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Science 16 July 1993:
Vol. 261. no. 5119, pp. 358 - 361
DOI: 10.1126/science.8332901
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Articles

Science, Vol 261, Issue 5119, 358-361
Copyright © 1993 by American Association for the Advancement of Science

articles

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

DJ Rawlings, DC Saffran, S Tsukada, DA Largaespada, JC Grimaldi, L Cohen, RN Mohr, JF Bazan, M Howard, NG Copeland, and al. et

Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024.

The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.


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J. Biol. Chem. 274, 29323-29330
   Abstract »    Full Text »    PDF »
Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity.
C. Tatu, J. Ye, L. W. Arnold, and S. H. Clarke (1999)
J. Exp. Med. 190, 903-914
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Identification of the SH2 Domain Binding Protein of Bruton's Tyrosine Kinase as BLNK---Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling.
S. Hashimoto, A. Iwamatsu, M. Ishiai, K. Okawa, T. Yamadori, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada (1999)
Blood 94, 2357-2364
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Bruton's Tyrosine Kinase Deficiency in Macrophages Inhibits Nitric Oxide Generation Leading to Enhancement of IL-12 Induction.
S. Mukhopadhyay, A. George, V. Bal, B. Ravindran, and S. Rath (1999)
J. Immunol. 163, 1786-1792
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Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton's Tyrosine Kinase.
C. D. Novina, S. Kumar, U. Bajpai, V. Cheriyath, K. Zhang, S. Pillai, H. H. Wortis, and A. L. Roy (1999)
Mol. Cell. Biol. 19, 5014-5024
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BALB/c.CBA/N mice carrying the defective Btkxid gene are resistant to pristane-induced plasmacytomagenesis.
M. Potter, J. S. Wax, C. T. Hansen, and J. J. Kenny (1999)
Int. Immunol. 11, 1059-1064