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Science 16 April 1993:
Vol. 260. no. 5106, pp. 367 - 369
DOI: 10.1126/science.8469990
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Articles

Science, Vol 260, Issue 5106, 367-369
Copyright © 1993 by American Association for the Advancement of Science

articles

Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex

WQ Gao and ME Hatten

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

The migration of postmitotic neurons away from compact, germinal zones is a critical step in neuronal differentiation in the developing brain. To study the molecular signals necessary for cerebellar granule cell migration in situ, precursor cells from the neurological mutant mouse weaver, an animal with phenotypic defects in migration, were implanted into the external germinal layer (EGL) of wild-type cerebellar cortex. In this region, labeled weaver precursor cells of the EGL progressed through all stages of granule neuron differentiation, including the extension of parallel fibers, migration through the molecular and Purkinje cell layers, positioning in the internal granule cell layer, and extension of dendrites. Thus, the weaver gene acts nonautonomously in vivo, and local cell interactions may induce early steps in neuronal differentiation that are required for granule cell migration.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear Factor I Coordinates Multiple Phases of Cerebellar Granule Cell Development via Regulation of Cell Adhesion Molecules.
W. Wang, D. Mullikin-Kilpatrick, J. E. Crandall, R. M. Gronostajski, E. D. Litwack, and D. L. Kilpatrick (2007)
J. Neurosci. 27, 6115-6127
   Abstract »    Full Text »    PDF »
The Inwardly Rectifying K+ Channel Subunit GIRK1 Rescues the GIRK2 weaver Phenotype.
P. Hou, S. Yan, W. Tang, and D. J. Nelson (1999)
J. Neurosci. 19, 8327-8336
   Abstract »    Full Text »    PDF »
Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.
D. Vaudry, B. J. Gonzalez, M. Basille, A. Fournier, and H. Vaudry (1999)
PNAS 96, 9415-9420
   Abstract »    Full Text »    PDF »
Migration Defects of cdk5-/- Neurons in the Developing Cerebellum is Cell Autonomous.
T. Ohshima, E. C. Gilmore, G. Longenecker, D. M. Jacobowitz, R. O. Brady, K. Herrup, and A. B. Kulkarni (1999)
J. Neurosci. 19, 6017-6026
   Abstract »    Full Text »    PDF »
The weaver Mutation Causes a Loss of Inward Rectifier Current Regulation in Premigratory Granule Cells of the Mouse Cerebellum.
P. Rossi, G. De Filippi, S. Armano, V. Taglietti, and E. D'Angelo (1998)
J. Neurosci. 18, 3537-3547
   Abstract »    Full Text »    PDF »
Mutations affecting development of the zebrafish retina.
J Malicki, S. Neuhauss, A. Schier, L Solnica-Krezel, D. Stemple, D. Stainier, S Abdelilah, F Zwartkruis, Z Rangini, and W Driever (1996)
Development 123, 263-273
   Abstract »    PDF »
Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation..
A E Mjaatvedt, D E Cabin, S E Cole, L J Long, G E Breitwieser, and R H Reeves (1995)
Genome Res. 5, 453-463
   Abstract »    PDF »
Striatal precursors adopt cortical identities in response to local cues.
G Fishell (1995)
Development 121, 803-812
   Abstract »    PDF »


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