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Science 2 April 1993: Vol. 260. no. 5104, pp. 95 - 97 DOI: 10.1126/science.8096653
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Articles
Science, Vol 260, Issue 5104, 95-97
Copyright © 1993 by American Association for the Advancement of Science
Modulation of neuronal migration by NMDA receptors
H Komuro
and
P Rakic
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is essential for neuronal differentiation and establishment or elimination of synapses in a developing brain. The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations of the developing mouse cerebellum. First, blockade of NMDA receptors by specific antagonists resulted in the curtailment of cell migration. Second, enhancement of NMDA receptor activity by the removal of magnesium or by the application of glycine increased the rate of cell movement. Third, increase of endogenous extracellular glutamate by inhibition of its uptake accelerated the rate of cell migration. These results suggest that NMDA receptors may play an early role in the regulation of calcium-dependent cell migration before neurons reach their targets and form synaptic contacts.
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- Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons.
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- Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse.
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- Functional Change of NMDA Receptors Related to Enhancement of Susceptibility to Neurotoxicity in the Developing Pontine Nucleus.
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- Immediate and long-term effects of neonatal MK-801 treatment on nonspatial learning.
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- Spontaneous activity regulates calcium-dependent K+ current expression in developing ascidian muscle.
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- Glutamate Transporter GLT-1 Is Transiently Localized on Growing Axons of the Mouse Spinal Cord before Establishing Astrocytic Expression.
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- Involvement of Receptor-like Protein Tyrosine Phosphatase zeta /RPTPbeta and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration.
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- Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development.
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- AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
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- The weaver Mutation Causes a Loss of Inward Rectifier Current Regulation in Premigratory Granule Cells of the Mouse Cerebellum.
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