Science 2 July 1993: Vol. 261. no. 5117, pp. 101 - 103 DOI: 10.1126/science.8316840

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Articles

A Critical Role of Protein Kinase C{delta} Activation Loop Phosphorylation in Formyl-Methionyl-Leucyl-Phenylalanine-Induced Phosphorylation of p47phox and Rapid Activation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase.

N. Cheng, R. He, J. Tian, M. C. Dinauer, and R. D. Ye (2007)
J. Immunol. 179, 7720-7728
 |  Abstract »  |  Full Text »  |  PDF »

G{alpha}i2 is required for chemokine-induced neutrophil arrest.

A. Zarbock, T. L. Deem, T. L. Burcin, and K. Ley (2007)
Blood 110, 3773-3779
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.

G. Shi, S. Partida-Sanchez, R. S. Misra, M. Tighe, M. T. Borchers, J. J. Lee, M. I. Simon, and F. E. Lund (2007)
J. Exp. Med. 204, 2705-2718
 |  Abstract »  |  Full Text »  |  PDF »

G-protein-coupled receptor expression, function, and signaling in macrophages.

J. Lattin, D. A. Zidar, K. Schroder, S. Kellie, D. A. Hume, and M. J. Sweet (2007)
J. Leukoc. Biol. 82, 16-32
 |  Abstract »  |  Full Text »  |  PDF »

Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1{alpha}.

M. Rey, A. Valenzuela-Fernandez, A. Urzainqui, M. Yanez-Mo, M. Perez-Martinez, P. Penela, F. Mayor Jr, and F. Sanchez-Madrid (2007)
J. Cell Sci. 120, 1126-1133
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration.

V. Govindaraju, M.-C. Michoud, M. Al-Chalabi, P. Ferraro, W. S. Powell, and J. G. Martin (2006)
Am J Physiol Cell Physiol 291, C957-C965
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis.

C. J. Lockwood, F. Arcuri, P. Toti, C. D. Felice, G. Krikun, S. Guller, L. F. Buchwalder, and F. Schatz (2006)
Am. J. Pathol. 169, 1294-1302
 |  Abstract »  |  Full Text »  |  PDF »

Protein Chip Discovery of Secreted Proteins Regulated by the Phosphatidylinositol 3-Kinase Pathway in Ovarian Cancer Cell Lines.

M. Moscova, D. J. Marsh, and R. C. Baxter (2006)
Cancer Res. 66, 1376-1383
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Abruption-Induced Premature Rupture of the Fetal Membranes: Thrombin-Enhanced Interleukin-8 Expression in Term Decidua.

C. J. Lockwood, P. Toti, F. Arcuri, M. Paidas, L. Buchwalder, G. Krikun, and F. Schatz (2005)
Am. J. Pathol. 167, 1443-1449
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Neutrophil Migration Associated with Specific Bovine CXCR2 Genotypes.

M. Rambeaud and G. M. Pighetti (2005)
Infect. Immun. 73, 4955-4959
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Cytokine and Thrombin Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 Expression in First Trimester Human Decidua.

C. J. Lockwood, M. Paidas, G. Krikun, L. A. Koopman, R. Masch, E. Kuczynski, H. Kliman, R. N. Baergen, and F. Schatz (2005)
J. Clin. Endocrinol. Metab. 90, 4710-4715
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function.

S. Verploegen, L. Ulfman, H. W. M. van Deutekom, C. van Aalst, H. Honing, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer (2005)
Blood 106, 1076-1083
 |  Abstract »  |  Full Text »  |  PDF »

Silencing the expression of multiple G{beta}-subunits eliminates signaling mediated by all four families of G proteins.

J.-I. Hwang, S. Choi, I. D. C. Fraser, M. S. Chang, and M. I. Simon (2005)
PNAS 102, 9493-9498
 |  Abstract »  |  Full Text »  |  PDF »

Macrophage Inflammatory Protein 2 Inhibits {beta}-Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways.

K. Watson and G.-H. Fan (2005)
Mol. Pharmacol. 67, 757-765
 |  Abstract »  |  Full Text »  |  PDF »

Activation of CD38 by Interleukin-8 Signaling Regulates Intracellular Ca2+ Level and Motility of Lymphokine-activated Killer Cells.

S.-Y. Rah, K.-H. Park, M.-K. Han, M.-J. Im, and U.-H. Kim (2005)
J. Biol. Chem. 280, 2888-2895
 |  Abstract »  |  Full Text »  |  PDF »

Chemokines in acute respiratory distress syndrome.

P. Puneet, S. Moochhala, and M. Bhatia (2005)
Am J Physiol Lung Cell Mol Physiol 288, L3-L15
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of Chemotactic Peptide-Induced Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase Activation in Transgenic COS-phox Cells.

R. He, M. Nanamori, H. Sang, H. Yin, M. C. Dinauer, and R. D. Ye (2004)
J. Immunol. 173, 7462-7470
 |  Abstract »  |  Full Text »  |  PDF »

The CXC Chemokine Receptor Encoded by Herpesvirus saimiri, ECRF3, Shows Ligand-regulated Signaling through Gi, Gq, and G12/13 Proteins but Constitutive Signaling Only through Gi and G12/13 Proteins.

M. M. Rosenkilde, K. A. McLean, P. J. Holst, and T. W. Schwartz (2004)
J. Biol. Chem. 279, 32524-32533
 |  Abstract »  |  Full Text »  |  PDF »

Interactions of Chemokines and Chemokine Receptors Mediate the Migration of Mesenchymal Stem Cells to the Impaired Site in the Brain After Hypoglossal Nerve Injury.

J. F. Ji, B. P. He, S. T. Dheen, and S. S. W. Tay (2004)
Stem Cells 22, 415-427
 |  Abstract »  |  Full Text »  |  PDF »

Rab11-Family Interacting Protein 2 and Myosin Vb Are Required for CXCR2 Recycling and Receptor-mediated Chemotaxis.

G.-H. Fan, L. A. Lapierre, J. R. Goldenring, J. Sai, and A. Richmond (2004)
Mol. Biol. Cell 15, 2456-2469
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Murine Herpesvirus 68- and Kaposi's Sarcoma-Associated Herpesvirus-Encoded ORF74 G Protein-Coupled Receptors by Human and Murine Chemokines.

D. Verzijl, C. P. Fitzsimons, M. van Dijk, J. P. Stewart, H. Timmerman, M. J. Smit, and R. Leurs (2004)
J. Virol. 78, 3343-3351
 |  Abstract »  |  Full Text »  |  PDF »

The chemokine KC regulates HGF-stimulated epithelial cell morphogenesis.

J. M. Ueland, J. Gwira, Z.-X. Liu, and L. G. Cantley (2004)
Am J Physiol Renal Physiol 286, F581-F589
 |  Abstract »  |  Full Text »

From the Cover: Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.

J.-I. Hwang, I. D. C. Fraser, S. Choi, X.-F. Qin, and M. I. Simon (2004)
PNAS 101, 488-493
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus.

C Eriksson, K Eneslatt, J Ivanoff, S Rantapaa-Dahlqvist, and K-G Sundqvist (2003)
Lupus 12, 766-774
 |  Abstract »  |  PDF »

CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.

M. J. Smit, P. Verdijk, E. M. H. van der Raaij-Helmer, M. Navis, P. J. Hensbergen, R. Leurs, and C. P. Tensen (2003)
Blood 102, 1959-1965
 |  Abstract »  |  Full Text »  |  PDF »

Differential regulation of CXCR2 trafficking by Rab GTPases.

G.-H. Fan, L. A. Lapierre, J. R. Goldenring, and A. Richmond (2003)
Blood 101, 2115-2124
 |  Abstract »  |  Full Text »  |  PDF »

Rac2 Regulation of Phospholipase C-beta 2 Activity and Mode of Membrane Interactions in Intact Cells.

D. Illenberger, C. Walliser, J. Strobel, O. Gutman, H. Niv, V. Gaidzik, Y. Kloog, P. Gierschik, and Y. I. Henis (2003)
J. Biol. Chem. 278, 8645-8652
 |  Abstract »  |  Full Text »  |  PDF »

Specificity and Structural Requirements of Phospholipase C-beta Stimulation by Rho GTPases Versus G Protein beta gamma Dimers.

D. Illenberger, C. Walliser, B. Nurnberg, M. D. Lorente, and P. Gierschik (2003)
J. Biol. Chem. 278, 3006-3014
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Association of the Motor Protein Nonmuscle Myosin Heavy Chain-IIA with the C Terminus of the Chemokine Receptor CXCR4 in T Lymphocytes.

M. Rey, M. Vicente-Manzanares, F. Viedma, M. Yanez-Mo, A. Urzainqui, O. Barreiro, J. Vazquez, and F. Sanchez-Madrid (2002)
J. Immunol. 169, 5410-5414
 |  Abstract »  |  Full Text »  |  PDF »

Chemokines and chemokine receptors in leukocyte trafficking.

T. S. Olson and K. Ley (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R7-R28
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Pathways Involved in IL-8-Dependent Activation of Adhesion Through Mac-1.

M. Takami, V. Terry, and L. Petruzzelli (2002)
J. Immunol. 168, 4559-4566
 |  Abstract »  |  Full Text »  |  PDF »

Lineage-specific defect in gene expression in human platelet phospholipase C-beta 2 deficiency.

G. F. Mao, V. R. Vaidyula, S. P. Kunapuli, and A. K. Rao (2002)
Blood 99, 905-911
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of nuclear factor {kappa}B activation by G-protein-coupled receptors.

R. D. Ye (2001)
J. Leukoc. Biol. 70, 839-848
 |  Abstract »  |  Full Text »  |  PDF »

A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma.

H. Geminder, O. Sagi-Assif, L. Goldberg, T. Meshel, G. Rechavi, I. P. Witz, and A. Ben-Baruch (2001)
J. Immunol. 167, 4747-4757
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions.

S. W. Chensue (2001)
Clin. Microbiol. Rev. 14, 821-835
 |  Abstract »  |  Full Text »  |  PDF »

IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways.

I. U. Schraufstatter, J. Chung, and M. Burger (2001)
Am J Physiol Lung Cell Mol Physiol 280, L1094-L1103
 |  Abstract »  |  Full Text »  |  PDF »

G{{alpha}}16 Couples Chemoattractant Receptors to NF-{{kappa}}B Activation.

M. Yang, H. Sang, A. Rahman, D. Wu, A. B. Malik, and R. D. Ye (2001)
J. Immunol. 166, 6885-6892
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Chemokine Induction of Activation Protein-1 and Cyclic AMP Responsive Element Activation in Human Myeloid Cells.

Y.-M. Yang, W. C. Hatch, Z.-Y. Liu, B. Du, and J. E. Groopman (2001)
Cell Growth Differ. 12, 211-221
 |  Abstract »  |  Full Text »

Actin Filaments Are Involved in the Regulation of Trafficking of Two Closely Related Chemokine Receptors, CXCR1 and CXCR2.

A. Zaslaver, R. Feniger-Barish, and A. Ben-Baruch (2001)
J. Immunol. 166, 1272-1284
 |  Abstract »  |  Full Text »  |  PDF »

Transepithelial Neutrophil Migration Is CXCR1 Dependent In Vitro and Is Defective in IL-8 Receptor Knockout Mice.

G. Godaly, L. Hang, B. Frendeus, and C. Svanborg (2000)
J. Immunol. 165, 5287-5294
 |  Abstract »  |  Full Text »  |  PDF »

Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C.

M. J. Rebecchi and S. N. Pentyala (2000)
Physiol Rev 80, 1291-1335
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Proinflammatory Cytokines Tumor Necrosis Factor-alpha , IL-1beta , and IL-6 But Not IL-8 in the Development of Heat Hyperalgesia: Effects on Heat-Evoked Calcitonin Gene-Related Peptide Release from Rat Skin.

A. Opree and M. Kress (2000)
J. Neurosci. 20, 6289-6293
 |  Abstract »  |  Full Text »  |  PDF »

Chemokine receptors and their role in inflammation and infectious diseases.

C. Murdoch and A. Finn (2000)
Blood 95, 3032-3043
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Human Chemokine Receptor CCR1. CROSS-REGULATION BY CXCR1 AND CXCR2.

R. M. Richardson, B. C. Pridgen, B. Haribabu, and R. Snyderman (2000)
J. Biol. Chem. 275, 9201-9208
 |  Abstract »  |  Full Text »  |  PDF »

Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells.

G. Venkatakrishnan, R. Salgia, and J. E. Groopman (2000)
J. Biol. Chem. 275, 6868-6875
 |  Abstract »  |  Full Text »  |  PDF »

The Coupling of 5-Oxo-Eicosanoid Receptors to Heterotrimeric G Proteins.

J. T. O'Flaherty, J. S. Taylor, and M. Kuroki (2000)
J. Immunol. 164, 3345-3352
 |  Abstract »  |  Full Text »  |  PDF »

GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR+-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling.

R. Feniger-Barish, D. Belkin, A. Zaslaver, S. Gal, M. Dori, M. Ran, and A. Ben-Baruch (2000)
Blood 95, 1551-1559
 |  Abstract »  |  Full Text »  |  PDF »

Roles of PLC-2 and -3 and PI3K in Chemoattractant-Mediated Signal Transduction.

Z. Li, H. Jiang, W. Xie, Z. Zhang, A. V. Smrcka, and D. Wu (2000)
Science 287, 1046-1049
 |  Abstract »  |  Full Text »

Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Galpha 15 Knockout Mice.

I. Davignon, M. D. Catalina, D. Smith, J. Montgomery, J. Swantek, J. Croy, M. Siegelman, and T. M. Wilkie (2000)
Mol. Cell. Biol. 20, 797-804
 |  Abstract »  |  Full Text »

Roles of phospholipid signaling in chemoattractant-induced responses.

D Wu, C. Huang, and H Jiang (2000)
J. Cell Sci. 113, 2935-2940
 |  Abstract »  |  PDF »

Incorporation of Galpha z-Specific Sequence at the Carboxyl Terminus Increases the Promiscuity of Galpha 16 toward Gi-Coupled Receptors.

S. M. Mody, M. K. C. Ho, S. A. Joshi, and Y. H. Wong (2000)
Mol. Pharmacol. 57, 13-23
 |  Abstract »  |  Full Text »

Chemoattractant Receptors Activate Distinct Pathways for Chemotaxis and Secretion. ROLE OF G-PROTEIN USAGE.

B. Haribabu, D. V. Zhelev, B. C. Pridgen, R. M. Richardson, H. Ali, and R. Snyderman (1999)
J. Biol. Chem. 274, 37087-37092
 |  Abstract »  |  Full Text »  |  PDF »

The Growth-related Gene Product beta Induces Sphingomyelin Hydrolysis and Activation of c-Jun N-terminal Kinase in Rat Cerebellar Granule Neurones.

C. Limatola, A. M. Mileo, A. Giovannelli, F. Vacca, M. T. Ciotti, D. Mercanti, A. Santoni, and F. Eusebi (1999)
J. Biol. Chem. 274, 36537-36543
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory Effect of Interleukin-8 on the Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages.

Y. Kawano, H. Narahara, and J. M. Johnston (1999)
Reproductive Sciences 6, 328-332
 |  Abstract »  |  PDF »

Genetic alteration of phospholipase C beta 3 expression modulates behavioral and cellular responses to {micro} opioids.

W. Xie, G. M. Samoriski, J. P. McLaughlin, V. A. Romoser, A. Smrcka, P. M. Hinkle, J. M. Bidlack, R. A. Gross, H. Jiang, and D. Wu (1999)
PNAS 96, 10385-10390
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutation Causing Constitutive Signaling of CXCR2 Leads to Transforming Activity Similar to Kaposi's Sarcoma Herpesvirus-G Protein-Coupled Receptor.

M. Burger, J. A. Burger, R. C. Hoch, Z. Oades, H. Takamori, and I. U. Schraufstatter (1999)
J. Immunol. 163, 2017-2022
 |  Abstract »  |  Full Text »  |  PDF »

Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells.

R. Bertini, O.M. Zack Howard, H.-F. Dong, J. J. Oppenheim, C. Bizzarri, R. Sergi, G. Caselli, S. Pagliei, B. Romines, J. A. Wilshire, et al. (1999)
J. Exp. Med. 189, 1783-1789
 |  Abstract »  |  Full Text »  |  PDF »

Differential Signaling by the Thromboxane Receptor Isoforms via the Novel GTP-binding Protein, Gh.

R. Vezza, A. Habib, and G. A. FitzGerald (1999)
J. Biol. Chem. 274, 12774-12779
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Erythroid Differentiation by Altered Galpha 16 Activity as Detected by a Reporter Gene Assay in MB-02 Cells.

S. Ghose, H. Porzig, and K. Baltensperger (1999)
J. Biol. Chem. 274, 12848-12854
 |  Abstract »  |  Full Text »  |  PDF »

Role of Clathrin-mediated Endocytosis in CXCR2 Sequestration, Resensitization, and Signal Transduction.

W. Yang, D. Wang, and A. Richmond (1999)
J. Biol. Chem. 274, 11328-11333
 |  Abstract »  |  Full Text »  |  PDF »

Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4.

T. Jinquan, S. Quan, G. Feili, C. G. Larsen, and K. Thestrup-Pedersen (1999)
J. Immunol. 162, 4285-4292
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial Superantigens Induce Down-Modulation of CC Chemokine Responsiveness in Human Monocytes Via an Alternative Chemokine Ligand-Independent Mechanism.

R. Rahimpour, G. Mitchell, M. H. Khandaker, C. Kong, B. Singh, L. Xu, A. Ochi, R. D. Feldman, J. G. Pickering, B. M. Gill, et al. (1999)
J. Immunol. 162, 2299-2307
 |  Abstract »  |  Full Text »  |  PDF »

Galpha i Is Not Required for Chemotaxis Mediated by Gi-coupled Receptors.

E. R. Neptune, T. Iiri, and H. R. Bourne (1999)
J. Biol. Chem. 274, 2824-2828
 |  Abstract »  |  Full Text »  |  PDF »

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors.

J. Mao, H. Yuan, W. Xie, M. I. Simon, and D. Wu (1998)
J. Biol. Chem. 273, 27118-27123
 |  Abstract »  |  Full Text »  |  PDF »

Differential Cross-regulation of the Human Chemokine Receptors CXCR1 and CXCR2. EVIDENCE FOR TIME-DEPENDENT SIGNAL GENERATION.

R. M. Richardson, B. C. Pridgen, B. Haribabu, H. Ali, and R. Snyderman (1998)
J. Biol. Chem. 273, 23830-23836
 |  Abstract »  |  Full Text »  |  PDF »

Galpha 14 and Galpha q Mediate the Response to Trypsin in Xenopus Oocytes.

H. Shapira, I. Amit, M. Revach, Y. Oron, and J. F. Battey (1998)
J. Biol. Chem. 273, 19431-19436
 |  Abstract »  |  Full Text »  |  PDF »

Human Interferon-gamma -inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor.

E. Geras-Raaka, A. Varma, H. Ho, I. Clark-Lewis, and M. C. Gershengorn (1998)
J. Exp. Med. 188, 405-408
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Formyl Peptide and Platelet-activating Factor Receptors. ROLE OF PHOSPHOLIPASE Cbeta 3 PHOSPHORYLATION BY PROTEIN KINASE A.

H. Ali, S. Sozzani, I. Fisher, A. J. Barr, R. M. Richardson, B. Haribabu, and R. Snyderman (1998)
J. Biol. Chem. 273, 11012-11016
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Signaling Pathways of Human Interleukin-8 Receptor A. INDEPENDENT REGULATION BY PHOSPHORYLATION.

R. M. Richardson, H. Ali, B. C. Pridgen, B. Haribabu, and R. Snyderman (1998)
J. Biol. Chem. 273, 10690-10695
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-Coupled Receptor by Protein Kinases in Mammalian Cells in Culture.

E. Geras-Raaka, L. Arvanitakis, C. Bais, E. Cesarman, E. A. Mesri, and M. C. Gershengorn (1998)
J. Exp. Med. 187, 801-806
 |  Abstract »  |  Full Text »  |  PDF »

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P Acts as a Biased Agonist toward Neuropeptide and Chemokine Receptors.

M. B. Jarpe, C. Knall, F. M. Mitchell, A. M. Buhl, E. Duzic, and G. L. Johnson (1998)
J. Biol. Chem. 273, 3097-3104
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity.

J. Hesselgesser, M. Liang, J. Hoxie, M. Greenberg, L. F. Brass, M. J. Orsini, D. Taub, and R. Horuk (1998)
J. Immunol. 160, 877-883
 |  Abstract »  |  Full Text »  |  PDF »

Receptors induce chemotaxis by releasing the beta gamma subunit of Gi, not by activating Gq or Gs.

E. R. Neptune and H. R. Bourne (1997)
PNAS 94, 14489-14494
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Human Chemokine Receptors CXCR4. ROLE OF PHOSPHORYLATION IN DESENSITIZATION AND INTERNALIZATION.

B. Haribabu, R. M. Richardson, I. Fisher, S. Sozzani, S. C. Peiper, R. Horuk, H. Ali, and R. Snyderman (1997)
J. Biol. Chem. 272, 28726-28731
 |  Abstract »  |  Full Text »  |  PDF »

Two Basic Amino Acids in the Second Inner Loop of the Interleukin-8 Receptor Are Essential for Galpha 16 Coupling.

W. Xie, H. Jiang, Y. Wu, and D. Wu (1997)
J. Biol. Chem. 272, 24948-24951
 |  Abstract »  |  Full Text »  |  PDF »

beta gamma Subunits of Pertussis Toxin-sensitive G Proteins Mediate A1 Adenosine Receptor Agonist-induced Activation of Phospholipase C in Collaboration with Thyrotropin. A NOVEL STIMULATORY MECHANISM THROUGH THE CROSS-TALK OF TWO TYPES OF RECEPTORS.

H. Tomura, H. Itoh, K. Sho, K. Sato, M. Nagao, M. Ui, Y. Kondo, and F. Okajima (1997)
J. Biol. Chem. 272, 23130-23137
 |  Abstract »  |  Full Text »  |  PDF »

The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein beta  Subunit.

M. Liu, B. Yu, O. Nakanishi, T. Wieland, and M. Simon (1997)
J. Biol. Chem. 272, 18801-18807
 |  Abstract »  |  Full Text »  |  PDF »

Roles of phospholipase C beta 2 in chemoattractant-elicited responses.

H. Jiang, Y. Kuang, Y. Wu, W. Xie, M. I. Simon, and D. Wu (1997)
PNAS 94, 7971-7975
 |  Abstract »  |  Full Text »  |  PDF »

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a Gs Linkage to the CB1 Receptor.

M. Glass and C. C. Felder (1997)
J. Neurosci. 17, 5327-5333
 |  Abstract »  |  Full Text »  |  PDF »

The P2U Purinoceptor Obligatorily Engages the Heterotrimeric G Protein G16 to Mobilize Intracellular Ca2+ in Human Erythroleukemia Cells.

K. Baltensperger and H. Porzig (1997)
J. Biol. Chem. 272, 10151-10159
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Entry and Macrophage Inflammatory Protein-1beta -mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5.

M. Farzan, H. Choe, K. A. Martin, Y. Sun, M. Sidelko, C. R. Mackay, N. P. Gerard, J. Sodroski, and C. Gerard (1997)
J. Biol. Chem. 272, 6854-6857
 |  Abstract »  |  Full Text »  |  PDF »

Discrete Steps in Binding and Signaling of Interleukin-8 with Its Receptor.

L. Wu, N. Ruffing, X. Shi, W. Newman, D. Soler, C. R. Mackay, and S. Qin (1996)
J. Biol. Chem. 271, 31202-31209
 |  Abstract »  |  Full Text »  |  PDF »

Cross-desensitization Among Receptors for Platelet Activating Factor and Peptide Chemoattractants. EVIDENCE FOR INDEPENDENT REGULATORY PATHWAYS.

R. M. Richardson, B. Haribabu, H. Ali, and R. Snyderman (1996)
J. Biol. Chem. 271, 28717-28724
 |  Abstract »  |  Full Text »  |  PDF »

Carboxyl-terminal Fragments of Phospholipase C-beta 1 with Intrinsic Gq GTPase-activating Protein (GAP) Activity.

R. H. Paulssen, J. Woodson, Z. Liu, and E. M. Ross (1996)
J. Biol. Chem. 271, 26622-26629
 |  Abstract »  |  Full Text »  |  PDF »

Diverging Signal Transduction Pathways Activated by Interleukin 8(IL-8) and Related Chemokines in Human Neutrophils. IL-8 AND Gro-alpha DIFFERENTIALLY STIMULATE CALCIUM INFLUX THROUGH IL-8 RECEPTORS A AND B.

B. B. Damaj, S. R. McColl, K. Neote, C. A. Hebert, and P. H. Naccache (1996)
J. Biol. Chem. 271, 20540-20544
 |  Abstract »  |  Full Text »  |  PDF »

Gbeta gamma Transduces [Ca2+]i Oscillations and Galpha q a Sustained Response during Stimulation of Pancreatic Acinar Cells with [Ca2+]i-mobilizing Agonists.

W. Zeng, X. Xu, and S. Muallem (1996)
J. Biol. Chem. 271, 18520-18526
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1beta , and MIP-1alpha.

C. J. Raport, J. Gosling, V. L. Schweickart, P. W. Gray, and I. F. Charo (1996)
J. Biol. Chem. 271, 17161-17166
 |  Abstract »  |  Full Text »  |  PDF »

P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells.

M. W. Verghese, T. B. Kneisler, and J. A. Boucheron (1996)
J. Biol. Chem. 271, 15597-15601
 |  Abstract »  |  Full Text »  |  PDF »

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors.

H. Jiang, Y. Kuang, Y. Wu, A. Smrcka, M. I. Simon, and D. Wu (1996)
J. Biol. Chem. 271, 13430-13434
 |  Abstract »  |  Full Text »  |  PDF »

Physical Association of Gi2alpha with Interleukin-8 Receptors.

B. B. Damaj, S. R. McColl, W. Mahana, M. F. Crouch, and P. H. Naccache (1996)
J. Biol. Chem. 271, 12783-12789
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Peptides That Stimulate the Phosphoinositide Hydrolysis in Lymphocyte Cell Lines from Peptide Libraries.

S. H. Baek, J. K. Seo, C.-B. Chae, P.-G. Suh, and S. H. Ryu (1996)
J. Biol. Chem. 271, 8170-8175
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Recognition and Specificity of Interleukin-8 Is Determined by Residues That Cluster Near a Surface-accessible Hydrophobic Pocket.

M. E. W. Hammond, V. Shyamala, M. A. Siani, C. A. Gallegos, P. H. Feucht, J. Abbott, G. R. Lapointe, M. Moghadam, H. Khoja, J. Zakel, et al. (1996)
J. Biol. Chem. 271, 8228-8235
 |  Abstract »  |  Full Text »  |  PDF »

Selective G Protein Coupling by C-C Chemokine Receptors.

Y. Kuang, Y. Wu, H. Jiang, and D. Wu (1996)
J. Biol. Chem. 271, 3975-3978
 |  Abstract »  |  Full Text »  |  PDF »

Thrombin Primes Responsiveness of Selective Chemoattractant Receptors at a Site Distal to G Protein Activation.

H. Ali, E. D. Tomhave, R. M. Richardson, B. Haribabu, and R. Snyderman (1996)
J. Biol. Chem. 271, 3200-3206
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-8 Regulation of the Ras/Raf/Mitogen-activated Protein Kinase Pathway in Human Neutrophils.

C. Knall, S. Young, J. A. Nick, A. M. Buhl, G. S. Worthen, and G. L. Johnson (1996)
J. Biol. Chem. 271, 2832-2838
 |  Abstract »  |  Full Text »  |  PDF »

Cross-desensitization of Chemoattractant Receptors Occurs at Multiple Levels.

R. M. Richardson, H. Ali, E. D. Tomhave, B. Haribabu, and R. Snyderman (1995)
J. Biol. Chem. 270, 27829-27833
 |  Abstract »  |  Full Text »  |  PDF »

Selective Coupling of [IMAGE][IMAGE]-Adrenergic Receptor to Hematopoietic-specific G Proteins.

D. Wu, Y. Kuang, Y. Wu, and H. Jiang (1995)
J. Biol. Chem. 270, 16008-16010
 |  Abstract »  |  Full Text »  |  PDF »

G[IMAGE][IMAGE] and G[IMAGE][IMAGE] Couple a Wide Variety of Receptors to Phospholipase C.

S. Offermanns and M. I. Simon (1995)
J. Biol. Chem. 270, 15175-15180
 |  Abstract »  |  Full Text »  |  PDF »

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