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Science 14 May 1993:
Vol. 260. no. 5110, pp. 989 - 991
DOI: 10.1126/science.8493536
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Articles

Science, Vol 260, Issue 5110, 989-991
Copyright © 1993 by American Association for the Advancement of Science

articles

Localization of a memory trace in the mammalian brain

DJ Krupa, JK Thompson, and RF Thompson

Neurosciences Program, University of Southern California, Los Angeles 90089.

The localization of sites of memory formation within the brain has proven to be a formidable task even for simple forms of learning and memory. In order to localize a particular site of memory formation within the brain, the rabbit eyeblink response was classically conditioned while regions of the cerebellum or red nucleus were temporarily inactivated by microinfusions of the gamma-aminobutyric acid agonist muscimol. Cerebellar inactivation completely blocked learning but had no effect on subsequent learning after inactivation, whereas red nucleus inactivation did not prevent learning but did block the expression of conditioned responses. The site of memory formation for this learned response thus appears to be localized within the cerebellum.


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Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response..
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