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Science 28 May 1993:
Vol. 260. no. 5112, pp. 1273 - 1279
DOI: 10.1126/science.8493571
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Articles

Science, Vol 260, Issue 5112, 1273-1279
Copyright © 1993 by American Association for the Advancement of Science

articles

How does HIV cause AIDS?

RA Weiss

Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.

Many questions have been posed about acquired immunodeficiency syndrome (AIDS) pathogenesis. Is human immunodeficiency virus (HIV) both necessary and sufficient to cause AIDS? Is AIDS essentially an autoimmune disease, triggering apoptosis, or is virus infection the cause of T helper lymphocyte depletion? What is the significance of HIV tropism and the role of macrophages and dendritic cells in AIDS? Is there viral latency and why is there usually a long period between infection and AIDS? Is HIV variation a crucial aspect of its pathogenesis and, if so, do virulent strains emerge? Although this article provides few definitive answers, it aims to focus commentary on salient points. Overall, it is increasingly evident that both the tropism and burden of HIV infection correlate closely with the manifestations of disease.


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Novel Derivatives of Phenethyl-5-Bromopyridylthiourea and Dihydroalkoxybenzyloxopyrimidine Are Dual-Function Spermicides with Potent Anti-Human Immunodeficiency Virus Activity.
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Differential Effects of Interleukin-13 on Cytomegalovirus and Human Immunodeficiency Virus Infection in Human Alveolar Macrophages.
W. C. Hatch, A. R. Freedman, D. M. Boldt-Houle, J. E. Groopman, and E. F. Terwilliger (1997)
Blood 89, 3443-3450
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Increased Uptake and Accumulation of Vitamin C in Human Immunodeficiency Virus 1-infected Hematopoietic Cell Lines.
C. I. Rivas, J. C. Vera, V. H. Guaiquil, F. V. Velasquez, O. A. Borquez-Ojeda, J. G. Carcamo, I. I. Concha, and D. W. Golde (1997)
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Sensitization of the HIV-1-LTR upon Long Term Low Dose Oxidative Stress.
S.-i. Kurata and S. Kurata (1996)
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