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Science 25 June 1993: Vol. 260. no. 5116, pp. 1931 - 1934 DOI: 10.1126/science.8100366
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Articles
Science, Vol 260, Issue 5116, 1931-1934
Copyright © 1993 by American Association for the Advancement of Science
The role of TH1 and TH2 cells in a rodent malaria infection
AW Taylor-Robinson,
RS Phillips,
A Severn,
S Moncada,
and
FY Liew
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.
CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
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