Science 28 May 1993: Vol. 260. no. 5112, pp. 1338 - 1343 DOI: 10.1126/science.8493579

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Articles

RasGRP1 Transgenic Mice Develop Cutaneous Squamous Cell Carcinomas in Response to Skin Wounding: Potential Role of Granulocyte Colony-Stimulating Factor.

F. R. Diez, A. A. Garrido, A. Sharma, C. T. Luke, J. C. Stone, N. A. Dower, J. M. Cline, and P. S. Lorenzo (2009)
Am. J. Pathol. 175, 392-399
 |  Abstract »  |  Full Text »  |  PDF »

pBT, a novel vector for tetracycline-regulated yeast three-hybrid assay.

K. Moriyoshi (2009)
Nucleic Acids Res. 37, e11
 |  Abstract »  |  Full Text »  |  PDF »

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

A. Prasad, J. Zikherman, J. Das, J. P. Roose, A. Weiss, and A. K. Chakraborty (2009)
PNAS 106, 528-533
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Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors.

S. Hoare, K. Hoare, M. K. Reinhard, Y. J. Lee, S. P. Oh, and W. S. May Jr. (2008)
Cancer Res. 68, 8723-8732
 |  Abstract »  |  Full Text »  |  PDF »

p66shc Negatively Regulates Insulin-Like Growth Factor I Signal Transduction via Inhibition of p52shc Binding to Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Leading to Impaired Growth Factor Receptor-Bound Protein-2 Membrane Recruitment.

G. Xi, X. Shen, and D. R. Clemmons (2008)
Mol. Endocrinol. 22, 2162-2175
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Activation Is Required To Form the NKG2D Immunological Synapse.

E. Giurisato, M. Cella, T. Takai, T. Kurosaki, Y. Feng, G. D. Longmore, M. Colonna, and A. S. Shaw (2007)
Mol. Cell. Biol. 27, 8583-8599
 |  Abstract »  |  Full Text »  |  PDF »

Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.

M. Morimatsu, H. Takagi, K. G. Ota, R. Iwamoto, T. Yanagida, and Y. Sako (2007)
PNAS 104, 18013-18018
 |  Abstract »  |  Full Text »  |  PDF »

Phage Display Derived Human Monoclonal Antibodies Isolated by Binding to the Surface of Live Primary Breast Cancer Cells Recognize GRP78.

C. G. Jakobsen, N. Rasmussen, A.-V. Laenkholm, and H. J. Ditzel (2007)
Cancer Res. 67, 9507-9517
 |  Abstract »  |  Full Text »  |  PDF »

Germ Line Gain of Function with SOS1 Mutation in Hereditary Gingival Fibromatosis.

S.-I. Jang, E.-J. Lee, P. S. Hart, M. Ramaswami, D. Pallos, and T. C. Hart (2007)
J. Biol. Chem. 282, 20245-20255
 |  Abstract »  |  Full Text »  |  PDF »

LAT and NTAL Mediate Immunoglobulin E-Induced Sustained Extracellular Signal-Regulated Kinase Activation Critical for Mast Cell Survival.

S. Yamasaki, E. Ishikawa, M. Sakuma, O. Kanagawa, A. M. Cheng, B. Malissen, and T. Saito (2007)
Mol. Cell. Biol. 27, 4406-4415
 |  Abstract »  |  Full Text »  |  PDF »

An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development.

K. Modzelewska, M. G. Elgort, J. Huang, G. Jongeward, A. Lauritzen, C. H. Yoon, P. W. Sternberg, and N. Moghal (2007)
Mol. Cell. Biol. 27, 3695-3707
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Lymphoma 10 Is Essential for Fc{epsilon}R-Mediated Degranulation and IL-6 Production in Mast Cells.

Y. Chen, B. P. Pappu, H. Zeng, L. Xue, S. W. Morris, X. Lin, R. Wen, and D. Wang (2007)
J. Immunol. 178, 49-57
 |  Abstract »  |  Full Text »  |  PDF »

The Grb2/Mek Pathway Represses Nanog in Murine Embryonic Stem Cells.

T. Hamazaki, S. M. Kehoe, T. Nakano, and N. Terada (2006)
Mol. Cell. Biol. 26, 7539-7549
 |  Abstract »  |  Full Text »  |  PDF »

Sos-mediated activation of rac1 by p66shc.

F. A. Khanday, L. Santhanam, K. Kasuno, T. Yamamori, A. Naqvi, J. DeRicco, A. Bugayenko, I. Mattagajasingh, A. Disanza, G. Scita, et al. (2006)
J. Cell Biol. 172, 817-822
 |  Abstract »  |  Full Text »  |  PDF »

Ras-MAPK Pathways.

A. Chan (2005)
Sci. STKE 2005, tr5
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Human RAS Superfamily Proteins and Related GTPases.

J. Colicelli (2004)
Sci. STKE 2004, re13
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-dependent Ubiquitination Is Required for Progression of EGF Receptors into Clathrin-coated Pits.

E. Stang, F. D. Blystad, M. Kazazic, V. Bertelsen, T. Brodahl, C. Raiborg, H. Stenmark, and I. H. Madshus (2004)
Mol. Biol. Cell 15, 3591-3604
 |  Abstract »  |  Full Text »  |  PDF »

PKC{delta} Associates with and Is Involved in the Phosphorylation of RasGRP3 in Response to Phorbol Esters.

C. Brodie, R. Steinhart, G. Kazimirsky, H. Rubinfeld, T. Hyman, J. N. Ayres, G. M. Hur, A. Toth, D. Yang, S. H. Garfield, et al. (2004)
Mol. Pharmacol. 66, 76-84
 |  Abstract »  |  Full Text »  |  PDF »

Diacylglycerols Containing Omega 3 and Omega 6 Fatty Acids Bind to RasGRP and Modulate MAP Kinase Activation.

S. Madani, A. Hichami, M. Charkaoui-Malki, and N. A. Khan (2004)
J. Biol. Chem. 279, 1176-1183
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling.

Y. M. Agazie and M. J. Hayman (2003)
Mol. Cell. Biol. 23, 7875-7886
 |  Abstract »  |  Full Text »  |  PDF »

IIGP1, an Interferon-{gamma}-inducible 47-kDa GTPase of the Mouse, Showing Cooperative Enzymatic Activity and GTP-dependent Multimerization.

R. C. Uthaiah, G. J. K. Praefcke, J. C. Howard, and C. Herrmann (2003)
J. Biol. Chem. 278, 29336-29343
 |  Abstract »  |  Full Text »  |  PDF »

SH2 and PTB Domains in Tyrosine Kinase Signaling.

J. Schlessinger and M. A. Lemmon (2003)
Sci. STKE 2003, re12
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Filamin A with the Insulin Receptor Alters Insulin-dependent Activation of the Mitogen-activated Protein Kinase Pathway.

H.-J. He, S. Kole, Y.-K. Kwon, M. T. Crow, and M. Bernier (2003)
J. Biol. Chem. 278, 27096-27104
 |  Abstract »  |  Full Text »  |  PDF »

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation.

S. J. Moeller, E. D. Head, and R. J. Sheaff (2003)
Mol. Cell. Biol. 23, 3735-3752
 |  Abstract »  |  Full Text »  |  PDF »

A General Strategy to Uncover Transcription Factor Properties Identifies a New Regulator of Drug Resistance in Yeast.

I. Hikkel, A. Lucau-Danila, T. Delaveau, P. Marc, F. Devaux, and C. Jacq (2003)
J. Biol. Chem. 278, 11427-11432
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.

K. Cichowski, S. Santiago, M. Jardim, B. W. Johnson, and T. Jacks (2003)
Genes & Dev. 17, 449-454
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis of Epidermal Growth Factor Receptor Regulated by Grb2-mediated Recruitment of the Rab5 GTPase-activating Protein RN-tre.

L. Martinu, A. Santiago-Walker, H. Qi, and M. M. Chou (2002)
J. Biol. Chem. 277, 50996-51002
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{gamma}2 Is Essential for Specific Functions of Fc{epsilon}R and Fc{gamma}R.

R. Wen, S.-T. Jou, Y. Chen, A. Hoffmeyer, and D. Wang (2002)
J. Immunol. 169, 6743-6752
 |  Abstract »  |  Full Text »  |  PDF »

hSos1 Contains a New Amino-terminal Regulatory Motif with Specific Binding Affinity for Its Pleckstrin Homology Domain.

R. Jorge, N. Zarich, J. L. Oliva, M. Azanedo, N. Martinez, X. de la Cruz, and J. M. Rojas (2002)
J. Biol. Chem. 277, 44171-44179
 |  Abstract »  |  Full Text »  |  PDF »

The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway.

G. Pelicci, F. Troglio, A. Bodini, R. M. Melillo, V. Pettirossi, L. Coda, A. De Giuseppe, M. Santoro, and P. G. Pelicci (2002)
Mol. Cell. Biol. 22, 7351-7363
 |  Abstract »  |  Full Text »  |  PDF »

R-Ras3/M-Ras Induces Neuronal Differentiation of PC12 Cells through Cell-Type-Specific Activation of the Mitogen-Activated Protein Kinase Cascade.

A. C. Kimmelman, N. N. Rodriguez, and A. M.-L. Chan (2002)
Mol. Cell. Biol. 22, 5946-5961
 |  Abstract »  |  Full Text »  |  PDF »

Ahi-1, a Novel Gene Encoding a Modular Protein with WD40-Repeat and SH3 Domains, Is Targeted by the Ahi-1 and Mis-2 Provirus Integrations.

X. Jiang, Z. Hanna, M. Kaouass, L. Girard, and P. Jolicoeur (2002)
J. Virol. 76, 9046-9059
 |  Abstract »  |  Full Text »  |  PDF »

The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor.

M. S. Iordanov, R. J. Choi, O. P. Ryabinina, T.-H. Dinh, R. K. Bright, and B. E. Magun (2002)
Mol. Cell. Biol. 22, 5380-5394
 |  Abstract »  |  Full Text »  |  PDF »

Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability.

R. Poirey, L. Despons, V. Leh, M.-J. Lafuente, S. Potier, J.-L. Souciet, and J.-C. Jauniaux (2002)
Microbiology 148, 2111-2123
 |  Abstract »  |  Full Text »  |  PDF »

Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase.

L. Zhang, M. Bewick, and R. M. Lafrenie (2002)
Carcinogenesis 23, 1251-1258
 |  Abstract »  |  Full Text »  |  PDF »

Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin.

J. J. Smith, D. A. Richardson, J. Kopf, M. Yoshida, R. E. Hollingsworth, and S. Kornbluth (2002)
Mol. Cell. Biol. 22, 1412-1423
 |  Abstract »  |  Full Text »  |  PDF »

Role of Grb2 in EGF-stimulated EGFR internalization.

T. Yamazaki, K. Zaal, D. Hailey, J. Presley, J. Lippincott-Schwartz, and L. E. Samelson (2002)
J. Cell Sci. 115, 1791-1802
 |  Abstract »  |  Full Text »  |  PDF »

Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.

M. Souchet, E. Portales-Casamar, D. Mazurais, S. Schmidt, I. Leger, J.-L. Javre, P. Robert, I. Berrebi-Bertrand, A. Bril, B. Gout, et al. (2002)
J. Cell Sci. 115, 629-640
 |  Abstract »  |  Full Text »  |  PDF »

Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity.

E. Vignal, A. Blangy, M. Martin, C. Gauthier-Rouviere, and P. Fort (2001)
Mol. Cell. Biol. 21, 8022-8034
 |  Abstract »  |  Full Text »  |  PDF »

Role of an ING1 Growth Regulator in Transcriptional Activation and Targeted Histone Acetylation by the NuA4 Complex.

A. Nourani, Y. Doyon, R. T. Utley, S. Allard, W. S. Lane, and J. Cote (2001)
Mol. Cell. Biol. 21, 7629-7640
 |  Abstract »  |  Full Text »  |  PDF »

Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.

F. Romero, M.-C. Multon, F. Ramos-Morales, A. Dominguez, J. A. Bernal, J. A. Pintor-Toro, and M. Tortolero (2001)
Nucleic Acids Res. 29, 1300-1307
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol Esters Modulate the Ras Exchange Factor RasGRP3.

P. S. Lorenzo, J. W. Kung, D. A. Bottorff, S. H. Garfield, J. C. Stone, and P. M. Blumberg (2001)
Cancer Res. 61, 943-949
 |  Abstract »  |  Full Text »

Small GTP-Binding Proteins.

Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Mitogen-activated Protein Kinase Kinase Selectively Inhibits Cell Proliferation in Human Breast Cancer Cells Displaying Enhanced Insulin-like Growth Factor I-mediated Mitogen-activated Protein Kinase Activation.

U. Hermanto, C. S. Zong, and L.-H. Wang (2000)
Cell Growth Differ. 11, 655-664
 |  Abstract »  |  Full Text »

Ras-GAP Binding and Phosphorylation by Herpes Simplex Virus Type 2 RR1 PK (ICP10) and Activation of the Ras/MEK/MAPK Mitogenic Pathway Are Required for Timely Onset of Virus Growth.

C. C. Smith, J. Nelson, L. Aurelian, M. Gober, and B. B. Goswami (2000)
J. Virol. 74, 10417-10429
 |  Abstract »  |  Full Text »

Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development.

L. M. Esteban, A. Fernández-Medarde, E. López, K. Yienger, C. Guerrero, J. M. Ward, L. Tessarollo, and E. Santos (2000)
Mol. Cell. Biol. 20, 6410-6413
 |  Abstract »  |  Full Text »

The Adaptor Protein Gads (Grb2-Related Adaptor Downstream of Shc) Is Implicated in Coupling Hemopoietic Progenitor Kinase-1 to the Activated TCR.

S. K. Liu, C. A. Smith, R. Arnold, F. Kiefer, and C. J. McGlade (2000)
J. Immunol. 165, 1417-1426
 |  Abstract »  |  Full Text »  |  PDF »

The Guanine Nucleotide Exchange Factor RasGRP Is a High -Affinity Target for Diacylglycerol and Phorbol Esters.

P. S. Lorenzo, M. Beheshti, G. R. Pettit, J. C. Stone, and P. M. Blumberg (2000)
Mol. Pharmacol. 57, 840-846
 |  Abstract »  |  Full Text »

Regulation of Long-Term Potentiation by H-Ras through NMDA Receptor Phosphorylation.

T. Manabe, A. Aiba, A. Yamada, T. Ichise, H. Sakagami, H. Kondo, and M. Katsuki (2000)
J. Neurosci. 20, 2504-2511
 |  Abstract »  |  Full Text »  |  PDF »

A Role for the Noncatalytic N Terminus in the Function of Cdc25, a Saccharomyces cerevisiae Ras-Guanine Nucleotide Exchange Factor.

R. A. Chen, T. Michaeli, L. Van Aelst, and R. Ballester (2000)
Genetics 154, 1473-1484
 |  Abstract »  |  Full Text »

Clathrin-mediated Endocytosis of MUC1 Is Modulated by Its Glycosylation State.

Y. Altschuler, C. L. Kinlough, P. A. Poland, J. B. Bruns, G. Apodaca, O. A. Weisz, and R. P. Hughey (2000)
Mol. Biol. Cell 11, 819-831
 |  Abstract »  |  Full Text »

Induction of Rac-Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm following Phosphorylation by the Nonreceptor Tyrosine Kinase Src.

M. Kiyono, Y. Kaziro, and T. Satoh (2000)
J. Biol. Chem. 275, 5441-5446
 |  Abstract »  |  Full Text »  |  PDF »

A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein.

I. Rebay, F. Chen, F. Hsiao, P. A. Kolodziej, B. H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G. M. Rubin (2000)
Genetics 154, 695-712
 |  Abstract »  |  Full Text »

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.

A Blangy, E Vignal, S Schmidt, A Debant, C Gauthier-Rouviere, and P Fort (2000)
J. Cell Sci. 113, 729-739
 |  Abstract »  |  PDF »

Essential Role of Mitogen-Activated Protein Kinase Pathway and c-Jun Induction in Epidermal Growth Factor-Induced Gene Expression of Human 12-Lipoxygenase.

B.-K. Chen, H.-C. Kung, T.-Y. Tsai, and W.-C. Chang (2000)
Mol. Pharmacol. 57, 153-161
 |  Abstract »  |  Full Text »

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans.

Y. Liao, K.-i. Kariya, C.-D. Hu, M. Shibatohge, M. Goshima, T. Okada, Y. Watari, X. Gao, T.-G. Jin, Y. Yamawaki-Kataoka, et al. (1999)
J. Biol. Chem. 274, 37815-37820
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Properties of Dominant-negative Mutants of the Ras-specific Guanine Nucleotide Exchange Factor CDC25Mm.

M. Vanoni, R. Bertini, E. Sacco, L. Fontanella, M. Rieppi, S. Colombo, E. Martegani, V. Carrera, A. Moroni, C. Bizzarri, et al. (1999)
J. Biol. Chem. 274, 36656-36662
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Association Between the Tyrosine Kinase Emt/Itk/Tsk and Phospholipase-C{gamma}1 in Human T Lymphocytes.

J. J. Perez-Villar and S. B. Kanner (1999)
J. Immunol. 163, 6435-6441
 |  Abstract »  |  Full Text »  |  PDF »

Vinexin Forms a Signaling Complex with Sos and Modulates Epidermal Growth Factor-induced c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activities.

M. Akamatsu, S.-i. Aota, A. Suwa, K. Ueda, T. Amachi, K. M. Yamada, S. K. Akiyama, and N. Kioka (1999)
J. Biol. Chem. 274, 35933-35937
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutations in Yeast CBF5 Can Abolish In Vivo Pseudouridylation of rRNA.

Y. Zebarjadian, T. King, M. J. Fournier, L. Clarke, and J. Carbon (1999)
Mol. Cell. Biol. 19, 7461-7472
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis.

T. Wada, T. Sasaoka, M. Ishiki, H. Hori, T. Haruta, H. Ishihara, and M. Kobayashi (1999)
Endocrinology 140, 4585-4594
 |  Abstract »  |  Full Text »

Association of the Ras to Mitogen-activated Protein Kinase Signal Transduction Pathway with Microfilaments. EVIDENCE FOR A p185neu-CONTAINING CELL SURFACE SIGNAL TRANSDUCTION PARTICLE LINKING THE MITOGENIC PATHWAY TO A MEMBRANE-MICROFILAMENT ASSOCIATION SITE.

C. A. C. Carraway, M. E. Carvajal, and K. L. Carraway (1999)
J. Biol. Chem. 274, 25659-25667
 |  Abstract »  |  Full Text »  |  PDF »

Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway.

A. Hashimoto, M. Kurosaki, N. Gotoh, M. Shibuya, and T. Kurosaki (1999)
J. Biol. Chem. 274, 20139-20143
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-induced Desensitization of Extracellular Signal-regulated Kinase Activation Results from an Inhibition of Raf Activity Independent of Ras Activation and Dissociation of the Grb2-SOS Complex.

R. V. Fucini, S. Okada, and J. E. Pessin (1999)
J. Biol. Chem. 274, 18651-18658
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22.

J. Yohannan, J. Wienands, K. M. Coggeshall, and L. B. Justement (1999)
J. Biol. Chem. 274, 18769-18776
 |  Abstract »  |  Full Text »  |  PDF »

16K Human Prolactin Inhibits Vascular Endothelial Growth Factor-Induced Activation of Ras in Capillary Endothelial Cells.

G. D’Angelo, J.-F. Martini, T. Iiri, W. J. Fantl, J. Martial, and R. I. Weiner (1999)
Mol. Endocrinol. 13, 692-704
 |  Abstract »  |  Full Text »

Hematopoietic Growth Factors Signal Through the Formation of Reactive Oxygen Species.

M. Sattler, T. Winkler, S. Verma, C. H. Byrne, G. Shrikhande, R. Salgia, and J. D. Griffin (1999)
Blood 93, 2928-2935
 |  Abstract »  |  Full Text »  |  PDF »

The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D.

A. Schurmann, M. Schmidt, M. Asmus, S. Bayer, F. Fliegert, S. Koling, S. Massmann, C. Schilf, M. C. Subauste, M. Voss, et al. (1999)
J. Biol. Chem. 274, 9744-9751
 |  Abstract »  |  Full Text »  |  PDF »

The Yeast C-Type Cyclin Ctk2p Is Phosphorylated and Rapidly Degraded by the Ubiquitin-Proteasome Pathway.

G. Hautbergue and V. Goguel (1999)
Mol. Cell. Biol. 19, 2527-2534
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Potential Effector Molecules of the Ras-related GTPase Rap2.

V. Nancy, R. M. F. Wolthuis, M.-F. de Tand, I. Janoueix-Lerosey, J. L. Bos, and J. de Gunzburg (1999)
J. Biol. Chem. 274, 8737-8745
 |  Abstract »  |  Full Text »  |  PDF »

DEF-1, a Novel Src SH3 Binding Protein That Promotes Adipogenesis in Fibroblastic Cell Lines.

F. J. King, E. Hu, D. F. Harris, P. Sarraf, B. M. Spiegelman, and T. M. Roberts (1999)
Mol. Cell. Biol. 19, 2330-2337
 |  Abstract »  |  Full Text »  |  PDF »

Polyomavirus Large T Antigen Induces Alterations in Cytoplasmic Signalling Pathways Involving Shc Activation.

V. Gottifredi, G. Pelicci, E. Munarriz, R. Maione, P. G. Pelicci, and P. Amati (1999)
J. Virol. 73, 1427-1437
 |  Abstract »  |  Full Text »

A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.

D. Cussac, M. Vidal, C. Leprince, W.-q. Liu, F. Cornille, G. Tiraboschi, B. P. Roques, and C. Garbay (1999)
FASEB J 13, 31-38
 |  Abstract »  |  Full Text »

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain.

C. E. Tognon, H. E. Kirk, L. A. Passmore, I. P. Whitehead, C. J. Der, and R. J. Kay (1998)
Mol. Cell. Biol. 18, 6995-7008
 |  Abstract »  |  Full Text »

Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion.

M. H. Pillinger, C. Capodici, P. Rosenthal, N. Kheterpal, S. Hanft, M. R. Philips, and G. Weissmann (1998)
PNAS 95, 14540-14545
 |  Abstract »  |  Full Text »  |  PDF »

Quality Assessment of Whole Genome Mapping Data in the Refined Familial Spastic Paraplegia Interval on Chromosome 14q.

C. Paternotte, D. Rudnicki, C. Fizames, C.-S. Davoine, D. Mavel, A. Dürr, D. Samson, C. Marquette, D. Muselet, N. Vega-Czarny, et al. (1998)
Genome Res. 8, 1216-1227
 |  Abstract »  |  Full Text »

Identification of Limiting Steps for Efficient Trans-activation of HIV-1 Promoter by Tat in Saccharomyces cerevisiae.

L. Daviet, F. Bois, P.-L. Battisti, and A. Gatignol (1998)
J. Biol. Chem. 273, 28219-28228
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Guanosine Triphosphatases and Phospholipase C-gamma 2 in Extracellular Signal-regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor.

A. Hashimoto, H. Okada, A. Jiang, M. Kurosaki, S. Greenberg, E. A. Clark, and T. Kurosaki (1998)
J. Exp. Med. 188, 1287-1295
 |  Abstract »  |  Full Text »  |  PDF »

Grb2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor.

M. Pomerance, M.-C. Multon, F. Parker, C. Venot, J.-P. Blondeau, B. Tocque, and F. Schweighoffer (1998)
J. Biol. Chem. 273, 24301-24304
 |  Abstract »  |  Full Text »  |  PDF »

Structural Requirements for Function of the Crkl Adapter Protein in Fibroblasts and Hematopoietic Cells.

K. Senechal, C. Heaney, B. Druker, and C. L. Sawyers (1998)
Mol. Cell. Biol. 18, 5082-5090
 |  Abstract »  |  Full Text »

Ras-GAP Controls Rho-Mediated Cytoskeletal Reorganization through Its SH3 Domain.

V. Leblanc, B. Tocque, and I. Delumeau (1998)
Mol. Cell. Biol. 18, 5567-5578
 |  Abstract »  |  Full Text »

Mutation of a Shc Binding Site Tyrosine Residue in ErbB3/HER3 Blocks Heregulin-dependent Activation of Mitogen-activated Protein Kinase.

U. Vijapurkar, K. Cheng, and J. G. Koland (1998)
J. Biol. Chem. 273, 20996-21002
 |  Abstract »  |  Full Text »  |  PDF »

Disabled Is a Putative Adaptor Protein That Functions during Signaling by the Sevenless Receptor Tyrosine Kinase.

N. Le and M. A. Simon (1998)
Mol. Cell. Biol. 18, 4844-4854
 |  Abstract »  |  Full Text »

A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes.

F. Gesbert, C. Guenzi, and J. Bertoglio (1998)
J. Biol. Chem. 273, 18273-18281
 |  Abstract »  |  Full Text »  |  PDF »

Growth Factor Receptor-Bound Protein 2 (Grb2) Association with Hemopoietic Specific Protein 1: Linkage Between Lck and Grb2.

Y. Takemoto, M. Furuta, M. Sato, P. R. Findell, W. Ramble, and Y. Hashimoto (1998)
J. Immunol. 161, 625-630
 |  Abstract »  |  Full Text »  |  PDF »

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs.

C. Gauthier-Rouvière, E. Vignal, M. Mériane, P. Roux, P. Montcourier, and P. Fort (1998)
Mol. Biol. Cell 9, 1379-1394
 |  Abstract »  |  Full Text »

Insulin Receptor-mediated Dissociation of Grb2 from Sos Involves Phosphorylation of Sos by Kinase(s) Other than Extracellular Signal-regulated Kinase.

H. Zhao, S. Okada, J. E. Pessin, and G. A. Koretzky (1998)
J. Biol. Chem. 273, 12061-12067
 |  Abstract »  |  Full Text »  |  PDF »

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs.

J. O. Ebinu, D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone (1998)
Science 280, 1082-1086
 |  Abstract »  |  Full Text »

Diversity of HIV-1 Vpr Interactions Involves Usage of the WXXF Motif of Host Cell Proteins.

M. BouHamdan, Y. Xue, Y. Baudat, B. Hu, J. Sire, R. J. Pomerantz, and L.-X. Duan (1998)
J. Biol. Chem. 273, 8009-8016
 |  Abstract »  |  Full Text »  |  PDF »

Grb2 and Its Apoptotic Isoform Grb3-3 Associate with Heterogeneous Nuclear Ribonucleoprotein C, and These Interactions Are Modulated by Poly(U) RNA.

F. Romero, F. Ramos-Morales, A. Dominguez, R. M. Rios, F. Schweighoffer, B. Tocque, J. A. Pintor-Toro, S. Fischer, and M. Tortolero (1998)
J. Biol. Chem. 273, 7776-7781
 |  Abstract »  |  Full Text »  |  PDF »

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.

I. Rogatsky, S. K. Logan, and M. J. Garabedian (1998)
PNAS 95, 2050-2055
 |  Abstract »  |  Full Text »  |  PDF »

Differential Coupling of Membrane Ig and CD40 to the Extracellularly Regulated Kinase Signaling Pathway.

J. M. Purkerson and D. C. Parker (1998)
J. Immunol. 160, 2121-2129
 |  Abstract »  |  Full Text »  |  PDF »

N Terminus of Sos1 Ras Exchange Factor: Critical Roles for the Dbl and Pleckstrin Homology Domains.

X. Qian, W. C. Vass, A. G. Papageorge, P. H. Anborgh, and D. R. Lowy (1998)
Mol. Cell. Biol. 18, 771-778
 |  Abstract »  |  Full Text »

Regulation of Sos Activity by Intramolecular Interactions.

S. Corbalan-Garcia, S. M. Margarit, D. Galron, S.-s. Yang, and D. Bar-Sagi (1998)
Mol. Cell. Biol. 18, 880-886
 |  Abstract »  |  Full Text »

Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway.

N. Clarke, N. Arenzana, T. Hai, A. Minden, and R. Prywes (1998)
Mol. Cell. Biol. 18, 1065-1073
 |  Abstract »  |  Full Text »

Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Protein in Vivo.

M. K. Jones and J. H. Jackson (1998)
J. Biol. Chem. 273, 1782-1787
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells.

S. Chien, S. Li, and J. Y-J. Shyy (1998)
Hypertension 31, 162-169
 |  Abstract »  |  Full Text »  |  PDF »

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