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Science 2 April 1993:
Vol. 260. no. 5104, pp. 98 - 100
DOI: 10.1126/science.7682013
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Articles

Science, Vol 260, Issue 5104, 98-100
Copyright © 1993 by American Association for the Advancement of Science

articles

HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population

PO de Campos-Lima, R Gavioli, QJ Zhang, LE Wallace, R Dolcetti, M Rowe, AB Rickinson, and MG Masucci

Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.

Cytotoxic T lymphocytes (CTLs) control viral infections by recognizing viral peptides presented by major histocompatibility complex (MHC) class I molecules. Human leukocyte antigen (HLA)-A11-restricted CTLs that recognize peptide residues 416 to 424 of the Epstein-Barr virus (EBV) nuclear antigen-4 frequently dominate EBV-induced responses in A11+ Caucasian donors. This epitope is conserved in type A EBV strains from Caucasians and central African populations, where A11 is relatively infrequent. However, strains from highly A11+ populations in New Guinea carry a lysine-to-threonine mutation at residue 424 that abrogates CTL recognition and binding of the peptide to nascent A11 molecules. The results suggest that evolution of a widespread and genetically stable virus such as EBV is influenced by pressure from MHC-restricted CTL responses.


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