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Science 9 July 1993:
Vol. 261. no. 5118, pp. 215 - 218
DOI: 10.1126/science.8392225
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Articles

Science, Vol 261, Issue 5118, 215-218
Copyright © 1993 by American Association for the Advancement of Science

articles

Separable regulatory elements governing myogenin transcription in mouse embryogenesis

TC Cheng, MC Wallace, JP Merlie, and EN Olson

Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.


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Caspase 3 activity is required for skeletal muscle differentiation.
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Regulation of retinoic acid signaling during lung morphogenesis.
S Malpel, C Mendelsohn, and W. Cardoso (2000)
Development 127, 3057-3067
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Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.
B Kablar, S Tajbakhsh, and M. Rudnicki (2000)
Development 127, 1627-1639
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Regulation of Smooth Muscle {alpha}-Actin Expression In Vivo Is Dependent on CArG Elements Within the 5' and First Intron Promoter Regions.
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Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis.
D Brown, D Wagner, X Li, J. Richardson, and E. Olson (1999)
Development 126, 4317-4329
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Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.
F. Naya, C Wu, J. Richardson, P Overbeek, and E. Olson (1999)
Development 126, 2045-2052
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prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.
M. Lu, H. Cheng, M. Kern, S. Potter, B Tran, T. Diekwisch, and J. Martin (1999)
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Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
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D. Meierhans and R. K. Allemann (1998)
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Synergistic Activation of the N-Methyl-D-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1.
D. Krainc, G. Bai, S.-i. Okamoto, M. Carles, J. W. Kusiak, R. N. Brent, and S. A. Lipton (1998)
J. Biol. Chem. 273, 26218-26224
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Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5'-Flanking and First Intronic DNA Sequence.
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The Rho Family G Proteins Play a Critical Role in Muscle Differentiation.
H. Takano, I. Komuro, T. Oka, I. Shiojima, Y. Hiroi, T. Mizuno, and Y. Yazaki (1998)
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Requirement of the MADS-box transcription factor MEF2C for vascular development.
Q Lin, J Lu, H Yanagisawa, R Webb, G. Lyons, J. Richardson, and E. Olson (1998)
Development 125, 4565-4574
   Abstract »    PDF »
A distinct developmental programme for the cranial paraxial mesoderm in the chick embryo.
A Hacker and S Guthrie (1998)
Development 125, 3461-3472
   Abstract »    PDF »
A Minimal Murine Msx-1 Gene Promoter. ORGANIZATION OF ITS cis-REGULATORY MOTIFS AND THEIR ROLE IN TRANSCRIPTIONAL ACTIVATION IN CELLS IN CULTURE AND IN TRANSGENIC MICE.
T. Takahashi, C. Guron, S. Shetty, H. Matsui, and R. Raghow (1997)
J. Biol. Chem. 272, 22667-22678
   Abstract »    Full Text »    PDF »
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation..
C T Kuo, E E Morrisey, R Anandappa, K Sigrist, M M Lu, M S Parmacek, C Soudais, and J M Leiden (1997)
Genes & Dev. 11, 1048-1060
   Abstract »    PDF »
Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis..
A N Gerber, T R Klesert, D A Bergstrom, and S J Tapscott (1997)
Genes & Dev. 11, 436-450
   Abstract »    PDF »
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.
Y Wang and R Jaenisch (1997)
Development 124, 2507-2513
   Abstract »    PDF »
Distinct Domains of Myocyte Enhancer Binding Factor-2A Determining Nuclear Localization and Cell Type-specific Transcriptional Activity.
Y.-T. Yu and Y. T. Yu (1996)
J. Biol. Chem. 271, 24675-24683
   Abstract »    Full Text »    PDF »
MEF2 Protein Expression, DNA Binding Specificity and Complex Composition, and Transcriptional Activity in Muscle and Non-muscle Cells.
O. I. Ornatsky and J. C. McDermott (1996)
J. Biol. Chem. 271, 24927-24933
   Abstract »    Full Text »    PDF »
Structure and Expression of the Murine Muscle Adenylosuccinate Synthetase Gene.
A. L. Lewis, O. M. Guicherit, S. K. Datta, G. R. Hanten, and R. E. Kellems (1996)
J. Biol. Chem. 271, 22647-22656
   Abstract »    Full Text »    PDF »
Stimulation of Myogenic Differentiation by a Neuregulin, Glial Growth Factor 2. ARE NEUREGULINS THE LONG-SOUGHT MUSCLE TROPHIC FACTORS SECRETED BY NERVES?.
J. R. Florini, D. S. Samuel, D. Z. Ewton, C. Kirk, and R. M. Sklar (1996)
J. Biol. Chem. 271, 12699-12702
   Abstract »    Full Text »    PDF »
Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells : Association With the Activated Phenotype.
A. B. Firulli, J. M. Miano, W. Bi, A. D. Johnson, W. Casscells, E. N. Olson, and J. J. Schwarz (1996)
Circ. Res. 78, 196-204
   Abstract »    Full Text »
Functional Dissection of the Brain-specific Rat Aldolase C Gene Promoter in Transgenic Mice.
M. Thomas, H. Skala, A. Kahn, and F.ço. P. D. Tuy (1995)
J. Biol. Chem. 270, 20316-20321
   Abstract »    Full Text »    PDF »
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies..
W Zhang, R R Behringer, and E N Olson (1995)
Genes & Dev. 9, 1388-1399
   Abstract »    PDF »
Drosophila MEF2, a transcription factor that is essential for myogenesis..
B A Bour, M A O'Brien, W L Lockwood, E S Goldstein, R Bodmer, P H Taghert, S M Abmayr, and H T Nguyen (1995)
Genes & Dev. 9, 730-741
   Abstract »    PDF »
The Mouse MRF4 Promoter Is trans-Activated Directly and Indirectly by Muscle-specific Transcription Factors.
B. L. Black, J. F. Martin, and E. N. Olson (1995)
J. Biol. Chem. 270, 2889-2892
   Abstract »    Full Text »    PDF »
Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila.
B Lilly, B Zhao, G Ranganayakulu, B. Paterson, R. Schulz, and E. Olson (1995)
Science 267, 688-693
   Abstract »    PDF »
tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.
S. Evans, W Yan, M. Murillo, J Ponce, and N Papalopulu (1995)
Development 121, 3889-3899
   Abstract »    PDF »
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
A Patapoutian, J. Yoon, J. Miner, S Wang, K Stark, and B Wold (1995)
Development 121, 3347-3358
   Abstract »    PDF »
Embryonic activation of the myoD gene is regulated by a highly conserved distal control element.
D. Goldhamer, B. Brunk, A Faerman, A King, M Shani, and C. Emerson (1995)
Development 121, 637-649
   Abstract »    PDF »
Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD.
S Kaushal, J. Schneider, B Nadal-Ginard, and V Mahdavi (1994)
Science 266, 1236-1240
   Abstract »    PDF »
The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos..
A E Chambers, M Logan, S Kotecha, N Towers, D Sparrow, and T J Mohun (1994)
Genes & Dev. 8, 1324-1334
   Abstract »    PDF »
Separate pathways for synapse-specific and electrical activity-dependent gene expression in skeletal muscle.
J Tang, S. Jo, and S. Burden (1994)
Development 120, 1799-1804
   Abstract »    PDF »
Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.
D. Edmondson, G. Lyons, J. Martin, and E. Olson (1994)
Development 120, 1251-1263
   Abstract »    PDF »
Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.
A. Michelson (1994)
Development 120, 755-768
   Abstract »    PDF »
bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out..
E N Olson and W H Klein (1994)
Genes & Dev. 8, 1-8
   PDF »
Phosphoinositide 3-Kinase Induces the Transcriptional Activity of MEF2 Proteins during Muscle Differentiation.
Y. Tamir and E. Bengal (2000)
J. Biol. Chem. 275, 34424-34432
   Abstract »    Full Text »    PDF »
Positive- and Negative-acting Kruppel-like Transcription Factors Bind a Transforming Growth Factor beta Control Element Required for Expression of the Smooth Muscle Cell Differentiation Marker SM22alpha in Vivo.
P. J. Adam, C. P. Regan, M. B. Hautmann, and G. K. Owens (2000)
J. Biol. Chem. 275, 37798-37806
   Abstract »    Full Text »    PDF »


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