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Science 4 June 1993:
Vol. 260. no. 5113, pp. 1513 - 1516
DOI: 10.1126/science.8502996
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Articles

Science, Vol 260, Issue 5113, 1513-1516
Copyright © 1993 by American Association for the Advancement of Science

articles

Relation of phenotype evolution of HIV-1 to envelope V2 configuration

M Groenink, RA Fouchier, S Broersen, CH Baker, M Koot, AB van't Wout, HG Huisman, F Miedema, M Tersmette, and H Schuitemaker

Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.

Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp120 contained the major determinants of SI capacity. The configuration of a hypervariable locus in the V2 domain appeared to be predictive for non-SI to SI phenotype conversion. Early prediction of HIV-1 phenotype evolution may be useful for clinical monitoring and treatment of asymptomatic infection.


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