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Science 14 May 1993: Vol. 260. no. 5110, pp. 926 - 932 DOI: 10.1126/science.8493530
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Articles
Science, Vol 260, Issue 5110, 926-932
Copyright © 1993 by American Association for the Advancement of Science
The basic science of gene therapy
RC Mulligan
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.
The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. However, despite substantial progress, a number of key technical issues need to be resolved before gene therapy can be safely and effectively applied in the clinic. Future technological developments, particularly in the areas of gene delivery and cell transplantation, will be critical for the successful practice of gene therapy.
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