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Science 9 July 1993:
Vol. 261. no. 5118, pp. 221 - 224
DOI: 10.1126/science.7687074
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Articles

Science, Vol 261, Issue 5118, 221-224
Copyright © 1993 by American Association for the Advancement of Science

articles

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels

A Butler, S Tsunoda, DP McCobb, A Wei, and L Salkoff

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.


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Functional Effects of Auxiliary {beta}4-Subunit on Rat Large-Conductance Ca2+-Activated K+ Channel.
T. S. Ha, M.-S. Heo, and C.-S. Park (2004)
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Sci. STKE 2004, pe16
   Abstract »    Full Text »    PDF »
Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects.
C. B. Woda, N. Miyawaki, S. Ramalakshmi, M. Ramkumar, R. Rojas, B. Zavilowitz, T. R. Kleyman, and L. M. Satlin (2003)
Am J Physiol Renal Physiol 285, F629-F639
   Abstract »    Full Text »    PDF »
Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.
L. Hu, J. Shi, Z. Ma, G. Krishnamoorthy, F. Sieling, G. Zhang, F. T. Horrigan, and J. Cui (2003)
PNAS 100, 10488-10493
   Abstract »    Full Text »    PDF »
{beta}1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms.
X. Qian and K. L. Magleby (2003)
PNAS 100, 10061-10066
   Abstract »    Full Text »    PDF »
Contribution of BK Ca2+-Activated K+ Channels to Auditory Neurotransmission in the Guinea Pig Cochlea.
L. J. Skinner, V. Enee, M. Beurg, H. H. Jung, A. F. Ryan, A. Hafidi, J.-M. Aran, and D. Dulon (2003)
J Neurophysiol 90, 320-332
   Abstract »    Full Text »    PDF »
Ethanol sensitivity of BKCa channels from arterial smooth muscle does not require the presence of the beta 1-subunit.
A. M. Dopico (2003)
Am J Physiol Cell Physiol 284, C1468-C1480
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Stimulatory Action of Internal Protons on Slo1 BK Channels.
V. Avdonin, X. D. Tang, and T. Hoshi (2003)
Biophys. J. 84, 2969-2980
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Effect of Phosphatidylserine on Unitary Conductance and Ba2+ Block of the BK Ca2+-activated K+ Channel: Re-examination of the Surface Charge Hypothesis.
J. B. Park, H. J. Kim, P. D. Ryu, and E. Moczydlowski (2003)
J. Gen. Physiol. 121, 375-398
   Abstract »    Full Text »    PDF »
Leucine Zipper Domain Targets cAMP-dependent Protein Kinase to Mammalian BK Channels.
L. Tian, L. S. Coghill, S. H.-F. MacDonald, D. L. Armstrong, and M. J. Shipston (2003)
J. Biol. Chem. 278, 8669-8677
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Gating Mechanism of BK (Slo1) Channels: So Near, Yet So Far.
K. L. Magleby (2003)
J. Gen. Physiol. 121, 81-96
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Molecular identification of Ca2+-activated K+ channels in parotid acinar cells.
K. Nehrke, C. C. Quinn, and T. Begenisich (2003)
Am J Physiol Cell Physiol 284, C535-C546
   Abstract »    Full Text »    PDF »
The Cytoplasmic Tail of Large Conductance, Voltage- and Ca2+-activated K+ (MaxiK) Channel Is Necessary for Its Cell Surface Expression.
S.-X. Wang, M. Ikeda, and W. B. Guggino (2003)
J. Biol. Chem. 278, 2713-2722
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Slo1 Tail Domains, but Not the Ca2+ Bowl, Are Required for the {beta}1 Subunit to Increase the Apparent Ca2+ Sensitivity of BK Channels.
X. Qian, C. M. Nimigean, X. Niu, B. L. Moss, and K. L. Magleby (2002)
J. Gen. Physiol. 120, 829-843
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Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels.
F. T. Horrigan and R. W. Aldrich (2002)
J. Gen. Physiol. 120, 267-305
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Setting the Stage for Molecular Dissection of the Regulatory Components of BK Channels.
C. J. Lingle (2002)
J. Gen. Physiol. 120, 261-265
   Full Text »    PDF »
Elimination of the BKCa Channel's High-Affinity Ca2+ Sensitivity.
L. Bao, A. M. Rapin, E. C. Holmstrand, and D. H. Cox (2002)
J. Gen. Physiol. 120, 173-189
   Abstract »    Full Text »    PDF »
Interacting Effects of N-terminal Variation and Strex Exon Splicing on slo Potassium Channel Regulation by Calcium, Phosphorylation, and Oxidation.
C. Erxleben, A. L. Everhart, C. Romeo, H. Florance, M. B. Bauer, D. A. Alcorta, S. Rossie, M. J. Shipston, and D. L. Armstrong (2002)
J. Biol. Chem. 277, 27045-27052
   Abstract »    Full Text »    PDF »
Ca2+ Influx and Opening of Ca2+-Activated K+ Channels in Muscle Fibers from Control and mdx Mice.
N. Mallouk and B. Allard (2002)
Biophys. J. 82, 3012-3021
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Consequences of the Stoichiometry of Slo1alpha and Auxiliary beta Subunits on Functional Properties of Large-Conductance Ca2+-Activated K+ Channels.
Y.-W. Wang, J. P. Ding, X.-M. Xia, and C. J. Lingle (2002)
J. Neurosci. 22, 1550-1561
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Cloning and Characterization of Glioma BK, a Novel BK Channel Isoform Highly Expressed in Human Glioma Cells.
X. Liu, Y. Chang, P. H. Reinhart, and H. Sontheimer (2002)
J. Neurosci. 22, 1840-1849
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Opposite Actions of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on Firing Features and Ion Channel Composition of Murine Spiral Ganglion Neurons.
C. L. Adamson, M. A. Reid, and R. L. Davis (2002)
J. Neurosci. 22, 1385-1396
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A Molecular Switch for Specific Stimulation of the BKCa Channel by cGMP and cAMP Kinase.
X.-B. Zhou, C. Arntz, S. Kamm, K. Motejlek, U. Sausbier, G.-X. Wang, P. Ruth, and M. Korth (2001)
J. Biol. Chem. 276, 43239-43245
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NMR Structure of the "Ball-and-chain" Domain of KCNMB2, the beta 2-Subunit of Large Conductance Ca2+- and Voltage-activated Potassium Channels.
D. Bentrop, M. Beyermann, R. Wissmann, and B. Fakler (2001)
J. Biol. Chem. 276, 42116-42121
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Potent inhibition of the aortic smooth muscle maxi-K channel by clinical doses of ethanol.
F. S. Walters, M. Covarrubias, and J. S. Ellingson (2000)
Am J Physiol Cell Physiol 279, C1107-C1115
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17-beta -Estradiol Modulation of Area Postrema Potassium Currents.
Z. Li and M. Hay (2000)
J Neurophysiol 84, 1385-1391
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Rectification and Rapid Activation at Low Ca2+ of Ca2+-Activated, Voltage-Dependent BK Currents: Consequences of Rapid Inactivation by a Novel beta Subunit.
X.-M. Xia, J.-P. Ding, X.-H. Zeng, K.-L. Duan, and C. J. Lingle (2000)
J. Neurosci. 20, 4890-4903
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A Novel Nervous System beta Subunit that Downregulates Human Large Conductance Calcium-Dependent Potassium Channels.
T. M. Weiger, M. H. Holmqvist, I. B. Levitan, F. T. Clark, S. Sprague, W.-J. Huang, P. Ge, C. Wang, D. Lawson, M. E. Jurman, et al. (2000)
J. Neurosci. 20, 3563-3570
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Endothelial K+ channel lacks the Ca2+ sensitivity-regulating {beta} subunit.
J. PAPASSOTIRIOU, R. KÖHLER, J. PRENEN, H. KRAUSE, M. AKBAR, J. EGGERMONT, M. PAUL, A. DISTLER, B. NILIUS, and J. HOYER (2000)
FASEB J 14, 885-894
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beta Subunits Modulate Alternatively Spliced, Large Conductance, Calcium-Activated Potassium Channels of Avian Hair Cells.
K. Ramanathan, T. H. Michael, and P. A. Fuchs (2000)
J. Neurosci. 20, 1675-1684
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of the Intermediate-Conductance Ca2+-Activated K+ Channel in Vascular Smooth Muscle : Relationship Between KCa Channel Diversity and Smooth Muscle Cell Function.
C. B. Neylon, R. J. Lang, Y. Fu, A. Bobik, and P. H. Reinhart (1999)
Circ. Res. 85 , e33-e43
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Molecular Components of Large Conductance Calcium-Activated Potassium (BK) Channels in Mouse Pituitary Corticotropes.
M. J. Shipston, R. R. Duncan, A. G. Clark, F. A. Antoni, and L. Tian (1999)
Mol. Endocrinol. 13, 1728-1737
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Acute Activation of Maxi-K Channels (hSlo) by Estradiol Binding to the  Subunit.
M. A. Valverde, P. Rojas, J. Amigo, D. Cosmelli, P. Orio, M. I. Bahamonde, G. E. Mann, C. Vergara, and R. Latorre (1999)
Science 285, 1929-1931
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Molecular Basis for the Inactivation of Ca2+- and Voltage-Dependent BK Channels in Adrenal Chromaffin Cells and Rat Insulinoma Tumor Cells.
X.-M. Xia, J. P. Ding, and C. J. Lingle (1999)
J. Neurosci. 19, 5255-5264
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Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release.
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff (1999)
Physiol Rev 79, 1019-1088
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Molecular Diversity of K+ Channels.
W. A. COETZEE, Y. AMARILLO, J. CHIU, A. CHOW, D. LAU, T. McCORMACK, H. MORENA, M. S. NADAL, A. OZAITA, D. POUNTNEY, et al. (1999)
Ann. N.Y. Acad. Sci. 868, 233-255
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The Functional Role of Alternative Splicing of Ca2+-Activated K+ Channels in Auditory Hair Cells.
E.M. C. JONES, M. GRAY-KELLER, J. J. ART, and R. FETTIPLACE (1999)
Ann. N.Y. Acad. Sci. 868, 379-385
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Cyclic GMP-dependent Protein Kinase Activates Cloned BKCa Channels Expressed in Mammalian Cells by Direct Phosphorylation at Serine 1072.
M. Fukao, H. S. Mason, F. C. Britton, J. L. Kenyon, B. Horowitz, and K. D. Keef (1999)
J. Biol. Chem. 274, 10927-10935
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Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance Channel, IKCa1.
C. M. Fanger, S. Ghanshani, N. J. Logsdon, H. Rauer, K. Kalman, J. Zhou, K. Beckingham, K. G. Chandy, M. D. Cahalan, and J. Aiyar (1999)
J. Biol. Chem. 274, 5746-5754
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RINm5f Cells Express Inactivating BK Channels Whereas HIT Cells Express Noninactivating BK Channels.
Z.-W. Li, J. P. Ding, V. Kalyanaraman, and C. J. Lingle (1999)
J Neurophysiol 81, 611-624
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Role of the S4 Segment in a Voltage-dependent Calcium-sensitive Potassium (hSlo) Channel.
L. Diaz, P. Meera, J. Amigo, E. Stefani, O. Alvarez, L. Toro, and R. Latorre (1998)
J. Biol. Chem. 273, 32430-32436
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Behavioral and Electrophysiological Analysis of Ca-activated K-channel Transgenes in Drosophila.
N. S. ATKINSON, R. BRENNER, R. A. BOHM, J. Y. YU, and J. L. WILBUR (1998)
Ann. N.Y. Acad. Sci. 860, 296-305
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