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Science 18 June 1993:
Vol. 260. no. 5115, pp. 1802 - 1805
DOI: 10.1126/science.8511588
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Articles

Science, Vol 260, Issue 5115, 1802-1805
Copyright © 1993 by American Association for the Advancement of Science

articles

Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells

F Erard, MT Wild, JA Garcia-Sanz, and G Le Gros

Department of Allergy/Immunology, Ciba-Geigy Ltd., Basel, Switzerland.

CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.


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Recent advances: Immunology.
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Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation.
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