Science 30 April 1993: Vol. 260. no. 5108, pp. 682 - 687 DOI: 10.1126/science.8097594

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Articles

Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism.

S. C. Lieber, H. Qiu, L. Chen, Y.-T. Shen, C. Hong, W. C. Hunter, N. Aubry, S. F. Vatner, and D. E. Vatner (2008)
Am J Physiol Heart Circ Physiol 295, H860-H866
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Comparative Proteomics Analysis of Vascular Smooth Muscle Cells Incubated with S- and R-Enantiomers of Atenolol Using iTRAQ-coupled Two-dimensional LC-MS/MS.

J. Sui, J. Zhang, T. L. Tan, C. B. Ching, and W. N. Chen (2008)
Mol. Cell. Proteomics 7, 1007-1018
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A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart.

G. Cheng, M. R. Zile, M. Takahashi, C. F. Baicu, D. D. Bonnema, F. Cabral, D. R. Menick, and G. Cooper 4th (2008)
Am J Physiol Heart Circ Physiol 294, H2231-H2241
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Microtubule-dependent distribution of mRNA in adult cardiocytes.

D. Scholz, C. F. Baicu, W. J. Tuxworth, L. Xu, H. Kasiganesan, D. R. Menick, and G. Cooper IV (2008)
Am J Physiol Heart Circ Physiol 294, H1135-H1144
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Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.

K. K Parker and D. E Ingber (2007)
Phil Trans R Soc B 362, 1267-1279
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Microtubules and Actin Microfilaments Regulate Lipid Raft/Caveolae Localization of Adenylyl Cyclase Signaling Components.

B. P. Head, H. H. Patel, D. M. Roth, F. Murray, J. S. Swaney, I. R. Niesman, M. G. Farquhar, and P. A. Insel (2006)
J. Biol. Chem. 281, 26391-26399
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Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction.

G. Cooper IV (2006)
Am J Physiol Heart Circ Physiol 291, H1003-H1014
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Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes.

D. Scholz, P. McDermott, M. Garnovskaya, T. N. Gallien, S. Huettelmaier, C. DeRienzo, and G. Cooper IV (2006)
Cardiovasc Res 71, 506-516
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Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement.

C. P. Brangwynne, F. C. MacKintosh, S. Kumar, N. A. Geisse, J. Talbot, L. Mahadevan, K. K. Parker, D. E. Ingber, and D. A. Weitz (2006)
J. Cell Biol. 173, 733-741
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MLP accumulation and remodelling in the infarcted rat heart.

J. R. Wilding, C. A. Lygate, K. E. Davies, S. Neubauer, and K. Clarke (2006)
Eur J Heart Fail 8, 343-346
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Microtubules Modulate the Stiffness of Cardiomyocytes Against Shear Stress.

S. Nishimura, S. Nagai, M. Katoh, H. Yamashita, Y. Saeki, J.-i. Okada, T. Hisada, R. Nagai, and S. Sugiura (2006)
Circ. Res. 98, 81-87
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Inhibition of {beta}-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.

G. Cheng, F. Qiao, T. N. Gallien, D. Kuppuswamy, and G. Cooper IV (2005)
Am J Physiol Heart Circ Physiol 288, H1193-H1202
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Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of {alpha}-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility.

F. J. Davis, J. B Pillai, M. Gupta, and M. P. Gupta (2005)
Am J Physiol Heart Circ Physiol 288, H1477-H1490
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Differential expression of cytokines in the rat heart in response to sustained volume overload.

R.P. Dai, S.T. Dheen, B.P. He, and S.S.W. Tay (2004)
Eur J Heart Fail 6, 693-703
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Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.

A. S. McElhinny, C. N. Perry, C. C. Witt, S. Labeit, and C. C. Gregorio (2004)
J. Cell Sci. 117, 3175-3188
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What Mechanisms Underlie Diastolic Dysfunction in Heart Failure?.

D. A. Kass, J. G.F. Bronzwaer, and W. J. Paulus (2004)
Circ. Res. 94, 1533-1542
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Phenotypic consequences of {beta}1-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes.

M. Takahashi, H. Shiraishi, Y. Ishibashi, K. L. Blade, P. J. McDermott, D. R. Menick, D. Kuppuswamy, and G. Cooper IV (2003)
Am J Physiol Heart Circ Physiol 285, H2072-H2083
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Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.

Y. Ishibashi, M. Takahashi, Y. Isomatsu, F. Qiao, Y. Iijima, H. Shiraishi, J. M. Simsic, C. F. Baicu, J. Robbins, M. R. Zile, et al. (2003)
Am J Physiol Heart Circ Physiol 285, H1270-H1285
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Tensegrity II. How structural networks influence cellular information processing networks.

D. E. Ingber (2003)
J. Cell Sci. 116, 1397-1408
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Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments.

C. G. Dos Remedios, D. Chhabra, M. Kekic, I. V. Dedova, M. Tsubakihara, D. A. Berry, and N. J. Nosworthy (2003)
Physiol Rev 83, 433-473
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Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats.

B. S. Scopacasa, V. P. A. Teixeira, and K. G. Franchini (2003)
J Appl Physiol 94, 1627-1633
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Inhibition of G protein-coupled receptor trafficking in neuroblastoma cells by MAP 4 decoration of microtubules.

G. Cheng, Y. Iijima, Y. Ishibashi, D. Kuppuswamy, and G. Cooper IV (2002)
Am J Physiol Heart Circ Physiol 283, H2379-H2388
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Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology.

D. E. Ingber (2002)
Circ. Res. 91, 877-887
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A Unifying Mechanism for the Role of Microtubules in the Regulation of [Ca2+]i and Contraction in the Cardiac Myocyte.

S. Calaghan, E. White, and J.-Y. Le Guennec (2001)
Circ. Res. 89 , e31
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Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes.

B. G. Kerfant, G. Vassort, and A. M. Gomez (2001)
Circ. Res. 88 , e59-e65
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Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy.

M. R. Zile, G. R. Green, G. T. Schuyler, G. P. Aurigemma, D. C. Miller, and G. Cooper IV (2001)
J. Am. Coll. Cardiol. 37, 1080-1084
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Modulation of Ca2+ Signaling by Microtubule Disruption in Rat Ventricular Myocytes and Its Dependence on the Ruptured Patch-Clamp Configuration.

S. C. Calaghan, J.-Y. Le Guennec, and E. White (2001)
Circ. Res. 88 , e32-e37
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Right Ventricular Hypertrophy Secondary to Pulmonary Hypertension Is Linked to Rat Chromosome 17 : Evaluation of Cardiac Ryanodine Ryr2 Receptor as a Candidate.

L. Zhao, A. Sebkhi, D. J. R. Nunez, L. Long, C. S. Haley, J. Szpirer, C. Szpirer, A. J. Williams, and M. R. Wilkins (2001)
Circulation 103, 442-447
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Changes in myocardial cytoskeletal intermediate filaments and myocyte contractile dysfunction in dilated cardiomyopathy: an in vivo study in humans.

S Di Somma, M Marotta, G Salvatore, G Cudemo, G Cuda, F De Vivo, M P Di Benedetto, F Ciaramella, G Caputo, and O de Divitiis (2000)
Heart 84, 659-667
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Myocyte cytoskeletal disorganization and right heart failure in hypoxia-induced neonatal pulmonary hypertension.

M. S. Lemler, R. D. Bies, M. G. Frid, A. Sastravaha, L. S. Zisman, T. Bohlmeyer, A. M. Gerdes, J. T. Reeves, and K. R. Stenmark (2000)
Am J Physiol Heart Circ Physiol 279, H1365-H1376
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Microtubule Depolymerization Normalizes In Vivo Myocardial Contractile Function in Dogs With Pressure-Overload Left Ventricular Hypertrophy.

M. Koide, M. Hamawaki, T. Narishige, H. Sato, S. Nemoto, G. DeFreyte, M. R. Zile, G. Cooper IV, and B. A. Carabello (2000)
Circulation 102, 1045-1052
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Rapid Electrical Stimulation of Contraction Reduces the Density of {beta}-Adrenergic Receptors and Responsiveness of Cultured Neonatal Rat Cardiomyocytes : Possible Involvement of Microtubule Disassembly Secondary to Mechanical Stress.

H. Yonemochi, S. Yasunaga, Y. Teshima, N. Takahashi, M. Nakagawa, M. Ito, and T. Saikawa (2000)
Circulation 101, 2625-2630
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Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset.

D. R. Webster and D. L. Patrick (2000)
Am J Physiol Heart Circ Physiol 278, H1653-H1661
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Increased Expression of Cytoskeletal, Linkage, and Extracellular Proteins in Failing Human Myocardium.

A. Heling, R. Zimmermann, S. Kostin, Y. Maeno, S. Hein, B. Devaux, E. Bauer, W.-P. Klovekorn, M. Schlepper, W. Schaper, et al. (2000)
Circ. Res. 86, 846-853
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MYOCYTE CONTRACTILE DYSFUNCTION WITH HYPERTROPHY AND FAILURE: RELEVANCE TO CARDIAC SURGERY.

C. A. Walker, F. A. Crawford Jr, and F. G. Spinale (2000)
J. Thorac. Cardiovasc. Surg. 119, 388-400
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The role of the cytoskeleton in heart failure.

S. Hein, S. Kostin, A. Heling, Y. Maeno, and J. Schaper (2000)
Cardiovasc Res 45, 273-278
 |  Abstract »  |  Full Text »  |  PDF »

Microtubule Disruption Modulates Ca2+ Signaling in Rat Cardiac Myocytes.

A. M. Gomez, B. G. Kerfant, and G. Vassort (2000)
Circ. Res. 86, 30-36
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THE STRUCTURE AND FUNCTION OF THE CARDIAC MYOCYTE: A REVIEW OF FUNDAMENTAL CONCEPTS.

C. A. Walker and F. G. Spinale (1999)
J. Thorac. Cardiovasc. Surg. 118, 375-382
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Ionic basis of ventricular arrhythmias in remodeled rat heart during long-term myocardial infarction.

F. Aimond, J. L Alvarez, J.-M. Rauzier, P. Lorente, and G. Vassort (1999)
Cardiovasc Res 42, 402-415
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Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes.

F C Howarth, S C Calaghan, M R Boyett, and E White (1999)
J. Physiol. 516, 409-419
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Cardiac Hypertrophic and Developmental Regulation of the beta -Tubulin Multigene Family.

T. Narishige, K. L. Blade, Y. Ishibashi, T. Nagai, M. Hamawaki, D. R. Menick, D. Kuppuswamy, and G. Cooper IV (1999)
J. Biol. Chem. 274, 9692-9697
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Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction.

H. Schoder, R. Campisi, T. Ohtake, C. K. Hoh, D. H. Moon, J. Czernin, and H. R. Schelbert (1999)
J. Am. Coll. Cardiol. 33, 1328-1337
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Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility.

H. M. Thai, H. T. Van, M. A. Gaballa, S. Goldman, and T. E. Raya (1999)
Am J Physiol Heart Circ Physiol 276, H873-H880
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Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells.

H. Nguyen, D Gruber, and J. Bulinski (1999)
J. Cell Sci. 112, 1813-1824
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Role of microtubules in the contractile dysfunction of hypertrophied myocardium.

M. R. Zile, M. Koide, H. Sato, Y. Ishiguro, C. H. Conrad, J. M. Buckley, J. P. Morgan, and G. Cooper IV (1999)
J. Am. Coll. Cardiol. 33, 250-260
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Direct Effects of Colchicine on Myocardial Function : Studies in Hypertrophied and Failing Spontaneously Hypertensive Rats.

A. C. Cicogna, K. G. Robinson, C. H. Conrad, K. Singh, R. Squire, M. P. Okoshi, and O. H. L. Bing (1999)
Hypertension 33, 60-65
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Potential paracrine role of the pericardium in the regulation of cardiac function.

A. Mebazaa, R. C. Wetzel, J. M. Dodd-o, E. M. Redmond, A. M. Shah, K. Maeda, G. Maistre, E. G. Lakatta, and J. L. Robotham (1998)
Cardiovasc Res 40, 332-342
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Constitutive Properties of Adult Mammalian Cardiac Muscle Cells.

M. R. Zile, K. Richardson, M. K. Cowles, J. M. Buckley, M. Koide, B. A. Cowles, V. Gharpuray, and G. Cooper IV (1998)
Circulation 98, 567-579
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Microtubules are involved in early hypertrophic responses of myocardium during pressure overload.

M. Takahashi, H. Tsutsui, H. Tagawa, K. Igarashi-Saito, K. Imanaka-Yoshida, and A. Takeshita (1998)
Am J Physiol Heart Circ Physiol 275, H341-H348
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Physio-pharmacological evaluation of myocardial performance: an integrative approach.

A. M Shah, S. J Sollott, and E. G Lakatta (1998)
Cardiovasc Res 39, 148-154
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Expression of a beta -adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.

H. A. Rockman, K. R. Chien, D.-J. Choi, G. Iaccarino, J. J. Hunter, J. Ross Jr., R. J. Lefkowitz, and W. J. Koch (1998)
PNAS 95, 7000-7005
 |  Abstract »  |  Full Text »  |  PDF »

Terminal Warm Blood Cardioplegia Improves Cardiac Function Through Microtubule Repolymerization.

H. Tenpaku, K. Onoda, K. Imanaka-Yoshida, T. Yoshida, T. Shimono, H. Shimpo, and I. Yada (1998)
Ann. Thorac. Surg. 65, 1580-1587
 |  Abstract »  |  Full Text »  |  PDF »

Cytoskeletal Role in the Transition From Compensated to Decompensated Hypertrophy During Adult Canine Left Ventricular Pressure Overloading.

H. Tagawa, M. Koide, H. Sato, M. R. Zile, B. A. Carabello, and G. Cooper IV (1998)
Circ. Res. 82, 751-761
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Microtubules in Cardiac Hypertrophy : A Mechanical Role in Decompensation?.

H. E. D. J. ter Keurs (1998)
Circ. Res. 82, 828-831
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Differential Effects of Paclitaxel and Derivatives on Guinea Pig Isolated Heart and Papillary Muscle.

G. Alloatti, C. Penna, M. P. Gallo, R. C. Levi, E. Bombardelli, and G. Appendino (1998)
J. Pharmacol. Exp. Ther. 284, 561-567
 |  Abstract »  |  Full Text »

Altered contractile function in heart failure.

P. P de Tombe (1998)
Cardiovasc Res 37, 367-380
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Effect of Altering Filling Pattern on Diastolic Pressure-Volume Curve.

T. J. Fraites Jr, A. Saeki, and D. A. Kass (1997)
Circulation 96, 4408-4414
 |  Abstract »  |  Full Text »

Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy.

H. Sato, T. Nagai, D. Kuppuswamy, T. Narishige, M. Koide, D. R. Menick, and G. C. IV (1997)
J. Cell Biol. 139, 963-973
 |  Abstract »  |  Full Text »  |  PDF »

Association of Tyrosine-phosphorylated c-Src with the Cytoskeleton of Hypertrophying Myocardium.

D. Kuppuswamy, C. Kerr, T. Narishige, V. S. Kasi, D. R. Menick, and G. Cooper IV (1997)
J. Biol. Chem. 272, 4500-4508
 |  Abstract »  |  Full Text »  |  PDF »

Cytoskeletal Mechanics in Pressure-Overload Cardiac Hypertrophy.

H. Tagawa, N. Wang, T. Narishige, D. E. Ingber, M. R. Zile, and G. Cooper IV (1997)
Circ. Res. 80, 281-289
 |  Abstract »  |  Full Text »

Microtubules and Pressure-Overload Hypertrophy.

R. A. Walsh (1997)
Circ. Res. 80, 295-296
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Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein Metavinculin.

M. Maeda, E. Holder, B. Lowes, S. Valent, and R. D. Bies (1997)
Circulation 95, 17-20
 |  Abstract »  |  Full Text »

Effects of Dobutamine Stimulation on Myocardial Blood Flow, Glucose Metabolism, and Wall Motion in Normal and Dysfunctional Myocardium.

K. T. Sun, J. Czernin, J. Krivokapich, Y.-K. Lau, M. Bottcher, G. Maurer, M. E. Phelps, and H. R. Schelbert (1996)
Circulation 94, 3146-3154
 |  Abstract »  |  Full Text »

Long-term Angiotensin-Converting Enzyme Inhibition With Fosinopril Improves Depressed Responsiveness to Ca2+ in Myocytes From Aortic-Banded Rats.

Y. Kagaya, R. J. Hajjar, J. K. Gwathmey, W. H. Barry, and B. H. Lorell (1996)
Circulation 94, 2915-2922
 |  Abstract »  |  Full Text »

Basis for Increased Microtubules in Pressure-Hypertrophied Cardiocytes.

H. Tagawa, J. D. Rozich, H. Tsutsui, T. Narishige, D. Kuppuswamy, H. Sato, P. J. McDermott, M. Koide, and G. Cooper IV (1996)
Circulation 93, 1230-1243
 |  Abstract »  |  Full Text »

Pressure- and Volume-Induced Left Ventricular Hypertrophies Are Associated With Distinct Myocyte Phenotypes and Differential Induction of Peptide Growth Factor mRNAs.

A. Calderone, N. Takahashi, N. J. Izzo Jr, C. M. Thaik, and W. S. Colucci (1995)
Circulation 92, 2385-2390
 |  Abstract »  |  Full Text »

Myocardial Fibrosis and Stiffness With Hypertrophy and Heart Failure in the Spontaneously Hypertensive Rat.

C. H. Conrad, W. W. Brooks, J. A. Hayes, S. Sen, K. G. Robinson, and O. H. L. Bing (1995)
Circulation 91, 161-170
 |  Abstract »  |  Full Text »

Molecular advances in cardiovascular biology.

K. Chien (1993)
Science 260, 916-917
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Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy.

M. Laser, C. D. Willey, W. Jiang, G. Cooper IV, D. R. Menick, M. R. Zile, and D. Kuppuswamy (2000)
J. Biol. Chem. 275, 35624-35630
 |  Abstract »  |  Full Text »  |  PDF »

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