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Science 11 June 1993:
Vol. 260. no. 5114, pp. 1640 - 1643
DOI: 10.1126/science.8503009
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Articles

Science, Vol 260, Issue 5114, 1640-1643
Copyright © 1993 by American Association for the Advancement of Science

articles

A nonpeptidyl growth hormone secretagogue

RG Smith, K Cheng, WR Schoen, SS Pong, G Hickey, T Jacks, B Butler, WW Chan, LY Chaung, F Judith, and al. et

Department of Basic Animal Science Research, Merck Research Laboratories, Rahway, NJ 07065.

A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-([2'-(1H-tetrazol-5 -yl) (1,1'-biphenyl)-4-yl]methyl)-1H-1-benzazepin-3(R)-yl)-butanamid e (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.


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Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor.
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Mimetics of a T Cell Epitope Based on Poly-N-acylated Amine Backbone Structures Induce T Cells in Vitro and in Vivo.
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