Science 18 June 1993: Vol. 260. no. 5115, pp. 1805 - 1808 DOI: 10.1126/science.8390097

Prev | Table of Contents | Next

Articles

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity.

G. R. Steinberg, M. J. Watt, M. Ernst, M. J. Birnbaum, B. E. Kemp, and S. B. Jorgensen (2009)
Diabetes 58, 829-839
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor {alpha} Chain.

F. Rousseau, S. Chevalier, C. Guillet, E. Ravon, C. Diveu, J. Froger, F. Barbier, L. Grimaud, and H. Gascan (2008)
J. Biol. Chem. 283, 30341-30350
 |  Abstract »  |  Full Text »  |  PDF »

Neuropoietin Attenuates Adipogenesis and Induces Insulin Resistance in Adipocytes.

U. A. White, W. C. Stewart, R. L. Mynatt, and J. M. Stephens (2008)
J. Biol. Chem. 283, 22505-22512
 |  Abstract »  |  Full Text »  |  PDF »

Chemotactic Effect of Ciliary Neurotrophic Factor on Macrophages in Retinal Ganglion Cell Survival and Axonal Regeneration.

L.-P. Cen, J.-M. Luo, C.-W. Zhang, Y.-M. Fan, Y. Song, K.-F. So, N. van Rooijen, C. P. Pang, D. S. C. Lam, and Q. Cui (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4257-4266
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Cellular Alterations Induced by Sustained Expression of Ciliary Neurotrophic Factor in a Mouse Model of Retinitis Pigmentosa.

K. D. Rhee, A. Ruiz, J. L. Duncan, W. W. Hauswirth, M. M. LaVail, D. Bok, and X.-J. Yang (2007)
Invest. Ophthalmol. Vis. Sci. 48, 1389-1400
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Functional Characterization of a Soluble Form of Oncostatin M/Interleukin-31 Shared Receptor.

C. Diveu, E. Venereau, J. Froger, E. Ravon, L. Grimaud, F. Rousseau, S. Chevalier, and H. Gascan (2006)
J. Biol. Chem. 281, 36673-36682
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

F. Rousseau, J.-F. Gauchat, J. G. McLeod, S. Chevalier, C. Guillet, F. Guilhot, I. Cognet, J. Froger, A. F. Hahn, P. M. Knappskog, et al. (2006)
PNAS 103, 10068-10073
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity..

S. V. Y. Raju, M. Zheng, K. H. Schuleri, A. C. Phan, D. Bedja, R. M. Saraiva, O. Yiginer, K. Vandegaer, K. L. Gabrielson, C. P. O'Donnell, et al. (2006)
PNAS 103, 4222-4227
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk among gp130 Cytokines in Adipocytes.

S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
 |  Abstract »  |  Full Text »  |  PDF »

Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression.

T. Kuroda, M. Tada, H. Kubota, H. Kimura, S.-y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada (2005)
Mol. Cell. Biol. 25, 2475-2485
 |  Abstract »  |  Full Text »  |  PDF »

Triple Knock-Out of CNTF, LIF, and CT-1 Defines Cooperative and Distinct Roles of these Neurotrophic Factors for Motoneuron Maintenance and Function.

B. Holtmann, S. Wiese, M. Samsam, K. Grohmann, D. Pennica, R. Martini, and M. Sendtner (2005)
J. Neurosci. 25, 1778-1787
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Mechanisms Associated with Spontaneous and Ciliary Neurotrophic Factor-cAMP-Induced Survival and Axonal Regeneration of Adult Retinal Ganglion Cells.

K. Park, J.-M. Luo, S. Hisheh, A. R. Harvey, and Q. Cui (2004)
J. Neurosci. 24, 10806-10815
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-Induced Activation of Signal Transducer and Activator of Transcription in Photoreceptor Precursors Regulates Rod Differentiation in the Developing Mouse Retina.

K. D. Rhee, O. Goureau, S. Chen, and X.-J. Yang (2004)
J. Neurosci. 24, 9779-9788
 |  Abstract »  |  Full Text »  |  PDF »

The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor {alpha} Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway.

M. A. Ozog, S. M. Bernier, D. C. Bates, B. Chatterjee, C. W. Lo, and C. C.G. Naus (2004)
Mol. Biol. Cell 15, 4761-4774
 |  Abstract »  |  Full Text »  |  PDF »

Signal transducer and activator of transcription 3 (Stat3) expression and activation in rat uterus during early pregnancy.

C.-B. Teng, H.-L. Diao, H. Ma, J. Cong, H. Yu, X.-H. Ma, L.-B. Xu, and Z.-M. Yang (2004)
Reproduction 128, 197-205
 |  Abstract »  |  Full Text »  |  PDF »

The Function of Neurotrophic Factor Receptors Expressed by the Developing Adductor Motor Pool In Vivo.

T. W. Gould and R. W. Oppenheim (2004)
J. Neurosci. 24, 4668-4682
 |  Abstract »  |  Full Text »  |  PDF »

Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

D. Derouet, F. Rousseau, F. Alfonsi, J. Froger, J. Hermann, F. Barbier, D. Perret, C. Diveu, C. Guillet, L. Preisser, et al. (2004)
PNAS 101, 4827-4832
 |  Abstract »  |  Full Text »  |  PDF »

GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor.

C. Diveu, E. Lelievre, D. Perret, A.-H. L. Lak-Hal, J. Froger, C. Guillet, S. Chevalier, F. Rousseau, A. Wesa, L. Preisser, et al. (2003)
J. Biol. Chem. 278, 49850-49859
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.

M. W. Sleeman, K. Garcia, R. Liu, J. D. Murray, L. Malinova, M. Moncrieffe, G. D. Yancopoulos, and S. J. Wiegand (2003)
PNAS 100, 14297-14302
 |  Abstract »  |  Full Text »  |  PDF »

Cloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor {alpha} (CNTFR{alpha}).

W. A. Beltran, Q. Zhang, J. W. Kijas, D. Gu, H. Rohrer, J. A. Jordan, and G. D. Aguirre (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3642-3649
 |  Abstract »  |  Full Text »  |  PDF »

Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development.

S. Brown, N. Hu, and J. C.-G. Hombria (2003)
Development 130, 3077-3084
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor.

H. Plun-Favreau, D. Perret, C. Diveu, J. Froger, S. Chevalier, E. Lelievre, H. Gascan, and M. Chabbert (2003)
J. Biol. Chem. 278, 27169-27179
 |  Abstract »  |  Full Text »  |  PDF »

Glial Reactivity in Ciliary Neurotrophic Factor-Deficient Mice after Optic Nerve Lesion.

A. Martin, H.-D. Hofmann, and M. Kirsch (2003)
J. Neurosci. 23, 5416-5424
 |  Abstract »  |  Full Text »  |  PDF »

Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.

R. Oda, K. Suardita, K. Fujimoto, H. Pan, W. Yan, A. Shimazu, H. Shintani, and Y. Kato (2003)
J. Cell Sci. 116, 2029-2038
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Suppression of Dopamine-beta -hydroxylase by Extracellular Signal-regulated Kinase-dependent and -independent Pathways.

S. Dziennis and B. A. Habecker (2003)
J. Biol. Chem. 278, 15897-15904
 |  Abstract »  |  Full Text »  |  PDF »

Signaling of Human Ciliary Neurotrophic Factor (CNTF) Revisited. THE INTERLEUKIN-6 RECEPTOR CAN SERVE AS AN alpha -RECEPTOR FOR CNTF.

B. Schuster, M. Kovaleva, Y. Sun, P. Regenhard, V. Matthews, J. Grotzinger, S. Rose-John, and K.-J. Kallen (2003)
J. Biol. Chem. 278, 9528-9535
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

M. Hayashi, M.-C. Rho, A. Enomoto, A. Fukami, Y.-P. Kim, Y. Kikuchi, T. Sunazuka, T. Hirose, K. Komiyama, and S. Omura (2002)
PNAS 99, 14728-14733
 |  Abstract »  |  Full Text »  |  PDF »

Microglia-Muller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration.

T. Harada, C. Harada, S. Kohsaka, E. Wada, K. Yoshida, S. Ohno, H. Mamada, K. Tanaka, L. F. Parada, and K. Wada (2002)
J. Neurosci. 22, 9228-9236
 |  Abstract »  |  Full Text »  |  PDF »

Damage-Induced Neuronal Endopeptidase (DINE/ECEL) Expression Is Regulated by Leukemia Inhibitory Factor and Deprivation of Nerve Growth Factor in Rat Sensory Ganglia after Nerve Injury.

R. Kato, S. Kiryu-Seo, and H. Kiyama (2002)
J. Neurosci. 22, 9410-9418
 |  Abstract »  |  Full Text »  |  PDF »

Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20S,21-Epoxy-resibufogenin-3-formate.

M. Hayashi, M.-C. Rho, A. Fukami, A. Enomoto, S. Nonaka, Y. Sekiguchi, T. Yanagisawa, A. Yamashita, T. Nogawa, Y. Kamano, et al. (2002)
J. Pharmacol. Exp. Ther. 303, 104-109
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor as a Transient Negative Regulator of Rod Development in Rat Retina.

S. Schulz-Key, H.-D. Hofmann, C. Beisenherz-Huss, C. Barbisch, and M. Kirsch (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3099-3108
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory Effects of Novel Neurotrophin-1/B Cell-Stimulating Factor-3 (Cardiotrophin-Like Cytokine) on B Cell Function.

G. Senaldi, M. Stolina, J. Guo, R. Faggioni, S. McCabe, S. A. Kaufman, G. Van, W. Xu, F. A. Fletcher, T. Boone, et al. (2002)
J. Immunol. 168, 5690-5698
 |  Abstract »  |  Full Text »  |  PDF »

Menstrual cycle-specific inhibition of endometrial stromal cell proliferation by oncostatin M.

Y. Ohata, T. Harada, A. Fujii, S. Yoshida, T. Iwabe, and N. Terakawa (2001)
Mol. Hum. Reprod. 7, 665-670
 |  Abstract »  |  Full Text »  |  PDF »

Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines.

J. Nichols, I. Chambers, T. Taga, and A. Smith (2001)
Development 128, 2333-2339
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor {{alpha}} in Rat Kidney with Ischemia-Reperfusion Injury.

C. W. YANG, S. W. LIM, K. W. HAN, H. J. AHN, J. H. PARK, Y. H. KIM, M. KIRSH, J. H. CHA, J. H. PARK, Y. S. KIM, et al. (2001)
J. Am. Soc. Nephrol. 12, 749-757
 |  Abstract »  |  Full Text »  |  PDF »

The soluble interleukin 6 receptor: mechanisms of production and implications in disease.

S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER (2001)
FASEB J 15, 43-58
 |  Abstract »  |  Full Text »  |  PDF »

The Caenorhabditis elegans odr-2 Gene Encodes a Novel Ly-6-Related Protein Required for Olfaction.

J. H. Chou, C. I. Bargmann, and P. Sengupta (2001)
Genetics 157, 211-224
 |  Abstract »  |  Full Text »

Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses.

D. H. Wyllie, E. Kiss-Toth, A. Visintin, S. C. Smith, S. Boussouf, D. M. Segal, G. W. Duff, and S. K. Dower (2000)
J. Immunol. 165, 7125-7132
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor, Leukemia Inhibitory Factor Receptor, and Glycoprotein 130 in Rhesus Monkey Uterus During Menstrual Cycle and Early Pregnancy.

Z.-P. Yue, Z.-M. Yang, P. Wei, S.-J. Li, H.-B. Wang, J.-H. Tan, and M. J.K. Harper (2000)
Biol Reprod 63, 508-512
 |  Abstract »  |  Full Text »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130.

I. Kurth, U. Horsten, S. Pflanz, A. Timmermann, A. Kuster, H. Dahmen, I. Tacken, P. C. Heinrich, and G. Muller-Newen (2000)
J. Immunol. 164, 273-282
 |  Abstract »  |  Full Text »  |  PDF »

Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization. ASSOCIATION OF JAK2 WITH THE GHR IS ENHANCED BY RECEPTOR DIMERIZATION.

Y. Zhang, J. Jiang, J. J. Kopchick, and S. J. Frank (1999)
J. Biol. Chem. 274, 33072-33084
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury.

B. C. Sheridan, C. A. Dinarello, D. R. Meldrum, D. A. Fullerton, C. H. Selzman, and R. C. McIntyre Jr. (1999)
Am J Physiol Lung Cell Mol Physiol 277, L861-L867
 |  Abstract »  |  Full Text »  |  PDF »

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family.

G. Senaldi, B. C. Varnum, U. Sarmiento, C. Starnes, J. Lile, S. Scully, J. Guo, G. Elliott, J. McNinch, C. L. Shaklee, et al. (1999)
PNAS 96, 11458-11463
 |  Abstract »  |  Full Text »  |  PDF »

A Dominant Negative Receptor for Specific Secreted Semaphorins Is Generated by Deleting an Extracellular Domain from Neuropilin-1.

M. J. Renzi, L. Feiner, A. M. Koppel, and J. A. Raper (1999)
J. Neurosci. 19, 7870-7880
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth.

K. Nakayama, T. Hara, M. Hibi, T. Hirano, and A. Miyajima (1999)
J. Biol. Chem. 274, 24766-24772
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2.

R.-B. Yang, M. R. Mark, A. L. Gurney, and P. J. Godowski (1999)
J. Immunol. 163, 639-643
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation.

K. Nakashima, S. Wiese, M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, K. Yoshida, T. Kishimoto, M. Sendtner, and T. Taga (1999)
J. Neurosci. 19, 5429-5434
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Leukemia Inhibitory Factor (LIF) to Mutants of Its Low Affinity Receptor, gp190, Reveals a LIF Binding Site Outside and Interactions between the Two Cytokine Binding Domains.

J.-L. Taupin, V. Miossec, V. Pitard, F. Blanchard, S. Daburon, S. Raher, Y. Jacques, A. Godard, and J.-F. Moreau (1999)
J. Biol. Chem. 274, 14482-14489
 |  Abstract »  |  Full Text »  |  PDF »

Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.

C. Bjørbæk, J. K. Elmquist, K. El-Haschimi, J. Kelly, R. S. Ahima, S. Hileman, and J. S. Flier (1999)
Endocrinology 140, 2035-2043
 |  Abstract »  |  Full Text »

GATA-5 Is Involved in Leukemia Inhibitory Factor-responsive Transcription of the beta -Myosin Heavy Chain Gene in Cardiac Myocytes.

T. Morimoto, K. Hasegawa, S. Kaburagi, T. Kakita, H. Masutani, R. N. Kitsis, A. Matsumori, and S. Sasayama (1999)
J. Biol. Chem. 274, 12811-12818
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Recognition Sites of Cytokines Are Organized as Exchangeable Modules. TRANSFER OF THE LEUKEMIA INHIBITORY FACTOR RECEPTOR-BINDING SITE FROM CILIARY NEUROTROPHIC FACTOR TO INTERLEUKIN-6.

K.-J. Kallen, J. Grotzinger, E. Lelievre, P. Vollmer, D. Aasland, C. Renne, J. Mullberg, K.-H. M. zum Buschenfelde, H. Gascan, and S. Rose-John (1999)
J. Biol. Chem. 274, 11859-11867
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role for STAT3 in Murine Pituitary Adrenocorticotropin Hormone Leukemia Inhibitory Factor Signaling.

C. Bousquet and S. Melmed (1999)
J. Biol. Chem. 274, 10723-10730
 |  Abstract »  |  Full Text »  |  PDF »

Complex Conserved Organization of the Mammalian Leukemia Inhibitory Factor Gene: Regulated Expression of Intracellular and Extracellular Cytokines.

B. P. Haines, R. B. Voyle, T. A. Pelton, R. Forrest, and P. D. Rathjen (1999)
J. Immunol. 162, 4637-4646
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. INVOLVEMENT OF STAT3.

M. Ernst, U. Novak, S. E. Nicholson, J. E. Layton, and A. R. Dunn (1999)
J. Biol. Chem. 274, 9729-9737
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor is a Regulator of Muscular Strength in Aging.

C. Guillet, P. Auguste, W. Mayo, P. Kreher, and H. Gascan (1999)
J. Neurosci. 19, 1257-1262
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes.

I. Kurth, U. Horsten, S. Pflanz, H. Dahmen, A. Kuster, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (1999)
J. Immunol. 162, 1480-1487
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of the Functional Mouse Oncostatin M (OSM) Receptor: Molecular Cloning of the Mouse OSM Receptor beta  Subunit.

M. Tanaka, T. Hara, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. Miyajima (1999)
Blood 93, 804-815
 |  Abstract »  |  Full Text »  |  PDF »

The Box-1 Region of the Leukemia Inhibitory Factor Receptor alpha -Chain Cytoplasmic Domain Is Sufficient for Hemopoietic Cell Proliferation and Differentiation.

Y. Zhang, T. Willson, D. Metcalf, D. Cary, D. J. Hilton, R. Clark, and N. A. Nicola (1998)
J. Biol. Chem. 273, 34370-34383
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Receptor alpha  in Spinal Motoneurons is Regulated by Gonadal Hormones.

N. G. Forger, C. K. Wagner, M. Contois, L. Bengston, and A. J. MacLennan (1998)
J. Neurosci. 18, 8720-8729
 |  Abstract »  |  Full Text »  |  PDF »

Functional Map of a Placenta-specific Enhancer of the Human Leukemia Inhibitory Factor Receptor Gene.

Z. Wang and S. Melmed (1998)
J. Biol. Chem. 273, 26069-26077
 |  Abstract »  |  Full Text »  |  PDF »

Reciprocal Regulation of Ciliary Neurotrophic Factor Receptors and Acetylcholine Receptors during Synaptogenesis in Embryonic Chick Atria.

X. Wang and S. W. Halvorsen (1998)
J. Neurosci. 18, 7372-7380
 |  Abstract »  |  Full Text »  |  PDF »

Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family.

D. Agnello, C. Meazza, C. G. Rowan, P. Villa, P. Ghezzi, and G. Senaldi (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R913-R919
 |  Abstract »  |  Full Text »  |  PDF »

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor.

A. Hammacher, R. T. Richardson, J. E. Layton, D. K. Smith, L. J. L. Angus, D. J. Hilton, N. A. Nicola, J. Wijdenes, and R. J. Simpson (1998)
J. Biol. Chem. 273, 22701-22707
 |  Abstract »  |  Full Text »  |  PDF »

A Bidirectional Regulation between the TR2/TR4 Orphan Receptors (TR2/TR4) and the Ciliary Neurotrophic Factor (CNTF) Signaling Pathway.

W.-J. Young, Y.-F. Lee, S. M. Smith, and C. Chang (1998)
J. Biol. Chem. 273, 20877-20885
 |  Abstract »  |  Full Text »  |  PDF »

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.

H. Niwa, T. Burdon, I. Chambers, and A. Smith (1998)
Genes & Dev. 12, 2048-2060
 |  Abstract »  |  Full Text »

Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor alpha -Chain in Normal Human Urine and Plasma.

J.-G. Zhang, Y. Zhang, C. M. Owczarek, L. D. Ward, R. L. Moritz, R. J. Simpson, K. Yasukawa, and N. A. Nicola (1998)
J. Biol. Chem. 273, 10798-10805
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Regulation of STAT Signaling and c-fos Expression by the Tyrosine Phosphatase SHP-2.

T. Servidei, Y. Aoki, S. E. Lewis, A. Symes, J. S. Fink, and S. A. Reeves (1998)
J. Biol. Chem. 273, 6233-6241
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of GFRalpha -3, a Novel Co-receptor Belonging to the Glial Cell Line-derived Neurotrophic Receptor Family.

C. A. Worby, Q. C. Vega, H. H.-J. Chao, A. F. Seasholtz, R. C. Thompson, and J. E. Dixon (1998)
J. Biol. Chem. 273, 3502-3508
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Cys Motif in the Common beta  Chain of the Interleukin 3, Granulocyte-Macrophage Colony-stimulating Factor, and Interleukin 5 Receptors Essential for Disulfide-linked Receptor Heterodimerization and Activation of All Three Receptors.

F. C. Stomski, J. M. Woodcock, B. Zacharakis, C. J. Bagley, Q. Sun, and A. F. Lopez (1998)
J. Biol. Chem. 273, 1192-1199
 |  Abstract »  |  Full Text »  |  PDF »

Nitric oxide and thiol redox regulation of Janus kinase activity.

R. J. Duhe, G. A. Evans, R. A. Erwin, R. A. Kirken, G. W. Cox, and W. L. Farrar (1998)
PNAS 95, 126-131
 |  Abstract »  |  Full Text »  |  PDF »

Sexual Dimorphism in the Spinal Cord Is Absent in Mice Lacking the Ciliary Neurotrophic Factor Receptor.

N. G. Forger, M. L. Howell, L. Bengston, L. MacKenzie, T. M. DeChiara, and G. D. Yancopoulos (1997)
J. Neurosci. 17, 9605-9612
 |  Abstract »  |  Full Text »  |  PDF »

A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways.

B. A. Habecker, A. J. Symes, N. Stahl, N. J. Francis, A. Economides, J. S. Fink, G. D. Yancopoulos, and S. C. Landis (1997)
J. Biol. Chem. 272, 30421-30428
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an Upstream Enhancer within a Functional Promoter of the Human Leukemia Inhibitory Factor Receptor Gene and Its Alternative Promoter Usage.

Z. Wang and S. Melmed (1997)
J. Biol. Chem. 272, 27957-27965
 |  Abstract »  |  Full Text »  |  PDF »

An Antagonist for the Leukemia Inhibitory Factor Receptor Inhibits Leukemia Inhibitory Factor, Cardiotrophin-1, Ciliary Neurotrophic Factor, and Oncostatin M.

A. B. Vernallis, K. R. Hudson, and J. K. Heath (1997)
J. Biol. Chem. 272, 26947-26952
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway.

A. Bonni, Y. Sun, M. Nadal-Vicens, A. Bhatt, D. A. Frank, I. Rozovsky, N. Stahl, G. D. Yancopoulos, and M. E. Greenberg (1997)
Science 278, 477-483
 |  Abstract »  |  Full Text »

The Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated by GM-CSF, Interleukin-3, or Interleukin-5.

J. M. Woodcock, B. J. McClure, F. C. Stomski, M. J. Elliott, C. J. Bagley, and A. F. Lopez (1997)
Blood 90, 3005-3017
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Stimulates the Phosphorylation of Two Forms of STAT3 in Chick Ciliary Ganglion Neurons.

M. A. Wishingrad, S. Koshlukova, and S. W. Halvorsen (1997)
J. Biol. Chem. 272, 19752-19757
 |  Abstract »  |  Full Text »  |  PDF »

HNMP-1: A Novel Hematopoietic and Neural Membrane Protein Differentially Regulated in Neural Development and Injury.

L. M. Bolin, T. McNeil, L. A. Lucian, B. DeVaux, K. Franz-Bacon, D. M. Gorman, S. Zurawski, R. Murray, and T. K. McClanahan (1997)
J. Neurosci. 17, 5493-5502
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6.

K. K. Kuropatwinski, C. De Imus, D. Gearing, H. Baumann, and B. Mosley (1997)
J. Biol. Chem. 272, 15135-15144
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use.

X. Du and D. A. Williams (1997)
Blood 89, 3897-3908
 |  Full Text »  |  PDF »

A Common Pro-opiomelanocortin-binding Element Mediates Leukemia Inhibitory Factor and Corticotropin-releasing Hormone Transcriptional Synergy.

C. Bousquet, D. W. Ray, and S. Melmed (1997)
J. Biol. Chem. 272, 10551-10557
 |  Abstract »  |  Full Text »  |  PDF »

Integration of Jak-Stat and AP-1 Signaling Pathways at the Vasoactive Intestinal Peptide Cytokine Response Element Regulates Ciliary Neurotrophic Factor-dependent Transcription.

A. Symes, T. Gearan, J. Eby, and J. S. Fink (1997)
J. Biol. Chem. 272, 9648-9654
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

A. Kumanogoh, S. Marukawa, T. Kumanogoh, H. Hirota, K. Yoshida, I.-S. Lee, T. Yasui, K. Yoshida, T. Taga, and T. Kishimoto (1997)
PNAS 94, 2478-2482
 |  Abstract »  |  Full Text »  |  PDF »

The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common beta  Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors.

C. J. Bagley, J. M. Woodcock, F. C. Stomski, and A. F. Lopez (1997)
Blood 89, 1471-1482
 |  Full Text »  |  PDF »

Signaling of the Cardiotrophin-1 Receptor. EVIDENCE FOR A THIRD RECEPTOR COMPONENT.

O. Robledo, M. Fourcin, S. Chevalier, C. Guillet, P. Auguste, A. Pouplard-Barthelaix, D. Pennica, and H. Gascan (1997)
J. Biol. Chem. 272, 4855-4863
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor alpha  Expression in Astrocytes and Neurons of the Fascia Dentata after Entorhinal Cortex Lesion.

M.-Y. Lee, T. Deller, M. Kirsch, M. Frotscher, and H.-D. Hofmann (1997)
J. Neurosci. 17, 1137-1146
 |  Abstract »  |  Full Text »  |  PDF »

Induction of the Intronic Enhancer of the Human Ciliary Neurotrophic Factor Receptor (CNTFRalpha ) Gene by the TR4 Orphan Receptor. A MEMBER OF STEROID RECEPTOR SUPERFAMILY.

W.-J. Young, S. M. Smith, and C. Chang (1997)
J. Biol. Chem. 272, 3109-3116
 |  Abstract »  |  Full Text »  |  PDF »

Dual Oncostatin M (OSM) Receptors. CLONING AND CHARACTERIZATION OF AN ALTERNATIVE SIGNALING SUBUNIT CONFERRING OSM-SPECIFIC RECEPTOR ACTIVATION.

B. Mosley, C. De Imus, D. Friend, N. Boiani, B. Thoma, L. S. Park, and D. Cosman (1996)
J. Biol. Chem. 271, 32635-32643
 |  Abstract »  |  Full Text »  |  PDF »

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system..

K K Johe, T G Hazel, T Muller, M M Dugich-Djordjevic, and R D McKay (1996)
Genes & Dev. 10, 3129-3140
 |  Abstract »  |  PDF »

Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor alpha and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130.

P. Neddermann, R. Graziani, G. Ciliberto, and G. Paonessa (1996)
J. Biol. Chem. 271, 30986-30991
 |  Abstract »  |  Full Text »  |  PDF »

gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways.

M. Ernst, A. Oates, and A. R. Dunn (1996)
J. Biol. Chem. 271, 30136-30143
 |  Abstract »  |  Full Text »  |  PDF »

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common beta -Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands.

J. M. Woodcock, C. J. Bagley, B. Zacharakis, and A. F. Lopez (1996)
J. Biol. Chem. 271, 25999-26006
 |  Abstract »  |  Full Text »  |  PDF »

Alanine Substitution for Thr268 and Asp269 of Soluble Ciliary Neurotrophic Factor (CNTF) Receptor alpha Component Defines a Specific Antagonist for the CNTF Response.

P. Auguste, O. Robledo, C. Olivier, J. Froger, V. Praloran, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 26049-26056
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Induces Down-regulation of Its Receptor and Desensitization of Signal Transduction Pathways in Vivo:. NON-EQUIVALENCE WITH PHARMACOLOGICAL ACTIVITY.

P. S. DiStefano, T. G. Boulton, J. L. Stark, Y. Zhu, K. M. Adryan, T. E. Ryan, and R. M. Lindsay (1996)
J. Biol. Chem. 271, 22839-22846
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex.

L. D. Ward, A. Hammacher, G. J. Howlett, J. M. Matthews, L. Fabri, R. L. Moritz, E. C. Nice, J. Weinstock, and R. J. Simpson (1996)
J. Biol. Chem. 271, 20138-20144
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of an Ovarian-specific Protein That Associates with the Short Form of the Prolactin Receptor.

W. R. Duan, D. I.H. Linzer, and G. Gibori (1996)
J. Biol. Chem. 271, 15602-15607
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein.

S. Chevalier, M. Fourcin, O. Robledo, J. Wijdenes, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 14764-14772
 |  Abstract »  |  Full Text »  |  PDF »

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses.

M. Fourcin, S. Chevalier, C. Guillet, O. Robledo, J. Froger, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 11756-11760
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Receptor Binding Sites of Human Leukemia Inhibitory Factor and Creation of Antagonists.

K. R. Hudson, A. B. Vernallis, and J. K. Heath (1996)
J. Biol. Chem. 271, 11971-11978
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products