Science 23 April 1993: Vol. 260. no. 5107, pp. 536 - 539 DOI: 10.1126/science.8475385

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Articles

Inhibition of Autoregulated TGF{beta} Signaling Simultaneously Enhances Proliferation and Differentiation of Kidney Epithelium and Promotes Repair Following Renal Ischemia.

H. Geng, R. Lan, G. Wang, A. R. Siddiqi, M. C. Naski, A. I. Brooks, J. L. Barnes, P. Saikumar, J. M. Weinberg, and M. A. Venkatachalam (2009)
Am. J. Pathol. 174, 1291-1308
 |  Abstract »  |  Full Text »  |  PDF »

The in vivo modulatory effects of an anterior-chamber microenvironment on uveal melanoma.

H S Mudhar, E Saunders, P Rundle, I G Rennie, and K Sisley (2009)
Br. J. Ophthalmol. 93, 535-540
 |  Abstract »  |  Full Text »  |  PDF »

CDK2 Phosphorylation of Smad2 Disrupts TGF-{beta} Transcriptional Regulation in Resistant Primary Bone Marrow Myeloma Cells.

L. B. Baughn, M. Di Liberto, R. Niesvizky, H. J. Cho, D. Jayabalan, J. Lane, F. Liu, and S. Chen-Kiang (2009)
J. Immunol. 182, 1810-1817
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4.

M. D. Larrea, J. Liang, T. Da Silva, F. Hong, S. H. Shao, K. Han, D. Dumont, and J. M. Slingerland (2008)
Mol. Cell. Biol. 28, 6462-6472
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Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers.

X.-J. Cheng, W. Xu, Q.-Y. Zhang, and R.-L. Zhou (2008)
Ann. Onc. 19, 527-532
 |  Abstract »  |  Full Text »  |  PDF »

Differential Modification of p27Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity.

M. K. James, A. Ray, D. Leznova, and S. W. Blain (2008)
Mol. Cell. Biol. 28, 498-510
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Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis.

C. R. Loehberg, T. Thompson, M. B. Kastan, K. H. Maclean, D. G. Edwards, F. S. Kittrell, D. Medina, O. M. Conneely, and B. W. O'Malley (2007)
Cancer Res. 67, 12026-12033
 |  Abstract »  |  Full Text »  |  PDF »

Cooperation between p27 and p107 during Endochondral Ossification Suggests a Genetic Pathway Controlled by p27 and p130.

N. Yeh, J. P. Miller, T. Gaur, T. D. Capellini, J. Nikolich-Zugich, C. de la Hoz, L. Selleri, T. G. Bromage, A. J. van Wijnen, G. S. Stein, et al. (2007)
Mol. Cell. Biol. 27, 5161-5171
 |  Abstract »  |  Full Text »  |  PDF »

Cdh1-Anaphase-Promoting Complex Targets Skp2 for Destruction in Transforming Growth Factor {beta}-Induced Growth Inhibition.

W. Liu, G. Wu, W. Li, D. Lobur, and Y. Wan (2007)
Mol. Cell. Biol. 27, 2967-2979
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The Endogenous Ratio of Smad2 and Smad3 Influences the Cytostatic Function of Smad3.

S. G. Kim, H.-A. Kim, H.-S. Jong, J.-H. Park, N. K. Kim, S. H. Hong, T.-Y. Kim, and Y.-J. Bang (2005)
Mol. Biol. Cell 16, 4672-4683
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitination of p27Kip1 Requires Physical Interaction with Cyclin E and Probable Phosphate Recognition by SKP2.

D. Ungermannova, Y. Gao, and X. Liu (2005)
J. Biol. Chem. 280, 30301-30309
 |  Abstract »  |  Full Text »  |  PDF »

Early Growth Response 1 Acts as a Tumor Suppressor In vivo and In vitro via Regulation of p53.

A. Krones-Herzig, S. Mittal, K. Yule, H. Liang, C. English, R. Urcis, T. Soni, E. D. Adamson, and D. Mercola (2005)
Cancer Res. 65, 5133-5143
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta} and Platelet-Derived Growth Factor Signal via c-Jun N-Terminal Kinase-Dependent Smad2/3 Phosphorylation in Rat Hepatic Stellate Cells after Acute Liver Injury.

K. Yoshida, K. Matsuzaki, S. Mori, Y. Tahashi, H. Yamagata, F. Furukawa, T. Seki, M. Nishizawa, J. Fujisawa, and K. Okazaki (2005)
Am. J. Pathol. 166, 1029-1039
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Effects of TGF-{beta}1 on CD4+ and CD8+ T Cell Survival, Division, and IL-2 Production: A Role for T Cell Intrinsic Smad3.

S. C. McKarns and R. H. Schwartz (2005)
J. Immunol. 174, 2071-2083
 |  Abstract »  |  Full Text »  |  PDF »

Acceleration of Smad2 and Smad3 Phosphorylation via c-Jun NH2-Terminal Kinase during Human Colorectal Carcinogenesis.

H. Yamagata, K. Matsuzaki, S. Mori, K. Yoshida, Y. Tahashi, F. Furukawa, G. Sekimoto, T. Watanabe, Y. Uemura, N. Sakaida, et al. (2005)
Cancer Res. 65, 157-165
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Autocrine and Exogenous Transforming Growth Factor {beta} Control Cell Cycle Inhibition through Pathways with Different Sensitivity.

J. Wang, N. Sergina, T. C. Ko, J. Gong, and M. G. Brattain (2004)
J. Biol. Chem. 279, 40237-40244
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Control of Cell Cycle Progression by Autocrine Transforming Growth Factor {beta} in Breast Cancer Cells.

S. Ammanamanchi, M. P. M. Tillekeratne, T. C. Ko, and M. G. Brattain (2004)
Cancer Res. 64, 2509-2515
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Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in Cancer.

S. E. Reed, C. H. Spruck, O. Sangfelt, F. van Drogen, E. Mueller-Holzner, M. Widschwendter, A. Zetterberg, and S. I. Reed (2004)
Cancer Res. 64, 795-800
 |  Abstract »  |  Full Text »  |  PDF »

The Prognostic and Therapeutic Relevance of p27kip1 in Ewing's Family Tumors.

T. Matsunobu, K. Tanaka, Y. Matsumoto, F. Nakatani, R. Sakimura, M. Hanada, X. Li, Y. Oda, I. Naruse, H. Hoshino, et al. (2004)
Clin. Cancer Res. 10, 1003-1012
 |  Abstract »  |  Full Text »  |  PDF »

Energy Restriction Reduces the Number of Advanced Aberrant Crypt Foci and Attenuates the Expression of Colonic Transforming Growth Factor {beta} and Cyclooxygenase Isoforms in Zucker Obese (fa/fa) Rats.

J. Raju and R. P. Bird (2003)
Cancer Res. 63, 6595-6601
 |  Abstract »  |  Full Text »  |  PDF »

Spy1 Interacts with p27Kip1 to Allow G1/S Progression.

L. A. Porter, M. Kong-Beltran, and D. J. Donoghue (2003)
Mol. Biol. Cell 14, 3664-3674
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Transforming Growth Factor {beta}1 Increases the Stability of p21/WAF1/CIP1 Protein and Inhibits CDK2 Kinase Activity in Human Colon Carcinoma FET Cells.

J. Gong, S. Ammanamanchi, T. C. Ko, and M. G. Brattain (2003)
Cancer Res. 63, 3340-3346
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p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation.

S. J. Moeller, E. D. Head, and R. J. Sheaff (2003)
Mol. Cell. Biol. 23, 3735-3752
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Transforming Growth Factor-{beta} Signal Transduction and Progressive Renal Disease.

J. Cheng and J. P. Grande (2002)
Experimental Biology and Medicine 227, 943-956
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Non-malignant and Tumor-derived Cells Differ in Their Requirement for p27Kip1 in Transforming Growth Factor-beta -mediated G1 Arrest.

J. C. H. Donovan, J. M. Rothenstein, and J. M. Slingerland (2002)
J. Biol. Chem. 277, 41686-41692
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The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 to Facilitate the Activation of Cdk4/6 and Early G1 Phase Progression.

A. J. Obaya, I. Kotenko, M. D. Cole, and J. M. Sedivy (2002)
J. Biol. Chem. 277, 31263-31269
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Altered p27Kip1 Phosphorylation, Localization, and Function in Human Epithelial Cells Resistant to Transforming Growth Factor {beta}-Mediated G1 Arrest.

S. Ciarallo, V. Subramaniam, W. Hung, J.-H. Lee, R. Kotchetkov, C. Sandhu, A. Milic, and J. M. Slingerland (2002)
Mol. Cell. Biol. 22, 2993-3002
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta}1 Is an Autocrine Mediator of Renal Tubular Epithelial Cell Growth and Collagen IV Production.

J. P. Grande, G. M. Warner, H. J. Walker, A. N. K. Yusufi, J. Cheng, C. E. Gray, J. B. Kopp, and K. A. Nath (2002)
Experimental Biology and Medicine 227, 171-181
 |  Abstract »  |  Full Text »  |  PDF »

Pituitary Adenylate Cyclase Activating Polypeptide Anti-Mitogenic Signaling in Cerebral Cortical Progenitors Is Regulated by p57Kip2-Dependent CDK2 Activity.

R. G. Carey, B. Li, and E. DiCicco-Bloom (2002)
J. Neurosci. 22, 1583-1591
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Signaling and Cardiovascular Disease.

E.G. NABEL, M. BOEHM, L.M. AKYUREK, T. YOSHIMOTO, M.F. CROOK, M. OLIVE, H. SAN, and X. QU (2002)
Cold Spring Harb Symp Quant Biol 67, 163-170
 |  Abstract »  |  PDF »

HIRA, the Human Homologue of Yeast Hir1p and Hir2p, Is a Novel Cyclin-cdk2 Substrate Whose Expression Blocks S-Phase Progression.

C. Hall, D. M. Nelson, X. Ye, K. Baker, J. A. DeCaprio, S. Seeholzer, M. Lipinski, and P. D. Adams (2001)
Mol. Cell. Biol. 21, 1854-1865
 |  Abstract »  |  Full Text »

Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells.

C. A. Ghiani and V. Gallo (2001)
J. Neurosci. 21, 1274-1282
 |  Abstract »  |  Full Text »  |  PDF »

Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 Function.

J. S. Foster, D. C. Henley, A. Bukovsky, P. Seth, and J. Wimalasena (2001)
Mol. Cell. Biol. 21, 794-810
 |  Abstract »  |  Full Text »

Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27Kip1 and inactivation of cdk2 kinase.

F. F. Hsieh, L. A. Barnett, W. F. Green, K. Freedman, I. Matushansky, A. I. Skoultchi, and L. L. Kelley (2000)
Blood 96, 2746-2754
 |  Abstract »  |  Full Text »  |  PDF »

Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important?.

F. M. Vaccarino (2000)
Neuroscientist 6, 338-352
 |  Abstract »  |  PDF »

Cell Cycle Control of Schwann Cell Proliferation: Role of Cyclin-Dependent Kinase-2.

R. Tikoo, G. Zanazzi, D. Shiffman, J. Salzer, and M. V. Chao (2000)
J. Neurosci. 20, 4627-4634
 |  Abstract »  |  Full Text »  |  PDF »

Arrest of G1-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription.

D. Guardavaccaro, G. Corrente, F. Covone, L. Micheli, I. D'Agnano, G. Starace, M. Caruso, and F. Tirone (2000)
Mol. Cell. Biol. 20, 1797-1815
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Cyclin D2 Overexpression and Lack of p27 Correlate Positively and Cyclin E Inversely with a Poor Prognosis in Gastric Cancer Cases.

Y. Takano, Y. Kato, P. J. van Diest, M. Masuda, H. Mitomi, and I. Okayasu (2000)
Am. J. Pathol. 156, 585-594
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Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity.

H. Nagahara, S. A. Ezhevsky, A. M. Vocero-Akbani, P. Kaldis, M. J. Solomon, and S. F. Dowdy (1999)
PNAS 96, 14961-14966
 |  Abstract »  |  Full Text »  |  PDF »

Cdc2 and Cdk2 Kinase Activated by Transforming Growth Factor-beta 1 Trigger Apoptosis through the Phosphorylation of Retinoblastoma Protein in FaO Hepatoma Cells.

K. S. Choi, Y. W. Eom, Y. Kang, M. J. Ha, H. Rhee, J.-W. Yoon, and S.-J. Kim (1999)
J. Biol. Chem. 274, 31775-31783
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta}2 in Aqueous Humor Suppresses S-Phase Entry in Cultured Corneal Endothelial Cells.

K.-H. Chen, D. L. Harris, and N. C. Joyce (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2513-2519
 |  Abstract »  |  Full Text »  |  PDF »

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

J. D. Singer, M. Gurian-West, B. Clurman, and J. M. Roberts (1999)
Genes & Dev. 13, 2375-2387
 |  Abstract »  |  Full Text »

Myc Downregulation by Transforming Growth Factor beta Required for Activation of the p15Ink4b G1 Arrest Pathway.

B. J. Warner, S. W. Blain, J. Seoane, and J. Massague (1999)
Mol. Cell. Biol. 19, 5913-5922
 |  Abstract »  |  Full Text »  |  PDF »

TGF-beta 1-mediated hypertrophy involves inhibiting pRB phosphorylation by blocking activation of cyclin E kinase.

B. Liu and P. Preisig (1999)
Am J Physiol Renal Physiol 277, F186-F194
 |  Abstract »  |  Full Text »  |  PDF »

CDK inhibitors: positive and negative regulators of G1-phase progression.

C. J. Sherr and J. M. Roberts (1999)
Genes & Dev. 13, 1501-1512
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Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.

P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
 |  Abstract »  |  Full Text »  |  PDF »

Bovine Papillomavirus E2 Protein Activates a Complex Growth-inhibitory Program in p53-negative HT-3 Cervical Carcinoma Cells that Includes Repression of Cyclin A and cdc25A Phosphatase Genes and Accumulation of Hypophosphorylated Retinoblastoma Protein.

L. K. Naeger, E. C. Goodwin, E.-S. Hwang, R. A. DeFilippis, H. Zhang, and D. DiMaio (1999)
Cell Growth Differ. 10, 413-422
 |  Abstract »  |  Full Text »

sst2 Somatostatin Receptor Mediates Cell Cycle Arrest and Induction of p27Kip1. EVIDENCE FOR THE ROLE OF SHP-1.

P. Pages, N. Benali, N. Saint-Laurent, J.-P. Esteve, A. V. Schally, J. Tkaczuk, N. Vaysse, C. Susini, and L. Buscail (1999)
J. Biol. Chem. 274, 15186-15193
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Releases Mink Epithelial Cells from Transforming Growth Factor beta 1-Induced Growth Arrest by Restoring Cdk6 Expression and Cyclin E-Associated Cdk2 Activity.

M. Tsubari, J. Taipale, E. Tiihonen, J. Keski-Oja, and M. Laiho (1999)
Mol. Cell. Biol. 19, 3654-3663
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of a Regulatory Motif That Controls the Exposure of Specific Upstream Cyclin-dependent Kinase Sites That Determine Both Conformation and Growth Suppressing Activity of pRb.

B. Driscoll, A. T'Ang, Y.-H. Hu, C. L. Yan, Y. Fu, Y. Luo, K. J. Wu, S. Wen, X.-H. Shi, L. Barsky, et al. (1999)
J. Biol. Chem. 274, 9463-9471
 |  Abstract »  |  Full Text »  |  PDF »

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras.

M. Kretzschmar, J. Doody, I. Timokhina, and J. Massagué (1999)
Genes & Dev. 13, 804-816
 |  Abstract »  |  Full Text »

Regulation of Exit from Quiescence by p27 and Cyclin D1-CDK4.

M. H. Ladha, K. Y. Lee, T. M. Upton, M. F. Reed, and M. E. Ewen (1998)
Mol. Cell. Biol. 18, 6605-6615
 |  Abstract »  |  Full Text »

Control of Cyclin D1, p27Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension.

S. Huang, C. S. Chen, and D. E. Ingber (1998)
Mol. Biol. Cell 9, 3179-3193
 |  Abstract »  |  Full Text »

Cardiac Fibroblasts Arrest at the G1/S Restriction Point in Response to Interleukin (IL)-1beta . EVIDENCE FOR IL-1beta -INDUCED HYPOPHOSPHORYLATION OF THE RETINOBLASTOMA PROTEIN.

F. Koudssi, J. E. Lopez, S. Villegas, and C. S. Long (1998)
J. Biol. Chem. 273, 25796-25803
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta} Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes.

J. J. Bright and S. Sriram (1998)
J. Immunol. 161, 1772-1777
 |  Abstract »  |  Full Text »  |  PDF »

Protein Expression of the Cell-Cycle Inhibitor p27Kip1 in Malignant Melanoma : Inverse Correlation with Disease-Free Survival.

V. A. Florenes, G. M. Mælandsmo, R. S. Kerbel, J. M. Slingerland, J. M. Nesland, and R. Holm (1998)
Am. J. Pathol. 153, 305-312
 |  Abstract »  |  Full Text »  |  PDF »

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability.

S. Hashemolhosseini, Y. Nagamine, S. J. Morley, S. Desrivieres, L. Mercep, and S. Ferrari (1998)
J. Biol. Chem. 273, 14424-14429
 |  Abstract »  |  Full Text »  |  PDF »

Astrocyte Progression from G1 to S Phase of the Cell Cycle Depends upon Multiple Protein Interaction.

A. Pedram, M. Razandi, R.-M. Hu, and E. R. Levin (1998)
J. Biol. Chem. 273, 13966-13972
 |  Abstract »  |  Full Text »  |  PDF »

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).

M. Cheng, V. Sexl, C. J. Sherr, and M. F. Roussel (1998)
PNAS 95, 1091-1096
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E.

L. G. Martin, G. W. Demers, and D. A. Galloway (1998)
J. Virol. 72, 975-985
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta}1 Induces the Cyclin-Dependent Kinase Inhibitor p27Kip1 mRNA and Protein in Murine B Cells.

H. Kamesaki, K. Nishizawa, G. Y. Michaud, J. Cossman, and T. Kiyono (1998)
J. Immunol. 160, 770-777
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor beta  Stimulates the Human Immunodeficiency Virus 1 Enhancer and Requires NF-kappa B Activity.

J.-M. Li, X. Shen, P. P.-C. Hu, and X.-F. Wang (1998)
Mol. Cell. Biol. 18, 110-121
 |  Abstract »  |  Full Text »

Complex Regulation of CDK2 During Phorbol Ester-Induced Hematopoietic Differentiation.

C. Asiedu, J. Biggs, and A. S. Kraft (1997)
Blood 90, 3430-3437
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin E-CDK2 is a regulator of p27Kip1..

R J Sheaff, M Groudine, M Gordon, J M Roberts, and B E Clurman (1997)
Genes & Dev. 11, 1464-1478
 |  Abstract »  |  PDF »

2-Aminopurine Unravels a Role for pRB in the Regulation of Gene Expression by Transforming Growth Factor beta.

G. Giannini, L. Di Marcotullio, F. Zazzeroni, E. Alesse, M. Zani, A. T'Ang, V. Sorrentino, I. Screpanti, L. Frati, and A. Gulino (1997)
J. Biol. Chem. 272, 5313-5319
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Different Mechanisms of Growth Inhibition of T-cell Lymphoma by Phorbol Esters and Concanavalin A.

S. Desrivieres, S. Desrivières, and S. Ferrari (1997)
J. Biol. Chem. 272, 2470-2476
 |  Abstract »  |  Full Text »  |  PDF »

Expression of p24, a novel p21Waf1/Cip1/Sdi1-related protein, correlates with measurement of the finite proliferative potential of rodent embryo fibroblasts.

G. R. Mazars and P. S. Jat (1997)
PNAS 94, 151-156
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Cyclin-dependent Kinase 2and p27kip1 Accompany Glial Cell Differentiation of Central Glia-4 Cells.

R. Tikoo, P. Casaccia-Bonnefil, M. V. Chao, and A. Koff (1997)
J. Biol. Chem. 272, 442-447
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Activation of the Human p21WAF1/CIP1 Gene by Retinoic Acid Receptor. CORRELATION WITH RETINOID INDUCTION OF U937 CELL DIFFERENTIATION.

M. Liu, A. Iavarone, and LeonardP. Freedman (1996)
J. Biol. Chem. 271, 31723-31728
 |  Abstract »  |  Full Text »  |  PDF »

Altered Regulation of G1 Cyclins in Oxidant-induced Growth Arrest of Lung Alveolar Epithelial Cells. ACCUMULATION OF INACTIVE CYCLIN E-CDK2 COMPLEXES.

S. Corroyer, B. Maitre, V. Cazals, and A. Clement (1996)
J. Biol. Chem. 271, 25117-25125
 |  Abstract »  |  Full Text »  |  PDF »

Altered Transforming Growth Factor beta Signaling in Epithelial Cells when Ras Activation Is Blocked.

M. T. Hartsough, R. S. Frey, P. A. Zipfel, A. Buard, S. J. Cook, F. McCormick, and K. M. Mulder (1996)
J. Biol. Chem. 271, 22368-22375
 |  Abstract »  |  Full Text »  |  PDF »

Fetuin/alpha 2-HS Glycoprotein Is a Transforming Growth Factor-beta Type II Receptor Mimic and Cytokine Antagonist.

M. Demetriou, C. Binkert, B. Sukhu, H. C. Tenenbaum, and J. W. Dennis (1996)
J. Biol. Chem. 271, 12755-12761
 |  Abstract »  |  Full Text »  |  PDF »

Differential Modulation of G(1) Cyclins and the Cdk Inhibitor p27[IMAGE] by Platelet-derived Growth Factor and Plasma Factors in Density-arrested Fibroblasts.

J. Winston, F. Dong, and W. J. Pledger (1996)
J. Biol. Chem. 271, 11253-11260
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol Ester Inhibits the Phosphorylation of the Retinoblastoma Protein without Suppressing Cyclin D-associated Kinase in Vascular Smooth Muscle Cells.

T. Sasaguri, A. Ishida, C. Kosaka, H. Nojima, and J. Ogata (1996)
J. Biol. Chem. 271, 8345-8351
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-beta1 Modulates p107 Function in Myeloid Cells.

O.-S. Bang, F. W. Ruscetti, M.-H. Lee, S.-J. Kim, and M. C. Birchenall-Roberts (1996)
J. Biol. Chem. 271, 7811-7819
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Releases Epithelial and Endothelial Cells from Growth Arrest Induced by Transforming Growth Factor-beta1.

J. Taipale and J. Keski-Oja (1996)
J. Biol. Chem. 271, 4342-4348
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937..

M Liu, M H Lee, M Cohen, M Bommakanti, and L P Freedman (1996)
Genes & Dev. 10, 142-153
 |  Abstract »  |  PDF »

Xenopus cyclin E, a nuclear phosphoprotein, accumulates when oocytes gain the ability to initiate DNA replication.

S Chevalier, A Couturier, I Chartrain, R Le Guellec, C Beckhelling, K Le Guellec, M Philippe, and C. Ford (1996)
J. Cell Sci. 109, 1173-1184
 |  Abstract »  |  PDF »

Functional Analysis of the Transforming Growth Factor beta Responsive Elements in the WAF1/Cip1/p21 Promoter.

M. B. Datto, Y. Yu, and X.-F. Wang (1995)
J. Biol. Chem. 270, 28623-28628
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-beta (TGF-beta)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-beta Receptor Complex.

X.-H. Feng, E. H. Filvaroff, and R. Derynck (1995)
J. Biol. Chem. 270, 24237-24245
 |  Abstract »  |  Full Text »  |  PDF »

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta..

I Reynisdottir, K Polyak, A Iavarone, and J Massague (1995)
Genes & Dev. 9, 1831-1845
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The DNA Binding Activity of C/EBP Transcription Factors Is Regulated in the G[IMAGE] Phase of the Hepatocyte Cell Cycle.

B. Rana, Y. Xie, D. Mischoulon, N. L. R. Bucher, and S. R. Farmer (1995)
J. Biol. Chem. 270, 18123-18132
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Involvement of Phosphatidylcholine-Phospholipase C and Protein Kinase C in Transforming Growth Factor-[IMAGE] Signaling.

J. Halstead, K. Kemp, and R. A. Ignotz (1995)
J. Biol. Chem. 270, 13600-13603
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitors of mammalian G1 cyclin-dependent kinases..

C J Sherr and J M Roberts (1995)
Genes & Dev. 9, 1149-1163
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Transforming Growth Factor beta Activation of p44[IMAGE] in Proliferating Cultures of Epithelial Cells.

M. T. Hartsough and K. M. Mulder (1995)
J. Biol. Chem. 270, 7117-7124
 |  Abstract »  |  Full Text »  |  PDF »

Maternal Xenopus Cdk2-Cyclin E Complexes Function during Meiotic and Early Embryonic Cell Cycles That Lack a G(1) Phase.

R. E. Rempel, S. B. Sleight, and J. L. Maller (1995)
J. Biol. Chem. 270, 6843-6855
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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution..

M H Lee, I Reynisdottir, and J Massague (1995)
Genes & Dev. 9, 639-649
 |  Abstract »  |  PDF »

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-beta Cytoinhibitory Effect.

C.-Y. Li, L. Suardet, and J. B. Little (1995)
J. Biol. Chem. 270, 4971-4974
 |  Abstract »  |  Full Text »  |  PDF »

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest..

M E Ewen, C J Oliver, H K Sluss, S J Miller, and D S Peeper (1995)
Genes & Dev. 9, 204-217
 |  Abstract »  |  PDF »

pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ cultures.

R Serra and H. Moses (1995)
Development 121, 3057-3066
 |  Abstract »  |  PDF »

Cell cycle control and cancer.

L. Hartwell and M. Kastan (1994)
Science 266, 1821-1828
 |  Abstract »  |  PDF »

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts..

A Di Leonardo, S P Linke, K Clarkin, and G M Wahl (1994)
Genes & Dev. 8, 2540-2551
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Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma..

A B Glick, M M Lee, N Darwiche, A B Kulkarni, S Karlsson, and S H Yuspa (1994)
Genes & Dev. 8, 2429-2440
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Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells.

C. Burger, M. Wick, and R. Muller (1994)
J. Cell Sci. 107, 2047-2054
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Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression..

D G Johnson, K Ohtani, and J R Nevins (1994)
Genes & Dev. 8, 1514-1525
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Initiation of growth inhibition by TGF beta 1 is unlikely to occur in G1.

I. Kramer, R Patel, D Spargo, and P Riley (1994)
J. Cell Sci. 107, 3469-3475
 |  Abstract »  |  PDF »

Developmental control of a G1-S transcriptional program in Drosophila.

R. Duronio and P. O'Farrell (1994)
Development 120, 1503-1515
 |  Abstract »  |  PDF »

The Cancer Cell and the Cell Cycle Clock.

M. Hatakeyama, R.A. Herrera, T. Makela, S.F. Dowdy, T. Jacks, and R.A. Weinberg (1994)
Cold Spring Harb Symp Quant Biol 59, 1-10
 |  Abstract »  |  PDF »

D-Type Cyclins and Their Cyclin-dependent Kinases: G1 Phase Integrators of the Mitogenic Response.

C.J. Sherr, J. Kato, D.E. Quelle, M. Matsuoka, and M.F. Roussel (1994)
Cold Spring Harb Symp Quant Biol 59, 11-19
 |  Abstract »  |  PDF »

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