Science 18 June 1993: Vol. 260. no. 5115, pp. 1808 - 1810 DOI: 10.1126/science.8511589

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Articles

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity.

G. R. Steinberg, M. J. Watt, M. Ernst, M. J. Birnbaum, B. E. Kemp, and S. B. Jorgensen (2009)
Diabetes 58, 829-839
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2.

S. Feng, Q. Tang, M. Sun, J. Y. Chun, C. P. Evans, and A. C. Gao (2009)
Mol. Cancer Ther. 8, 665-671
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130.

Y. Tanaka, N. Tanaka, Y. Saeki, K. Tanaka, M. Murakami, T. Hirano, N. Ishii, and K. Sugamura (2008)
Mol. Cell. Biol. 28, 4805-4818
 |  Abstract »  |  Full Text »  |  PDF »

IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3.

C. A. Fielding, R. M. McLoughlin, L. McLeod, C. S. Colmont, M. Najdovska, D. Grail, M. Ernst, S. A. Jones, N. Topley, and B. J. Jenkins (2008)
J. Immunol. 181, 2189-2195
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Receptor-Mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes Choroidal Neovascularization.

K. Izumi-Nagai, N. Nagai, Y. Ozawa, M. Mihara, Y. Ohsugi, T. Kurihara, T. Koto, S. Satofuka, M. Inoue, K. Tsubota, et al. (2007)
Am. J. Pathol. 170, 2149-2158
 |  Abstract »  |  Full Text »  |  PDF »

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.

B. J. Jenkins, A. W. Roberts, C. J. Greenhill, M. Najdovska, T. Lundgren-May, L. Robb, D. Grail, and M. Ernst (2007)
Blood 109, 2380-2388
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Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure.

B. G. Helwig, T. I. Musch, R. A. Craig, and M. J. Kenney (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1165-R1173
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Functional Characterization of a Soluble Form of Oncostatin M/Interleukin-31 Shared Receptor.

C. Diveu, E. Venereau, J. Froger, E. Ravon, L. Grimaud, F. Rousseau, S. Chevalier, and H. Gascan (2006)
J. Biol. Chem. 281, 36673-36682
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk among gp130 Cytokines in Adipocytes.

S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes.

S. Kralisch, J. Klein, U. Lossner, M. Bluher, R. Paschke, M. Stumvoll, and M. Fasshauer (2005)
Am J Physiol Endocrinol Metab 289, E586-E590
 |  Abstract »  |  Full Text »  |  PDF »

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.

O. Obreja, W. Biasio, M. Andratsch, K. S. Lips, P. K. Rathee, A. Ludwig, S. Rose-John, and M. Kress (2005)
Brain 128, 1634-1641
 |  Abstract »  |  Full Text »  |  PDF »

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst (2005)
Blood 105, 3512-3520
 |  Abstract »  |  Full Text »  |  PDF »

Cooling-induced contraction and protein tyrosine kinase activity of isolated arterioles in secondary Raynaud's phenomenon.

P. B. Furspan, S. Chatterjee, M. D. Mayes, and R. R. Freedman (2005)
Rheumatology 44, 488-494
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Contact Sites Are Recruited by Cardiotrophin-like Cytokine (CLC) to Generate the CLC/CLF and CLC/sCNTFR{alpha} Composite Cytokines.

D. Perret, C. Guillet, G. Elson, J. Froger, H. Plun-Favreau, F. Rousseau, M. Chabbert, J.-F. Gauchat, and H. Gascan (2004)
J. Biol. Chem. 279, 43961-43970
 |  Abstract »  |  Full Text »  |  PDF »

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow.

A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong (2004)
Blood 104, 100-106
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Cytokines and Postmyocardial Infarction Remodeling.

M. Nian, P. Lee, N. Khaper, and P. Liu (2004)
Circ. Res. 94, 1543-1553
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of Oligodendrocyte Differentiation from Murine Embryonic Stem Cells by an Activator of gp130 Signaling.

P. Zhang, J. Chebath, P. Lonai, and M. Revel (2004)
Stem Cells 22, 344-354
 |  Abstract »  |  Full Text »  |  PDF »

Androgen Receptor in Prostate Cancer.

C. A. Heinlein and C. Chang (2004)
Endocr. Rev. 25, 276-308
 |  Abstract »  |  Full Text »  |  PDF »

Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression.

B. J. Jenkins, D. Grail, M. Inglese, C. Quilici, S. Bozinovski, P. Wong, and M. Ernst (2004)
Mol. Cell. Biol. 24, 1453-1463
 |  Abstract »  |  Full Text »  |  PDF »

GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor.

C. Diveu, E. Lelievre, D. Perret, A.-H. L. Lak-Hal, J. Froger, C. Guillet, S. Chevalier, F. Rousseau, A. Wesa, L. Preisser, et al. (2003)
J. Biol. Chem. 278, 49850-49859
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis C Virus Core Protein Differently Regulates the JAK-STAT Signaling Pathway under Interleukin-6 and Interferon-{gamma} Stimuli.

A. Hosui, K. Ohkawa, H. Ishida, A. Sato, F. Nakanishi, K. Ueda, T. Takehara, A. Kasahara, Y. Sasaki, M. Hori, et al. (2003)
J. Biol. Chem. 278, 28562-28571
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor.

H. Plun-Favreau, D. Perret, C. Diveu, J. Froger, S. Chevalier, E. Lelievre, H. Gascan, and M. Chabbert (2003)
J. Biol. Chem. 278, 27169-27179
 |  Abstract »  |  Full Text »  |  PDF »

JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes. ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION.

F. Legendre, J. Dudhia, J.-P. Pujol, and P. Bogdanowicz (2003)
J. Biol. Chem. 278, 2903-2912
 |  Abstract »  |  Full Text »  |  PDF »

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130.

U. Lehmann, J. Schmitz, M. Weissenbach, R. M. Sobota, M. Hortner, K. Friederichs, I. Behrmann, W. Tsiaris, A. Sasaki, J. Schneider-Mergener, et al. (2003)
J. Biol. Chem. 278, 661-671
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Promotes Androgen-independent Growth in LNCaP Human Prostate Cancer Cells.

S. O. Lee, W. Lou, M. Hou, F. de Miguel, L. Gerber, and A. C. Gao (2003)
Clin. Cancer Res. 9, 370-376
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

M. Hayashi, M.-C. Rho, A. Enomoto, A. Fukami, Y.-P. Kim, Y. Kikuchi, T. Sunazuka, T. Hirose, K. Komiyama, and S. Omura (2002)
PNAS 99, 14728-14733
 |  Abstract »  |  Full Text »  |  PDF »

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway.

M. Chatterjee, D. Honemann, S. Lentzsch, K. Bommert, C. Sers, P. Herrmann, S. Mathas, B. Dorken, and R. C. Bargou (2002)
Blood 100, 3311-3318
 |  Abstract »  |  Full Text »  |  PDF »

Interdomain Interaction of Stat3 Regulates Its Src Homology 2 Domain-mediated Receptor Binding Activity.

T. Zhang, K. T. Seow, C. T. Ong, and X. Cao (2002)
J. Biol. Chem. 277, 17556-17563
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Amino Acid Residues of gp130 Signal Transducer and gp80 {alpha} Receptor Subunit That Are Involved in Ligand Binding and Signaling by Human Herpesvirus 8-Encoded Interleukin-6.

H. Li and J. Nicholas (2002)
J. Virol. 76, 5627-5636
 |  Abstract »  |  Full Text »  |  PDF »

Shedding of the Interleukin-6 (IL-6) Receptor (gp80) Determines the Ability of IL-6 to Induce gp130 Phosphorylation in Human Osteoblasts.

C. Vermes, J. J. Jacobs, J. Zhang, G. Firneisz, K. A. Roebuck, and T. T. Glant (2002)
J. Biol. Chem. 277, 16879-16887
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Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6.

S. Viswanathan, T. Benatar, S. Rose-John, D. A. Lauffenburger, and P. W. Zandstra (2002)
Stem Cells 20, 119-138
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome.

W. Y. PARK, R. B. GOODMAN, K. P. STEINBERG, J. T. RUZINSKI, F. RADELLA II, D. R. PARK, J. PUGIN, S. J. SKERRETT, L. D. HUDSON, and T. R. MARTIN (2001)
Am. J. Respir. Crit. Care Med. 164, 1896-1903
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle-dependent Interaction of Mad2 with Conserved Box1/2 Region of Human Granulocyte-Macrophage Colony-stimulating Factor Receptor Common beta c.

M. Takeda, N. Dohmae, K. Takio, K.-i. Arai, and S. Watanabe (2001)
J. Biol. Chem. 276, 41803-41809
 |  Abstract »  |  Full Text »  |  PDF »

Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3-dependent manner.

S. Smola-Hess, U. Sandaradura de Silva, D. Hadaschik, and H. J. Pfister (2001)
J. Gen. Virol. 82, 2335-2339
 |  Abstract »  |  Full Text »  |  PDF »

Prostate Cancer Cells (LNCaP) Generated after Long-Term Interleukin 6 (IL-6) Treatment Express IL-6 and Acquire an IL-6 Partially Resistant Phenotype.

A. Hobisch, R. Ramoner, D. Fuchs, S. Godoy-Tundidor, G. Bartsch, H. Klocker, and Z. Culig (2001)
Clin. Cancer Res. 7, 2941-2948
 |  Abstract »  |  Full Text »  |  PDF »

The interleukin-13 receptor {alpha}2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway.

K. Kawakami, J. Taguchi, T. Murata, and R. K. Puri (2001)
Blood 97, 2673-2679
 |  Abstract »  |  Full Text »  |  PDF »

The soluble interleukin 6 receptor: mechanisms of production and implications in disease.

S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER (2001)
FASEB J 15, 43-58
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses.

D. H. Wyllie, E. Kiss-Toth, A. Visintin, S. C. Smith, S. Boussouf, D. M. Segal, G. W. Duff, and S. K. Dower (2000)
J. Immunol. 165, 7125-7132
 |  Abstract »  |  Full Text »  |  PDF »

Anti-interleukin 6 receptor antibody treatment in rheumatic disease.

N. Nishimoto, T. Kishimoto, and K. Yoshizaki (2000)
Ann Rheum Dis 59, i21-27
 |  Abstract »  |  Full Text »  |  PDF »

Expression of interleukin-11 during the human menstrual cycle: coincidence with stromal cell decidualization and relationship to leukaemia inhibitory factor and prolactin.

E. Dimitriadis, L.A. Salamonsen, and L. Robb (2000)
Mol. Hum. Reprod. 6, 907-914
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Intracellular Interleukin-1 {beta} Signals via Type II Interleukin-1 Receptor in Human Gingival Fibroblasts.

H.-H. Chou, S. Takashiba, H. Maeda, K. Naruishi, F. Nishimura, H. Arai, H.-k. Lu, and Y. Murayama (2000)
Journal of Dental Research 79, 1683-1688
 |  Abstract »  |  PDF »

Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production.

S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister (2000)
J. Immunol. 165, 1939-1948
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga (2000)
Blood 95, 3765-3770
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function.

C. J. Auernhammer and S. Melmed (2000)
Endocr. Rev. 21, 313-345
 |  Abstract »  |  Full Text »

Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi's Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6.

T. Hideshima, D. Chauhan, G. Teoh, N. Raje, S. P. Treon, Y.-T. Tai, Y. Shima, and K. C. Anderson (2000)
Clin. Cancer Res. 6, 1180-1189
 |  Abstract »  |  Full Text »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130.

I. Kurth, U. Horsten, S. Pflanz, A. Timmermann, A. Kuster, H. Dahmen, I. Tacken, P. C. Heinrich, and G. Muller-Newen (2000)
J. Immunol. 164, 273-282
 |  Abstract »  |  Full Text »  |  PDF »

Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization. ASSOCIATION OF JAK2 WITH THE GHR IS ENHANCED BY RECEPTOR DIMERIZATION.

Y. Zhang, J. Jiang, J. J. Kopchick, and S. J. Frank (1999)
J. Biol. Chem. 274, 33072-33084
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury.

B. C. Sheridan, C. A. Dinarello, D. R. Meldrum, D. A. Fullerton, C. H. Selzman, and R. C. McIntyre Jr. (1999)
Am J Physiol Lung Cell Mol Physiol 277, L861-L867
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Increases Rat Metalloproteinase-13 Gene Expression through Stimulation of Activator Protein 1 Transcription Factor in Cultured Fibroblasts.

J. A. Solis-Herruzo, R. A. Rippe, L. W. Schrum, P. de la Torre, I. Garcia, J. J. Jeffrey, T. Munoz-Yague, and D. A. Brenner (1999)
J. Biol. Chem. 274, 30919-30926
 |  Abstract »  |  Full Text »  |  PDF »

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family.

G. Senaldi, B. C. Varnum, U. Sarmiento, C. Starnes, J. Lile, S. Scully, J. Guo, G. Elliott, J. McNinch, C. L. Shaklee, et al. (1999)
PNAS 96, 11458-11463
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a 14-3-3 Binding Sequence in the Common beta Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF.

F.C. Stomski, M. Dottore, W. Winnall, M.A. Guthridge, J. Woodcock, C.J. Bagley, D.T. Thomas, R.K. Andrews, M.C. Berndt, and A.F. Lopez (1999)
Blood 94, 1933-1942
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Inhibits Transforming Growth Factor-beta -induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways.

R.-H. Chen, M.-C. Chang, Y.-H. Su, Y.-T. Tsai, and M.-L. Kuo (1999)
J. Biol. Chem. 274, 23013-23019
 |  Abstract »  |  Full Text »  |  PDF »

The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34+CD38-/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice.

O. Kollet, R. Aviram, J. Chebath, H. ben-Hur, A. Nagler, L. Shultz, M. Revel, and T. Lapidot (1999)
Blood 94, 923-931
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2.

R.-B. Yang, M. R. Mark, A. L. Gurney, and P. J. Godowski (1999)
J. Immunol. 163, 639-643
 |  Abstract »  |  Full Text »  |  PDF »

Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts.

B. Sporri, K. M. Muller, U. Wiesmann, and M. Bickel (1999)
Int. Immunol. 11, 1053-1058
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation.

K. Nakashima, S. Wiese, M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, K. Yoshida, T. Kishimoto, M. Sendtner, and T. Taga (1999)
J. Neurosci. 19, 5429-5434
 |  Abstract »  |  Full Text »  |  PDF »

Growth Inhibition of a Human Myeloma Cell Line by All-trans Retinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21WAF1.

Y.-H. Chen, D. Lavelle, J. DeSimone, S. Uddin, L. C. Platanias, and M. Hankewych (1999)
Blood 94, 251-259
 |  Abstract »  |  Full Text »  |  PDF »

GATA-5 Is Involved in Leukemia Inhibitory Factor-responsive Transcription of the beta -Myosin Heavy Chain Gene in Cardiac Myocytes.

T. Morimoto, K. Hasegawa, S. Kaburagi, T. Kakita, H. Masutani, R. N. Kitsis, A. Matsumori, and S. Sasayama (1999)
J. Biol. Chem. 274, 12811-12818
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. INVOLVEMENT OF STAT3.

M. Ernst, U. Novak, S. E. Nicholson, J. E. Layton, and A. R. Dunn (1999)
J. Biol. Chem. 274, 9729-9737
 |  Abstract »  |  Full Text »  |  PDF »

The STAT3-independent Signaling Pathway by Glycoprotein 130 in Hepatic Cells.

C.-f. Lai, J. Ripperger, Y. Wang, H. Kim, R. B. Hawley, and H. Baumann (1999)
J. Biol. Chem. 274, 7793-7802
 |  Abstract »  |  Full Text »  |  PDF »

Disulfide Bond Structure and N-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor.

A. R. Cole, N. E. Hall, H. R. Treutlein, J. S. Eddes, G. E. Reid, R. L. Moritz, and R. J. Simpson (1999)
J. Biol. Chem. 274, 7207-7215
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11.

V. A. Barton, K. R. Hudson, and J. K. Heath (1999)
J. Biol. Chem. 274, 5755-5761
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes.

I. Kurth, U. Horsten, S. Pflanz, H. Dahmen, A. Kuster, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (1999)
J. Immunol. 162, 1480-1487
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of CCAAT/Enhancer Binding Protein, Interleukin-6, Interleukin-6 Receptor, and gp130 Expression During Myocardial Ischemia/Reperfusion.

B. Chandrasekar, D. H. Mitchell, J. T. Colston, and G. L. Freeman (1999)
Circulation 99, 427-433
 |  Abstract »  |  Full Text »  |  PDF »

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses.

G. Muller-Newen, A. Kuster, U. Hemmann, R. Keul, U. Horsten, A. Martens, L. Graeve, J. Wijdenes, and P. C. Heinrich (1998)
J. Immunol. 161, 6347-6355
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo and In Vitro Activities of the gp130-Stimulating Designer Cytokine Hyper-IL-6.

M. Peters, G. Blinn, F. Solem, M. Fischer, K.-H. M. zum Buschenfelde, and S. Rose-John (1998)
J. Immunol. 161, 3575-3581
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Analysis of Human Interleukin-9 Receptor Transcripts in Peripheral Blood Mononuclear Cells. IDENTIFICATION OF A SPLICE VARIANT ENCODING FOR A NONFUNCTIONAL CELL SURFACE RECEPTOR.

L. Grasso, M. Huang, C. D. Sullivan, C. J. Messler, M. B. Kiser, C. R. Dragwa, K. J. Holroyd, J.-C. Renauld, R. C. Levitt, and N. C. Nicolaides (1998)
J. Biol. Chem. 273, 24016-24024
 |  Abstract »  |  Full Text »  |  PDF »

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor.

A. Hammacher, R. T. Richardson, J. E. Layton, D. K. Smith, L. J. L. Angus, D. J. Hilton, N. A. Nicola, J. Wijdenes, and R. J. Simpson (1998)
J. Biol. Chem. 273, 22701-22707
 |  Abstract »  |  Full Text »  |  PDF »

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.

H. Niwa, T. Burdon, I. Chambers, and A. Smith (1998)
Genes & Dev. 12, 2048-2060
 |  Abstract »  |  Full Text »

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes.

H. Oh, Y. Fujio, K. Kunisada, H. Hirota, H. Matsui, T. Kishimoto, and K. Yamauchi-Takihara (1998)
J. Biol. Chem. 273, 9703-9710
 |  Abstract »  |  Full Text »  |  PDF »

Sympathetic neurons can produce and respond to interleukin 6.

P. Marz, J.-G. Cheng, R. A. Gadient, P. H. Patterson, T. Stoyan, U. Otten, and S. Rose-John (1998)
PNAS 95, 3251-3256
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Cys Motif in the Common beta  Chain of the Interleukin 3, Granulocyte-Macrophage Colony-stimulating Factor, and Interleukin 5 Receptors Essential for Disulfide-linked Receptor Heterodimerization and Activation of All Three Receptors.

F. C. Stomski, J. M. Woodcock, B. Zacharakis, C. J. Bagley, Q. Sun, and A. F. Lopez (1998)
J. Biol. Chem. 273, 1192-1199
 |  Abstract »  |  Full Text »  |  PDF »

High proliferative potential-quiescent cells: a working model to study primitive quiescent hematopoietic cells.

N Fortunel, P Batard, A Hatzfeld, M. Monier, B Panterne, J Lebkowski, and J Hatzfeld (1998)
J. Cell Sci. 111, 1867-1875
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Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process.

M. Hallek, P. Leif Bergsagel, and K. C. Anderson (1998)
Blood 91, 3-21
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A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways.

B. A. Habecker, A. J. Symes, N. Stahl, N. J. Francis, A. Economides, J. S. Fink, G. D. Yancopoulos, and S. C. Landis (1997)
J. Biol. Chem. 272, 30421-30428
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The Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated by GM-CSF, Interleukin-3, or Interleukin-5.

J. M. Woodcock, B. J. McClure, F. C. Stomski, M. J. Elliott, C. J. Bagley, and A. F. Lopez (1997)
Blood 90, 3005-3017
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Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex.

U. Horsten, G. Muller-Newen, C. Gerhartz, A. Wollmer, J. Wijdenes, P. C. Heinrich, and J. Grotzinger (1997)
J. Biol. Chem. 272, 23748-23757
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A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit.

J. Molden, Y. Chang, Y. You, P. S. Moore, and M. A. Goldsmith (1997)
J. Biol. Chem. 272, 19625-19631
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Suppression of Tyrosine Kinase Activity Inhibits [3H]Thymidine Uptake in Cultured Human Pituitary Tumor Cells.

T. H. Jones, S. K. Justice, and A. Price (1997)
J. Clin. Endocrinol. Metab. 82, 2143-2147
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Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

A. Kumanogoh, S. Marukawa, T. Kumanogoh, H. Hirota, K. Yoshida, I.-S. Lee, T. Yasui, K. Yoshida, T. Taga, and T. Kishimoto (1997)
PNAS 94, 2478-2482
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The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common beta  Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors.

C. J. Bagley, J. M. Woodcock, F. C. Stomski, and A. F. Lopez (1997)
Blood 89, 1471-1482
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Analysis of the Human Interleukin-6/Human Interleukin-6 Receptor Binding Interface at the Amino Acid Level: Proposed Mechanism of Interaction.

M. Kalai, F. A. Montero-Julian, J. Grotzinger, V. Fontaine, P. Vandenbussche, R. Deschuyteneer, A. Wollmer, H. Brailly, and J. Content (1997)
Blood 89, 1319-1333
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Roles of the N and C Terminal Domains of the Interleukin-3 Receptor alpha  Chain in Receptor Function.

S.C. Barry, E. Korpelainen, Q. Sun, F.C. Stomski, P.A.B. Moretti, H. Wakao, R.J. D'Andrea, M.A. Vadas, A.F. Lopez, and G.J. Goodall (1997)
Blood 89, 842-852
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Activating Mutations in Cytokine Receptors: Implications for Receptor Function and Role in Disease.

T. J. Gonda and R. J. D'Andrea (1997)
Blood 89, 355-369
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Dual Oncostatin M (OSM) Receptors. CLONING AND CHARACTERIZATION OF AN ALTERNATIVE SIGNALING SUBUNIT CONFERRING OSM-SPECIFIC RECEPTOR ACTIVATION.

B. Mosley, C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman (1996)
J. Biol. Chem. 271, 32635-32643
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Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor alpha and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130.

P. Neddermann, R. Graziani, G. Ciliberto, and G. Paonessa (1996)
J. Biol. Chem. 271, 30986-30991
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Interacting Residues in the Extracellular Region of the Common beta Subunit of the Human Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptors Involved in Constitutive Activation.

B. J. Jenkins, C. J. Bagley, J. Woodcock, A. F. Lopez, and T. J. Gonda (1996)
J. Biol. Chem. 271, 29707-29714
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Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes.

K. Kunisada, H. Hirota, Y. Fujio, H. Matsui, Y. Tani, K. Yamauchi-Takihara, and T. Kishimoto (1996)
Circulation 94, 2626-2632
 |  Abstract »  |  Full Text »

Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.

T Hara and A Miyajima (1996)
Stem Cells 14, 605-618
 |  Abstract »

Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex.

L. D. Ward, A. Hammacher, G. J. Howlett, J. M. Matthews, L. Fabri, R. L. Moritz, E. C. Nice, J. Weinstock, and R. J. Simpson (1996)
J. Biol. Chem. 271, 20138-20144
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein.

S. Chevalier, M. Fourcin, O. Robledo, J. Wijdenes, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 14764-14772
 |  Abstract »  |  Full Text »  |  PDF »

Structural Analysis of the Gene Encoding the Murine Interleukin-11 Receptor alpha -Chain and a Related Locus.

L. Robb, D. J. Hilton, T. A. Willson, and C. G. Begley (1996)
J. Biol. Chem. 271, 13754-13761
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Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. I. DEFINITION OF A NOVEL PHOSPHOTYROSINE MOTIF MEDIATING STAT1 ACTIVATION.

C. Gerhartz, B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve (1996)
J. Biol. Chem. 271, 12991-12998
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. II. Src HOMOLOGY SH2 DOMAINS DEFINE THE SPECIFICITY OF STAT FACTOR ACTIVATION.

U. Hemmann, C. Gerhartz, B. Heesel, J. Sasse, G. Kurapkat, J. Grotzinger, A. Wollmer, Z. Zhong, J. E. Darnell Jr., L. Graeve, et al. (1996)
J. Biol. Chem. 271, 12999-13007
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Neurite Outgrowth by Interleukin-6 Is Accompanied by Activation of Stat3 Signaling Pathway in a Variant PC12 Cell (E2) Line.

Y. Y. Wu and R. A. Bradshaw (1996)
J. Biol. Chem. 271, 13023-13032
 |  Abstract »  |  Full Text »  |  PDF »

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses.

M. Fourcin, S. Chevalier, C. Guillet, O. Robledo, J. Froger, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 11756-11760
 |  Abstract »  |  Full Text »  |  PDF »

Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy.

K. C. Wollert, T. Taga, M. Saito, M. Narazaki, T. Kishimoto, C. C. Glembotski, A. B. Vernallis, J. K. Heath, D. Pennica, W. I. Wood, et al. (1996)
J. Biol. Chem. 271, 9535-9545
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of an Interleukin 6 Cytokine Family Antagonist Protein from a Marine Sponge, Callyspongia sp..

J. V. Peppard, P. Loo, M. A. Sills, D. Munster, S. A. Pomponi, and A. E. Wright (1996)
J. Biol. Chem. 271, 7281-7284
 |  Abstract »  |  Full Text »  |  PDF »

The Interleukin-6 (IL-6) Partial Antagonist (Q159E,T162P)IL-6 Interacts with the IL-6 Receptor and gp130 but Fails to Induce a Stable Hexameric Receptor Complex.

A. Hammacher, R. J. Simpson, and E. C. Nice (1996)
J. Biol. Chem. 271, 5464-5473
 |  Abstract »  |  Full Text »  |  PDF »

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