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Science 7 May 1993:
Vol. 260. no. 5109, pp. 805 - 807
DOI: 10.1126/science.8387228
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Articles

Science, Vol 260, Issue 5109, 805-807
Copyright © 1993 by American Association for the Advancement of Science

articles

Protein-induced bending as a transcriptional switch

J Perez-Martin and M Espinosa

Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.

The question of whether protein-induced DNA bending can act as a switch factor when placed upstream of an array of promoters located in tandem was investigated in vivo. The catabolite activating protein binding site of the fur operon was replaced by the binding site of the RepA repressor protein, which is able to bend DNA immediately after binding. Appropriately phased induced bending could act as a transcriptional switch factor in vivo.


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J. Bacteriol. 190, 3700-3711
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Catabolite Repression of the Propionate Catabolic Genes in Escherichia coli and Salmonella enterica: Evidence for Involvement of the Cyclic AMP Receptor Protein.
S. K. Lee, J. D. Newman, and J. D. Keasling (2005)
J. Bacteriol. 187, 2793-2800
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Supercoil-induced extrusion of a regulatory DNA hairpin.
X. Dai, M. B. Greizerstein, K. Nadas-Chinni, and L. B. Rothman-Denes (1997)
PNAS 94, 2174-2179
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Intrinsically Bent DNA in a Eukaryotic Transcription Factor Recognition Sequence Potentiates Transcription Activation.
J. Kim, S. Klooster, and D. J. Shapiro (1995)
J. Biol. Chem. 270, 1282-1288
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DNA bending and orientation-dependent function of YY1 in the c-fos promoter..
S Natesan and M Z Gilman (1993)
Genes & Dev. 7, 2497-2509
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DNA Bending in Transcription Initiation.
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Cold Spring Harb Symp Quant Biol 58, 115-122
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The Smooth Muscle gamma -Actin Gene Promoter Is a Molecular Target for the Mouse bagpipe Homologue, mNkx3-1, and Serum Response Factor.
J. A. Carson, R. A. Fillmore, R. J. Schwartz, and W. E. Zimmer (2000)
J. Biol. Chem. 275, 39061-39072
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Constitutive Mutations of the OccR Regulatory Protein Affect DNA Bending in Response to Metabolites Released from Plant Tumors.
R. Akakura and S. C. Winans (2002)
J. Biol. Chem. 277, 5866-5874
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