Science 25 June 1993: Vol. 260. no. 5116, pp. 1953 - 1955 DOI: 10.1126/science.8316835

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Articles

Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.

S. Antoku and B. J. Mayer (2009)
J. Cell Sci. 122, 4228-4238
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SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.

E. Neumann-Haefelin, W. Qi, E. Finkbeiner, G. Walz, R. Baumeister, and M. Hertweck (2008)
Genes & Dev. 22, 2721-2735
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Neurogenesis and Epidermal Growth Factor Receptor Signaling by the Insulin Receptor/Target of Rapamycin Pathway in Drosophila.

H. McNeill, G. M. Craig, and J. M. Bateman (2008)
Genetics 179, 843-853
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53BP2S, Interacting with Insulin Receptor Substrates, Modulates Insulin Signaling.

F. Hakuno, S. Kurihara, R. T. Watson, J. E. Pessin, and S.-I. Takahashi (2007)
J. Biol. Chem. 282, 37747-37758
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Oxygen Tension Regulates the Stability of Insulin Receptor Substrate-1 (IRS-1) through Caspase-mediated Cleavage.

S. G. Kang, A. L. Brown, and J. H. Chung (2007)
J. Biol. Chem. 282, 6090-6097
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Insulin Resistance and Atherosclerosis.

J. Nigro, N. Osman, A. M. Dart, and P. J. Little (2006)
Endocr. Rev. 27, 242-259
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Differential Activation of Insulin Receptor Isoforms by Insulin-Like Growth Factors Is Determined by the C Domain.

A. Denley, G. V. Brierley, J. M. Carroll, A. Lindenberg, G. W. Booker, L. J. Cosgrove, J. C. Wallace, B. E. Forbes, and C. T. Roberts Jr. (2006)
Endocrinology 147, 1029-1036
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RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth.

W. Zhang, C. S. Zong, U. Hermanto, P. Lopez-Bergami, Z. Ronai, and L.-H. Wang (2006)
Mol. Cell. Biol. 26, 413-424
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Molecular Biology of the 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Gene Family.

J. Simard, M.-L. Ricketts, S. Gingras, P. Soucy, F. A. Feltus, and M. H. Melner (2005)
Endocr. Rev. 26, 525-582
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Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes.

E. M. Allister, N. M. Borradaile, J. Y. Edwards, and M. W. Huff (2005)
Diabetes 54, 1676-1683
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Phosphorylation of p66Shc and forkhead proteins mediates A{beta} toxicity.

W. W. Smith, D. D. Norton, M. Gorospe, H. Jiang, S. Nemoto, N. J. Holbrook, T. Finkel, and J. W. Kusiak (2005)
J. Cell Biol. 169, 331-339
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Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation.

S Najib and V Sanchez-Margalet (2005)
J. Mol. Endocrinol. 34, 119-126
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Diabetes Induces p66shc Gene Expression in Human Peripheral Blood Mononuclear Cells: Relationship to Oxidative Stress.

E. Pagnin, G. Fadini, R. de Toni, A. Tiengo, L. Calo, and A. Avogaro (2005)
J. Clin. Endocrinol. Metab. 90, 1130-1136
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Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells.

M. Bustamante, U. Hasler, O. Kotova, A. V. Chibalin, D. Mordasini, M. Rousselot, A. Vandewalle, P.-Y. Martin, and E. Feraille (2005)
Am J Physiol Renal Physiol 288, F334-F344
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Mouse Models of Insulin Resistance.

A. NANDI, Y. KITAMURA, C. R. KAHN, and D. ACCILI (2004)
Physiol Rev 84, 623-647
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The Cross-Talk between Angiotensin and Insulin Differentially Affects Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Mediated Signaling in Rat Heart: Implications for Insulin Resistance.

J. B. C. Carvalheira, V. C. Calegari, H. G. Zecchin, W. Nadruz Jr., R. B. Guimaraes, E. B. Ribeiro, K. G. Franchini, L. A. Velloso, and M. J. A. Saad (2003)
Endocrinology 144, 5604-5614
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Ras Participates in CpG Oligodeoxynucleotide Signaling through Association with Toll-like Receptor 9 and Promotion of Interleukin-1 Receptor-associated Kinase/Tumor Necrosis Factor Receptor-associated Factor 6 Complex Formation in Macrophages.

H. Xu, H. An, Y. Yu, M. Zhang, R. Qi, and X. Cao (2003)
J. Biol. Chem. 278, 36334-36340
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Morphine Induces Desensitization of Insulin Receptor Signaling.

Y. Li, S. Eitan, J. Wu, C. J. Evans, B. Kieffer, X. Sun, and R. D. Polakiewicz (2003)
Mol. Cell. Biol. 23, 6255-6266
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Ethanol Impairs Insulin-stimulated Neuronal Survival in the Developing Brain: ROLE OF PTEN PHOSPHATASE.

J. Xu, J. E. Yeon, H. Chang, G. Tison, G. J. Chen, J. Wands, and S. de la Monte (2003)
J. Biol. Chem. 278, 26929-26937
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Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts.

S. Uttamsingh, C. S. Zong, and L.-H. Wang (2003)
J. Biol. Chem. 278, 18798-18810
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Novel Signal Transduction Pathway for Luteinizing Hormone and Its Interaction with Insulin: Activation of Janus Kinase/Signal Transducer and Activator of Transcription and Phosphoinositol 3-Kinase/Akt Pathways.

C. R. O. Carvalho, J. B. C. Carvalheira, M. H. M. Lima, S. F. Zimmerman, L. C. Caperuto, A. Amanso, A. L. Gasparetti, V. Meneghetti, L. F. Zimmerman, L. A. Velloso, et al. (2003)
Endocrinology 144, 638-647
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Insulin-like Growth Factor I-mediated Protection from Rapamycin-induced Apoptosis Is Independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3'-Kinase-Akt Signaling Pathways.

K. N. Thimmaiah, J. Easton, S. Huang, K. A. Veverka, G. S. Germain, F. C. Harwood, and P. J. Houghton (2003)
Cancer Res. 63, 364-374
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Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.

D. R. McFarlin, M. J. Lindstrom, and M. N. Gould (2003)
Carcinogenesis 24, 99-105
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The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP3 levels.

S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen (2002)
Development 129, 4103-4109
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A Randomized Phase II and Pharmacokinetic Study of the Antisense Oligonucleotides ISIS 3521 and ISIS 5132 in Patients with Hormone-refractory Prostate Cancer.

A. W. Tolcher, L. Reyno, P. M. Venner, S. D. Ernst, M. Moore, R. S. Geary, K. Chi, S. Hall, W. Walsh, A. Dorr, et al. (2002)
Clin. Cancer Res. 8, 2530-2535
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TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.

J. M.-Y. Ho, M. H.-H. Nguyen, J. K. Dierov, K. M. Badger, B. K. Beattie, P. Tartaro, R. Haq, B. W. Zanke, M. P. Carroll, and D. L. Barber (2002)
Blood 100, 1438-1448
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In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents.

L.-y. Qiao, R. Zhande, T. L. Jetton, G. Zhou, and X. J. Sun (2002)
J. Biol. Chem. 277, 26530-26539
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Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma.

K Saito, S Inoue, T Saito, S Kiso, N Ito, S Tamura, H Watanabe, H Takeda, H Misawa, H Togashi, et al. (2002)
Gut 51, 100-104
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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.

A. Schmidt and A. Hall (2002)
Genes & Dev. 16, 1587-1609
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RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix.

U. Hermanto, C. S. Zong, W. Li, and L.-H. Wang (2002)
Mol. Cell. Biol. 22, 2345-2365
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Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q.

M P Hitchins, S Abu-Amero, S Apostolidou, D Monk, P Stanier, M A Preece, and G E Moore (2002)
J. Med. Genet. 39, e13-13
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c-Jun N-terminal Kinase Specifically Phosphorylates p66ShcA at Serine 36 in Response to Ultraviolet Irradiation.

S. Le, T. J. Connors, and A. C. Maroney (2001)
J. Biol. Chem. 276, 48332-48336
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Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regions.

M. P Hitchins, P. Stanier, M. A Preece, and G. E Moore (2001)
J. Med. Genet. 38, 810-819
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Inhibition of Mitogen-activated Protein Kinase Kinase Selectively Inhibits Cell Proliferation in Human Breast Cancer Cells Displaying Enhanced Insulin-like Growth Factor I-mediated Mitogen-activated Protein Kinase Activation.

U. Hermanto, C. S. Zong, and L.-H. Wang (2000)
Cell Growth Differ. 11, 655-664
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Insulin-Activated Protein Kinase Cbeta Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells.

P. Formisano, F. Oriente, F. Fiory, M. Caruso, C. Miele, M. A. Maitan, F. Andreozzi, G. Vigliotta, G. Condorelli, and F. Beguinot (2000)
Mol. Cell. Biol. 20, 6323-6333
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Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses.

U. Schaeper, N. H. Gehring, K. P. Fuchs, M. Sachs, B. Kempkes, and W. Birchmeier (2000)
J. Cell Biol. 149, 1419-1432
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The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor.

P. Soni, M. Lakkis, M. N. Poy, M. A. Fernstrom, and S. M. Najjar (2000)
Mol. Cell. Biol. 20, 3896-3905
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A Phase I Trial of c-Raf Kinase Antisense Oligonucleotide ISIS 5132 Administered as a Continuous Intravenous Infusion in Patients with Advanced Cancer.

C. C. Cunningham, J. T. Holmlund, J. H. Schiller, R. S. Geary, T. J. Kwoh, A. Dorr, and J. Nemunaitis (2000)
Clin. Cancer Res. 6, 1626-1631
 |  Abstract »  |  Full Text »  |  PDF »

Brain Insulin Receptor Causes Activity-Dependent Current Suppression in the Olfactory Bulb Through Multiple Phosphorylation of Kv1.3.

D. A. Fadool, K. Tucker, J. J. Phillips, and J. A. Simmen (2000)
J Neurophysiol 83, 2332-2348
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Interleukin-4 Mediates Cell Growth Inhibition through Activation of Stat1.

T. L.-Y. Chang, X. Peng, and X.-Y. Fu (2000)
J. Biol. Chem. 275, 10212-10217
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Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B. POSSIBLE FACILITATION BY THE FORMATION OF A TERNARY COMPLEX WITH THE GRB2 ADAPTOR PROTEIN.

B. J. Goldstein, A. Bittner-Kowalczyk, M. F. White, and M. Harbeck (2000)
J. Biol. Chem. 275, 4283-4289
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Effect of Contraction on Mitogen-activated Protein Kinase Signal Transduction in Skeletal Muscle. INVOLVEMENT OF THE MITOGEN- AND STRESS-ACTIVATED PROTEIN KINASE 1.

J. W. Ryder, R. Fahlman, H. Wallberg-Henriksson, D. R. Alessi, A. Krook, and J. R. Zierath (2000)
J. Biol. Chem. 275, 1457-1462
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IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis.

T. Uchida, M. G. Myers Jr., and M. F. White (2000)
Mol. Cell. Biol. 20, 126-138
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Vinexin Forms a Signaling Complex with Sos and Modulates Epidermal Growth Factor-induced c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activities.

M. Akamatsu, S.-i. Aota, A. Suwa, K. Ueda, T. Amachi, K. M. Yamada, S. K. Akiyama, and N. Kioka (1999)
J. Biol. Chem. 274, 35933-35937
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Accelerated Mammary Tumor Development in Mutant Polyomavirus Middle T Transgenic Mice Expressing Elevated Levels of Either the Shc or Grb2 Adapter Protein.

M. J. Rauh, V. Blackmore, E. R. Andrechek, C. G. Tortorice, R. Daly, V. K.-M. Lai, T. Pawson, R. D. Cardiff, P. M. Siegel, and W. J. Muller (1999)
Mol. Cell. Biol. 19, 8169-8179
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Cas Mediates Transcriptional Activation of the Serum Response Element by Src.

Y. Hakak and G. S. Martin (1999)
Mol. Cell. Biol. 19, 6953-6962
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Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis.

T. Wada, T. Sasaoka, M. Ishiki, H. Hori, T. Haruta, H. Ishihara, and M. Kobayashi (1999)
Endocrinology 140, 4585-4594
 |  Abstract »  |  Full Text »

Insulin-induced Desensitization of Extracellular Signal-regulated Kinase Activation Results from an Inhibition of Raf Activity Independent of Ras Activation and Dissociation of the Grb2-SOS Complex.

R. V. Fucini, S. Okada, and J. E. Pessin (1999)
J. Biol. Chem. 274, 18651-18658
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes.

N. Takahashi, Y. Seko, E. Noiri, K. Tobe, T. Kadowaki, H. Sabe, and Y. Yazaki (1999)
Circ. Res. 84, 1194-1202
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Insulin-Like Growth Factor I Synergizes with Interleukin 4 for Hematopoietic Cell Proliferation Independent of Insulin Receptor Substrate Expression.

L. Soon, L. Flechner, J. S. Gutkind, L.-H. Wang, R. Baserga, J. H. Pierce, and W. Li (1999)
Mol. Cell. Biol. 19, 3816-3828
 |  Abstract »  |  Full Text »  |  PDF »

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells.

C. Montrose-Rafizadeh, P. Avdonin, M. J. Garant, B. D. Rodgers, S. Kole, H. Yang, M. A. Levine, W. Schwindinger, and M. Bernier (1999)
Endocrinology 140, 1132-1140
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Insulin-Like Growth Factor I Suppresses Parathyroid Hormone (PTH)/PTH-Related Protein Receptor Expression via a Mitogen-Activated Protein Kinase Pathway in UMR-106 Osteoblast-Like Cells.

T. Kawane and N. Horiuchi (1999)
Endocrinology 140, 871-879
 |  Abstract »  |  Full Text »

Shc Dominant Negative Disrupts Cell Cycle Progression in Both G0-G1 and G2-M of ErbB2-positive Breast Cancer Cells.

L. E. Stevenson, K. S. Ravichandran, and A. R. Frackelton Jr. (1999)
Cell Growth Differ. 10, 61-71
 |  Abstract »  |  Full Text »

Insulin Receptor Substrate 2 And Shc Play Different Roles In Insulin-like Growth Factor I Signaling.

B. Kim, H.-L. Cheng, B. Margolis, and E. L. Feldman (1998)
J. Biol. Chem. 273, 34543-34550
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Differential Regulation of Insulin Receptor Substrate-2 and Mitogen-Activated Protein Kinase Tyrosine Phosphorylation by Phosphatidylinositol 3-Kinase Inhibitors in SH-SY5Y Human Neuroblastoma Cells.

B. Kim, P. S. Leventhal, M. F. White, and E. L. Feldman (1998)
Endocrinology 139, 4881-4889
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Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression.

T. Tsakiridis, A. Bergman, R. Somwar, C. Taha, K. Aktories, T. F. Cruz, A. Klip, and G. P. Downey (1998)
J. Biol. Chem. 273, 28322-28331
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Reconstitution of Insulin Signaling Pathways in Rat 3Y1 Cells Lacking Insulin Receptor and Insulin Receptor Substrate-1. EVIDENCE THAT ACTIVATION OF Akt IS INSUFFICIENT FOR INSULIN-STIMULATED GLYCOGEN SYNTHESIS OR GLUCOSE UPTAKE IN RAT 3Y1 CELLS.

T. Imanaka, H. Hayashi, K. Kishi, L. Wang, K. Ishii, O. Hazeki, T. Katada, and Y. Ebina (1998)
J. Biol. Chem. 273, 25347-25355
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Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction.

K. Okkenhaug and R. Rottapel (1998)
J. Biol. Chem. 273, 21194-21202
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Insulin Receptor Substrate Protein, xIRS-u, Potentiates Insulin Signaling: Functional Importance of Its Pleckstrin Homology Domain.

N. Ohan, M. Bayaa, P. Kumar, L. Zhu, and X. J. Liu (1998)
Mol. Endocrinol. 12, 1086-1098
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Replacement of Tyrosine 1251 in the Carboxyl Terminus of the Insulin-like Growth Factor-I Receptor Disrupts the Actin Cytoskeleton and Inhibits Proliferation and Anchorage-independent Growth.

V. A. Blakesley, A. P. Koval, B. S. Stannard, A. Scrimgeour, and D. LeRoith (1998)
J. Biol. Chem. 273, 18411-18422
 |  Abstract »  |  Full Text »  |  PDF »

Growth Factor Receptor-Bound Protein 2 (Grb2) Association with Hemopoietic Specific Protein 1: Linkage Between Lck and Grb2.

Y. Takemoto, M. Furuta, M. Sato, P. R. Findell, W. Ramble, and Y. Hashimoto (1998)
J. Immunol. 161, 625-630
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation.

Y. R. Hadari, H. Kouhara, I. Lax, and J. Schlessinger (1998)
Mol. Cell. Biol. 18, 3966-3973
 |  Abstract »  |  Full Text »  |  PDF »

Interplay of the Proto-oncogene Proteins CrkL and CrkII in Insulin-like Growth Factor-I Receptor-mediated Signal Transduction.

A. P. Koval, M. Karas, Y. Zick, and D. LeRoith (1998)
J. Biol. Chem. 273, 14780-14787
 |  Abstract »  |  Full Text »  |  PDF »

Association of the Insulin Receptor with Phospholipase C-gamma (PLCgamma ) in 3T3-L1 Adipocytes Suggests a Role for PLCgamma in Metabolic Signaling by Insulin.

A. G. Kayali, J. Eichhorn, T. Haruta, A. J. Morris, J. G. Nelson, P. Vollenweider, J. M. Olefsky, and N. J. G. Webster (1998)
J. Biol. Chem. 273, 13808-13818
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Receptor-mediated Dissociation of Grb2 from Sos Involves Phosphorylation of Sos by Kinase(s) Other than Extracellular Signal-regulated Kinase.

H. Zhao, S. Okada, J. E. Pessin, and G. A. Koretzky (1998)
J. Biol. Chem. 273, 12061-12067
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-like Growth Factor-1 (IGF-1) Receptor-Insulin Receptor Substrate Complexes in the Uterus. ALTERED SIGNALING RESPONSE TO ESTRADIOL IN THE IGF-1m/m MOUSE.

R. G. Richards, M. P. Walker, J. Sebastian, and R. P. DiAugustine (1998)
J. Biol. Chem. 273, 11962-11969
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Receptor Substrate (IRS) Proteins IRS-1 and IRS-2 Differential Signaling in the Insulin/Insulin-Like Growth Factor-I Pathways in Fetal Brown Adipocytes.

A. M. Valverde, M. Lorenzo, S. Pons, M. F. White, and M. Benito (1998)
Mol. Endocrinol. 12, 688-697
 |  Abstract »  |  Full Text »

Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation.

T. Takada, T. Matozaki, H. Takeda, K. Fukunaga, T. Noguchi, Y. Fujioka, I. Okazaki, M. Tsuda, T. Yamao, F. Ochi, et al. (1998)
J. Biol. Chem. 273, 9234-9242
 |  Abstract »  |  Full Text »  |  PDF »

Anti-apoptotic Signaling by a Colony-stimulating Factor-1 Receptor/Insulin Receptor Chimera with a Juxtamembrane Deletion.

J. E. Boehm, O. V. Chaika, and R. E. Lewis (1998)
J. Biol. Chem. 273, 7169-7176
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane Skeleton.

S. F. Clark, S. Martin, A. J. Carozzi, M. M. Hill, and D. E. James (1998)
J. Cell Biol. 140, 1211-1225
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-like Protein-tyrosine Phosphatase alpha  Specifically Inhibits Insulin-increased Prolactin Gene Expression.

K. K. Jacob, J. Sap, and F. M. Stanley (1998)
J. Biol. Chem. 273, 4800-4809
 |  Abstract »  |  Full Text »  |  PDF »

Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Protein in Vivo.

M. K. Jones and J. H. Jackson (1998)
J. Biol. Chem. 273, 1782-1787
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-Independent GLUT4 Translocation Induced by Guanosine 5'-O-(3-Thiotriphosphate) Involves Tyrosine Phosphorylation.

T. Haruta, A. J. Morris, P. Vollenweider, J. G. Nelson, D. W. Rose, M. Mueckler, and J. M. Olefsky (1998)
Endocrinology 139, 358-364
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process.

M. Hallek, P. Leif Bergsagel, and K. C. Anderson (1998)
Blood 91, 3-21
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Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase.

B. Dufourny, J. Alblas, H. A. A. M. van Teeffelen, F. M. A van Schaik, B. van der Burg, P. H. Steenbergh, and J. S. Sussenbach (1997)
J. Biol. Chem. 272, 31163-31171
 |  Abstract »  |  Full Text »  |  PDF »

Insulin and Epidermal Growth Factor Stimulate a Conformational Change in Rap1 and Dissociation of the CrkII-C3G Complex.

S. Okada and J. E. Pessin (1997)
J. Biol. Chem. 272, 28179-28182
 |  Abstract »  |  Full Text »  |  PDF »

Differential Signaling to Glycogen Synthesis by the Intracellular Domain of the Insulin versus the Insulin-like Growth Factor-1 Receptor. EVIDENCE FROM STUDIES OF TrkC-CHIMERAS.

H. E. Kalloo-Hosein, J. P. Whitehead, M. Soos, J. M. Tavare, K. Siddle, and S. O'Rahilly (1997)
J. Biol. Chem. 272, 24325-24332
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action.

H. Eldar-Finkelman and E. G. Krebs (1997)
PNAS 94, 9660-9664
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Differential Utilization of ShcA Tyrosine Residues and Functional Domains in the Transduction of Epidermal Growth Factor-induced Mitogen-activated Protein Kinase Activation in 293T Cells and Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells. IDENTIFICATION OF A NEW Grb2·Sos1 BINDING SITE.

D. Thomas and R. A. Bradshaw (1997)
J. Biol. Chem. 272, 22293-22299
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Tyrosine Residues in the C-Terminal Domain of the Insulin-Like Growth Factor-I Receptor Mediate Mitogenic and Tumorigenic Signals.

D. L. Esposito, V. A. Blakesley, A. P. Koval, A. G. Scrimgeour, and D. LeRoith (1997)
Endocrinology 138, 2979-2988
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Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways.

A. W. Kao, S. B. Waters, S. Okada, and J. E. Pessin (1997)
Endocrinology 138, 2474-2480
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CSF-1 Receptor/Insulin Receptor Chimera Permits CSF-1-dependent Differentiation of 3T3-L1 Preadipocytes.

O. V. Chaika, N. Chaika, D. J. Volle, P. A. Wilden, S. J. Pirrucello, and R. E. Lewis (1997)
J. Biol. Chem. 272, 11968-11974
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Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins.

D. L. Barber, J. M. Mason, T. Fukazawa, K. A. Reedquist, B. J. Druker, H. Band, and A. D. D'Andrea (1997)
Blood 89, 3166-3174
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Shc Interaction with Src Homology 2Domain Containing Inositol Phosphatase (SHIP) in Vivo Requires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP.

T. D. Lamkin, S. F. Walk, L. Liu, J. E. Damen, G. Krystal, and K. S. Ravichandran (1997)
J. Biol. Chem. 272, 10396-10401
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Functional Importance of Shc Tyrosine 317on Insulin Signaling in Rat1 Fibroblasts Expressing Insulin Receptors.

H. Ishihara, T. Sasaoka, M. Ishiki, Y. Takata, T. Imamura, I. Usui, W. J. Langlois, T. Sawa, and M. Kobayashi (1997)
J. Biol. Chem. 272, 9581-9586
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Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling.

H. Ueno, K. Sasaki, K. Miyagawa, H. Honda, K. Mitani, Y. Yazaki, and H. Hirai (1997)
J. Biol. Chem. 272, 8739-8743
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Stat5 is a physiological substrate of the insulin receptor.

J. Chen, H. B. Sadowski, R. A. Kohanski, and L.-H. Wang (1997)
PNAS 94, 2295-2300
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A Molecular Redox Switch on p21ras. STRUCTURAL BASIS FOR THE NITRIC OXIDE-p21ras INTERACTION.

HarryM. Lander, DavidP. Hajjar, BarbaraL. Hempstead, UroojA. Mirza, BrianT. Chait, S. Campbell, and LawrenceA. Quilliam (1997)
J. Biol. Chem. 272, 4323-4326
 |  Abstract »  |  Full Text »  |  PDF »

A Casein Kinase I Activity Is Constitutively Associated with Nck.

G. Lussier and L. Larose (1997)
J. Biol. Chem. 272, 2688-2694
 |  Abstract »  |  Full Text »  |  PDF »

High Affinity Binding of the Pleckstrin Homology Domain of mSos1 to Phosphatidylinositol (4,5)-Bisphosphate.

T. J. Kubiseski, Y. M. Chook, W. E. Parris, M. Rozakis-Adcock, and T. Pawson (1997)
J. Biol. Chem. 272, 1799-1804
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells.

D. L. Barber, C. N. Corless, K. Xia, T. M. Roberts, and A. D. D'Andrea (1997)
Blood 89, 55-64
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Signaling and Its Regulation of System A Amino Acid Uptake in Cultured Rat Vascular Smooth Muscle Cells.

T. Obata, A. Kashiwagi, H. Maegawa, Y. Nishio, S. Ugi, H. Hidaka, and R. Kikkawa (1996)
Circ. Res. 79, 1167-1176
 |  Abstract »  |  Full Text »

Regulation of the Association of p120cbl with Grb2 in Jurkat T Cells.

JeraldA. Donovan, Y. Ota, WallaceY. Langdon, and LawrenceE. Samelson (1996)
J. Biol. Chem. 271, 26369-26374
 |  Abstract »  |  Full Text »  |  PDF »

Interactions between Src Homology (SH) 2/SH3 Adapter Proteins and the Guanylnucleotide Exchange Factor SOS Are Differentially Regulated by Insulin and Epidermal Growth Factor.

S. Okada and J. E. Pessin (1996)
J. Biol. Chem. 271, 25533-25538
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Rad Inhibits Glucose Uptake in Cultured Muscle and Fat Cells.

J. S. Moyers, P. J. Bilan, C. Reynet, and C. R. Kahn (1996)
J. Biol. Chem. 271, 23111-23116
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase.

T. Tsakiridis, C. Taha, S. Grinstein, and A. Klip (1996)
J. Biol. Chem. 271, 19664-19667
 |  Abstract »  |  Full Text »  |  PDF »

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling.

K. A. Kenner, E. Anyanwu, J. M. Olefsky, and J. Kusari (1996)
J. Biol. Chem. 271, 19810-19816
 |  Abstract »  |  Full Text »  |  PDF »

MAP Kinase Activation by Flow in Endothelial Cells: Role of ß1 Integrins and Tyrosine Kinases.

T. Ishida, T. E. Peterson, N. L. Kovach, and B. C. Berk (1996)
Circ. Res. 79, 310-316
 |  Abstract »  |  Full Text »

Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation.

S. B. Waters, D. Chen, A. W. Kao, S. Okada, K. H. Holt, and J. E. Pessin (1996)
J. Biol. Chem. 271, 18224-18230
 |  Abstract »  |  Full Text »  |  PDF »

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