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Science 28 May 1993:
Vol. 260. no. 5112, pp. 1323 - 1327
DOI: 10.1126/science.8493576
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Articles

Science, Vol 260, Issue 5112, 1323-1327
Copyright © 1993 by American Association for the Advancement of Science

articles

Protection against vaginal SIV transmission with microencapsulated vaccine

PA Marx, RW Compans, A Gettie, JK Staas, RM Gilley, MJ Mulligan, GV Yamshchikov, D Chen, and JH Eldridge

New Mexico Regional Primate Research Laboratory, New Mexico State University, Holloman Air Force Base 88330.

Although protection in animal models against intravenous challenges with simian immunodeficiency virus (SIV) has been reported, no previous vaccines have protected against a heterosexual route of infection. In this study, five of six macaques were protected against vaginal challenge when immunized with formalin-treated SIV in biodegradable microspheres by the intramuscular plus oral or plus intratracheal route. Oral immunization alone did not protect. After a second vaginal challenge, three of four intramuscularly primed and mucosally boosted macaques remained protected. The data suggest that protection against human immunodeficiency virus vaginal transmission could be provided by microsphere-based booster vaccines when used to immunize women who are systemically primed.


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