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Science 2 July 1993:
Vol. 261. no. 5117, pp. 86 - 90
DOI: 10.1126/science.7686306
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Articles

Science, Vol 261, Issue 5117, 86-90
Copyright © 1993 by American Association for the Advancement of Science

articles

Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes

L Juntti-Berggren, O Larsson, P Rorsman, C Ammala, K Bokvist, K Wahlander, P Nicotera, J Dypbukt, S Orrenius, A Hallberg, and al. et

Rolf Luft Center for Diabetes Research, Department of Endocrinology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.

Type I diabetes [insulin-dependent diabetes mellitus (IDDM)] is an autoimmune disease associated with the destruction of pancreatic beta cells. Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of GH3 cells derived from a pituitary tumor. The subsequent increase in the concentration of free cytoplasmic Ca2+ ([Ca2+]i) was associated with DNA fragmentation typical of programmed cell death or apoptosis. These effects of the serum were prevented by adding a blocker of voltage-activated L-type Ca2+ channels. When the serum was depleted of immunoglobulin M (IgM), it no longer affected [Ca2+]i. An IgM-mediated increase in Ca2+ influx may thus be part of the autoimmune reaction associated with IDDM and contribute to the destruction of beta cells in vivo.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)