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Science 30 April 1993:
Vol. 260. no. 5108, pp. 695 - 698
DOI: 10.1126/science.8480181
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Articles

Science, Vol 260, Issue 5108, 695-698
Copyright © 1993 by American Association for the Advancement of Science

articles

Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice

JB Prins, JA Todd, NR Rodrigues, S Ghosh, PM Hogarth, LS Wicker, E Gaffney, PL Podolin, PA Fischer, A Sirotina, and al. et

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom.

A congenic, non-obese diabetic (NOD) mouse strain that contains a segment of chromosome 3 from the diabetes-resistant mouse strain B6.PL-Thy-1a was less susceptible to diabetes than NOD mice. A fully penetrant immunological defect also mapped to this segment, which encodes the high-affinity Fc receptor for immunoglobulin G (IgG), Fc gamma RI. The NOD Fcgr1 allele, which results in a deletion of the cytoplasmic tail, caused a 73 percent reduction in the turnover of cell surface receptor-antibody complexes. The development of congenic strains and the characterization of Mendelian traits that are specific to the disease phenotype demonstrate the feasibility of dissecting the pathophysiology of complex, non-Mendelian diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
B Cell Depletion Inhibits Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice.
S. Yu, R. Dunn, M. R. Kehry, and H. Braley-Mullen (2008)
J. Immunol. 180, 7706-7713
   Abstract »    Full Text »    PDF »
B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in Fc{gamma}R Effector Functions.
Y. Xiu, C. P. Wong, J.-D. Bouaziz, Y. Hamaguchi, Y. Wang, S. M. Pop, R. M. Tisch, and T. F. Tedder (2008)
J. Immunol. 180, 2863-2875
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Interactions between Idd5.1/Ctla4 and Other Type 1 Diabetes Genes.
K. Hunter, D. Rainbow, V. Plagnol, J. A. Todd, L. B. Peterson, and L. S. Wicker (2007)
J. Immunol. 179, 8341-8349
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Human Autoantibodies Modulate the T Cell Epitope Repertoire but Fail to Unmask a Pathogenic Cryptic Epitope.
S. Quaratino, J. Ruf, M. Osman, J. Guo, S. McLachlan, B. Rapoport, and M. Londei (2005)
J. Immunol. 174, 557-563
   Abstract »    Full Text »    PDF »
Unique Monoclonal Antibodies Define Expression of Fc{gamma}RI on Macrophages and Mast Cell Lines and Demonstrate Heterogeneity Among Subcutaneous and Other Dendritic Cells.
P. S. Tan, A. L. Gavin, N. Barnes, D. W. Sears, D. Vremec, K. Shortman, S. Amigorena, P. L. Mottram, and P. M. Hogarth (2003)
J. Immunol. 170, 2549-2556
   Abstract »    Full Text »    PDF »
Critical Contribution of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) to Apoptosis of Human CD4+ T Cells in HIV-1-infected hu-PBL-NOD-SCID Mice.
Y. Miura, N. Misawa, N. Maeda, Y. Inagaki, Y. Tanaka, M. Ito, N. Kayagaki, N. Yamamoto, H. Yagita, H. Mizusawa, et al. (2001)
J. Exp. Med. 193, 651-660
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of Human Fcgamma RIa Alters the Functional Properties of the Fcgamma RI{middle dot}gamma -Chain Receptor Complex.
J. C. Edberg, A. M. F. Yee, D. S. Rakshit, D. J. Chang, J. A. Gokhale, Z. K. Indik, A. D. Schreiber, and R. P. Kimberly (1999)
J. Biol. Chem. 274, 30328-30333
   Abstract »    Full Text »    PDF »
Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice.
S. Trembleau, G. Penna, S. Gregori, H. D. Chapman, D. V. Serreze, J. Magram, and L. Adorini (1999)
J. Immunol. 163, 2960-2968
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Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.
M. Mahler, I. J. Bristol, E. H. Leiter, A. E. Workman, E. H. Birkenmeier, C. O. Elson, and J. P. Sundberg (1998)
Am J Physiol Gastrointest Liver Physiol 274, G544-G551
   Abstract »    Full Text »    PDF »
Extracellular Mutations of Non-obese Diabetic Mouse Fcgamma RI Modify Surface Expression and Ligand Binding.
A. L. Gavin, J. A. Hamilton, and P. M. Hogarth (1996)
J. Biol. Chem. 271, 17091-17099
   Abstract »    Full Text »    PDF »
A genetic linkage map of the mouse: current applications and future prospects.
N. Copeland, N. Jenkins, D. Gilbert, J. Eppig, L. Maltais, J. Miller, W. Dietrich, A Weaver, S. Lincoln, R. Steen, et al. (1993)
Science 262, 57-66
   Abstract »    PDF »


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