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Science 16 July 1993:
Vol. 261. no. 5119, pp. 345 - 348
DOI: 10.1126/science.8332899

Articles

Science, Vol 261, Issue 5119, 345-348
Copyright © 1993 by American Association for the Advancement of Science


articles

Induction of apoptosis by the low-affinity NGF receptor

S Rabizadeh, J Oh, LT Zhong, J Yang, CM Bitler, LL Butcher, and DE Bredesen

Department of Neurology, University of California, Los Angeles 90024.

Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to TrkA, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75NGFR, remains uncertain. Expression of p75NGFR induced neural cell death constitutively when p75NGFR was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75NGFR. Thus, expression of p75NGFR may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75NGFR has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.


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p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure.
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Overlapping and Divergent Actions of Estrogen and the Neurotrophins on Cell Fate and p53-Dependent Signal Transduction in Conditionally Immortalized Cerebral Cortical Neuroblasts.
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The p75NTR-induced Apoptotic Program Develops through a Ceramide-Caspase Pathway Negatively Regulated by Nitric Oxide.
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Oligodendrocyte Apoptosis Mediated by Caspase Activation.
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Neural cell surface differentiation antigen gp130RB13-6 induces fibroblasts and glioma cells to express astroglial proteins and invasive properties.
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Regulation of Neurotrophin Receptor Expression by Retinoic Acid in Mouse Sympathetic Neuroblasts.
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Expression of Neurotrophins and their Receptors in Human Bone Marrow.
E. Labouyrie, P. Dubus, A. Groppi, F. X. Mahon, J. Ferrer, M. Parrens, J. Reiffers, A. de Mascarel, and J. P. Merlio (1999)
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Association of the p75 Neurotrophin Receptor with TRAF6.
G. Khursigara, J. R. Orlinick, and M. V. Chao (1999)
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Multiple Pathways of Apoptosis in PC12 Cells. CrmA INHIBITS APOPTOSIS INDUCED BY beta -AMYLOID.
K. J. Ivins, J. K. Ivins, J. P. Sharp, and C. W. Cotman (1999)
J. Biol. Chem. 274, 2107-2112
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P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors.
R. S. Aloyz, S. X. Bamji, C. D. Pozniak, J. G. Toma, J. Atwal, D. R. Kaplan, and F. D. Miller (1998)
J. Cell Biol. 143, 1691-1703
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A Critical Role of the p75 Tumor Necrosis Factor Receptor (p75TNF-R) in Organ Inflammation Independent of  TNF, Lymphotoxin alpha , or the p55TNF-R.
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J. Exp. Med. 188, 1343-1352
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Cell Cycle Phase-Specific Surface Expression of Nerve Growth Factor Receptors TrkA and p75NTR.
J. L. Urdiales, E. Becker, M. Andrieu, A. Thomas, J. Jullien, L. A. van Grunsven, S. Menut, G. I. Evan, D. Martin-Zanca, and B. B. Rudkin (1998)
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Axotomy Upregulates the Anterograde Transport and Expression of Brain-Derived Neurotrophic Factor by Sensory Neurons.
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J. Neurosci. 18, 4374-4383
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Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival.
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J. Neurosci. 18, 3273-3281
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The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death.
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J. Cell Biol. 140, 911-923
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A Second Determinant of Binding to the p75 Neurotrophin Receptor Revealed by Alanine-scanning Mutagenesis of a Conserved Loop in Nerve Growth Factor.
M. Ryden and C. F. Ibanez (1997)
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Absence of p75NTR Causes Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation.
T. T. Yeo, J. Chua-Couzens, L. L. Butcher, D. E. Bredesen, J. D. Cooper, J. S. Valletta, W. C. Mobley, and F. M. Longo (1997)
J. Neurosci. 17, 7594-7605
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J. Neurosci. 17, 7644-7654
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J. Neurosci. 17, 6952-6960
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Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor.
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Neurotrophins Protect Cultured Cerebellar Granule Neurons against the Early Phase of Cell Death by a TwoComponent Mechanism.
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Tyrosine Kinase Receptors Concentrated in Caveolae-like Domains from Neuronal Plasma Membrane.
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Nerve Growth Factor and Neurotrophin-3 Differentially Regulate the Proliferation and Survival of Developing Rat Brain Oligodendrocytes.
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Nerve Growth Factor (NGF)-Mediated Protection of Neural Crest Cells from Antimitotic Agent-Induced Apoptosis: The Role of the Low-Affinity NGF Receptor.
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REVIEW {blacksquare} : Keeping Neurons Alive: The Molecular Control of Apoptosis (Part I.
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Retrograde Transport of Neurotrophins from the Eye to the Brain in Chick Embryos: Roles of the p75NTR and trkB Receptors.
C. S. von Bartheld, R. Williams, F. Lefcort, D. O. Clary, L. F. Reichardt, and M. Bothwell (1996)
J. Neurosci. 16, 2995-3008
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The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo.
S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim (1996)
Development 122, 715-724
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis.
Z. Xia, M. Dickens, J.ėl Raingeaud, R. J. Davis, and M. E. Greenberg (1995)
Science 270, 1326-1331
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Neurotrophic Factor Protection against Excitotoxic Neuronal Death.
S. B. Tatter, W. R. Galpern, and O. Isacson (1995)
Neuroscientist 1, 286-297
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Structural Determinants of Neurotrophin Action.
N. Q. McDonald and M. V. Chao (1995)
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A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain.
M. P. Boldin, E. E. Varfolomeev, Z. Pancer, I. L. Mett, J. H. Camonis, and D. Wallach (1995)
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Small Peptide Mimics of Nerve Growth Factor Bind TrkA Receptors and Affect Biological Responses.
L. LeSauteur, L. Wei, B. F. Gibbs, and H. U. Saragovi (1995)
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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
R. Dobrowsky, M. Werner, A. Castellino, M. Chao, and Y. Hannun (1994)
Science 265, 1596-1599
   Abstract »    PDF »
NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR.
J. Mukai, T. Hachiya, S. Shoji-Hoshino, M. T. Kimura, D. Nadano, P. Suvanto, T. Hanaoka, Y. Li, S. Irie, L. A. Greene, et al. (2000)
J. Biol. Chem. 275, 17566-17570
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p75 Reduces TrkB Tyrosine Autophosphorylation in Response to Brain-derived Neurotrophic Factor and Neurotrophin 4/5.
J. Vesa, A. Kruttgen, and E. M. Shooter (2000)
J. Biol. Chem. 275, 24414-24420
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Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death.
E. J. Coulson, K. Reid, M. Baca, K. A. Shipham, S. M. Hulett, T. J. Kilpatrick, and P. F. Bartlett (2000)
J. Biol. Chem. 275, 30537-30545
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The Ectodermal Dysplasia Receptor Activates the Nuclear Factor-kappa B, JNK, and Cell Death Pathways and Binds to Ectodysplasin A.
A. Kumar, M. T. Eby, S. Sinha, A. Jasmin, and P. M. Chaudhary (2001)
J. Biol. Chem. 276, 2668-2677
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Nerve Growth Factor Stimulates Prol