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Science 18 June 1993:
Vol. 260. no. 5115, pp. 1816 - 1819
DOI: 10.1126/science.8511591
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Articles

Science, Vol 260, Issue 5115, 1816-1819
Copyright © 1993 by American Association for the Advancement of Science

articles

Molecular cloning of an apolipoprotein B messenger RNA editing protein

B Teng, CF Burant, and NO Davidson

Department of Medicine, University of Chicago, IL 60637.

Mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene. The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine deamination produces a UAA termination codon. A full-length complementary DNA clone encoding an apo B messenger RNA editing protein (REPR) was isolated from rat small intestine. The 229-residue protein contains consensus phosphorylation sites and leucine zipper domains. HepG2 cell extracts acquire editing activity when mixed with REPR from oocyte extracts. REPR is essential for apo B messenger RNA editing, and the isolation and characterization of REPR may lead to the identification of other eukaryotic RNA editing proteins.


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J. Biol. Chem. 273, 9435-9442
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Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.
Y. Yang, Y. Yang, and H. C. Smith (1997)
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X. Qian, M. E. Balestra, and T. L. Innerarity (1997)
J. Biol. Chem. 272, 18060-18070
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Cloning of an Apobec-1-binding Protein That Also Interacts with Apolipoprotein B mRNA and Evidence for Its Involvement in RNA Editing.
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RED2, a Brain-specific Member of the RNA-specific Adenosine Deaminase Family.
T. Melcher, S. Maas, A. Herb, R. Sprengel, M. Higuchi, and P. H. Seeburg (1996)
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Length suppression in histone messenger RNA 3'-end maturation: Processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA.
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Apobec-1 Interacts with a 65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro.
A. Mehta, S. Banerjee, and D. M. Driscoll (1996)
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Complete Phenotypic Characterization of apobec-1 Knockout Mice with a Wild-type Genetic Background and a Human Apolipoprotein B Transgenic Background, and Restoration of Apolipoprotein B mRNA Editing by Somatic Gene Transfer of Apobec-1.
M. Nakamuta, B. H.-J. Chang, E. Zsigmond, K. Kobayashi, H. Lei, B. Y. Ishida, K. Oka, E. Li, and L. Chan (1996)
J. Biol. Chem. 271, 25981-25988
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Apolipoprotein B Sequence Requirements for Hepatic Very Low Density Lipoprotein Assembly. EVIDENCE THAT HYDROPHOBIC SEQUENCES WITHIN APOLIPOPROTEIN B48 MEDIATE LIPID RECRUITMENT.
R. S. McLeod, Y. Wang, S. Wang, A. Rusinol, P. Links, and Z. Yao (1996)
J. Biol. Chem. 271, 18445-18455
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Hyperediting of Multiple Cytidines of Apolipoprotein B mRNA by APOBEC-1 Requires Auxiliary Protein(s) but Not a Mooring Sequence Motif.
S. Yamanaka, K. S. Poksay, D. M. Driscoll, and T. L. Innerarity (1996)
J. Biol. Chem. 271, 11506-11510
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Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48.
K.-I. Hirano, S. G. Young, R. V. Farese Jr., J. Ng, E. Sande, C. Warburton, L. M. Powell-Braxton, and N. O. Davidson (1996)
J. Biol. Chem. 271, 9887-9890
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Overexpression of APOBEC-1 Results in Mooring Sequence-dependent Promiscuous RNA Editing.
M. Sowden, J. K. Hamm, and H. C. Smith (1996)
J. Biol. Chem. 271, 3011-3017
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Biosynthesis of Apolipoprotein B48-containing Lipoproteins.
T. L. Innerarity, J. Borén, S. Yamanaka, and S.-O. Olofsson (1996)
J. Biol. Chem. 271, 2353-2356
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Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment.
C.-N. Wang, T. C. Hobman, and D. N. Brindley (1995)
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Alternative mRNA Splicing and Differential Promoter Utilization Determine Tissue-specific Expression of the Apolipoprotein B mRNA-editing Protein (Apobec1) Gene in Mice.
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RNA editing in the Wilms' tumor susceptibility gene, WT1..
P M Sharma, M Bowman, S L Madden, F J Rauscher, and S Sukumar (1994)
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Purification and Molecular Cloning of a Novel Essential Component of the Apolipoprotein B mRNA Editing Enzyme-Complex.
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