Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 28 May 1993:
Vol. 260. no. 5112, pp. 1335 - 1338
DOI: 10.1126/science.8388126

Articles

Science, Vol 260, Issue 5112, 1335-1338
Copyright © 1993 by American Association for the Advancement of Science


articles

Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities

RH Chen, R Ebner, and R Derynck

Department of Growth and Development, University of California, San Francisco 94143.

Transforming growth factor-beta (TGF-beta) is a multifunctional protein that regulates cell proliferation and differentiation and extracellular matrix production. Although two receptor types, the type I and type II receptors, have been implicated in TGF-beta-induced signaling, it is unclear how the many activities of TGF-beta are mediated through these receptors. With the use of cells overexpressing truncated type II receptors as dominant negative mutants to selectively block type II receptor signaling, the existence of two receptor pathways was shown. The type II receptors, possibly in conjunction with type I receptors, mediate the induction of growth inhibition and hypophosphorylation of the retinoblastoma gene product pRB. The type I receptors are responsible for effects on extracellular matrix, such as the induction of fibronectin and plasminogen activator inhibitor I, and for increased JunB expression. Selective inactivation of the type II receptors alters the TGF-beta response in a similar manner to the functional inactivation of pRB, suggesting a role for pRB in the type II, but not the type I, receptor pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disruption of TGF-{beta} Signaling Prevents the Generation of Tumor-Sensitized Regulatory T Cells and Facilitates Therapeutic Antitumor Immunity.
U. Petrausch, S. M. Jensen, C. Twitty, C. H. Poehlein, D. P. Haley, E. B. Walker, and B. A. Fox (2009)
J. Immunol. 183, 3682-3689
   Abstract »    Full Text »    PDF »
Cancer-Associated Transforming Growth Factor {beta} Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype.
S. Bharathy, W. Xie, J. M. Yingling, and M. Reiss (2008)
Cancer Res. 68, 1656-1666
   Abstract »    Full Text »    PDF »
Transforming growth factor-{beta} signaling and ubiquitinators in cancer.
E. Glasgow and L. Mishra (2008)
Endocr. Relat. Cancer 15, 59-72
   Abstract »    Full Text »    PDF »
Cripto Is a Noncompetitive Activin Antagonist That Forms Analogous Signaling Complexes with Activin and Nodal.
J. A. Kelber, G. Shani, E. C. Booker, W. W. Vale, and P. C. Gray (2008)
J. Biol. Chem. 283, 4490-4500
   Abstract »    Full Text »    PDF »
Clinical features in a family with an R460H mutation in transforming growth factor {beta} receptor 2 gene.
C Law, D Bunyan, B Castle, L Day, I Simpson, G Westwood, and B Keeton (2006)
J. Med. Genet. 43, 908-916
   Abstract »    Full Text »    PDF »
Smad4-dependent Regulation of Urokinase Plasminogen Activator Secretion and RNA Stability Associated with Invasiveness by Autocrine and Paracrine Transforming Growth Factor-beta.
S.-R. Shiou, P. K. Datta, P. Dhawan, B. K. Law, J. M. Yingling, D. A. Dixon, and R. D. Beauchamp (2006)
J. Biol. Chem. 281, 33971-33981
   Abstract »    Full Text »    PDF »
Signaling cross-talk between IGF-binding protein-3 and transforming growth factor-{beta} in mesenchymal chondroprogenitor cell growth.
L O'Rear, L Longobardi, M Torello, B K Law, H L Moses, F Chiarelli, and A Spagnoli (2005)
J. Mol. Endocrinol. 34, 723-737
   Abstract »    Full Text »    PDF »
THE ROLE OF TGF-{beta} IN EPITHELIAL MALIGNANCY AND ITS RELEVANCE TO THE PATHOGENESIS OF ORAL CANCER (PART II).
S.S. Prime, M. Davies, M. Pring, and I.C. Paterson (2004)
Critical Reviews in Oral Biology & Medicine 15, 337-347
   Abstract »    Full Text »    PDF »
Concomitant Overexpression of Cyclooxygenase-2 in HER-2-Positive on Smad4-Reduced Human Gastric Carcinomas Is Associated with a Poor Patient Outcome.
H. Okano, H. Shinohara, A. Miyamoto, K. Takaori, and N. Tanigawa (2004)
Clin. Cancer Res. 10, 6938-6945
   Abstract »    Full Text »    PDF »
Targeting Endogenous Transforming Growth Factor {beta} Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype1.
G. Subramanian, R. E. Schwarz, L. Higgins, G. McEnroe, S. Chakravarty, S. Dugar, and M. Reiss (2004)
Cancer Res. 64, 5200-5211
   Abstract »    Full Text »    PDF »
Transforming Growth Factor {beta}/Smad3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter.
J. Qing, C. Liu, L. Choy, R.-Y. Wu, J. S. Pagano, and R. Derynck (2004)
Mol. Cell. Biol. 24, 1411-1425
   Abstract »    Full Text »    PDF »
CLAVATA1 Dominant-Negative Alleles Reveal Functional Overlap between Multiple Receptor Kinases That Regulate Meristem and Organ Development.
A. Dievart, M. Dalal, F. E. Tax, A. D. Lacey, A. Huttly, J. Li, and S. E. Clark (2003)
PLANT CELL 15, 1198-1211
   Abstract »    Full Text »
Smads 2 and 3 Are Differentially Activated by Transforming Growth Factor-beta (TGF-beta ) in Quiescent and Activated Hepatic Stellate Cells. CONSTITUTIVE NUCLEAR LOCALIZATION OF Smads IN ACTIVATED CELLS IS TGF-beta -INDEPENDENT.
C. Liu, M. D. A. Gaca, E. S. Swenson, V. F. Vellucci, M. Reiss, and R. G. Wells (2003)
J. Biol. Chem. 278, 11721-11728
   Abstract »    Full Text »    PDF »
Reconstitution of Lethally Irradiated Adult Mice with Dominant Negative TGF-{beta} Type II Receptor-Transduced Bone Marrow Leads to Myeloid Expansion and Inflammatory Disease.
A. H. Shah, W. B. Tabayoyong, S. Y. Kimm, S.-J. Kim, L. van Parijs, and C. Lee (2002)
J. Immunol. 169, 3485-3491
   Abstract »    Full Text »    PDF »
Metapopulation dynamics and spatial heterogeneity in cancer.
I. Gonzalez-Garcia, R. V. Sole, and J. Costa (2002)
PNAS 99, 13085-13089
   Abstract »    Full Text »    PDF »
Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia.
A. G. Vicencio, O. Eickelberg, M. C. Stankewich, M. Kashgarian, and G. G. Haddad (2002)
J Appl Physiol 93, 1123-1130
   Abstract »    Full Text »    PDF »
When cell biology meets development: endocytic regulation of signaling pathways.
E. S. Seto, H. J. Bellen, and T. E. Lloyd (2002)
Genes & Dev. 16, 1314-1336
   Full Text »    PDF »
Disruption of Transforming Growth Factor {beta} Signaling by a Novel Ligand-dependent Mechanism.
T. Fernandez, S. Amoroso, S. Sharpe, G. M. Jones, V. Bliskovski, A. Kovalchuk, L. M. Wakefield, S.-J. Kim, M. Potter, and J. J. Letterio (2002)
J. Exp. Med. 195, 1247-1255
   Abstract »    Full Text »    PDF »
Transient Disruption of Autocrine TGF-{beta} Signaling Leads to Enhanced Survival and Proliferation Potential in Single Primitive Human Hemopoietic Progenitor Cells.
X. Fan, G. Valdimarsdottir, J. Larsson, A. Brun, M. Magnusson, S. E. Jacobsen, P. ten Dijke, and S. Karlsson (2002)
J. Immunol. 168, 755-762
   Abstract »    Full Text »    PDF »
Integrin beta 1 Signaling Is Necessary for Transforming Growth Factor-beta Activation of p38MAPK and Epithelial Plasticity.
N. A. Bhowmick, R. Zent, M. Ghiassi, M. McDonnell, and H. L. Moses (2001)
J. Biol. Chem. 276, 46707-46713
   Abstract »    Full Text »    PDF »
Inducible Expression of Transforming Growth Factor {beta}1 in Papillomas Causes Rapid Metastasis.
B. H. Weeks, W. He, K. L. Olson, and X.-J. Wang (2001)
Cancer Res. 61, 7435-7443
   Abstract »    Full Text »    PDF »
Soluble Type II Transforming Growth Factor-{beta} (TGF-{beta}) Receptor Inhibits TGF-{beta} Signaling in COLO-357 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation.
M. A. Rowland-Goldsmith, H. Maruyama, T. Kusama, S. Ralli, and M. Korc (2001)
Clin. Cancer Res. 7, 2931-2940
   Abstract »    Full Text »    PDF »
Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta.
J. Zavadil, M. Bitzer, D. Liang, Y.-C. Yang, A. Massimi, S. Kneitz, E. Piek, and E. P. Bottinger (2001)
PNAS 98, 6686-6691
   Abstract »    Full Text »    PDF »
Stimulation of pro-{alpha}1(I) collagen by TGF-{beta}1 in mesangial cells: role of the p38 MAPK pathway.
B. Y. Chin, A. Mohsenin, S. X. Li, A. M. K. Choi, and M. E. Choi (2001)
Am J Physiol Renal Physiol 280, F495-F504
   Abstract »    Full Text »    PDF »
Fibrogenesis: V. TGF-beta signaling pathways.
R. G. Wells (2000)
Am J Physiol Gastrointest Liver Physiol 279, G845-G850
   Abstract »    Full Text »    PDF »
Role of Transforming Growth Factor-{beta} Signaling in Cancer.
M. P. de Caestecker, E. Piek, and A. B. Roberts (2000)
J Natl Cancer Inst 92, 1388-1402
   Abstract »    Full Text »    PDF »
Ontogeny and localization of TGF-beta type I receptor expression during lung development.
Y. Zhao, S. L. Young, J. C. McIntosh, M. P. Steele, and R. Silbajoris (2000)
Am J Physiol Lung Cell Mol Physiol 278, L1231-L1239
   Abstract »    Full Text »    PDF »
Roles of Autocrine TGF-{beta} Receptor and Smad Signaling in Adipocyte Differentiation.
L. Choy, J. Skillington, and R. Derynck (2000)
J. Cell Biol. 149, 667-682
   Abstract »    Full Text »    PDF »
Disruption of T Cell Homeostasis in Mice Expressing a T Cell-Specific Dominant Negative Transforming Growth Factor {beta} II Receptor.
P. J. Lucas, S.-J. Kim, S. J. Melby, and R. E. Gress (2000)
J. Exp. Med. 191, 1187-1196
   Abstract »    Full Text »    PDF »
Selective Loss of the Transforming Growth Factor-{beta} Apoptotic Signaling Pathway in Mutant NRP-154 Rat Prostatic Epithelial Cells.
S. Larisch-Bloch, D. Danielpour, N. S. Roche, R. Lotan, A. Y. Hsing, H. Kerner, T. Hajouj, R. J. Lechleider, and A. B. Roberts (2000)
Cell Growth Differ. 11, 1-10
   Abstract »    Full Text »
Transforming Growth Factor-beta -mediated p15INK4B Induction and Growth Inhibition in Astrocytes Is SMAD3-dependent and a Pathway Prominently Altered in Human Glioma Cell Lines.
J. N. Rich, M. Zhang, M. B. Datto, D. D. Bigner, and X.-F. Wang (1999)
J. Biol. Chem. 274, 35053-35058
   Abstract »    Full Text »    PDF »
Loss of Responsiveness to Transforming Growth Factor {beta} Induces Malignant Transformation of Nontumorigenic Rat Prostate Epithelial Cells.
B. Tang, K. de Castro, H. E. Barnes, W. T. Parks, L. Stewart, E. P. Bottinger, D. Danielpour, and L. M. Wakefield (1999)
Cancer Res. 59, 4834-4842
   Abstract »    Full Text »    PDF »
Blocking Transforming Growth Factor {beta} Signaling in Transgenic Epidermis Accelerates Chemical Carcinogenesis: A Mechanism Associated with Increased Angiogenesis.
C. Go, P. Li, and X.-J. Wang (1999)
Cancer Res. 59, 2861-2868
   Abstract »    Full Text »    PDF »
Evidence for Control of Nitric Oxide Synthesis by Intracellular Transforming Growth Factor-ß1 in Tumor Cells : Implications for Tumor Development.
P. Lagadec, S. Raynal, B. Lieubeau, N. Onier, L. Arnould, V. Saint-Giorgio, D. A. Lawrence, and J.-F. Jeannin (1999)
Am. J. Pathol. 154, 1867-1876
   Abstract »    Full Text »    PDF »
Role of Elevated Plasma Transforming Growth Factor-ß1 Levels in Wound Healing.
M. Shah, D. Revis, S. Herrick, R. Baillie, S. Thorgeirson, M. Ferguson, and A. Roberts (1999)
Am. J. Pathol. 154, 1115-1124
   Abstract »    Full Text »    PDF »
Coordinate regulation of cyclooxygenase-2 and TGF-ß1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors.
J. Shao, H. Sheng, R. Aramandla, M. A. Pereira, R. A. Lubet, E. Hawk, L. Grogan, I. R. Kirsch, M. K. Washington, R. D. Beauchamp, et al. (1999)
Carcinogenesis 20, 185-191
   Abstract »    Full Text »    PDF »
Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.
E Filvaroff, A Erlebacher, J Ye, S. Gitelman, J Lotz, M Heillman, and R Derynck (1999)
Development 126, 4267-4279
   Abstract »    PDF »
Heteromeric and Homomeric Transforming Growth Factor-beta Receptors Show Distinct Signaling and Endocytic Responses in Epithelial Cells.
J. J. E. Dore Jr., M. Edens, N. Garamszegi, and E. B. Leof (1998)
J. Biol. Chem. 273, 31770-31777
   Abstract »    Full Text »    PDF »
The Type II Transforming Growth Factor (TGF)-beta Receptor-interacting Protein TRIP-1 Acts as a Modulator of the TGF-beta Response.
L. Choy and R. Derynck (1998)
J. Biol. Chem. 273, 31455-31462
   Abstract »    Full Text »    PDF »
Gestational Changes in the Levels of Transforming Growth Factor-{beta}1 (TGF{beta}1) and TGF{beta} Receptor Types I and II in the Human Myometrium.
P. Hatthachote, J. Morgan, W. Dunlop, G. N. Europe-Finner, and J. I. Gillespie (1998)
J. Clin. Endocrinol. Metab. 83, 2987-2992
   Abstract »    Full Text »
Role of Transforming Growth Factor (TGF)-{beta} Type I and TGF-{beta} Type II Receptors in the TGF-{beta}1-Regulated Gene Expression in Pituitary Prolactin-Secreting Lactotropes.
D. K. Sarkar, M. Pastorcic, A. De, M. Engel, H. Moses, and M. B. Ghasemzadeh (1998)
Endocrinology 139, 3620-3628
   Abstract »    Full Text »    PDF »
Osteoblastic Responses to TGF-beta during Bone Remodeling.
A. Erlebacher, E. H. Filvaroff, J.-Q. Ye, and R. Derynck (1998)
Mol. Biol. Cell 9, 1903-1918
   Abstract »    Full Text »
TGF-{beta}1 as an Endogenous Defender Against Macrophage-Triggered Stromelysin Gene Expression in the Glomerulus.
M. Kitamura (1998)
J. Immunol. 160, 5163-5168
   Abstract »    Full Text »    PDF »
Growth factor involvement in progression of prostate cancer.
P. J. Russell, S. Bennett, and P. Stricker (1998)
Clin. Chem. 44, 705-723
   Abstract »    Full Text »    PDF »
Up-regulation of Transforming Growth Factor (TGF)-beta Receptors by TGF-beta 1 in COLO-357 Cells.
J. Kleeff and M. Korc (1998)
J. Biol. Chem. 273, 7495-7500
   Abstract »    Full Text »    PDF »
XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues.
A Frisch and C. Wright (1998)
Development 125, 431-442
   Abstract »    PDF »
Inhibition of Protein Tyrosine Kinases Attenuates Increases in Expression of Transforming Growth Factor-ß Isoforms and Their Receptors Following Arterial Injury.
M. R. Ward, A. Agrotis, P. Kanellakis, R. Dilley, G. Jennings, and A. Bobik (1997)
Arterioscler Thromb Vasc Biol 17, 2461-2470
   Abstract »    Full Text »
Expression of a Truncated, Kinase-Defective TGF-{beta} Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis.
R. Serra, M. Johnson, E. H. Filvaroff, J. LaBorde, D. M. Sheehan, R. Derynck, and H. L. Moses (1997)
J. Cell Biol. 139, 541-552
   Abstract »    Full Text »    PDF »
The Role of Transforming Growth Factor-{beta} in the Regulation of Estrogen Receptor Expression in the MCF-7 Breast Cancer Cell Line.
A. Stoica, M. Saceda, A. Fakhro, H. B. Solomon, B. D. Fenster, and M. B. Martin (1997)
Endocrinology 138, 1498-1505
   Abstract »    Full Text »    PDF »
Expression of a dominant-negative type II transforming growth factor beta  (TGF-beta ) receptor in the epidermis of transgenic mice blocks TGF-beta -mediated growth inhibition.
X.-J. Wang, D. A. Greenhalgh, J. R. Bickenbach, A. Jiang, D. S. Bundman, T. Krieg, R. Derynck, and D. R. Roop (1997)
PNAS 94, 2386-2391
   Abstract »    Full Text »    PDF »
Processing of the Transforming Growth Factor beta Type I and II Receptors. BIOSYNTHESIS AND LIGAND-INDUCED REGULATION.
K. M. Koli and C. L. Arteaga (1997)
J. Biol. Chem. 272, 6423-6427
   Abstract »    Full Text »    PDF »
A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis.
C Chang, P. Wilson, L. Mathews, and A Hemmati-Brivanlou (1997)
Development 124, 827-837
   Abstract »    PDF »
Binding Affinity of Transforming Growth Factor-beta for Its Type II Receptor Is Determined by the C-terminal Region of the Molecule.
S. W. Qian, J. K. Burmester, M. L.-S. Tsang, J. A. Weatherbee, A. P. Hinck, D. J. Ohlsen, M. B. Sporn, and A. B. Roberts (1996)
J. Biol. Chem. 271, 30656-30662
   Abstract »    Full Text »    PDF »
FKBP-12 Recognition Is Dispensable For Signal Generation by Type I Transforming Growth Factor-beta Receptors.
M.-J. Charng, P. Kinnunen, J. Hawker, T. Brand, and M. D. Schneider (1996)
J. Biol. Chem. 271, 22941-22944
   Abstract »    Full Text »    PDF »
Chimeric Granulocyte/Macrophage Colony-stimulating Factor/Transforming Growth Factor-beta (TGF-beta ) Receptors Define a Model System for Investigating the Role of Homomeric and Heteromeric Receptors in TGF-beta Signaling.
R. A. Anders and E. B. Leof (1996)
J. Biol. Chem. 271, 21758-21766
   Abstract »    Full Text »    PDF »
Reduced Expression of Transforming Growth Factor beta Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells.
J. Wang, W. Han, E. Zborowska, J. Liang, X. Wang, J. K.V. Willson, L. Sun, and M. G. Brattain (1996)
J. Biol. Chem. 271, 17366-17371
   Abstract »    Full Text »    PDF »
Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-beta (TGF-beta ) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-beta in Vascular Wall Cells in Primary Culture.
H. Yamamoto, H. Ueno, A. Ooshima, and A. Takeshita (1996)
J. Biol. Chem. 271, 16253-16259
   Abstract »    Full Text »    PDF »
Requirement of Transforming Growth Factor-beta (TGF-beta) Type II Receptor for TGF-beta-induced Proliferation and Growth Inhibition.
Y. Zhao and S. L. Young (1996)
J. Biol. Chem. 271, 2369-2372
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-beta (TGF-beta)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-beta Receptor Complex.
X.-H. Feng, E. H. Filvaroff, and R. Derynck (1995)
J. Biol. Chem. 270, 24237-24245
   Abstract »    Full Text »    PDF »
Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-beta Receptors.
M. E. Choi and B. J. Ballermann (1995)
J. Biol. Chem. 270, 21144-21150
   Abstract »    Full Text »    PDF »
Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor [IMAGE]2.
S. Sankar, N. Mahooti-Brooks, M. Centrella, T. L. McCarthy, and J. A. Madri (1995)
J. Biol. Chem. 270, 13567-13572
   Abstract »    Full Text »    PDF »
Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-[IMAGE] Receptors.
R.-H. Chen, H. L. Moses, E. M. Maruoka, R. Derynck, and M. Kawabata (1995)
J. Biol. Chem. 270, 12235-12241
   Abstract »    Full Text »    PDF »
Inactive Type II and Type I Receptors for TGFbeta Are Dominant Inhibitors of TGFbeta-dependent Transcription.
T. Brand and M. D. Schneider (1995)
J. Biol. Chem. 270, 8274-8284
   Abstract »    Full Text »    PDF »
Transforming Growth Factor beta Activation of p44[IMAGE] in Proliferating Cultures of Epithelial Cells.
M. T. Hartsough and K. M. Mulder (1995)
J. Biol. Chem. 270, 7117-7124
   Abstract »    Full Text »    PDF »
Signaling Activity of Homologous and Heterologous Transforming Growth Factor-beta Receptor Kinase Complexes.
D. Vivien, L. Attisano, and J. Massagué (1995)
J. Biol. Chem. 270, 7134-7141
   Abstract »    Full Text »    PDF »
GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor beta and Activin-A.
A. Moustakas, T. Takumi, H. Y. Lin, and H. F. Lodish (1995)
J. Biol. Chem. 270, 765-769
   Abstract »    Full Text »    PDF »
pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ cultures.
R Serra and H. Moses (1995)
Development 121, 3057-3066
   Abstract »    PDF »
Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring.
M Shah, D. Foreman, and M. Ferguson (1995)
J. Cell Sci. 108, 985-1002
   Abstract »    PDF »
Collagen matrices attenuate the collagen-synthetic response of cultured fibroblasts to TGF-beta.
R. Clark, L. Nielsen, M. Welch, and J. McPherson (1995)
J. Cell Sci. 108, 1251-1261
   Abstract »    PDF »
Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12.
T Wang, P. Donahoe, and A. Zervos (1994)
Science 265, 674-676
   Abstract »    PDF »
Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.
E. Filvaroff, R Ebner, and R Derynck (1994)
Development 120, 1085-1095
   Abstract »    PDF »
Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
W. Rettig, H. Erickson, A. Albino, and P Garin-Chesa (1994)
J. Cell Sci. 107, 487-497
   Abstract »    PDF »
The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1.
S Lawler, A. Candia, R Ebner, L Shum, A. Lopez, H. Moses, C. Wright, and R Derynck (1994)
Development 120, 165-175
   Abstract »    PDF »
A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the mullerian duct.
W. Baarends, M. van Helmond, M Post, P. van der Schoot, J. Hoogerbrugge, J. de Winter, J. Uilenbroek, B Karels, L. Wilming, J. Meijers, et al. (1994)
Development 120, 189-197
   Abstract »    PDF »
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
R Ebner, R. Chen, S Lawler, T Zioncheck, and R Derynck (1993)
Science 262, 900-902
   Abstract »    PDF »
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
R Ebner, R. Chen, L Shum, S Lawler, T. Zioncheck, A Lee, A. Lopez, and R Derynck (1993)
Science 260, 1344-1348
   Abstract »    PDF »
Transforming Growth Factor-beta 1-induced Activation of the ERK Pathway/Activator Protein-1 in Human Lung Fibroblasts Requires the Autocrine Induction of Basic Fibroblast Growth Factor.
G. A. Finlay, V. J. Thannickal, B. L. Fanburg, and K. E. Paulson (2000)
J. Biol. Chem. 275, 27650-27656
   Abstract »    Full Text »    PDF »
Smad7-dependent Regulation of Heme Oxygenase-1 by Transforming Growth Factor-beta in Human Renal Epithelial Cells.
N. Hill-Kapturczak, L. Truong, V. Thamilselvan, G. A. Visner, H. S. Nick, and A. Agarwal (2000)
J. Biol. Chem. 275, 40904-40909
   Abstract »    Full Text »    PDF »
Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor beta Receptor in Regulating Transforming Growth Factor beta Signaling.
G. C. Blobe, W. P. Schiemann, M.-C. Pepin, M. Beauchemin, A. Moustakas, H. F. Lodish, and M. D. O'Connor-McCourt (2001)
J. Biol. Chem. 276, 24627-24637
   Abstract »    Full Text »    PDF »
Rapid and dynamic regulation of TGF-beta receptors on blood vessels and fibroblasts during ischemia-reperfusion injury.
R. Mortazavi-Haghighat, K. Taghipour-Khiabani, S. David, C. L. Kerrigan, and A. Philip (2002)
Am J Physiol Cell Physiol 282, C1161-C1169
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)