Science 11 June 1993: Vol. 260. no. 5114, pp. 1658 - 1661 DOI: 10.1126/science.8503013

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Articles

p204 Protein Is a Novel Modulator of Ras Activity.

B. Ding and P. Lengyel (2008)
J. Biol. Chem. 283, 5831-5848
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Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.

F. Hohla, A. V. Schally, C. A. Kanashiro, S. Buchholz, B. Baker, C. Kannadka, A. Moder, E. Aigner, C. Datz, and G. Halmos (2007)
PNAS 104, 18671-18676
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced cell signaling: inside-out and outside-in.

K. Valerie, A. Yacoub, M. P. Hagan, D. T. Curiel, P. B. Fisher, S. Grant, and P. Dent (2007)
Mol. Cancer Ther. 6, 789-801
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Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel.

F. Hohla, A. V. Schally, K. Szepeshazi, J. L. Varga, S. Buchholz, F. Koster, E. Heinrich, G. Halmos, F. G. Rick, C. Kannadka, et al. (2006)
PNAS 103, 14513-14518
 |  Abstract »  |  Full Text »  |  PDF »

Inorganic Mercury Inhibits the Activation of LAT in T-Cell Receptor-Mediated Signal Transduction.

S. E. Ziemba, R. R. Mattingly, M. J. McCabe Jr., and A. J. Rosenspire (2006)
Toxicol. Sci. 89, 145-153
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DYRK1A Enhances the Mitogen-activated Protein Kinase Cascade in PC12 Cells by Forming a Complex with Ras, B-Raf, and MEK1.

P. A. Kelly and Z. Rahmani (2005)
Mol. Biol. Cell 16, 3562-3573
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Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype.

T. Yamaguchi, D. P. Wallace, B. S. Magenheimer, S. J. Hempson, J. J. Grantham, and J. P. Calvet (2004)
J. Biol. Chem. 279, 40419-40430
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Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.

C. Chen and A. J. Sytkowski (2004)
Blood 104, 73-80
 |  Abstract »  |  Full Text »  |  PDF »

Cation Diffusion Facilitator Proteins Modulate Raf-1 Activity.

T. Jirakulaporn and A. J. Muslin (2004)
J. Biol. Chem. 279, 27807-27815
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Identification and Characterization of Rain, a Novel Ras-interacting Protein with a Unique Subcellular Localization.

N. Y. Mitin, M. B. Ramocki, A. J. Zullo, C. J. Der, S. F. Konieczny, and E. J. Taparowsky (2004)
J. Biol. Chem. 279, 22353-22361
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K-Ras and H-Ras Activation Promote Distinct Consequences on Endometrial Cell Survival.

Y. Ninomiya, K. Kato, A. Takahashi, Y. Ueoka, T. Kamikihara, T. Arima, T. Matsuda, H. Kato, J.-i. Nishida, and N. Wake (2004)
Cancer Res. 64, 2759-2765
 |  Abstract »  |  Full Text »  |  PDF »

RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity.

E. D. Gallagher, S. Gutowski, P. C. Sternweis, and M. H. Cobb (2004)
J. Biol. Chem. 279, 1872-1877
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Membrane Localization, Oligomerization, and Phosphorylation Are Required for Optimal Raf Activation.

C. A. Goetz, J. J. O'Neil, and M. A. Farrar (2003)
J. Biol. Chem. 278, 51184-51189
 |  Abstract »  |  Full Text »  |  PDF »

Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma.

W. Q. Yang, D. Senger, H. Muzik, Z. Q. Shi, D. Johnson, P. M. A. Brasher, N. B. Rewcastle, M. Hamilton, J. Rutka, J. Wolff, et al. (2003)
Cancer Res. 63, 3162-3172
 |  Abstract »  |  Full Text »  |  PDF »

Serine 338 Phosphorylation Is Dispensable for Activation of c-Raf1.

W. Oehrl, I. Rubio, and R. Wetzker (2003)
J. Biol. Chem. 278, 17819-17826
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Identification of Novel ERK2 Substrates through Use of an Engineered Kinase and ATP Analogs.

S. T. Eblen, N. V. Kumar, K. Shah, M. J. Henderson, C. K. W. Watts, K. M. Shokat, and M. J. Weber (2003)
J. Biol. Chem. 278, 14926-14935
 |  Abstract »  |  Full Text »  |  PDF »

Ras-dependent ERK Activation by the Human Gs-coupled Serotonin Receptors 5-HT4(b) and 5-HT7(a).

J. H. Norum, K. Hart, and F. O. Levy (2003)
J. Biol. Chem. 278, 3098-3104
 |  Abstract »  |  Full Text »  |  PDF »

Activation of RAF-1 through Ras and Protein Kinase Calpha Mediates 1alpha ,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells.

C. G. Buitrago, V. G. Pardo, A. R. de Boland, and R. Boland (2003)
J. Biol. Chem. 278, 2199-2205
 |  Abstract »  |  Full Text »  |  PDF »

Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.

D. R. McFarlin, M. J. Lindstrom, and M. N. Gould (2003)
Carcinogenesis 24, 99-105
 |  Abstract »  |  Full Text »  |  PDF »

E7 Abolishes Raf-Induced Arrest via Mislocalization of p21Cip1.

T. F. Westbrook, D. X. Nguyen, B. R. Thrash, and D. J. McCance (2002)
Mol. Cell. Biol. 22, 7041-7052
 |  Abstract »  |  Full Text »  |  PDF »

Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes.

S. T. Eblen, J. K. Slack, M. J. Weber, and A. D. Catling (2002)
Mol. Cell. Biol. 22, 6023-6033
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Secretory Leukocyte Protease Inhibitor Mediates Proliferation of Human Endometrial Epithelial Cells by Positive and Negative Regulation of Growth-associated Genes.

D. Zhang, R. C. M. Simmen, F. J. Michel, G. Zhao, D. Vale-Cruz, and F. A. Simmen (2002)
J. Biol. Chem. 277, 29999-30009
 |  Abstract »  |  Full Text »  |  PDF »

Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38.

J. C. Wolfman, T. Palmby, C. J. Der, and A. Wolfman (2002)
Mol. Cell. Biol. 22, 1589-1606
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation Regulates the Nucleocytoplasmic Distribution of Kinase Suppressor of Ras.

J. A. Brennan, D. J. Volle, O. V. Chaika, and R. E. Lewis (2002)
J. Biol. Chem. 277, 5369-5377
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Association of Mitogen-Activated Protein Kinase Pathways with Gingival Epithelial Cell Responses to Porphyromonas gingivalis Infection.

K. Watanabe, O. Yilmaz, S. F. Nakhjiri, C. M. Belton, and R. J. Lamont (2001)
Infect. Immun. 69, 6731-6737
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Hepatitis C Virus Core Protein Inhibits Human T Lymphocyte Responses by a Complement-Dependent Regulatory Pathway.

Z. Q. Yao, D. T. Nguyen, A. I. Hiotellis, and Y. S. Hahn (2001)
J. Immunol. 167, 5264-5272
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A Direct Interaction between Oncogenic Ha-Ras and Phosphatidylinositol 3-Kinase Is Not Required for Ha-Ras-dependent Transformation of Epithelial Cells.

M. Karasarides, B. Anand-Apte, and A. Wolfman (2001)
J. Biol. Chem. 276, 39755-39764
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1.

J. M. Schmitt and P. J. S. Stork (2001)
Mol. Cell. Biol. 21, 3671-3683
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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.

G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
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Characterization of the Antitumor Effects of the Selective Farnesyl Protein Transferase Inhibitor R115777 in Vivo and in Vitro.

D. W. End, G. Smets, A. V. Todd, T. L. Applegate, C. J. Fuery, P. Angibaud, M. Venet, G. Sanz, H. Poignet, S. Skrzat, et al. (2001)
Cancer Res. 61, 131-137
 |  Abstract »  |  Full Text »

Gonadotropin-Releasing Hormone Receptor Activation of Extracellular Signal-Regulated Kinase and Tyrosine Kinases in Transfected GH3 Cells and in {alpha}T3-1 Cells.

M. S. Johnson, E. M. Lutz, C. J. MacKenzie, W. B. Wolbers, D. N. Robertson, P. J. Holland, and R. Mitchell (2000)
Endocrinology 141, 3087-3097
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Receptor Substrate-1-Mediated Enhancement of Growth Hormone-Induced Mitogen-Activated Protein Kinase Activation.

L. Liang, J. Jiang, and S. J. Frank (2000)
Endocrinology 141, 3328-3336
 |  Abstract »  |  Full Text »  |  PDF »

E-Selectin-Dependent Signaling Via the Mitogen-Activated Protein Kinase Pathway in Vascular Endothelial Cells.

Y. Hu, J.-M. Kiely, B. E. Szente, A. Rosenzweig, and M. A. Gimbrone Jr. (2000)
J. Immunol. 165, 2142-2148
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein.

K. Yeung, P. Janosch, B. McFerran, D. W. Rose, H. Mischak, J. M. Sedivy, and W. Kolch (2000)
Mol. Cell. Biol. 20, 3079-3085
 |  Abstract »  |  Full Text »

Molecular and Genetic Aspects of Lung Cancer.

W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG (2000)
Am. J. Respir. Crit. Care Med. 161, 1355-1367
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Expression of the A-raf Proto-Oncogene in the Normal Adult and Embryonic Mouse.

J. C. A. Luckett, M. B. Hüser, N. Giagtzoglou, J. E. Brown, and C. A. Pritchard (2000)
Cell Growth Differ. 11, 163-171
 |  Abstract »  |  Full Text »

IFN-{alpha}2b Reduces IL-2 Production and IL-2 Receptor Function in Primary CD4+ T Cells.

D. Zella, F. Romerio, S. Curreli, P. Secchiero, C. Cicala, D. Zagury, and R. C. Gallo (2000)
J. Immunol. 164, 2296-2302
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Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation.

M. C. MacNicol, A. J. Muslin, and A. M. MacNicol (2000)
J. Biol. Chem. 275, 3803-3809
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of Mitogen-Activated Protein Kinase Pathway and c-Jun Induction in Epidermal Growth Factor-Induced Gene Expression of Human 12-Lipoxygenase.

B.-K. Chen, H.-C. Kung, T.-Y. Tsai, and W.-C. Chang (2000)
Mol. Pharmacol. 57, 153-161
 |  Abstract »  |  Full Text »

Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor.

E. Tassi, Z. Biesova, P. P. Di Fiore, J. S. Gutkind, and W. T. Wong (1999)
J. Biol. Chem. 274, 33287-33295
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein.

J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al. (1999)
Mol. Cell. Biol. 19, 7519-7528
 |  Abstract »  |  Full Text »  |  PDF »

Association of the Ras to Mitogen-activated Protein Kinase Signal Transduction Pathway with Microfilaments. EVIDENCE FOR A p185neu-CONTAINING CELL SURFACE SIGNAL TRANSDUCTION PARTICLE LINKING THE MITOGENIC PATHWAY TO A MEMBRANE-MICROFILAMENT ASSOCIATION SITE.

C. A. C. Carraway, M. E. Carvajal, and K. L. Carraway (1999)
J. Biol. Chem. 274, 25659-25667
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Differential Effects of cAMP in Neurons and Astrocytes. ROLE OF B-RAF.

L. L. Dugan, J. S. Kim, Y. Zhang, R. D. Bart, Y. Sun, D. M. Holtzman, and D. H. Gutmann (1999)
J. Biol. Chem. 274, 25842-25848
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Acts as a Postsynaptic Signaling Molecule in Calcium/Calmodulin-Induced Synaptic Potentiation in Hippocampal CA1 Pyramidal Neurons.

G. Y. Ko and P. T. Kelly (1999)
J. Neurosci. 19, 6784-6794
 |  Abstract »  |  Full Text »  |  PDF »

Morphological Transformation Induced by Activation of the Mitogen-activated Protein Kinase Pathway Requires Suppression of the T-type Ca2+ Channel.

M. W. Strobeck, M. Okuda, H. Yamaguchi, A. Schwartz, and K. Fukasawa (1999)
J. Biol. Chem. 274, 15694-15700
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers.

H. J. Schaeffer and M. J. Weber (1999)
Mol. Cell. Biol. 19, 2435-2444
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Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice.

K.L. MacKenzie, A. Dolnikov, M. Millington, Y. Shounan, and G. Symonds (1999)
Blood 93, 2043-2056
 |  Abstract »  |  Full Text »  |  PDF »

Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c-fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices.

P. Vanhoutte, J.-V. Barnier, B. Guibert, C. Pages, M.-J. Besson, R. A. Hipskind, and J. Caboche (1999)
Mol. Cell. Biol. 19, 136-146
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Growth Hormone Stimulates Phosphorylation and Activation of Elk-1 and Expression of c-fos, egr-1, and junB through Activation of Extracellular Signal-regulated Kinases 1 and 2.

C. Hodge, J. Liao, M. Stofega, K. Guan, C. Carter-Su, and J. Schwartz (1998)
J. Biol. Chem. 273, 31327-31336
 |  Abstract »  |  Full Text »  |  PDF »

The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation.

M. Daub, J. Jöckel, T. Quack, C. K. Weber, F. Schmitz, U. R. Rapp, A. Wittinghofer, and C. Block (1998)
Mol. Cell. Biol. 18, 6698-6710
 |  Abstract »  |  Full Text »

Regulation of Apoptosis by alpha -Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1.

Y. V. Berestetskaya, M. P. Faure, H. Ichijo, and T. A. Voyno-Yasenetskaya (1998)
J. Biol. Chem. 273, 27816-27823
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ha-Ras-dependent Mitogen-activated Protein Kinase Activity Requires Signaling Through the Epidermal Growth Factor Receptor.

M. Hamilton and A. Wolfman (1998)
J. Biol. Chem. 273, 28155-28162
 |  Abstract »  |  Full Text »  |  PDF »

Sam68 Association with p120GAP in CD4+ T Cells Is Dependent on CD4 Molecule Expression.

N. Jabado, S. Jauliac, A. Pallier, F. Bernard, A. Fischer, and C. Hivroz (1998)
J. Immunol. 161, 2798-2803
 |  Abstract »  |  Full Text »  |  PDF »

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase.

J. Yan, S. Roy, A. Apolloni, A. Lane, and J. F. Hancock (1998)
J. Biol. Chem. 273, 24052-24056
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity.

J. A. Thorson, L. W. K. Yu, A. L. Hsu, N.-Y. Shih, P. R. Graves, J. W. Tanner, P. M. Allen, H. Piwnica-Worms, and A. S. Shaw (1998)
Mol. Cell. Biol. 18, 5229-5238
 |  Abstract »  |  Full Text »

Activation of NF-kappa B via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells.

J.-D. Li, W. Feng, M. Gallup, J.-H. Kim, J. Gum, Y. Kim, and C. Basbaum (1998)
PNAS 95, 5718-5723
 |  Abstract »  |  Full Text »  |  PDF »

Substitution of ras for the Herpesvirus Saimiri STP Oncogene in Lymphocyte Transformation.

J. Guo, K. Williams, S. M. Duboise, L. Alexander, R. Veazey, and J. U. Jung (1998)
J. Virol. 72, 3698-3704
 |  Abstract »  |  Full Text »  |  PDF »

PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase.

J. Liu, D. Fitzli, M. Liu, I. Tseu, I. Caniggia, D. Rotin, and M. Post (1998)
Am J Physiol Lung Cell Mol Physiol 274, L702-L713
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the Mitogen-activated Protein Kinase Pathway Triggers B16 Melanoma Cell Differentiation.

W. Englaro, C. Bertolotto, R. Busca, A. Brunet, G. Pages, J.-P. Ortonne, and R. Ballotti (1998)
J. Biol. Chem. 273, 9966-9970
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C.

R. Marais, Y. Light, C. Mason, H. Paterson, M. F. Olson, and C. J. Marshall (1998)
Science 280, 109-112
 |  Abstract »  |  Full Text »

Modulation of Insulin-Like Growth Factor I Mitogenic Signaling in 3T3-L1 Preadipocyte Differentiation.

C. M. Boney, R. M. Smith, and P. A. Gruppuso (1998)
Endocrinology 139, 1638-1644
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase Kinase (MEK) Activity Is Required for Inhibition of Skeletal Muscle Differentiation by Insulin-Like Growth Factor 1 or Fibroblast Growth Factor 2.

C. M. Weyman and A. Wolfman (1998)
Endocrinology 139, 1794-1800
 |  Abstract »  |  Full Text »  |  PDF »

Kinase Suppressor of Ras Inhibits the Activation of Extracellular Ligand-regulated (ERK) Mitogen-activated Protein (MAP) Kinase by Growth Factors, Activated Ras, and Ras Effectors.

T. Joneson, J. A. Fulton, D. J. Volle, O. V. Chaika, D. Bar-Sagi, and R. E. Lewis (1998)
J. Biol. Chem. 273, 7743-7748
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Q227L-Galpha s in MCF-7 human breast cancer cells inhibits tumorigenesis.

J. Chen, J. A. Bander, T. A. Santore, Y. Chen, P. T. Ram, M. J. Smit, and R. Iyengar (1998)
PNAS 95, 2648-2652
 |  Abstract »  |  Full Text »  |  PDF »

Tumor necrosis factor in the heart.

D. R. Meldrum (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R577-R595
 |  Abstract »  |  Full Text »  |  PDF »

Microtubule Integrity Regulates Src-like and Extracellular Signal-regulated Kinase Activities in Human Pro-monocytic Cells. IMPORTANCE FOR INTERLEUKIN-1 PRODUCTION.

A. Schmid-Alliana, L. Menou, S. Manie, H. Schmid-Antomarchi, M.-A. Millet, S. Giuriato, B. Ferrua, and B. Rossi (1998)
J. Biol. Chem. 273, 3394-3400
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway.

N. Clarke, N. Arenzana, T. Hai, A. Minden, and R. Prywes (1998)
Mol. Cell. Biol. 18, 1065-1073
 |  Abstract »  |  Full Text »

Dual function of Ras in Raf activation.

W Li, M Melnick, and N Perrimon (1998)
Development 125, 4999-5008
 |  Abstract »  |  PDF »

Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant Analysis.

B. K. Jaitner, J. Becker, T. Linnemann, C. Herrmann, A. Wittinghofer, and C. Block (1997)
J. Biol. Chem. 272, 29927-29933
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of Murine Glial Cell-Derived Neurotrophic Factor Inducible Transcription Factor (MGIF).

S. Yajima, C.-H. Lammers, S.-H. Lee, Y. Hara, K. Mizuno, and M. M. Mouradian (1997)
J. Neurosci. 17, 8657-8666
 |  Abstract »  |  Full Text »  |  PDF »

Insulin and Epidermal Growth Factor Stimulate a Conformational Change in Rap1 and Dissociation of the CrkII-C3G Complex.

S. Okada and J. E. Pessin (1997)
J. Biol. Chem. 272, 28179-28182
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin. DEPENDENCE ON SIGNAL STRENGTH.

B. C. Duckworth and L. C. Cantley (1997)
J. Biol. Chem. 272, 27665-27670
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1.

V. A. Boussiotis, G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler (1997)
Science 278, 124-128
 |  Abstract »  |  Full Text »

Differential Regulation of Mitogen-Activated Protein/ERK Kinase (MEK)1 and MEK2 and Activation by a Ras-Independent Mechanism.

S. Xu, S. Khoo, A. Dang, S. Witt, V. Do, E. Zhen, E. M. Schaefer, and M. H. Cobb (1997)
Mol. Endocrinol. 11, 1618-1625
 |  Abstract »  |  Full Text »

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.

K. Diener, X. S. Wang, C. Chen, C. F. Meyer, G. Keesler, M. Zukowski, T.-H. Tan, and Z. Yao (1997)
PNAS 94, 9687-9692
 |  Abstract »  |  Full Text »  |  PDF »

Reversion of Ras- and Phosphatidylcholine-hydrolyzing Phospholipase C-mediated Transformation of NIH 3T3 Cells by a Dominant Interfering Mutant of Protein Kinase C lambda Is Accompanied by the Loss of Constitutive Nuclear Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Activity.

G. Bjorkoy, M. Perander, A. Overvatn, and T. Johansen (1997)
J. Biol. Chem. 272, 11557-11565
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction.

G. Li, C. D'Souza-Schorey, M. A. Barbieri, J. A. Cooper, and P. D. Stahl (1997)
J. Biol. Chem. 272, 10337-10340
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through Intercellular Adhesion Molecule 1(ICAM-1) in a B Cell Lymphoma Line. THE ACTIVATION OF Lyn TYROSINE KINASE AND THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY.

J. Holland and T. Owens (1997)
J. Biol. Chem. 272, 9108-9112
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction Pathway of Human Fibroblast Growth Factor Receptor 3. IDENTIFICATION OF A NOVEL 66-kDa PHOSPHOPROTEIN.

M. Kanai, M. Goke, S. Tsunekawa, and D. K. Podolsky (1997)
J. Biol. Chem. 272, 6621-6628
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Cyclic Adenosine Monophosphate on the Mitogen-Activated Protein Kinase Pathway Depends on Both the Cell Type and the Type of Tyrosine Kinase-Receptor.

V. Calleja, P. Ruiz Enriquez, C. Filloux, P. Peraldi, V. Baron, and E. Van Obberghen (1997)
Endocrinology 138, 1111-1120
 |  Abstract »  |  Full Text »  |  PDF »

Cooperating oncogenes converge to regulate cyclin/cdk complexes..

A C Lloyd, F Obermuller, S Staddon, C F Barth, M McMahon, and H Land (1997)
Genes & Dev. 11, 663-677
 |  Abstract »  |  PDF »

Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation.

M. Wartmann, P. Hofer, P. Turowski, A. R. Saltiel, and N. E. Hynes (1997)
J. Biol. Chem. 272, 3915-3923
 |  Abstract »  |  Full Text »  |  PDF »

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase.

L. F. Stancato, A. M. Silverstein, J. K. Owens-Grillo, Y.-H. Chow, R. Jove, and W. B. Pratt (1997)
J. Biol. Chem. 272, 4013-4020
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases.

R. Marais, Y. Light, H. F. Paterson, C. S. Mason, and C. J. Marshall (1997)
J. Biol. Chem. 272, 4378-4383
 |  Abstract »  |  Full Text »  |  PDF »

Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-alpha Activation of SAPK in Melanoma Cells.

A. Marti, Z. Luo, C. Cunningham, Y. Ohta, J. Hartwig, T. P. Stossel, J. M. Kyriakis, and J. Avruch (1997)
J. Biol. Chem. 272, 2620-2628
 |  Abstract »  |  Full Text »  |  PDF »

Sequential Modification of Serines 621and 624in the Raf-1 Carboxyl Terminus Produces Alterations in Its Electrophoretic Mobility.

A. F. Ferrier, M. Lee, W. B. Anderson, G. Benvenuto, D. K. Morrison, D. R. Lowy, and J. E. DeClue (1997)
J. Biol. Chem. 272, 2136-2142
 |  Abstract »  |  Full Text »  |  PDF »

The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.

W Li, E. Skoulakis, R. Davis, and N Perrimon (1997)
Development 124, 4163-4171
 |  Abstract »  |  PDF »

Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells. N-ACETYLCYSTEINE UNCOUPLES THE SIGNAL TRANSDUCTION FROM Ras TO THE MITOGEN-ACTIVATED PROTEIN KINASE CASCADE.

H. Kamata, C. Tanaka, H. Yagisawa, S. Matsuda, Y. Gotoh, E. Nishida, and H. Hirata (1996)
J. Biol. Chem. 271, 33018-33025
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase.

X. S. Wang, K. Diener, D. Jannuzzi, D. Trollinger, T.-H. Tan, H. Lichenstein, M. Zukowski, and Z. Yao (1996)
J. Biol. Chem. 271, 31607-31611
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Signaling and Its Regulation of System A Amino Acid Uptake in Cultured Rat Vascular Smooth Muscle Cells.

T. Obata, A. Kashiwagi, H. Maegawa, Y. Nishio, S. Ugi, H. Hidaka, and R. Kikkawa (1996)
Circ. Res. 79, 1167-1176
 |  Abstract »  |  Full Text »

KSR modulates signal propagation within the MAPK cascade..

M Therrien, N R Michaud, G M Rubin, and D K Morrison (1996)
Genes & Dev. 10, 2684-2695
 |  Abstract »  |  PDF »

Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase.

M. J. Hart, S. Sharma, N. elMasry, R.-G. Qiu, P. McCabe, P. Polakis, and G. Bollag (1996)
J. Biol. Chem. 271, 25452-25458
 |  Abstract »  |  Full Text »  |  PDF »

The Renaturable 69-and 63-kDa Protein Kinases That Undergo Rapid Activation in Chemoattractant-stimulated Guinea Pig Neutrophils Are p21-Activated Kinases.

J. Ding, U. G. Knaus, J. P. Lian, G. M. Bokoch, and J. A. Badwey (1996)
J. Biol. Chem. 271, 24869-24873
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90.

R. K. Jaiswal, E. Weissinger, W. Kolch, and G. E. Landreth (1996)
J. Biol. Chem. 271, 23626-23629
 |  Abstract »  |  Full Text »  |  PDF »

Different Effects of Various Phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf Activation.

S. Kuroda, T. Ohtsuka, B. Yamamori, K. Fukui, K. Shimizu, and Y. Takai (1996)
J. Biol. Chem. 271, 14680-14683
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an Essential Signaling Cascade for Mitogen-activated Protein Kinase Activation by Angiotensin II in Cultured Rat Vascular Smooth Muscle Cells. POSSIBLE REQUIREMENT OF Gq-MEDIATED p21ras ACTIVATION COUPLED TO A Ca2+/CALMODULIN-SENSITIVE TYROSINE KINASE.

S. Eguchi, T. Matsumoto, E. D. Motley, H. Utsunomiya, and T. Inagami (1996)
J. Biol. Chem. 271, 14169-14175
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane.

C. Mineo, G. L. James, E. J. Smart, and R. G. W. Anderson (1996)
J. Biol. Chem. 271, 11930-11935
 |  Abstract »  |  Full Text »  |  PDF »

Association between Mitogen-activated Protein Kinase and the [IMAGE] Chain of the T Cell Receptor (TcR) with the SH2,3 Domain of p56[IMAGE].

A. August and B. Dupont (1996)
J. Biol. Chem. 271, 10054-10059
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Controls p21[IMAGE] Activity via pp60[IMAGE].

B. Schieffer, W. G. Paxton, Q. Chai, M. B. Marrero, and K. E. Bernstein (1996)
J. Biol. Chem. 271, 10329-10333
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Induction of Anchorage-independent Growth of NIH3T3 Mouse Fibroblasts by Cysteine Proteinase Inhibitors and a Tumor Promoter.

T. Hiwasa, T. Sawada, and S. Sakiyama (1996)
J. Biol. Chem. 271, 9181-9184
 |  Abstract »  |  Full Text »  |  PDF »

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