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Science 7 May 1993:
Vol. 260. no. 5109, pp. 807 - 809
DOI: 10.1126/science.8387229
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Articles

Science, Vol 260, Issue 5109, 807-809
Copyright © 1993 by American Association for the Advancement of Science

articles

Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart

S Gyorke and M Fill

Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555.

Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion (Ca2+) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second (larger) Ca2+ stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded Ca(2+)-induced Ca2+ release in heart and may be a fundamental feature of channels, including the inositol triphosphate receptor, that are involved in intracellular Ca2+ signaling in many cell types.


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Local calcium transients triggered by single L-type calcium channel currents in cardiac cells.
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Science 268, 1042-1045
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The control of calcium release in heart muscle.
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F Sachs, F Qin, and P Palade (1995)
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Ca(2+)-induced Ca2+ release in response to flash photolysis.
G. Lamb, M. Fryer, and D. Stephenson (1994)
Science 263, 986-988
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G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death.
L. B. Dale, M. Bhattacharya, P. H. Anborgh, B. Murdoch, M. Bhatia, S. Nakanishi, and S. S. G. Ferguson (2000)
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J. Gen. Physiol. 119, 373-388
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Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.
C. Dumitrescu, P. Narayan, Y. Cheng, I. R. Efimov, and R. A. Altschuld (2002)
Am J Physiol Heart Circ Physiol 282, H1311-H1319
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Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors).
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Circ. Res. 88, 1151-1158
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