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Science 25 June 1993:
Vol. 260. no. 5116, pp. 1931 - 1934
DOI: 10.1126/science.8100366

Articles

Science, Vol 260, Issue 5116, 1931-1934
Copyright © 1993 by American Association for the Advancement of Science


articles

The role of TH1 and TH2 cells in a rodent malaria infection

AW Taylor-Robinson, RS Phillips, A Severn, S Moncada, and FY Liew

Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.

CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.


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A Pathogenic Role of IL-12 in Blood-Stage Murine Malaria Lethal Strain Plasmodium berghei NK65 Infection.
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J. Immunol. 160, 5500-5505
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Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice.
J o. Koglin, T. Glysing-Jensen, J. S. Mudgett, and M. E. Russell (1998)
Circulation 97, 2059-2065
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Protective Role of Nitric Oxide in Staphylococcus aureus Infection in Mice.
S. Sasaki, T. Miura, S. Nishikawa, K. Yamada, M. Hirasue, and A. Nakane (1998)
Infect. Immun. 66, 1017-1022
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Deletion of Plasmodium berghei-specific CD4+ T cells adoptively transferred into recipient mice after challenge with homologous parasite.
C. Hirunpetcharat and M. F. Good (1998)
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Expression cloning of a protective Leishmania antigen.
E Mougneau, F Altare, A. Wakil, S Zheng, T Coppola, Z. Wang, R Waldmann, R. Locksley, and N Glaichenhaus (1995)
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Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.
C Graziosi, G Pantaleo, K. Gantt, J. Fortin, J. Demarest, O. Cohen, R. Sekaly, and A. Fauci (1994)
Science 265, 248-252
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The Mechanism and Significance of Deletion of Parasite-specific CD4+ T Cells in Malaria Infection.
H. Xu, J. Wipasa, H. Yan, M. Zeng, M. O. Makobongo, F. D. Finkelman, A. Kelso, and M. F. Good (2002)
J. Exp. Med. 195, 881-892
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