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Science 25 June 1993:
Vol. 260. no. 5116, pp. 1926 - 1928
DOI: 10.1126/science.8316832
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Articles

Science, Vol 260, Issue 5116, 1926-1928
Copyright © 1993 by American Association for the Advancement of Science

articles

Arabidopsis thaliana DNA methylation mutants

A Vongs, T Kakutani, RA Martienssen, and EJ Richards

Cold Spring Harbor Laboratory, NY 11724.

Three DNA hypomethylation mutants of the flowering plant Arabidopsis thaliana were isolated by screening mutagenized populations for plants containing centromeric repetitive DNA arrays susceptible to digestion by a restriction endonuclease that was sensitive to methylated cytosines. The mutations are recessive, and at least two are alleles of a single locus, designated DDM1 (for decrease in DNA methylation). Amounts of 5-methylcytosine were reduced over 70 percent in ddm1 mutants. Despite this reduction in DNA methylation levels, ddm1 mutants developed normally and exhibited no striking morphological phenotypes. However, the ddm1 mutations are associated with a segregation distortion phenotype. The ddm1 mutations were used to demonstrate that de novo DNA methylation in vivo is slow.


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Arabidopsis MET1 Cytosine Methyltransferase Mutants.
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Genetics 163, 557-570
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Plant Physiology 130, 1090-1101
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Two regulatory levels of transcriptional gene silencing in Arabidopsis.
O. M. Scheid, A. V. Probst, K. Afsar, and J. Paszkowski (2002)
PNAS 99, 13659-13662
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Epi-Alleles in Plants: Inheritance of Epigenetic Information over Generations.
T. Kakutani (2002)
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Genetics 162, 355-363
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Plant Physiology 129, 733-746
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Methylation Matters: Modeling a Manageable Genome.
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F. Pardo-Manuel de Villena, E. de la Casa-Esperón, T. L. Briscoe, and C. Sapienza (2000)
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Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis.
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