281, 10489-10495
 |  Abstract »  |  Full Text »  |  PDF »

Induction of In Vivo Antipolysaccharide Immunoglobulin Responses to Intact Streptococcus pneumoniae Is More Heavily Dependent on Btk-Mediated B-Cell Receptor Signaling than Antiprotein Responses.

A. Q. Khan, G. Sen, S. Guo, O. N. Witte, and C. M. Snapper (2006)
Infect. Immun. 74, 1419-1424
 |  Abstract »  |  Full Text »  |  PDF »

Btk expression is controlled by Oct and BOB.1/OBF.1..

C. Brunner and T. Wirth (2006)
Nucleic Acids Res. 34, 1807-1815
 |  Abstract »  |  Full Text »  |  PDF »

Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.

S. Guo, M. I. Wahl, and O. N. Witte (2006)
Int. Immunol. 18, 79-87
 |  Abstract »  |  Full Text »  |  PDF »

Human single-domain neutralizing intrabodies directed against Etk kinase: a novel approach to impair cellular transformation.

K. Paz, L. A. Brennan, M. Iacolina, J. Doody, Y. R. Hadari, and Z. Zhu (2005)
Mol. Cancer Ther. 4, 1801-1809
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Is Involved in p65-mediated Transactivation and Phosphorylation of p65 on Serine 536 during NF{kappa}B Activation by Lipopolysaccharide.

S. L. Doyle, C. A. Jefferies, and L. A. O'Neill (2005)
J. Biol. Chem. 280, 23496-23501
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Creates an Alternate Pathway for BCR Signaling That Activates I{kappa}B Kinase/I{kappa}B{alpha}/NF-{kappa}B without the Need for PI3K and Phospholipase C{gamma}.

T. Mizuno and T. L. Rothstein (2005)
J. Immunol. 174, 6062-6070
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Regulates Immunoglobulin Promoter Activation in Association with the Transcription Factor Bright.

J. Rajaiya, M. Hatfield, J. C. Nixon, D. J. Rawlings, and C. F. Webb (2005)
Mol. Cell. Biol. 25, 2073-2084
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Marginal Zone B Cell Development in the Mouse with Limited B Cell Diversity: Role of the Antigen Receptor Signals in the Recruitment of B Cells to the Marginal Zone.

N. Kanayama, M. Cascalho, and H. Ohmori (2005)
J. Immunol. 174, 1438-1445
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the DNA-binding Domain of the Transcription Factor Bright Act as Dominant Negative Proteins and Interfere with Immunoglobulin Transactivation.

J. C. Nixon, J. Rajaiya, and C. F. Webb (2004)
J. Biol. Chem. 279, 52465-52472
 |  Abstract »  |  Full Text »  |  PDF »

Bi-directional Regulation between Tyrosine Kinase Etk/BMX and Tumor Suppressor p53 in Response to DNA Damage.

T. Jiang, Z. Guo, B. Dai, M. Kang, D. K. Ann, H.-J. Kung, and Y. Qiu (2004)
J. Biol. Chem. 279, 50181-50189
 |  Abstract »  |  Full Text »  |  PDF »

Selective Gene Expression in Multigene Families from Yeast to Mammals.

J. Z. Dalgaard and S. Vengrova (2004)
Sci. STKE 2004, re17
 |  Abstract »  |  Full Text »  |  PDF »

Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization.

T. L. McCool and J. N. Weiser (2004)
Infect. Immun. 72, 5807-5813
 |  Abstract »  |  Full Text »  |  PDF »

The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane.

M. E. K. Olsten, D. A. Canton, C. Zhang, P. A. Walton, and D. W. Litchfield (2004)
J. Biol. Chem. 279, 42114-42127
 |  Abstract »  |  Full Text »  |  PDF »

A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-{gamma} activation.

S. Guo, G. Z. Ferl, R. Deora, M. Riedinger, S. Yin, J. L. Kerwin, J. A. Loo, and O. N. Witte (2004)
PNAS 101, 14180-14185
 |  Abstract »  |  Full Text »  |  PDF »

The Adaptor Protein Bam32 Regulates Rac1 Activation and Actin Remodeling through a Phosphorylation-dependent Mechanism.

A. Allam, H. Niiro, E. A. Clark, and A. J. Marshall (2004)
J. Biol. Chem. 279, 39775-39782
 |  Abstract »  |  Full Text »  |  PDF »

Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.

P. W. Yu, R. S. Tabuchi, R. M. Kato, A. Astrakhan, S. Humblet-Baron, K. Kipp, K. Chae, W. Ellmeier, O. N. Witte, and D. J. Rawlings (2004)
Blood 104, 1281-1290
 |  Abstract »  |  Full Text »  |  PDF »

Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses.

A. Mangla, A. Khare, V. Vineeth, N. N. Panday, A. Mukhopadhyay, B. Ravindran, V. Bal, A. George, and S. Rath (2004)
Blood 104, 1191-1197
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced T Cell Proliferation in Mice Lacking the p85{beta} Subunit of Phosphoinositide 3-Kinase.

J. A. Deane, M. J. Trifilo, C. M. Yballe, S. Choi, T. E. Lane, and D. A. Fruman (2004)
J. Immunol. 172, 6615-6625
 |  Abstract »  |  Full Text »  |  PDF »

IL-9-Induced Expansion of B-1b Cells Restores Numbers but Not Function of B-1 Lymphocytes in xid Mice.

L. Knoops, J. Louahed, and J.-C. Renauld (2004)
J. Immunol. 172, 6101-6106
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes.

M. Hirano, Y. Kikuchi, S. Nisitani, A. Yamaguchi, A. Satoh, T. Ito, H. Iba, and K. Takatsu (2004)
Int. Immunol. 16, 747-757
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Bruton's Tyrosine Kinase-mediated Recruitment and Regulation of TFII-I.

C. Sacristan, M. I. Tussie-Luna, S. M. Logan, and A. L. Roy (2004)
J. Biol. Chem. 279, 7147-7158
 |  Abstract »  |  Full Text »  |  PDF »

Salmonella typhimurium Persists within Macrophages in the Mesenteric Lymph Nodes of Chronically Infected Nramp1+/+ Mice and Can Be Reactivated by IFN{gamma} Neutralization.

D. M. Monack, D. M. Bouley, and S. Falkow (2004)
J. Exp. Med. 199, 231-241
 |  Abstract »  |  Full Text »  |  PDF »

Function of Bruton's Tyrosine Kinase during B Cell Development Is Partially Independent of Its Catalytic Activity.

S. Middendorp, G. M. Dingjan, A. Maas, K. Dahlenborg, and R. W. Hendriks (2003)
J. Immunol. 171, 5988-5996
 |  Abstract »  |  Full Text »  |  PDF »

Tec regulates platelet activation by GPVI in the absence of Btk.

B. T. Atkinson, W. Ellmeier, and S. P. Watson (2003)
Blood 102, 3592-3599
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Dosage of Bruton's Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn-/- Mice.

L. R. Whyburn, K. E. Halcomb, C. M. Contreras, C. A. Lowell, O. N. Witte, and A. B. Satterthwaite (2003)
J. Immunol. 171, 1850-1858
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Is a Toll/Interleukin-1 Receptor Domain-binding Protein That Participates in Nuclear Factor {kappa}B Activation by Toll-like Receptor 4.

C. A. Jefferies, S. Doyle, C. Brunner, A. Dunne, E. Brint, C. Wietek, E. Walch, T. Wirth, and L. A. J. O'Neill (2003)
J. Biol. Chem. 278, 26258-26264
 |  Abstract »  |  Full Text »  |  PDF »

GENETICALLY ALTERED MOUSE MODELS: THE GOOD, THE BAD, AND THE UGLY.

T. Thyagarajan, S. Totey, M. J. S. Danton, and A. B. Kulkarni (2003)
Critical Reviews in Oral Biology & Medicine 14, 154-174
 |  Abstract »  |  Full Text »  |  PDF »

Estradiol Rapidly Activates Akt via the ErbB2 Signaling Pathway.

G. E. Stoica, T. F. Franke, A. Wellstein, F. Czubayko, H.-J. List, R. Reiter, E. Morgan, M. B. Martin, and A. Stoica (2003)
Mol. Endocrinol. 17, 818-830
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: CD40 Engagement Eliminates the Need for Bruton's Tyrosine Kinase in B Cell Receptor Signaling for NF-{kappa}B.

T. Mizuno and T. L. Rothstein (2003)
J. Immunol. 170, 2806-2810
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase.

L. R. Whyburn, K. E. Halcomb, C. M. Contreras, R. Pappu, O. N. Witte, A. C. Chan, and A. B. Satterthwaite (2003)
Int. Immunol. 15, 383-392
 |  Abstract »  |  Full Text »  |  PDF »

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110{delta} in Signaling by the B-Cell Receptor Complex.

S.-T. Jou, N. Carpino, Y. Takahashi, R. Piekorz, J.-R. Chao, N. Carpino, D. Wang, and J. N. Ihle (2002)
Mol. Cell. Biol. 22, 8580-8591
 |  Abstract »  |  Full Text »  |  PDF »

Transitional Type 1 and 2 B Lymphocyte Subsets Are Differentially Responsive to Antigen Receptor Signaling.

J. B. Petro, R. M. Gerstein, J. Lowe, R. S. Carter, N. Shinners, and W. N. Khan (2002)
J. Biol. Chem. 277, 48009-48019
 |  Abstract »  |  Full Text »  |  PDF »

Complementary Roles for CD19 and Bruton's Tyrosine Kinase in B Lymphocyte Signal Transduction.

M. Fujimoto, J. C. Poe, A. B. Satterthwaite, M. I. Wahl, O. N. Witte, and T. F. Tedder (2002)
J. Immunol. 168, 5465-5476
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}3 Gene-Disrupted Mice Selectively Deficient in the Dominant IgG Subclass Made to Bacterial Polysaccharides. II. Increased Susceptibility to Fatal Pneumococcal Sepsis Due to Absence of Anti-Polysaccharide IgG3 Is Corrected by Induction of Anti-Polysaccharide IgG1.

J. McLay, E. Leonard, S. Petersen, D. Shapiro, N. S. Greenspan, and J. R. Schreiber (2002)
J. Immunol. 168, 3437-3443
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Precursor B Cell Differentiation in Bruton's Tyrosine Kinase-Deficient Mice.

S. Middendorp, G. M. Dingjan, and R. W. Hendriks (2002)
J. Immunol. 168, 2695-2703
 |  Abstract »  |  Full Text »  |  PDF »

BCR Engagement Induces Fas Resistance in Primary B Cells in the Absence of Functional Bruton's Tyrosine Kinase.

J. R. Tumang, R. S. Negm, L. A. Solt, T. J. Schneider, T. P. Colarusso, W. D. Hastings, R. T. Woodland, and T. L. Rothstein (2002)
J. Immunol. 168, 2712-2719
 |  Abstract »  |  Full Text »  |  PDF »

Functional Interaction of Caveolin-1 with Bruton's Tyrosine Kinase and Bmx.

L. Vargas, B. F. Nore, A. Berglof, J. E. Heinonen, P. T. Mattsson, C. I. E. Smith, and A. J. Mohamed (2002)
J. Biol. Chem. 277, 9351-9357
 |  Abstract »  |  Full Text »  |  PDF »

The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion.

W. Gao, H. H. Wortis, and M. A. Pereira (2002)
Int. Immunol. 14, 299-308
 |  Abstract »  |  Full Text »  |  PDF »

Transitional B Lymphocyte Subsets Operate as Distinct Checkpoints in Murine Splenic B Cell Development.

T. T. Su and D. J. Rawlings (2002)
J. Immunol. 168, 2101-2110
 |  Abstract »  |  Full Text »  |  PDF »

Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase.

A. T. Miller and L. J. Berg (2002)
J. Immunol. 168, 2163-2172
 |  Abstract »  |  Full Text »  |  PDF »

Significant Differences Between Mouse and Human Trophinins Are Revealed by Their Expression Patterns and Targeted Disruption of Mouse Trophinin Gene.

D. Nadano, K. Sugihara, B. C. Paria, S. Saburi, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, J. Nakayama, and M. N. Fukuda (2002)
Biol Reprod 66, 313-321
 |  Abstract »  |  Full Text »  |  PDF »

xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development.

M. P. Cancro, A. P. Sah, S. L. Levy, D. M. Allman, M. R. Schmidt, and R. T. Woodland (2001)
Int. Immunol. 13, 1501-1514
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-{{kappa}}B activation in primary B cells.

H. Bone and N. A. Williams (2001)
Int. Immunol. 13, 807-816
 |  Abstract »  |  Full Text »  |  PDF »

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain.

W.-C. Yang, K. A. Ching, C. D. Tsoukas, and L. J. Berg (2001)
J. Immunol. 166, 387-395
 |  Abstract »  |  Full Text »  |  PDF »

The Transcription Factor Bright Associates with Bruton's Tyrosine Kinase, the Defective Protein in Immunodeficiency Disease.

C. F. Webb, Y. Yamashita, N. Ayers, S. Evetts, Y. Paulin, M. E. Conley, and E. A. Smith (2000)
J. Immunol. 165, 6956-6965
 |  Abstract »  |  Full Text »  |  PDF »

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk.

W. Ellmeier, S. Jung, M. J. Sunshine, F. Hatam, Y. Xu, D. Baltimore, H. Mano, and D. R. Littman (2000)
J. Exp. Med. 192, 1611-1624
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk.

Y. Kikuchi, M. Hirano, M. Seto, and K. Takatsu (2000)
Int. Immunol. 12, 1397-1408
 |  Abstract »  |  Full Text »  |  PDF »

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation.

Y. Kawakami, J. Kitaura, A. B. Satterthwaite, R. M. Kato, K. Asai, S. E. Hartman, M. Maeda-Yamamoto, C. A. Lowell, D. J. Rawlings, O. N. Witte, et al. (2000)
J. Immunol. 165, 1210-1219
 |  Abstract »  |  Full Text »  |  PDF »

Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.

K. Nomura, H. Kanegane, H. Karasuyama, S. Tsukada, K. Agematsu, G. Murakami, S. Sakazume, M. Sako, R. Tanaka, Y. Kuniya, et al. (2000)
Blood 96, 610-617
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Inositol, LiCl, and Heparin on the Antibody Responses to SRBC by Normal and Immunodeficient XID Mice.

M. L. Tyan (2000)
Experimental Biology and Medicine 224, 187-190
 |  Abstract »  |  Full Text »

Bruton's Tyrosine Kinase Is Required for Activation of I{kappa}b Kinase and Nuclear Factor {kappa}b in Response to B Cell Receptor Engagement.

J. B. Petro, S.M. J. Rahman, D. W. Ballard, and W. N. Khan (2000)
J. Exp. Med. 191, 1745-1754
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor {kappa}b Activation.

U. D. Bajpai, K. Zhang, M. Teutsch, R. Sen, and H. H. Wortis (2000)
J. Exp. Med. 191, 1735-1744
 |  Abstract »  |  Full Text »  |  PDF »

A Novel B Lymphocyte-Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase.

A. J. Marshall, H. Niiro, C. G. Lerner, T. J. Yun, S. Thomas, C. M. Disteche, and E. A. Clark (2000)
J. Exp. Med. 191, 1319-1332
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Precursor to Phosphatidyl Choline-Specific B-1 Cells Suggesting That B-1 Cells Differentiate from Splenic Conventional B Cells In Vivo: Cyclosporin A Blocks Differentiation to B-1.

L. W. Arnold, S. K. McCray, C. Tatu, and S. H. Clarke (2000)
J. Immunol. 164, 2924-2930
 |  Abstract »  |  Full Text »  |  PDF »

A Phenotype Map of the Mouse X Chromosome: Models for Human X-linked Disease.

Y. Boyd, H. J. Blair, P. Cunliffe, W. K. Masson, and V. Reed (2000)
Genome Res. 10, 277-292
 |  Abstract »  |  Full Text »

Impaired Kit- but Not Fcepsilon RI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85alpha Gene Products.

J. M. Lu-Kuo, D. A. Fruman, D. M. Joyal, L. C. Cantley, and H. R. Katz (2000)
J. Biol. Chem. 275, 6022-6029
 |  Abstract »  |  Full Text »  |  PDF »

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells.

H. Schneider, B. Guerette, C. Guntermann, and C. E. Rudd (2000)
J. Biol. Chem. 275, 3835-3840
 |  Abstract »  |  Full Text »  |  PDF »

Similarities in Function and Gene Structure of Cytohesin-4 and Cytohesin-1, Guanine Nucleotide-exchange Proteins for ADP-ribosylation Factors.

M. Ogasawara, S.-C. Kim, R. Adamik, A. Togawa, V. J. Ferrans, K. Takeda, M. Kirby, J. Moss, and M. Vaughan (2000)
J. Biol. Chem. 275, 3221-3230
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade.

S. C. Bunnell, M. Diehn, M. B. Yaffe, P. R. Findell, L. C. Cantley, and L. J. Berg (2000)
J. Biol. Chem. 275, 2219-2230
 |  Abstract »  |  Full Text »  |  PDF »

Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells.

X. Wen, H. H. Lin, H.-M. Shih, H.-J. Kung, and D. K. Ann (1999)
J. Biol. Chem. 274, 38204-38210
 |  Abstract »  |  Full Text »  |  PDF »

IL-5 and Rp105 Signaling Defects in B Cells from Commonly Used 129 Mouse Substrains.

L. M. Corcoran and D. Metcalf (1999)
J. Immunol. 163, 5836-5842
 |  Abstract »  |  Full Text »  |  PDF »

Emt/Itk Associates with Activated TCR Complexes: Role of the Pleckstrin Homology Domain.

K. A. Ching, Y. Kawakami, T. Kawakami, and C. D. Tsoukas (1999)
J. Immunol. 163, 6006-6013
 |  Abstract »  |  Full Text »  |  PDF »

Correction of X-Linked Immunodeficient Mice by Competitive Reconstitution With Limiting Numbers of Normal Bone Marrow Cells.

J. Rohrer and M. E. Conley (1999)
Blood 94, 3358-3365
 |  Abstract »  |  Full Text »  |  PDF »

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment.

X. Shan and R. L. Wange (1999)
J. Biol. Chem. 274, 29323-29330
 |  Abstract »  |  Full Text »  |  PDF »

Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity.

C. Tatu, J. Ye, L. W. Arnold, and S. H. Clarke (1999)
J. Exp. Med. 190, 903-914
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the SH2 Domain Binding Protein of Bruton's Tyrosine Kinase as BLNK---Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling.

S. Hashimoto, A. Iwamatsu, M. Ishiai, K. Okawa, T. Yamadori, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada (1999)
Blood 94, 2357-2364
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase Deficiency in Macrophages Inhibits Nitric Oxide Generation Leading to Enhancement of IL-12 Induction.

S. Mukhopadhyay, A. George, V. Bal, B. Ravindran, and S. Rath (1999)
J. Immunol. 163, 1786-1792
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton's Tyrosine Kinase.

C. D. Novina, S. Kumar, U. Bajpai, V. Cheriyath, K. Zhang, S. Pillai, H. H. Wortis, and A. L. Roy (1999)
Mol. Cell. Biol. 19, 5014-5024
 |  Abstract »  |  Full Text »  |  PDF »

BALB/c.CBA/N mice carrying the defective Btkxid gene are resistant to pristane-induced plasmacytomagenesis.

M. Potter, J. S. Wax, C. T. Hansen, and J. J. Kenny (1999)
Int. Immunol. 11, 1059-1064
 |  Abstract »  |  Full Text »  |  PDF »

Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.

A. M. Wallace, B. Dass, S. E. Ravnik, V. Tonk, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and C. C. MacDonald (1999)
PNAS 96, 6763-6768
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.

T. Yamadori, Y. Baba, M. Matsushita, S. Hashimoto, M. Kurosaki, T. Kurosaki, T. Kishimoto, and S. Tsukada (1999)
PNAS 96, 6341-6346
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton's Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells.

P. Varnai, K. I. Rother, and T. Balla (1999)
J. Biol. Chem. 274, 10983-10989
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton's Tyrosine Kinase.

A. M. Buhl and J. C. Cambier (1999)
J. Immunol. 162, 4438-4446
 |  Abstract »  |  Full Text »  |  PDF »

Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK), LFM-A13 [alpha -Cyano-beta -Hydroxy-beta -Methyl-N-(2,5-Dibromophenyl)Propenamide].

S. Mahajan, S. Ghosh, E. A. Sudbeck, Y. Zheng, S. Downs, M. Hupke, and F. M. Uckun (1999)
J. Biol. Chem. 274, 9587-9599
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway.

Y. Baba, S. Nonoyama, M. Matsushita, T. Yamadori, S. Hashimoto, K. Imai, S. Arai, T. Kunikata, M. Kurimoto, T. Kurosaki, et al. (1999)
Blood 93, 2003-2012
 |  Abstract »  |  Full Text »  |  PDF »

Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.

Y. Kawakami, S. E. Hartman, E. Kinoshita, H. Suzuki, J. Kitaura, L. Yao, N. Inagaki, A. Franco, D. Hata, M. Maeda-Yamamoto, et al. (1999)
PNAS 96, 2227-2232
 |  Abstract »  |  Full Text »  |  PDF »

Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene.

V. R. Fantin, B. E. Lavan, Q. Wang, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, S. R. Keller, and G. E. Lienhard (1999)
Endocrinology 140, 1329-1337
 |  Abstract »  |  Full Text »

Cellular and Molecular Characterization of the scurfy Mouse Mutant.

L. B. Clark, M. W. Appleby, M. E. Brunkow, J. E. Wilkinson, S. F. Ziegler, and F. Ramsdell (1999)
J. Immunol. 162, 2546-2554
 |  Abstract »  |  Full Text »  |  PDF »

Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling.

Y. Banu and T. Watanabe (1999)
J. Exp. Med. 189, 673-682
 |  Abstract »  |  Full Text »  |  PDF »

Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex.

A. Vassilev, Z. Ozer, C. Navara, S. Mahajan, and F. M. Uckun (1999)
J. Biol. Chem. 274, 1646-1656
 |  Abstract »  |  Full Text »  |  PDF »

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