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Science 9 April 1993:
Vol. 260. no. 5105, pp. 229 - 232
DOI: 10.1126/science.8385801
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Articles

Science, Vol 260, Issue 5105, 229-232
Copyright © 1993 by American Association for the Advancement of Science

articles

Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx

S Girard and D Clapham

Department of Pharmacology, Mayo Foundation, Rochester, MN 55905.

Many cell membrane receptors stimulate the phosphoinositide (PI) cycle, which produces complex intracellular calcium signals that regulate diverse processes such as secretion and transcription. A major messenger of this cycle, inositol 1,4,5-triphosphate (IP3), stimulates its receptor channel on the endoplasmic reticulum to release calcium into the cytosol. Activation of the PI cycle also induces calcium influx, which refills the intracellular calcium stores. Confocal microscopy was used to show that receptor-activated calcium influx, enhanced by hyperpolarization, modulates the frequency and velocity of IP3-dependent calcium waves in Xenopus laevis oocytes. These results demonstrate that transmembrane voltage and calcium influx pathways may regulate spatial and temporal patterns of IP3-dependent calcium release.


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