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Science 30 April 1993:
Vol. 260. no. 5108, pp. 692 - 695
DOI: 10.1126/science.8480180
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Articles

Science, Vol 260, Issue 5108, 692-695
Copyright © 1993 by American Association for the Advancement of Science

articles

Retinoic acid stimulates regeneration of mammalian auditory hair cells

PP Lefebvre, B Malgrange, H Staecker, G Moonen, and TR Van de Water

Department of Human Physiology and Pathophysiology, University of Liege, Belgium.

Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults.
T. Michikawa, Y. Nishiwaki, Y. Kikuchi, K. Hosoda, K. Mizutari, H. Saito, K. Asakura, A. Milojevic, S. Iwasawa, M. Nakano, et al. (2009)
J Gerontol A Biol Sci Med Sci 64A, 910-915
   Abstract »    Full Text »    PDF »
Retinoic Acid Is Present in the Postnatal Rat Olfactory Organ and Persists in Vitamin A-Depleted Neural Tissue.
M. A. Asson-Batres, W. B. Smith, and G. Clark (2009)
J. Nutr. 139, 1067-1072
   Abstract »    Full Text »    PDF »
Directed differentiation of mouse cochlear neural progenitors in vitro.
J. Lin, L. Feng, Y. Hamajima, M. Komori, T. C. Burns, S. Fukudome, J. Anderson, D. Wang, C. M. Verfaillie, and W. C. Low (2009)
Am J Physiol Cell Physiol 296, C441-C452
   Abstract »    Full Text »    PDF »
Cellular studies of auditory hair cell regeneration in birds.
J. S. Stone and E. W Rubel (2000)
PNAS 97, 11714-11721
   Abstract »    Full Text »    PDF »
Differentiation of Mammalian Vestibular Hair Cells from Conditionally Immortal, Postnatal Supporting Cells.
P. Lawlor, W. Marcotti, M. N. Rivolta, C. J. Kros, and M. C. Holley (1999)
J. Neurosci. 19, 9445-9458
   Abstract »    Full Text »    PDF »
Immunocytochemical and Morphological Evidence for Intracellular Self-Repair as an Important Contributor to Mammalian Hair Cell Recovery.
J. L. Zheng, G. Keller, and W.-Q. Gao (1999)
J. Neurosci. 19, 2161-2170
   Abstract »    Full Text »    PDF »
Response.
H. Staecker, P. Lefebvre, B. Malgrange, G. Moonen, and T. R. Van De Water (1995)
Science 267, 709-711
   PDF »
The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture.
M. W. Kelley, X. M. Xu, M. A. Wagner, M. E. Warchol, and J. T. Corwin (1993)
Development 119, 1041-1053
   Abstract »    PDF »


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