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Science 14 May 1993:
Vol. 260. no. 5110, pp. 986 - 989
DOI: 10.1126/science.7684160
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Articles

Science, Vol 260, Issue 5110, 986-989
Copyright © 1993 by American Association for the Advancement of Science

articles

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

DA Tuveson, RH Carter, SP Soltoff, and DT Fearon

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Antigen receptors on B and T lymphocytes transduce signals by activating nonreceptor protein tyrosine kinases (PTKs). A family of receptor PTKs contains kinase insert regions with the sequence tyrosine-X-X-methionine (where X is any amino acid) that when phosphorylated mediate the binding and activation of phosphatidylinositol 3-kinase (PI 3-kinase). The CD19 membrane protein of B cells enhances activation through membrane immunoglobulin M (mIgM) and was found to contain a functional analog of the kinase insert region. Ligation of mIgM induced phosphorylation of CD19 and association with PI 3-kinase. Thus, CD19 serves as a surrogate kinase insert region for mIgM by providing the means for PI 3-kinase activation by nonreceptor PTKs.


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The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif.
Z. Songyang, B. Margolis, M. Chaudhuri, S. E. Shoelson, and L. C. Cantley (1995)
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Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
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Science 267, 886-891
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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.
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Science 263, 1609-1612
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CD19-dependent Activation of Akt Kinase in B-lymphocytes.
D. C. Otero, S. A. Omori, and R. C. Rickert (2001)
J. Biol. Chem. 276, 1474-1478
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R. J. Ingham, L. Santos, M. Dang-Lawson, M. Holgado-Madruga, P. Dudek, C. R. Maroun, A. J. Wong, L. Matsuuchi, and M. R. Gold (2001)
J. Biol. Chem. 276, 12257-12265
   Abstract »    Full Text »    PDF »
The CGM1a (CEACAM3/CD66d)-mediated Phagocytic Pathway of Neisseria gonorrhoeae Expressing Opacity Proteins Is Also the Pathway to Cell Death.
T. Chen, S. Bolland, I. Chen, J. Parker, M. Pantelic, F. Grunert, and W. Zimmermann (2001)
J. Biol. Chem. 276, 17413-17419
   Abstract »    Full Text »    PDF »
CD19 Amplification of B Lymphocyte Ca2+ Responses. A ROLE FOR Lyn SEQUESTRATION IN EXTINGUISHING NEGATIVE REGULATION.
M. Fujimoto, J. C. Poe, M. Hasegawa, and T. F. Tedder (2001)
J. Biol. Chem. 276, 44820-44827
   Abstract »    Full Text »    PDF »


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