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Science 16 July 1993:
Vol. 261. no. 5119, pp. 355 - 358
DOI: 10.1126/science.8332900
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Articles

Science, Vol 261, Issue 5119, 355-358
Copyright © 1993 by American Association for the Advancement of Science

articles

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

JD Thomas, P Sideras, CI Smith, I Vorechovsky, V Chapman, and WE Paul

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114 progeny revealed the colocalization of xid with Bruton's agammaglobulinemia tyrosine kinase (btk) gene, which is implicated in the human immune deficiency, X-linked agammaglobulinemia. Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk. Because this region of Btk lies outside any obvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function.


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B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–derived Signals.
F. Loder, B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti (1999)
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Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton's Tyrosine Kinase.
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Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton's Tyrosine Kinase.
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Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway.
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   Abstract »    Full Text »    PDF »
{gamma}3 Gene-Disrupted Mice Selectively Deficient in the Dominant IgG Subclass Made to Bacterial Polysaccharides Undergo Normal Isotype Switching After Immunization with Polysaccharide-Protein Conjugate Vaccines.
D. A. Shapiro, D. S. Threadgill, M. J. Copfer, D. A. Corey, T. L. McCool, L. L. McCormick, T. R. Magnuson, N. S. Greenspan, and J. R. Schreiber (1998)
J. Immunol. 161, 3393-3399
   Abstract »    Full Text »    PDF »
Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways.
A. B. Satterthwaite, C. A. Lowell, W. N. Khan, P. Sideras, F. W. Alt, and O. N. Witte (1998)
J. Exp. Med. 188, 833-844
   Abstract »    Full Text »    PDF »
The mechanism of IL-5 signal transduction.
T. Adachi and R. Alam (1998)
Am J Physiol Cell Physiol 275, C623-C633
   Abstract »    Full Text »    PDF »
Involvement of Ras in Bruton's Tyrosine Kinase-mediated JNK Activation.
J. Deng, Y. Kawakami, S. E. Hartman, T. Satoh, and T. Kawakami (1998)
J. Biol. Chem. 273, 16787-16791
   Abstract »    Full Text »    PDF »
T Cell Receptor-initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells.
K.-Q. Liu, S. C. Bunnell, C. B. Gurniak, and L. J. Berg (1998)
J. Exp. Med. 187, 1721-1727
   Abstract »    Full Text »    PDF »
Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY.
D. Hata, J. Kitaura, S. E. Hartman, Y. Kawakami, T. Yokota, and T. Kawakami (1998)
J. Biol. Chem. 273, 10979-10987
   Abstract »    Full Text »    PDF »
Involvement of Bruton's Tyrosine Kinase in Fcepsilon RI-dependent Mast Cell Degranulation and Cytokine Production.
D. Hata, Y. Kawakami, N. Inagaki, C. S. Lantz, T. Kitamura, W. N. Khan, M. Maeda-Yamamoto, T. Miura, W. Han, S. E. Hartman, et al. (1998)
J. Exp. Med. 187, 1235-1247
   Abstract »    Full Text »    PDF »
B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation.
S. H. Clarke and L. W. Arnold (1998)
J. Exp. Med. 187, 1325-1334
   Abstract »    Full Text »    PDF »
Activation of Lyn, Blk, and Btk But Not Syk in CD72-Stimulated B Lymphocytes.
C. Venkataraman, N. Muthusamy, S. Muthukkumar, and S. Bondada (1998)
J. Immunol. 160, 3322-3329
   Abstract »    Full Text »    PDF »
Expression and Activation of the Nonreceptor Tyrosine Kinase Tec in Human B Cells.
A. Kitanaka, H. Mano, M. Ellen Conley, and D. Campana (1998)
Blood 91, 940-948
   Abstract »    Full Text »    PDF »
Protein Kinase D Activation by Mutations within Its Pleckstrin Homology Domain.
T. Iglesias and E. Rozengurt (1998)
J. Biol. Chem. 273, 410-416
   Abstract »    Full Text »    PDF »
Transcriptional Regulatory Elements Within the First Intron of Bruton's Tyrosine Kinase.
J. Rohrer and M. Ellen Conley (1998)
Blood 91, 214-221
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.
Z. Li, M. I. Wahl, A. Eguinoa, L. R. Stephens, P. T. Hawkins, and O. N. Witte (1997)
PNAS 94, 13820-13825
   Abstract »    Full Text »    PDF »
Btk dosage determines sensitivity to B cell antigen receptor cross-linking.
A. B. Satterthwaite, H. Cheroutre, W. N. Khan, P. Sideras, and O. N. Witte (1997)
PNAS 94, 13152-13157
   Abstract »    Full Text »    PDF »
Identification of Two Tyrosine Phosphoproteins, pp70 and pp68, Which Interact with Phospholipase Cgamma , Grb2, and Vav after B Cell Antigen Receptor Activation.
C. Fu and A. C. Chan (1997)
J. Biol. Chem. 272, 27362-27368
   Abstract »    Full Text »    PDF »
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase.
A. August, A. Sadra, B. Dupont, and H. Hanafusa (1997)
PNAS 94, 11227-11232
   Abstract »    Full Text »    PDF »
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
M. I. Wahl, A.-C. Fluckiger, R. M. Kato, H. Park, O. N. Witte, and D. J. Rawlings (1997)
PNAS 94, 11526-11533
   Abstract »    Full Text »    PDF »


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