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Science 14 May 1993:
Vol. 260. no. 5110, pp. 920 - 926
DOI: 10.1126/science.8493529

Articles

Science, Vol 260, Issue 5110, 920-926
Copyright © 1993 by American Association for the Advancement of Science


articles

Tissue engineering

R Langer and JP Vacanti

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02319.

The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. A new field, tissue engineering, applies the principles of biology and engineering to the development of functional substitutes for damaged tissue. This article discusses the foundations and challenges of this interdisciplinary field and its attempts to provide solutions to tissue creation and repair.


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Mammalian cell survival and processing in supercritical CO2.
P. J. Ginty, D. Howard, F. R. A. J. Rose, M. J. Whitaker, J. J. A. Barry, P. Tighe, S. R. Mutch, G. Serhatkulu, R. O. C. Oreffo, S. M. Howdle, et al. (2006)
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Journal of Bioactive and Compatible Polymers 21, 207-220
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Tissue Engineering Special Feature: Microscale technologies for tissue engineering and biology.
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Silicate Biomaterials for Orthopaedic and Dental Implants.
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Novel Tissue-Engineered Biodegradable Material for Reconstruction of Vascular Wall.
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Dynamic reassembly of peptide RADA16 nanofiber scaffold.
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PNAS 102, 8414-8419
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Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells.
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J. Thorac. Cardiovasc. Surg. 129, 1330-1338
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From Stem Cells to Viable Autologous Semilunar Heart Valve.
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Circulation 111, 2783-2791
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Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces.
J. Y. Lim, J. C Hansen, C. A Siedlecki, J. Runt, and H. J Donahue (2005)
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First Evidence that Bone Marrow Cells Contribute to the Construction of Tissue Engineered Vascular Autografts In Vivo.
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Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.
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Comparative Physico-chemical and in Vitro Properties of Fibrillated Collagen Scaffolds from Different Sources.
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J Biomater Appl 18, 247-264
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Engineering biological structures of prescribed shape using self-assembling multicellular systems.
K. Jakab, A. Neagu, V. Mironov, R. R. Markwald, and G. Forgacs (2004)
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Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers.
G. A. Silva, C. Czeisler, K. L. Niece, E. Beniash, D. A. Harrington, J. A. Kessler, and S. I. Stupp (2004)
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Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine.
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Am J Physiol Gastrointest Liver Physiol 285, G1345-G1352
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Systemic dissemination of viral vectors during intratumoral injection.
Y. Wang, J. K. Hu, A. Krol, Y.-P. Li, C.-Y. Li, and F. Yuan (2003)
Mol. Cancer Ther. 2, 1233-1242
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First Evidence That Bone Marrow Cells Contribute to the Construction of Tissue-Engineered Vascular Autografts In Vivo.
G. Matsumura, S. Miyagawa-Tomita, T. Shin'oka, Y. Ikada, and H. Kurosawa (2003)
Circulation 108, 1729-1734
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Acellularized porcine heart valve scaffolds for heart valve tissue engineering and the risk of cross-species transmission of porcine endogenous retrovirus.
R. G. Leyh, M. Wilhelmi, T. Walles, K. Kallenbach, P. Rebe, A. Oberbeck, T. Herden, A. Haverich, and H. Mertsching (2003)
J. Thorac. Cardiovasc. Surg. 126, 1000-1004
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In vivo model for cross-species porcine endogenous retrovirus transmission using tissue engineered pulmonary arteries.
T. Walles, A. Lichtenberg, C. Puschmann, R. Leyh, M. Wilhelmi, K. Kallenbach, A. Haverich, and H. Mertsching (2003)
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Muscle Tissue Engineering for Partial Glossectomy Defects.
J. Kim, T. Hadlock, M. Cheney, M. Varvares, and J. Marler (2003)
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Tissue engineered cartilage generated from human trachea using DegraPol(R) scaffold.
L. Yang, S. Korom, M. Welti, S. P. Hoerstrup, G. Zund, F. J. Jung, P. Neuenschwander, and W. Weder (2003)
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Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial Aneurysms: Long-Term Experimental Study.
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Fabrication of Pulsatile Cardiac Tissue Grafts Using a Novel 3-Dimensional Cell Sheet Manipulation Technique and Temperature-Responsive Cell Culture Surfaces.
T. Shimizu, M. Yamato, Y. Isoi, T. Akutsu, T. Setomaru, K. Abe, A. Kikuchi, M. Umezu, and T. Okano (2002)
Circ. Res. 90 , e40-e48
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Tissue Engineering--Current Challenges and Expanding Opportunities.
L. G. Griffith and G. Naughton (2002)
Science 295, 1009-1014
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Science. ISSN 0036-8075 (print), 1095-9203 (online)