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Science 30 April 1993:
Vol. 260. no. 5108, pp. 689 - 692
DOI: 10.1126/science.8097595
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Articles

Science, Vol 260, Issue 5108, 689-692
Copyright © 1993 by American Association for the Advancement of Science

articles

Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates

DE Mosier, RJ Gulizia, PD MacIsaac, BE Torbett, and JA Levy

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Human immunodeficiency virus (HIV) isolates differ in cell tropism, replication, pathogenicity, and syncytial induction in vitro. CD4+ T cells were enumerated in severe combined immunodeficient mice transplanted with human peripheral blood leukocytes (hu-PBL-SCID mice) and infected with HIV isolates with different in vitro cytopathicity. Two noncytopathic, macrophage-tropic strains, HIV-1SF162 and HIV-2UC1, induced extensive CD4+ T cell depletion, whereas HIV-1SF33, which is highly cytopathic for T cells in vitro, caused little CD4+ T cell depletion at equivalent virus burden. In vitro cytopathicity assays therefore do not predict CD4 depletion in the hu-PBL-SCID model.


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