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Science 14 May 1993:
Vol. 260. no. 5110, pp. 937 - 944
DOI: 10.1126/science.8493532
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Articles

Science, Vol 260, Issue 5110, 937-944
Copyright © 1993 by American Association for the Advancement of Science

articles

Identifying strategies for immune intervention

A Lanzavecchia

Basel Institute for Immunology, Switzerland.

In recent years the molecular basis of antigen recognition by T cells has been unraveled and the various pathways that control T cell activation and functional specialization have been defined. Consequently, it is now possible to delineate various strategies for intervention with the immune system to design protective vaccines, to induce an effective response to tumor antigens, and to control graft rejection and autoimmune diseases.


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