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Science 2 April 1993:
Vol. 260. no. 5104, pp. 95 - 97
DOI: 10.1126/science.8096653

Articles

Science, Vol 260, Issue 5104, 95-97
Copyright © 1993 by American Association for the Advancement of Science


articles

Modulation of neuronal migration by NMDA receptors

H Komuro and P Rakic

Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.

The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is essential for neuronal differentiation and establishment or elimination of synapses in a developing brain. The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations of the developing mouse cerebellum. First, blockade of NMDA receptors by specific antagonists resulted in the curtailment of cell migration. Second, enhancement of NMDA receptor activity by the removal of magnesium or by the application of glycine increased the rate of cell movement. Third, increase of endogenous extracellular glutamate by inhibition of its uptake accelerated the rate of cell migration. These results suggest that NMDA receptors may play an early role in the regulation of calcium-dependent cell migration before neurons reach their targets and form synaptic contacts.


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Glutamate Transporter GLT-1 Is Transiently Localized on Growing Axons of the Mouse Spinal Cord before Establishing Astrocytic Expression.
K. Yamada, M. Watanabe, T. Shibata, M. Nagashima, K. Tanaka, and Y. Inoue (1998)
J. Neurosci. 18, 5706-5713
   Abstract »    Full Text »    PDF »
Involvement of Receptor-like Protein Tyrosine Phosphatase {zeta}/RPTP{beta} and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration.
N. Maeda and M. Noda (1998)
J. Cell Biol. 142, 203-216
   Abstract »    Full Text »    PDF »
Potentiation of GABAergic synaptic transmission by AMPA receptors in mouse cerebellar stellate cells: changes during development.
I. Bureau and C. Mulle (1998)
J. Physiol. 509, 817-831
   Abstract »    Full Text »    PDF »
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
E. L. Gleason and N. C. Spitzer (1998)
J Neurophysiol 79, 2986-2998
   Abstract »    Full Text »    PDF »
G Protein-Mediated Inhibition of Neuronal Migration Requires Calcium Influx.
A. M. Horgan and P. F. Copenhaver (1998)
J. Neurosci. 18, 4189-4200
   Abstract »    Full Text »    PDF »



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