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Science 14 May 1993:
Vol. 260. no. 5110, pp. 998 - 1000
DOI: 10.1126/science.8493539
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Articles

Science, Vol 260, Issue 5110, 998-1000
Copyright © 1993 by American Association for the Advancement of Science

articles

Induction of olfactory receptor sensitivity in mice

HW Wang, CJ Wysocki, and GH Gold

Monell Chemical Senses Center, Philadelphia, PA 19104-3308.

Repeated exposure to olfactory ligands (odorants) increased peripheral olfactory sensitivity in mice. For two unrelated ligands, androstenone and isovaleric acid, induction of olfactory sensitivity was odorant-specific and occurred only in inbred strains that initially had low sensitivity to the exposure odorant. These data demonstrate stimulus-induced plasticity in a sensory receptor cell, suggesting a form of stimulus-controlled gene expression. Induction with two unrelated odorants implies that olfactory induction is a general phenomenon that may occur in a large fraction of the human population.


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Symmetry, Stereotypy, and Topography of Odorant Representations in Mouse Olfactory Bulbs.
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Spatially Organized Response Zones in Rat Olfactory Epithelium.
J. W. Scott, D. E. Shannon, J. Charpentier, L. M. Davis, and C. Kaplan (1997)
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Selectivity and Response Characteristics of Human Olfactory Neurons.
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J Neurophysiol 77, 1606-1613
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Genetic Approaches to Mammalian Olfaction.
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