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Science 21 May 1993:
Vol. 260. no. 5111, pp. 1127 - 1130
DOI: 10.1126/science.8493556
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Articles

Science, Vol 260, Issue 5111, 1127-1130
Copyright © 1993 by American Association for the Advancement of Science

articles

Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication

L Passador, JM Cook, MJ Gambello, L Rust, and BH Iglewski

Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14620.

Pseudomonas aeruginosa is an opportunistic human pathogen that causes a variety of infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of elastase, one of the virulence factors produced by this organism, requires the transcriptional activator LasR. Experiments with gene fusions show that gene lasl is essential for high expression of elastase. The lasl gene is involved in the synthesis of a diffusible molecule termed Pseudomonas autoinducer (PAI). PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.


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Signal-mediated cross-talk regulates stress adaptation in Vibrio species.
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Posttranscriptional Control of Quorum-Sensing-Dependent Virulence Genes by DksA in Pseudomonas aeruginosa.
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Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa.
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J. Bacteriol. 184, 6472-6480
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Infect. Immun. 70, 3004-3011
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Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA.
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Microbiology 148, 1709-1723
   Abstract »    Full Text »    PDF »
Early Activation of Quorum Sensing.
J. P. Pearson (2002)
J. Bacteriol. 184, 2569-2571
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Advancing the Quorum in Pseudomonas aeruginosa: MvaT and the Regulation of N-Acylhomoserine Lactone Production and Virulence Gene Expression.
S. P. Diggle, K. Winzer, A. Lazdunski, P. Williams, and M. Camara (2002)
J. Bacteriol. 184, 2576-2586
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Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa.
I. L. Lamont, P. A. Beare, U. Ochsner, A. I. Vasil, and M. L. Vasil (2002)
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Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens.
H.-B. Zhang, L.-H. Wang, and L.-H. Zhang (2002)
PNAS 99, 4638-4643
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Lung Infections Associated with Cystic Fibrosis.
J. B. Lyczak, C. L. Cannon, and G. B. Pier (2002)
Clin. Microbiol. Rev. 15, 194-222
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Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species.
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Infect. Immun. 70, 1783-1790
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Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1.
C. Reimmann, N. Ginet, L. Michel, C. Keel, P. Michaux, V. Krishnapillai, M. Zala, K. Heurlier, K. Triandafillu, H. Harms, et al. (2002)
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Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens.
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Microbiology 148, 87-102
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Intra- and Interspecies Regulation of Gene Expression by Actinobacillus actinomycetemcomitans LuxS.
K. P. Fong, W. O. Chung, R. J. Lamont, and D. R. Demuth (2001)
Infect. Immun. 69, 7625-7634
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N-Acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.
K. Riedel, M. Hentzer, O. Geisenberger, B. Huber, A. Steidle, H. Wu, N. Hoiby, M. Givskov, S. Molin, and L. Eberl (2001)
Microbiology 147, 3249-3262
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Overexpression of the MexEF-OprN Multidrug Efflux System Affects Cell-to-Cell Signaling in Pseudomonas aeruginosa.
T. Kohler, C. van Delden, L. K. Curty, M. M. Hamzehpour, and J.-C. Pechere (2001)
J. Bacteriol. 183, 5213-5222
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DNA Microarray-Based Identification of Genes Controlled by Autoinducer 2-Stimulated Quorum Sensing in Escherichia coli.
M. P. DeLisa, C.-F. Wu, L. Wang, J. J. Valdes, and W. E. Bentley (2001)
J. Bacteriol. 183, 5239-5247
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Stringent Response Activates Quorum Sensing and Modulates Cell Density-Dependent Gene Expression in Pseudomonas aeruginosa.
C. van Delden, R. Comte, and A. M. Bally (2001)
J. Bacteriol. 183, 5376-5384
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Characterization of an Endoprotease (PrpL) Encoded by a PvdS-Regulated Gene in Pseudomonas aeruginosa.
P. J. Wilderman, A. I. Vasil, Z. Johnson, M. J. Wilson, H. E. Cunliffe, I. L. Lamont, and M. L. Vasil (2001)
Infect. Immun. 69, 5385-5394
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Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586.
A. K. El-Sayed, J. Hothersall, and C. M. Thomas (2001)
Microbiology 147, 2127-2139
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Indole Can Act as an Extracellular Signal in Escherichia coli.
D. Wang, X. Ding, and P. N. Rather (2001)
J. Bacteriol. 183, 4210-4216
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Signaling System in Porphyromonas gingivalis Based on a LuxS Protein.
W. O. Chung, Y. Park, R. J. Lamont, R. McNab, B. Barbieri, and D. R. Demuth (2001)
J. Bacteriol. 183, 3903-3909
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IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoyl Homoserine Lactone Is Transcriptionally Regulated by NF-{{kappa}}B and Activator Protein-2.
R. S. Smith, E. R. Fedyk, T. A. Springer, N. Mukaida, B. H. Iglewski, and R. P. Phipps (2001)
J. Immunol. 167, 366-374
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The languages of bacteria.
S. Schauder and B. L. Bassler (2001)
Genes & Dev. 15, 1468-1480
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Type II Secretion and Pathogenesis.
M. Sandkvist (2001)
Infect. Immun. 69, 3523-3535
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Periodontal Pathogens Produce Quorum Sensing Signal Molecules.
J. Frias, E. Olle, and M. Alsina (2001)
Infect. Immun. 69, 3431-3434
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Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection.
H. Wu, Z. Song, M. Givskov, G. Doring, D. Worlitzsch, K. Mathee, J. Rygaard, and N. Høiby (2001)
Microbiology 147, 1105-1113
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