Science 21 May 1993: Vol. 260. no. 5111, pp. 1130 - 1132 DOI: 10.1126/science.8493557

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Articles

Targeting the RET Pathway in Thyroid Cancer.

S. A. Wells Jr. and M. Santoro (2009)
Clin. Cancer Res. 15, 7119-7123
 |  Abstract »  |  Full Text »  |  PDF »

Neural Cell Adhesion Molecule Modulates Dopaminergic Signaling and Behavior by Regulating Dopamine D2 Receptor Internalization.

M.-F. Xiao, J.-C. Xu, Y. Tereshchenko, D. Novak, M. Schachner, and R. Kleene (2009)
J. Neurosci. 29, 14752-14763
 |  Abstract »  |  Full Text »  |  PDF »

Egr-1 Is Necessary for Fibroblast Growth Factor-2-induced Transcriptional Activation of the Glial Cell Line-derived Neurotrophic Factor in Murine Astrocytes.

S. Y. Shin, H. Song, C. G. Kim, Y.-K. Choi, K. S. Lee, S.-J. Lee, H.-J. Lee, Y. Lim, and Y. H. Lee (2009)
J. Biol. Chem. 284, 30583-30593
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Glutamate Controls Growth Rate and Branching of Dopaminergic Axons.

Y. Schmitz, J. Luccarelli, M. Kim, M. Wang, and D. Sulzer (2009)
J. Neurosci. 29, 11973-11981
 |  Abstract »  |  Full Text »  |  PDF »

Ape1/Ref-1 Induces Glial Cell-Derived Neurotropic Factor (GDNF) Responsiveness by Upregulating GDNF Receptor {alpha}1 Expression.

M.-H. Kim, H.-B. Kim, S. Acharya, H.-M. Sohn, J. Y. Jun, I.-Y. Chang, and H. J. You (2009)
Mol. Cell. Biol. 29, 2264-2277
 |  Abstract »  |  Full Text »  |  PDF »

The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING.

V. Parkash, V.-M. Leppanen, H. Virtanen, J. M. Jurvansuu, M. M. Bespalov, Y. A. Sidorova, P. Runeberg-Roos, M. Saarma, and A. Goldman (2008)
J. Biol. Chem. 283, 35164-35172
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cells as Players in Parkinsonism: The "Good," the "Bad," and the "Mysterious" Glia.

M. A. Mena and J. Garcia de Yebenes (2008)
Neuroscientist 14, 544-560
 |  Abstract »  |  PDF »

Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity.

S.-Y. Hung, H.-C. Liou, K.-H. Kang, R.-M. Wu, C.-C. Wen, and W.-M. Fu (2008)
Mol. Pharmacol. 74, 1564-1575
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Chemically defined sequential culture media for TH+ cell derivation from human embryonic stem cells.

T. Song, G. Chen, Y. Wang, G. Mao, Y. Wang, and H. Bai (2008)
Mol. Hum. Reprod. 14, 619-625
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Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels.

S. Guerreiro, D. Toulorge, E. Hirsch, M. Marien, P. Sokoloff, and P. P. Michel (2008)
Mol. Pharmacol. 74, 980-989
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Cell-Based Therapy for Contusion Spinal Cord Injury Using GDNF-Delivering NIH3T3 Cells with Dual Reporter Genes Monitored by Molecular Imaging.

W.-C. Lo, C.-H. Hsu, A. T.H. Wu, L.-Y. Yang, W.-H. Chen, W.-T. Chiu, W.-F. Lai, C.-H. Wu, J. G. Gelovani, and W.-P. Deng (2008)
J. Nucl. Med. 49, 1512-1519
 |  Abstract »  |  Full Text »  |  PDF »

CD2AP and Cbl-3/Cbl-c Constitute a Critical Checkpoint in the Regulation of Ret Signal Transduction.

C. C. Tsui and B. A. Pierchala (2008)
J. Neurosci. 28, 8789-8800
 |  Abstract »  |  Full Text »  |  PDF »

Death Receptors and Caspases But Not Mitochondria Are Activated in the GDNF- or BDNF-Deprived Dopaminergic Neurons.

L.-y. Yu, M. Saarma, and U. Arumae (2008)
J. Neurosci. 28, 7467-7475
 |  Abstract »  |  Full Text »  |  PDF »

GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse.

S. Carnicella, V. Kharazia, J. Jeanblanc, P. H. Janak, and D. Ron (2008)
PNAS 105, 8114-8119
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell Line-derived Neurotrophic Factor Reverses Ethanol-mediated Increases in Tyrosine Hydroxylase Immunoreactivity via Altering the Activity of Heat Shock Protein 90.

D.-Y. He and D. Ron (2008)
J. Biol. Chem. 283, 12811-12818
 |  Abstract »  |  Full Text »  |  PDF »

Lrig1 Is an Endogenous Inhibitor of Ret Receptor Tyrosine Kinase Activation, Downstream Signaling, and Biological Responses to GDNF.

F. Ledda, O. Bieraugel, S. S. Fard, M. Vilar, and G. Paratcha (2008)
J. Neurosci. 28, 39-49
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Glial Cell Derived Neurotrophic Factor Induced Expression by Inflammatory Cytokines and RET/GFR{alpha}1 Receptor Up-regulation in Breast Cancer.

S. Esseghir, S. K. Todd, T. Hunt, R. Poulsom, I. Plaza-Menacho, J. S. Reis-Filho, and C. M. Isacke (2007)
Cancer Res. 67, 11732-11741
 |  Abstract »  |  Full Text »  |  PDF »

RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.

S. Kowsky, C. Poppelmeyer, E. R. Kramer, B. H. Falkenburger, A. Kruse, R. Klein, and J. B. Schulz (2007)
PNAS 104, 20049-20054
 |  Abstract »  |  Full Text »  |  PDF »

Reprint: Six-Month Continuous Intraputamenal Infusion Toxicity Study of Recombinant Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (r-metHuGDNF) in Rhesus Monkeys.

D. N. Hovland Jr., R. B. Boyd, M. T. Butt, J. A. Engelhardt, M. S. Moxness, M. H. Ma, M. G. Emery, N. B. Ernst, R. P. Reed, J. R. Zeller, et al. (2007)
Toxicol Pathol 35, 1013-1029
 |  Abstract »  |  Full Text »  |  PDF »

Gfra1 Silencing in Mouse Spermatogonial Stem Cells Results in Their Differentiation Via the Inactivation of RET Tyrosine Kinase.

Z. He, J. Jiang, M.-C. Hofmann, and M. Dym (2007)
Biol Reprod 77, 723-733
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell Line-Derived Neurotrophic Factor: An Intraovarian Factor that Enhances Oocyte Developmental Competence in Vitro.

K. Linher, D. Wu, and J. Li (2007)
Endocrinology 148, 4292-4301
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Consequences of Methamphetamine Exposure in Young Adults Are Exacerbated in Glial Cell Line-Derived Neurotrophic Factor Heterozygous Mice.

H. A. Boger, L. D. Middaugh, K. S. Patrick, S. Ramamoorthy, E. D. Denehy, H. Zhu, A. M. Pacchioni, A.-C. Granholm, and J. F. McGinty (2007)
J. Neurosci. 27, 8816-8825
 |  Abstract »  |  Full Text »  |  PDF »

Six-Month Continuous Intraputamenal Infusion Toxicity Study of Recombinant Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (r-metHuGDNF) in Rhesus Monkeys.

D. N. Hovland Jr., R. B. Boyd, M. T. Butt, J. A. Engelhardt, M. S. Moxness, M. H. Ma, M. G. Emery, N. B. Ernst, R. P. Reed, J. R. Zeller, et al. (2007)
Toxicol Pathol 35, 676-692
 |  Abstract »  |  Full Text »  |  PDF »

Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice.

Y. Yan, K. Yamada, M. Niwa, T. Nagai, A. Nitta, and T. Nabeshima (2007)
FASEB J 21, 1994-2004
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Glial Cell Line-Derived Neurotrophic Factor and Neurturin Inhibit Neurite Outgrowth and Activate RhoA through GFR{alpha}2b, an Alternatively Spliced Isoform of GFR{alpha}2.

L. F. Yoong and H.-P. Too (2007)
J. Neurosci. 27, 5603-5614
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Ret Activity in Knock-In Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration via Enhanced Synthesis and Increases the Number of TH-Positive Cells in the Substantia Nigra.

J. Mijatovic, M. Airavaara, A. Planken, P. Auvinen, A. Raasmaja, T. P. Piepponen, F. Costantini, L. Ahtee, and M. Saarma (2007)
J. Neurosci. 27, 4799-4809
 |  Abstract »  |  Full Text »  |  PDF »

Modification of the number and phenotype of striatal dopaminergic cells by carotid body graft.

W. San Sebastian, J. Guillen, M. Manrique, S. Belzunegui, E. Ciordia, A. Izal-Azcarate, P. Garrido-Gil, M. Vazquez-Claverie, and M. R. Luquin (2007)
Brain 130, 1306-1316
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell-Derived Cytokines Attenuate the Breakdown of Vascular Integrity in Diabetic Retinopathy.

N. Nishikiori, M. Osanai, H. Chiba, T. Kojima, Y. Mitamura, H. Ohguro, and N. Sawada (2007)
Diabetes 56, 1333-1340
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Pleiotrophin is a neurotrophic factor for spinal motor neurons.

R. Mi, W. Chen, and A. Hoke (2007)
PNAS 104, 4664-4669
 |  Abstract »  |  Full Text »  |  PDF »

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease.

V. Ries, C. Henchcliffe, T. Kareva, M. Rzhetskaya, R. Bland, M. J. During, N. Kholodilov, and R. E. Burke (2006)
PNAS 103, 18757-18762
 |  Abstract »  |  Full Text »  |  PDF »

A specific survival response in dopamine neurons at most risk in Parkinson's disease..

S. Murase and R. D. McKay (2006)
J. Neurosci. 26, 9750-9760
 |  Abstract »  |  Full Text »  |  PDF »

Glial cell-line-derived neurotropic factor and its receptors are expressed by germinal and somatic cells of the rat testis..

S. Fouchecourt, M. Godet, O. Sabido, and P. Durand (2006)
J. Endocrinol. 190, 59-71
 |  Abstract »  |  Full Text »  |  PDF »

Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.

J. L. McBride, S. Ramaswamy, M. Gasmi, R. T. Bartus, C. D. Herzog, E. P. Brandon, L. Zhou, M. R. Pitzer, E. M. Berry-Kravis, and J. H. Kordower (2006)
PNAS 103, 9345-9350
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell Line-Derived Neurotrophic Factor and Its Receptor Ret Is a Novel Ligand-Receptor Complex Critical for Survival Response during Podocyte Injury.

C. C. Tsui, S. J. Shankland, and B. A. Pierchala (2006)
J. Am. Soc. Nephrol. 17, 1543-1552
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of SH2-B{beta} with RET is involved in signaling of GDNF-induced neurite outgrowth.

Y. Zhang, W. Zhu, Y.-G. Wang, X.-J. Liu, L. Jiao, X. Liu, Z.-H. Zhang, C.-L. Lu, and C. He (2006)
J. Cell Sci. 119, 1666-1676
 |  Abstract »  |  Full Text »  |  PDF »

GDNF Family Ligands Trigger Indirect Neuroprotective Signaling in Retinal Glial Cells..

S. M. Hauck, N. Kinkl, C. A. Deeg, M. Swiatek-de Lange, S. Schoffmann, and M. Ueffing (2006)
Mol. Cell. Biol. 26, 2746-2757
 |  Abstract »  |  Full Text »  |  PDF »

The G691S RET Polymorphism Increases Glial Cell Line-Derived Neurotrophic Factor-Induced Pancreatic Cancer Cell Invasion by Amplifying Mitogen-Activated Protein Kinase Signaling.

H. Sawai, Y. Okada, K. Kazanjian, J. Kim, S. Hasan, O. J. Hines, H. A. Reber, D. S.B. Hoon, and G. Eibl (2005)
Cancer Res. 65, 11536-11544
 |  Abstract »  |  Full Text »  |  PDF »

Thromboxane A2 Promotes Interleukin-6 Biosynthesis Mediated by an Activation of Cyclic AMP-Response Element-Binding Protein in 1321N1 Human Astrocytoma Cells.

Y. Obara, H. Kurose, and N. Nakahata (2005)
Mol. Pharmacol. 68, 670-679
 |  Abstract »  |  Full Text »  |  PDF »

GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region.

T. Morinaga, A. Enomoto, Y. Shimono, F. Hirose, N. Fukuda, A. Dambara, M. Jijiwa, K. Kawai, K. Hashimoto, M. Ichihara, et al. (2005)
Nucleic Acids Res. 33, 4191-4201
 |  Abstract »  |  Full Text »  |  PDF »

Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta.

Z. C. Baquet, P. C. Bickford, and K. R. Jones (2005)
J. Neurosci. 25, 6251-6259
 |  Abstract »  |  Full Text »  |  PDF »

Transcorneal Electrical Stimulation Rescues Axotomized Retinal Ganglion Cells by Activating Endogenous Retinal IGF-1 System.

T. Morimoto, T. Miyoshi, S. Matsuda, Y. Tano, T. Fujikado, and Y. Fukuda (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2147-2155
 |  Abstract »  |  Full Text »  |  PDF »

Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment.

N. Sofikitis, E. Pappas, A. Kawatani, D. Baltogiannis, D. Loutradis, N. Kanakas, D. Giannakis, F. Dimitriadis, K. Tsoukanelis, I. Georgiou, et al. (2005)
Hum. Reprod. Update 11, 229-259
 |  Abstract »  |  Full Text »  |  PDF »

Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation.

J. Villadiego, S. Mendez-Ferrer, T. Valdes-Sanchez, I. Silos-Santiago, I. Farinas, J. Lopez-Barneo, and J. J. Toledo-Aral (2005)
J. Neurosci. 25, 4091-4098
 |  Abstract »  |  Full Text »  |  PDF »

The Peptides ADNF-9 and NAP Increase Survival and Neurite Outgrowth of Rat Retinal Ganglion Cells In Vitro.

W. A. Lagreze, A. Pielen, R. Steingart, G. Schlunck, H.-D. Hofmann, I. Gozes, and M. Kirsch (2005)
Invest. Ophthalmol. Vis. Sci. 46, 933-938
 |  Abstract »  |  Full Text »  |  PDF »

Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells.

H. Kubota, M. R. Avarbock, and R. L. Brinster (2004)
PNAS 101, 16489-16494
 |  Abstract »  |  Full Text »  |  PDF »

Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.

S. Jain, C. K. Naughton, M. Yang, A. Strickland, K. Vij, M. Encinas, J. Golden, A. Gupta, R. Heuckeroth, E. M. Johnson Jr, et al. (2004)
Development 131, 5503-5513
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Is Required for Glial Cell Line-Derived Neurotrophic Factor-Induced Migration and Invasion of Pancreatic Carcinoma Cells.

C. Veit, F. Genze, A. Menke, S. Hoeffert, T. M. Gress, P. Gierschik, and K. Giehl (2004)
Cancer Res. 64, 5291-5300
 |  Abstract »  |  Full Text »  |  PDF »

Rescue of Mesencephalic Dopaminergic Neurons in Culture by Low-Level Stimulation of Voltage-Gated Sodium Channels.

B. Salthun-Lassalle, E. C. Hirsch, J. Wolfart, M. Ruberg, and P. P. Michel (2004)
J. Neurosci. 24, 5922-5930
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival.

M. Encinas, R. J. Crowder, J. Milbrandt, and E. M. Johnson Jr. (2004)
J. Biol. Chem. 279, 18262-18269
 |  Abstract »  |  Full Text »  |  PDF »

Identification of RET Autophosphorylation Sites by Mass Spectrometry.

Y. Kawamoto, K. Takeda, Y. Okuno, Y. Yamakawa, Y. Ito, R. Taguchi, M. Kato, H. Suzuki, M. Takahashi, and I. Nakashima (2004)
J. Biol. Chem. 279, 14213-14224
 |  Abstract »  |  Full Text »  |  PDF »

The Candidate Neuroprotective Agent Artemin Induces Autonomic Neural Dysplasia without Preventing Peripheral Nerve Dysfunction.

B. Bolon, S. Jing, F. Asuncion, S. Scully, M. Pisegna, G. Y. Van, Zheng Hu, Yan Bin Yu, H. Min, K. Wild, et al. (2004)
Toxicol Pathol 32, 275-294
 |  Abstract »  |  PDF »

Regulation of the Development of Mesencephalic Dopaminergic Systems by the Selective Expression of Glial Cell Line-Derived Neurotrophic Factor in Their Targets.

N. Kholodilov, O. Yarygina, T. F. Oo, H. Zhang, D. Sulzer, W. Dauer, and R. E. Burke (2004)
J. Neurosci. 24, 3136-3146
 |  Abstract »  |  Full Text »  |  PDF »

Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair.

L. Cao, L. Liu, Z.-Y. Chen, L.-M. Wang, J.-L. Ye, H.-Y. Qiu, C.-L. Lu, and C. He (2004)
Brain 127, 535-549
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Key Amino Acids of Glial Cell Line-derived Neurotrophic Factor Family Receptor {alpha}1 Involved in Its Biological Function.

L.-M. Wang, Q. Zhang, Q. Zhang, W. Zhu, C. He, C.-L. Lu, D.-F. Ding, and Z.-Y. Chen (2004)
J. Biol. Chem. 279, 109-116
 |  Abstract »  |  Full Text »  |  PDF »

Roles for GFR{alpha}1 receptors in zebrafish enteric nervous system development.

I. T. Shepherd, J. Pietsch, S. Elworthy, R. N. Kelsh, and D. W. Raible (2004)
Development 131, 241-249
 |  Abstract »  |  Full Text »  |  PDF »

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

A. Wallen-Mackenzie, A. M. de Urquiza, S. Petersson, F. J. Rodriguez, S. Friling, J. Wagner, P. Ordentlich, J. Lengqvist, R. A. Heyman, E. Arenas, et al. (2003)
Genes & Dev. 17, 3036-3047
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophic Effects of Vascular Endothelial Growth Factor on Organotypic Cortical Explants and Primary Cortical Neurons.

J. M. Rosenstein, N. Mani, A. Khaibullina, and J. M. Krum (2003)
J. Neurosci. 23, 11036-11044
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Surface for Binding to the GDNF-GFR{alpha}1 Complex in the First Cadherin-like Domain of RET.

S. Kjaer and C. F. Ibanez (2003)
J. Biol. Chem. 278, 47898-47904
 |  Abstract »  |  Full Text »  |  PDF »

Novel functions and signalling pathways for GDNF.

H. Sariola and M. Saarma (2003)
J. Cell Sci. 116, 3855-3862
 |  Abstract »  |  Full Text »  |  PDF »

Dramatic Expansion of Germinal Stem Cells by Ectopically Expressed Human Glial Cell Line-Derived Neurotrophic Factor in Mouse Sertoli Cells.

K. Yomogida, Y. Yagura, Y. Tadokoro, and Y. Nishimune (2003)
Biol Reprod 69, 1303-1307
 |  Abstract »  |  Full Text »  |  PDF »

Present and future directions in the management of motor complications in patients with advanced PD.

C. W. Olanow (2003)
Neurology 61, S24-33
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Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor.

A. Wilkins, H. Majed, R. Layfield, A. Compston, and S. Chandran (2003)
J. Neurosci. 23, 4967-4974
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Natural Cell Death in Dopaminergic Neurons of the Substantia Nigra by Striatal Glial Cell Line-Derived Neurotrophic Factor In Vivo.

T. F. Oo, N. Kholodilov, and R. E. Burke (2003)
J. Neurosci. 23, 5141-5148
 |  Abstract »  |  Full Text »  |  PDF »

The binding of human glial cell line-derived neurotrophic factor to heparin and heparan sulfate: importance of 2-O-sulfate groups and effect on its interaction with its receptor, GFR{alpha}1.

S. M. Rickard, R. S. Mummery, B. Mulloy, and C. C. Rider (2003)
Glycobiology 13, 419-426
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous TAT-GDNF Is Protective After Focal Cerebral Ischemia in Mice.

U. Kilic, E. Kilic, G. P.H. Dietz, and M. Bahr (2003)
Stroke 34, 1304-1310
 |  Abstract »  |  Full Text »  |  PDF »

DNA Fragmentation Decreased in Schizophrenia but Not Bipolar Disorder.

F. M. Benes, J. Walsh, S. Bhattacharyya, A. Sheth, and S. Berretta (2003)
Arch Gen Psychiatry 60, 359-364
 |  Abstract »  |  Full Text »  |  PDF »

Production of the Novel Mesangial Autocrine Growth Factors GDNF and IL-10 Is Regulated by the Immunomodulator AS101.

Y. Kalechman, B. Sredni, T. Weinstein, I. Freidkin, A. Tobar, M. Albeck, and U. Gafter (2003)
J. Am. Soc. Nephrol. 14, 620-630
 |  Abstract »  |  Full Text »  |  PDF »

Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease.

S Borrego, R M Fernandez, H Dziema, A Niess, M Lopez-Alonso, G Antinolo, and C Eng (2003)
J. Med. Genet. 40, e18-18
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Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers.

A. Hoke, T. Ho, T. O. Crawford, C. LeBel, D. Hilt, and J. W. Griffin (2003)
J. Neurosci. 23, 561-567
 |  Abstract »  |  Full Text »  |  PDF »

Trophic Restoration of the Nigrostriatal Dopaminergic Pathway in Long-Term Carotid Body-Grafted Parkinsonian Rats.

J. J. Toledo-Aral, S. Mendez-Ferrer, R. Pardal, M. Echevarria, and J. Lopez-Barneo (2003)
J. Neurosci. 23, 141-148
 |  Abstract »  |  Full Text »  |  PDF »

DARP-36aa Selectively Promotes Survival and Morphological Development of Cultured Mesencephalic Neurons.

S. M. Smith and V. D. Ramirez (2003)
J. Neurosci. 23, 252-259
 |  Abstract »  |  Full Text »  |  PDF »

Gene Therapy for Detached Retina by Adeno-Associated Virus Vector Expressing Glial Cell Line-Derived Neurotrophic Factor.

W.-C. Wu, C.-C. Lai, S.-L. Chen, X. Xiao, T.-L. Chen, R. J.-F. Tsai, S.-W. Kuo, and Y.-P. Tsao (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3480-3488
 |  Abstract »  |  Full Text »  |  PDF »

TGF{beta} induces GDNF responsiveness in neurons by recruitment of GFR{alpha}1 to the plasma membrane.

H. Peterziel, K. Unsicker, and K. Krieglstein (2002)
J. Cell Biol. 159, 157-167
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Mutant alpha -Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line.

J. Lotharius, S. Barg, P. Wiekop, C. Lundberg, H. K. Raymon, and P. Brundin (2002)
J. Biol. Chem. 277, 38884-38894
 |  Abstract »  |  Full Text »  |  PDF »

Book Review: Cellular Replacement Therapy for Parkinson's Disease--Where We Are Today?.

D. E. Redmond Jr. (2002)
Neuroscientist 8, 457-488
 |  Abstract »  |  PDF »

GDNF treatment in Parkinson's disease: time for controlled clinical trials?.

P. Brundin (2002)
Brain 125, 2149-2151
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Effects of cerebral ischemia in mice deficient in Persephin.

A. C. Tomac, A. D. Agulnick, N. Haughey, C.-F. Chang, Y. Zhang, C. Backman, M. Morales, M. P. Mattson, Y. Wang, H. Westphal, et al. (2002)
PNAS 99, 9521-9526
 |  Abstract »  |  Full Text »  |  PDF »

Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration.

S. Palfi, L. Leventhal, Y. Chu, S. Y. Ma, M. Emborg, R. Bakay, N. Deglon, P. Hantraye, P. Aebischer, and J. H. Kordower (2002)
J. Neurosci. 22, 4942-4954
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beta -Eudesmol Induces Neurite Outgrowth in Rat Pheochromocytoma Cells Accompanied by an Activation of Mitogen-Activated Protein Kinase.

Y. Obara, T. Aoki, M. Kusano, and Y. Ohizumi (2002)
J. Pharmacol. Exp. Ther. 301, 803-811
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Neurotrophic Factor Receptors in Epiretinal Membranes After Human Diabetic Retinopathy.

T. Harada, C. Harada, Y. Mitamura, C. Akazawa, K. Ohtsuka, S. Ohno, S. Takeuchi, and K. Wada (2002)
Diabetes Care 25, 1060-1065
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Transplantation of Germ Cells from Glial Cell Line-Derived Neurotrophic Factor-Overexpressing Mice to Host Testes Depleted of Endogenous Spermatogenesis by Fractionated Irradiation.

L.B. Creemers, X. Meng, K. den Ouden, A.M.M. van Pelt, F. Izadyar, M. Santoro, H. Sariola, and D.G. de Rooij (2002)
Biol Reprod 66, 1579-1584
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Glial Cell Line-Derived Neurotrophic Factor is a Survival Factor for Isolectin B4-Positive, but not Vanilloid Receptor 1-Positive, Neurons in the Mouse.

M. Zwick, B. M. Davis, C. J. Woodbury, J. N. Burkett, H. R. Koerber, J. F. Simpson, and K. M. Albers (2002)
J. Neurosci. 22, 4057-4065
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Regulation of Neuromuscular Synapse Development by Glial Cell Line-derived Neurotrophic Factor and Neurturin.

C.-Y. Wang, F. Yang, X.-P. He, H.-S. Je, J.-Z. Zhou, K. Eckermann, D. Kawamura, L. Feng, L. Shen, and B. Lu (2002)
J. Biol. Chem. 277, 10614-10625
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Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan.

M. W. Barnett, C. E. Fisher, G. Perona-Wright, and J. A. Davies (2002)
J. Cell Sci. 115, 4495-4503
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Effect of the intermolecular disulfide bond on the conformation and stability of glial cell line-derived neurotrophic factor.

T. Li, H. Yamane, T. Arakawa, L. O. Narhi, and J. Philo (2002)
Protein Eng. Des. Sel. 15, 59-64
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Functional Regeneration in a Rat Parkinson's Model after Intrastriatal Grafts of Glial Cell Line-Derived Neurotrophic Factor and Transforming Growth Factor beta 1-Expressing Extra-Adrenal Chromaffin Cells of the Zuckerkandl's Organ.

E. F. Espejo, M. C. Gonzalez-Albo, J.-P. Moraes, F. El Banoua, J. A. Flores, and I. Caraballo (2001)
J. Neurosci. 21, 9888-9895
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Effect of GDNF on Neuroblast Proliferation and Photoreceptor Survival: Additive Protection with Docosahexaenoic Acid.

L. E. Politi, N. P. Rotstein, and N. G. Carri (2001)
Invest. Ophthalmol. Vis. Sci. 42, 3008-3015
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Neuroprotection through Delivery of Glial Cell Line-Derived Neurotrophic Factor by Neural Stem Cells in a Mouse Model of Parkinson's Disease.

P. Akerud, J. M. Canals, E. Y. Snyder, and E. Arenas (2001)
J. Neurosci. 21, 8108-8118
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RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.

H. Enomoto, P. A. Crawford, A. Gorodinsky, R. O. Heuckeroth, E. M. Johnson Jr., and J. Milbrandt (2001)
Development 128, 3963-3974
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Multiple effects of artemin on sympathetic neurone generation, survival and growth.

R. Andres, A. Forgie, S. Wyatt, Q. Chen, F. J. de Sauvage, and A. M. Davies (2001)
Development 128, 3685-3695
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GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development.

E. Hashino, M. Shero, D. Junghans, H. Rohrer, J. Milbrandt, and E. M. Johnson Jr. (2001)
Development 128, 3773-3782
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GDNF as a candidate modifier in a type 1 neurofibromatosis (NF1) enteric phenotype.

M. Bahuau, A. Pelet, D. Vidaud, T. Lamireau, B. Le Bail, A. Munnich, M. Vidaud, S. Lyonnet, and D. Lacombe (2001)
J. Med. Genet. 38, 638-643
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Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid.

J. Widenfalk, K. Lundstromer, M. Jubran, S. Brene, and L. Olson (2001)
J. Neurosci. 21, 3457-3475
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Neuroprotection Mediated by Glial Cell Line-Derived Neurotrophic Factor: Involvement of a Reduction of NMDA-Induced Calcium Influx by the Mitogen-Activated Protein Kinase Pathway.

O. Nicole, C. Ali, F. Docagne, L. Plawinski, E. T. MacKenzie, D. Vivien, and A. Buisson (2001)
J. Neurosci. 21, 3024-3033
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Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes.

H. H. Simon, H. Saueressig, W. Wurst, M. D. Goulding, and D. D. M. O'Leary (2001)
J. Neurosci. 21, 3126-3134
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Scabronine G-Methylester Enhances Secretion of Neurotrophic Factors Mediated by an Activation of Protein Kinase C-zeta.

Y. Obara, H. Kobayashi, T. Ohta, Y. Ohizumi, and N. Nakahata (2001)
Mol. Pharmacol. 59, 1287-1297
 |  Abstract »  |  Full Text »

Promotion of Seminomatous Tumors by Targeted Overexpression of Glial Cell Line-derived Neurotrophic Factor in Mouse Testis.

X. Meng, D. G. de Rooij, K. Westerdahl, M. Saarma, and H. Sariola (2001)
Cancer Res. 61, 3267-3271
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c-Src Is Required for Glial Cell Line-Derived Neurotrophic Factor (GDNF) Family Ligand-Mediated Neuronal Survival via a Phosphatidylinositol-3 Kinase (PI-3K)-Dependent Pathway.

M. Encinas, M. G. Tansey, B. A. Tsui-Pierchala, J. X. Comella, J. Milbrandt, and E. M. Johnson Jr (2001)
J. Neurosci. 21, 1464-1472
 |  Abstract »  |  Full Text »  |  PDF »

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