Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 May 1993:
Vol. 260. no. 5111, pp. 1121 - 1124
DOI: 10.1126/science.8493555
Prev | Table of Contents | Next

Articles

Science, Vol 260, Issue 5111, 1121-1124
Copyright © 1993 by American Association for the Advancement of Science

articles

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C

M Colonna, EG Brooks, M Falco, GB Ferrara, and JL Strominger

Laboratory of Immunogenetics, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77,Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen. However, neither homozygous target cell stimulated the generation of alloreactive NK cells from heterozygous individuals. Thus, these data reveal an unanticipated difference between human NK alloreactivity defined by this system and murine "hybrid resistance."


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.
J. Shi, G. J. Tricot, T. K. Garg, P. A. Malaviarachchi, S. M. Szmania, R. E. Kellum, B. Storrie, A. Mulder, J. D. Shaughnessy Jr, B. Barlogie, et al. (2008)
Blood 111, 1309-1317
   Abstract »    Full Text »    PDF »
Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value..
L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, et al. (2007)
Blood 110, 433-440
   Abstract »    Full Text »    PDF »
KIR3DL1 Polymorphisms That Affect NK Cell Inhibition by HLA-Bw4 Ligand.
W. H. Carr, M. J. Pando, and P. Parham (2005)
J. Immunol. 175, 5222-5229
   Abstract »    Full Text »    PDF »
Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I.
M. Draghi, N. Yawata, M. Gleimer, M. Yawata, N. M. Valiante, and P. Parham (2005)
Blood 105, 2028-2035
   Abstract »    Full Text »    PDF »
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic.
G. Ferlazzo, D. Thomas, S.-L. Lin, K. Goodman, B. Morandi, W. A. Muller, A. Moretta, and C. Munz (2004)
J. Immunol. 172, 1455-1462
   Abstract »    Full Text »    PDF »
The Size of the Synaptic Cleft and Distinct Distributions of Filamentous Actin, Ezrin, CD43, and CD45 at Activating and Inhibitory Human NK Cell Immune Synapses.
F. E. McCann, B. Vanherberghen, K. Eleme, L. M. Carlin, R. J. Newsam, D. Goulding, and D. M. Davis (2003)
J. Immunol. 170, 2862-2870
   Abstract »    Full Text »    PDF »
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants.
L. Ruggeri, M. Capanni, E. Urbani, K. Perruccio, W. D. Shlomchik, A. Tosti, S. Posati, D. Rogaia, F. Frassoni, F. Aversa, et al. (2002)
Science 295, 2097-2100
   Abstract »    Full Text »    PDF »
Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses.
L. M. Carlin, K. Eleme, F. E. McCann, and D. M. Davis (2001)
J. Exp. Med. 194, 1507-1517
   Abstract »    Full Text »    PDF »
A Novel, Nonclassical MHC Class I Molecule Specific to the Common Chimpanzee.
E. J. Adams, S. Cooper, and P. Parham (2001)
J. Immunol. 167, 3858-3869
   Abstract »    Full Text »    PDF »
Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey.
I. I. Slukvin, D. P. Lunn, D. I. Watkins, and T. G. Golos (2000)
PNAS 97, 9104-9109
   Abstract »    Full Text »    PDF »
The human natural killer cell immune synapse.
D. M. Davis, I. Chiu, M. Fassett, G. B. Cohen, O. Mandelboim, and J. L. Strominger (1999)
PNAS 96, 15062-15067
   Abstract »    Full Text »    PDF »
Role of Natural Killer Cell Alloreactivity in HLA-Mismatched Hematopoietic Stem Cell Transplantation.
L. Ruggeri, M. Capanni, M. Casucci, I. Volpi, A. Tosti, K. Perruccio, E. Urbani, R. S. Negrin, M. F. Martelli, and A. Velardi (1999)
Blood 94, 333-339
   Abstract »    Full Text »    PDF »
Molecular Typing Shows a High Level of HLA Class I Incompatibility in Serologically Well Matched Donor/Patient Pairs: Implications for Unrelated Bone Marrow Donor Selection.
I. Scott, J. O'Shea, M. Bunce, J.-M. Tiercy, J. R. Arguello, H. Firman, J. Goldman, H. G. Prentice, A.-M. Little, and J. A. Madrigal (1998)
Blood 92, 4864-4871
   Abstract »    Full Text »    PDF »
NK Cell Natural Cytotoxicity and IFN-{gamma} Production Are Not Always Coordinately Regulated: Engagement of DX9 KIR+ NK Cells by HLA-B7 Variants and Target Cells.
Z. B. Kurago, C. T. Lutz, K. D. Smith, and M. Colonna (1998)
J. Immunol. 160, 1573-1580
   Abstract »    Full Text »    PDF »
Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA.
M. Molinari, M. Salio, C. Galli, N. Norais, R. Rappuoli, A. Lanzavecchia, and C. Montecucco (1998)
J. Exp. Med. 187, 135-140
   Abstract »    Full Text »    PDF »
What Goes Up Must Come Down: The Emerging Spectrum of Inhibitory Receptors.
W. M. Yokoyama (1997)
J. Exp. Med. 186, 1803-1808
   Full Text »    PDF »
The mother-child union: The case of missing-self and protection of the fetus.
W. M. Yokoyama (1997)
PNAS 94, 5998-6000
   Full Text »    PDF »
Self and viral peptides can initiate lysis by autologous natural killer cells.
O. Mandelboim, S. B. Wilson, M. Vales-Gomez, H. T. Reyburn, and J. L. Strominger (1997)
PNAS 94, 4604-4609
   Abstract »    Full Text »    PDF »
Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.
M Colonna and J Samaridis (1995)
Science 268, 405-408
   Abstract »    PDF »
Peptide specificity in the recognition of MHC class I by natural killer cell clones.
M. Malnati, M Peruzzi, K. Parker, W. Biddison, E Ciccone, A Moretta, and E. Long (1995)
Science 267, 1016-1018
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)