Science 7 May 1993: Vol. 260. no. 5109, pp. 810 - 812 DOI: 10.1126/science.8484120

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Immunohistochemistry versus Microsatellite Instability Testing for Screening Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part II. The Utility of Microsatellite Instability Testing.

L. Zhang (2008)
J. Mol. Diagn. 10, 301-307
 |  Abstract »  |  Full Text »  |  PDF »

Familial Colorectal Cancer: A Genetics Treasure Trove for Medical Discovery.

B. Pasche (2008)
JAMA 299, 2564-2565
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New Issues in Genetic Counseling of Hereditary Colon Cancer.

P. M. Lynch (2007)
Clin. Cancer Res. 13, 6857s-6861s
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of Pathogenic Human MSH2 Missense Mutations in Saccharomyces cerevisiae.

A. E. Gammie, N. Erdeniz, J. Beaver, B. Devlin, A. Nanji, and M. D. Rose (2007)
Genetics 177, 707-721
 |  Abstract »  |  Full Text »  |  PDF »

Cytochrome P450 17A1 and Catechol O-Methyltransferase Polymorphisms and Age at Lynch Syndrome Colon Cancer Onset in Newfoundland.

P. T. Campbell, L. Edwards, J. R. McLaughlin, J. Green, H. B. Younghusband, and M. O. Woods (2007)
Clin. Cancer Res. 13, 3783-3788
 |  Abstract »  |  Full Text »  |  PDF »

Toward a Consensus in Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome).

H. T. Lynch, J. F. Lynch, and P. M. Lynch (2007)
J Natl Cancer Inst 99, 261-263
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Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair-Deficient Colorectal Tumors.

R. M. Xicola, X. Llor, E. Pons, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2007)
J Natl Cancer Inst 99, 244-252
 |  Abstract »  |  Full Text »  |  PDF »

Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians.

Y. M.C. Hendriks, A. E. de Jong, H. Morreau, C. M.J. Tops, H. F. Vasen, J. Th. Wijnen, M. H. Breuning, and A. H.J.T. Brocker-Vriends (2006)
CA Cancer J Clin 56, 213-225
 |  Abstract »  |  Full Text »  |  PDF »

A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer.

T Djureinovic, J Skoglund, J Vandrovcova, X-L Zhou, A Kalushkova, L Iselius, and A Lindblom (2006)
Gut 55, 362-366
 |  Abstract »  |  Full Text »  |  PDF »

Molecular basis for subdividing hereditary colon cancer?.

W M Grady (2005)
Gut 54, 1676-1678
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Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway.

X. Llor, E. Pons, R. M. Xicola, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2005)
Clin. Cancer Res. 11, 7304-7310
 |  Abstract »  |  Full Text »  |  PDF »

Progress in Genetic Testing, Classification, and Identification of Lynch Syndrome.

H. F. A. Vasen and C. R. Boland (2005)
JAMA 293, 2028-2030
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Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.

C M Wright, O F Dent, R C Newland, M Barker, P H Chapuis, E L Bokey, J P Young, B A Leggett, J R Jass, and G A Macdonald (2005)
Gut 54, 103-108
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Cancer Susceptibility Genes by Genome-wide Single-Nucleotide Polymorphism Linkage-Disequilibrium Mapping.

N. Mitra, T.-Z. Ye, A. Smith, S. Chuai, T. Kirchhoff, P. Peterlongo, K. Nafa, M. S. Phillips, K. Offit, and N. A. Ellis (2004)
Cancer Res. 64, 8116-8125
 |  Abstract »  |  Full Text »  |  PDF »

Colon Cancer Screening Practices Following Genetic Testing for Hereditary Nonpolyposis Colon Cancer (HNPCC) Mutations.

C. H. Halbert, H. Lynch, J. Lynch, D. Main, S. Kucharski, A. K. Rustgi, and C. Lerman (2004)
Arch Intern Med 164, 1881-1887
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Pathogenic Human MSH2 Missense Mutations Using Yeast as a Model System: A Laboratory Course in Molecular Biology.

A. E. Gammie and N. Erdeniz (2004)
CBE Life Sci Educ 3, 31-48
 |  Abstract »  |  Full Text »  |  PDF »

A Founder Mutation of the MSH2 Gene and Hereditary Nonpolyposis Colorectal Cancer in the United States.

H. T. Lynch, S. M. Coronel, R. Okimoto, H. Hampel, K. Sweet, J. F. Lynch, A. Barrows, J. Wijnen, H. van der Klift, P. Franken, et al. (2004)
JAMA 291, 718-724
 |  Abstract »  |  Full Text »  |  PDF »

Genetic testing for polyposis: practical and ethical aspects.

H J Jarvinen (2003)
Gut 52, ii19-22
 |  Abstract »  |  Full Text »

Conventional and Tissue Microarray Immunohistochemical Expression Analysis of Mismatch Repair in Hereditary Colorectal Tumors.

Y. Hendriks, P. Franken, J. W. Dierssen, W. de Leeuw, J. Wijnen, E. Dreef, C. Tops, M. Breuning, A. Brocker-Vriends, H. Vasen, et al. (2003)
Am. J. Pathol. 162, 469-477
 |  Abstract »  |  Full Text »  |  PDF »

Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer: A HuGE Review.

R. J. Mitchell, S. M. Farrington, M. G. Dunlop, and H. Campbell (2002)
Am. J. Epidemiol. 156, 885-902
 |  Abstract »  |  Full Text »  |  PDF »

Multistage carcinogenesis and the incidence of colorectal cancer.

E. G. Luebeck and S. H. Moolgavkar (2002)
PNAS 99, 15095-15100
 |  Abstract »  |  Full Text »  |  PDF »

Genetic and clinical characterisation of familial adenomatous polyposis: a population based study.

A-L Moisio, H Jarvinen, and P Peltomaki (2002)
Gut 50, 845-850
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Aspects of Melanocytic Dysplastic Nevi.

M. R. A.-E. Hussein and G. S. Wood (2002)
J. Mol. Diagn. 4, 71-80
 |  Abstract »  |  Full Text »  |  PDF »

Conservation of the Class I {beta}-Tubulin Gene in Human Populations and Lack of Mutations in Lung Cancers and Paclitaxel-resistant Ovarian Cancers.

S. Sale, R. Sung, P. Shen, K. Yu, Y. Wang, G. E. Duran, J.-H. Kim, T. Fojo, P. J. Oefner, and B. I. Sikic (2002)
Mol. Cancer Ther. 1, 215-225
 |  Abstract »  |  Full Text »  |  PDF »

Non-syndromic progressive hearing loss DFNA38 is caused by heterozygous missense mutation in the Wolfram syndrome gene WFS1.

T.-L. Young, E. Ives, E. Lynch, R. Person, S. Snook, L. MacLaren, T. Cator, A. Griffin, B. Fernandez, M. K. Lee, et al. (2001)
Hum. Mol. Genet. 10, 2509-2514
 |  Abstract »  |  Full Text »  |  PDF »

The Genetic Epidemiology of Cancer: Interpreting Family and Twin Studies and Their Implications for Molecular Genetic Approaches.

N. Risch (2001)
Cancer Epidemiol. Biomarkers Prev. 10, 733-741
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite instability and the clinicopathological features of sporadic colorectal cancer.

R Ward, A Meagher, I Tomlinson, T O'Connor, M Norrie, R Wu, and N Hawkins (2001)
Gut 48, 821-829
 |  Abstract »  |  Full Text »  |  PDF »

Application of the National Cancer Institute International Criteria for Determination of Microsatellite Instability in Ovarian Cancer.

A. K. Sood, R. Holmes, M. J. C. Hendrix, and R. E. Buller (2001)
Cancer Res. 61, 4371-4374
 |  Abstract »  |  Full Text »  |  PDF »

Defects of DNA Mismatch Repair in Human Prostate Cancer.

Y. Chen, J. Wang, M. M. Fraig, J. Metcalf, W. R. Turner, N. K. Bissada, D. K. Watson, and C. W. Schweinfest (2001)
Cancer Res. 61, 4112-4121
 |  Abstract »  |  Full Text »

Deficient DNA mismatch repair: a common etiologic factor for colon cancer.

P. Peltomaki (2001)
Hum. Mol. Genet. 10, 735-740
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Pathways in the Evolution of Morphologically Distinct Colorectal Neoplasms.

M. Yashiro, J. M. Carethers, L. Laghi, K. Saito, P. Slezak, E. Jaramillo, C. Rubio, K. Koizumi, K. Hirakawa, and C. R. Boland (2001)
Cancer Res. 61, 2676-2683
 |  Abstract »  |  Full Text »

Age-associated Risk of Cancer among Individuals with N-Acetyltransferase 2 (NAT2) Mutations and Mutations in DNA Mismatch Repair Genes.

M. L. Frazier, F. T. O’Donnell, S. Kong, X. Gu, I. Campos, R. Luthra, P. M. Lynch, and C. I. Amos (2001)
Cancer Res. 61, 1269-1271
 |  Abstract »  |  Full Text »

MSH6 and MSH3 Are Rarely Involved in Genetic Predisposition to Nonpolypotic Colon Cancer.

J. Huang, S. A. Kuismanen, T. Liu, R. B. Chadwick, C. K. Johnson, M. W. Stevens, S. K. Richards, J. E. Meek, X. Gao, F. A. Wright, et al. (2001)
Cancer Res. 61, 1619-1623
 |  Abstract »  |  Full Text »

Histopathological Identification of Colon Cancer with Microsatellite Instability.

J. Alexander, T. Watanabe, T.-T. Wu, A. Rashid, S. Li, and S. R. Hamilton (2001)
Am. J. Pathol. 158, 527-535
 |  Abstract »  |  Full Text »  |  PDF »

Associations Between Cigarette Smoking, Lifestyle Factors, and Microsatellite Instability in Colon Tumors.

M. L. Slattery, K. Curtin, K. Anderson, K.-N. Ma, L. Ballard, S. Edwards, D. Schaffer, J. Potter, M. Leppert, and W. S. Samowitz (2000)
J Natl Cancer Inst 92, 1831-1836
 |  Abstract »  |  Full Text »  |  PDF »

Organizing Cancer Genetics Programs: The Swiss Model.

G. Pichert and R. A. Stahel (2000)
J. Clin. Oncol. 18, 65s-69
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenesis of non-familial colorectal carcinomas with high microsatellite instability.

K Shitoh, F Konishi, M Miyaki, T Iijima, T Furukawa, T Tsukamoto, and H Nagai (2000)
J. Clin. Pathol. 53, 841-845
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Hereditary Nonpolyposis Colorectal Cancer Families From a Population-Based Series of Cases.

D. J. Peel, A. Ziogas, E. A. Fox, M. Gildea, B. Laham, E. Clements, R. D. Kolodner, and H. Anton-Culver (2000)
J Natl Cancer Inst 92, 1517-1522
 |  Abstract »  |  Full Text »  |  PDF »

Recurrent germline mutation in MSH2 arises frequently de novo.

D. C Desai, J. C Lockman, R. B Chadwick, X. Gao, A. Percesepe, D G. R Evans, M. Miyaki, S. T. Yuen, P. Radice, E. R Maher, et al. (2000)
J. Med. Genet. 37, 646-652
 |  Abstract »  |  Full Text »

Evaluation of Microsatellite Analysis in Urine Sediment for Diagnosis of Bladder Cancer.

A. Schneider, S. Borgnat, H. Lang, O. Régine, V. Lindner, M. Kassem, C. Saussine, P. Oudet, D. Jacqmin, and M. P. Gaub (2000)
Cancer Res. 60, 4617-4622
 |  Abstract »  |  Full Text »

DNA mismatch repair genes and colorectal cancer.

J M D WHEELER, W F BODMER, and N J M. MORTENSEN (2000)
Gut 47, 148-153
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BRCA1 Susceptibility Markers and Postmenopausal Breast Cancer: The Iowa Women's Health Study.

J. A. Thompson, P-L. Chen, R. A. King, S. S. Rich, W. S. Oetting, C. Armstrong, A. R. Folsom, and T. A. Sellers (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 507-511
 |  Abstract »  |  Full Text »

1998 RSNA Annual Oration in Diagnostic Radiology : Colorectal Cancer Imaging: A Challenge for Radiologists.

G. W. Stevenson (2000)
Radiology 214, 615-621
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Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer.

B Curran, K Lenehan, H Mulcahy, O Tighe, M A Bennett, E W Kay, D P O'Donoghue, M Leader, and D T Croke (2000)
Gut 46, 200-204
 |  Abstract »  |  Full Text »  |  PDF »

How many mutations does it take to make a tumor?.

C. R. Boland and L. Ricciardiello (1999)
PNAS 96, 14675-14677
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Identification of hMutLbeta , a Heterodimer of hMLH1 and hPMS1.

M. Raschle, G. Marra, M. Nystrom-Lahti, P. Schar, and J. Jiricny (1999)
J. Biol. Chem. 274, 32368-32375
 |  Abstract »  |  Full Text »  |  PDF »

Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis.

M P. de Leon, M Pedroni, P Benatti, A Percesepe, C Di Gregorio, M Foroni, G Rossi, M Genuardi, G Neri, F Leonardi, et al. (1999)
Gut 45, 32-38
 |  Abstract »  |  Full Text »  |  PDF »

Novel hMLH1 and hMSH2 Germline Mutations in African Americans With Colorectal Cancer.

T. K. Weber, H.-M. Chin, M. Rodriguez-Bigas, B. Keitz, R. Gilligan, L. O'Malley, E. Urf, N. Diba, J. Pazik, and N. J. Petrelli (1999)
JAMA 281, 2316-2320
 |  Abstract »  |  Full Text »  |  PDF »

Colorectal Cancer: Molecules and Populations.

J. D. Potter (1999)
J Natl Cancer Inst 91, 916-932
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Testing in Families With Hereditary Nonpolyposis Colon Cancer.

C. Lerman, C. Hughes, B. J. Trock, R. E. Myers, D. Main, A. Bonney, M. R. Abbaszadegan, A. E. Harty, B. A. Franklin, J. F. Lynch, et al. (1999)
JAMA 281, 1618-1622
 |  Abstract »  |  Full Text »  |  PDF »

Intention to Learn Results of Genetic Testing for Hereditary Colon Cancer.

S. W. Vernon, E. R. Gritz, S. K. Peterson, C. A. Perz, S. Marani, C. I. Amos, and W. F. Baile (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 353-360
 |  Abstract »  |  Full Text »  |  PDF »

Transforming growth factor beta  stimulation of colorectal cancer cell lines: Type II receptor bypass and changes in adhesion molecule expression.

M. Ilyas, J. A. Efstathiou, J. Straub, H. C. Kim, and W. F. Bodmer (1999)
PNAS 96, 3087-3091
 |  Abstract »  |  Full Text »  |  PDF »

A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer.

N. J Froggatt, J. Green, C. Brassett, D G. R Evans, D T. Bishop, R. Kolodner, and E. R Maher (1999)
J. Med. Genet. 36, 97-102
 |  Abstract »  |  Full Text »

Frequency of replication errors in colorectal cancer and their association with family history.

S R Brown, P J Finan, L Cawkwell, P Quirke, and D T Bishop (1998)
Gut 43, 553-557
 |  Abstract »  |  Full Text »  |  PDF »

Optimized PCR labeling in mutational and microsatellite analysis.

D. L. Esposito, R. Palmirotta, M. C. Veri, S. Mammarella, F. D'Amico, M. C. Curia, G. Aceto, S. Crognale, B. Creati, R. Mariani-Costantini, et al. (1998)
Clin. Chem. 44, 1381-1387
 |  Abstract »  |  Full Text »  |  PDF »

Polymerase Chain Reaction-Based Microsatellite Polymorphism Analysis of Follicular and Hurthle Cell Neoplasms of the Thyroid.

D. L. Segev, M. Saji, G. S. Phillips, W. H. Westra, Y. Takiyama, S. Piantadosi, R. C. Smallridge, R. H. Nishiyama, R. Udelsman, and M. A. Zeiger (1998)
J. Clin. Endocrinol. Metab. 83, 2036-2042
 |  Abstract »  |  Full Text »

The Mutation Rate and Cancer.

A. L. Jackson and L. A. Loeb (1998)
Genetics 148, 1483-1490
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Testing in Hereditary Colorectal Cancer.

F. M. Giardiello (1997)
JAMA 278, 1278-1281
 |  Abstract »  |  PDF »

Microsatellite Instability Is Rare in B-Cell Non-Hodgkin's Lymphomas.

B. Gamberi, G. Gaidano, N. Parsa, A. Carbone, S. Roncella, D. M. Knowles, D. C. Louie, D. Shibata, R.S.K. Chaganti, and R. Dalla-Favera (1997)
Blood 89, 975-979
 |  Abstract »  |  Full Text »  |  PDF »

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair..

G T Marsischky, N Filosi, M F Kane, and R Kolodner (1996)
Genes & Dev. 10, 407-420
 |  Abstract »  |  PDF »

Mismatch repair deficiency in phenotypically normal human cells.

R Parsons, G. Li, M Longley, P Modrich, B Liu, T Berk, Hamilton SR, K. Kinzler, and B Vogelstein (1995)
Science 268, 738-740
 |  Abstract »  |  PDF »

The Molecular Basis of Turcot's Syndrome.

S. R. Hamilton, B. Liu, R. E. Parsons, N. Papadopoulos, J. Jen, S. M. Powell, A. J. Krush, T. Berk, Z. Cohen, B. Tetu, et al. (1995)
N. Engl. J. Med. 332, 839-847
 |  Abstract »  |  Full Text »  |  PDF »

Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes.

A. K. Rustgi (1994)
N. Engl. J. Med. 331, 1694-1702
 |  Full Text »

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein.

R Fishel, A Ewel, S Lee, M. Lescoe, and J Griffith (1994)
Science 266, 1403-1405
 |  Abstract »  |  PDF »

DNA repair comes into its own.

J Marx (1994)
Science 266, 728-730
 |  PDF »

Genetic Testing for Children and Adolescents: Who Decides?.

D. C. Wertz, J. H. Fanos, and P. R. Reilly (1994)
JAMA 272, 875-881
 |  Abstract »  |  PDF »

Mutation of a mutL homolog in hereditary colon cancer.

N Papadopoulos, N. Nicolaides, Y. Wei, S. Ruben, K. Carter, C. Rosen, W. Haseltine, R. Fleischmann, C. Fraser, M. Adams, et al. (1994)
Science 263, 1625-1629
 |  Abstract »  |  PDF »

Aspirin, NSAIDs, and Risk Reduction of Colorectal Cancer: The Problem Is Translation.

D. M. Waterhouse and D. Brenner (1994)
Arch Intern Med 154, 366-368
 |  Abstract »  |  PDF »

Role of a Cell Cycle Regulator in Hereditary and Sporadic Cancer.

A. Kamb (1994)
Cold Spring Harb Symp Quant Biol 59, 39-47
 |  Abstract »  |  PDF »

Human Mismatch Repair Genes and Their Association with Hereditary Non-Polyposis Colon Cancer.

R.D. Kolodner, N.R. Hall, J. Lipford, M.F. Kane, M.R.S. Rao, P. Morrison, L. Wirth, P.J. Finan, J. Burn, P. Chapman, et al. (1994)
Cold Spring Harb Symp Quant Biol 59, 331-338
 |  Abstract »  |  PDF »

Defects in Replication Fidelity of Simple Repeated Sequences Reveal a New Mutator Mechanism for Oncogenesis.

M. Perucho, M.A. Peinado, Y. Ionov, S. Casares, S. Malkhosyan, and E. Stanbridge (1994)
Cold Spring Harb Symp Quant Biol 59, 339-348
 |  Abstract »  |  PDF »

Ovarian Tumors Display Persistent Microsatellite Instability Caused by Mutation in the Mismatch Repair Gene hMSH-2.

K. Orth, J. Hung, A. Gazdar, M. Mathis, A. Bowcock, and J. Sambrook (1994)
Cold Spring Harb Symp Quant Biol 59, 349-356
 |  Abstract »  |  PDF »

Colorectal Cancer and the Intersection between Basic and Clinical Research.

B. Vogelstein and K.W. Kinzler (1994)
Cold Spring Harb Symp Quant Biol 59, 517-521
 |  Abstract »  |  PDF »

Gene defect identified in common hereditary colon cancer.

J Marx (1993)
Science 262, 1645
 |  PDF »

The Human Genome Project and the Future of Medicine.

M. S. Guyer and F. S. Collins (1993)
Arch Pediatr Adolesc Med 147, 1145-1152
 |  Abstract »  |  PDF »

Clinical Implications of the p53 Tumor-Suppressor Gene.

C. C. Harris and M. Hollstein (1993)
N. Engl. J. Med. 329, 1318-1327
 |  Full Text »

A New Colon Cancer Gene.

(1993)
Journal Watch Dermatology 1993, 12
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A NEW COLON CANCER GENE.

(1993)
Journal Watch (General) 1993, 6
 |  Full Text »

New colon cancer gene discovered.

J Marx (1993)
Science 260, 751-752
 |  PDF »

Clues to the pathogenesis of familial colorectal cancer.

L. Aaltonen, P Peltomaki, F. Leach, P Sistonen, L Pylkkanen, J. Mecklin, H Jarvinen, S. Powell, J Jen, Hamilton SR, et al. (1993)
Science 260, 812-816
 |  Abstract »  |  PDF »

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