Science 2 April 1993: Vol. 260. no. 5104, pp. 88 - 91 DOI: 10.1126/science.8385367

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Articles

Intracellular Phospholipase A1{gamma} (iPLA1{gamma}) Is a Novel Factor Involved in Coat Protein Complex I- and Rab6-independent Retrograde Transport between the Endoplasmic Reticulum and the Golgi Complex.

R. K. Morikawa, J. Aoki, F. Kano, M. Murata, A. Yamamoto, M. Tsujimoto, and H. Arai (2009)
J. Biol. Chem. 284, 26620-26630
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide Signaling: New Tools and Insights.

T. Balla, Z. Szentpetery, and Y. J. Kim (2009)
Physiology 24, 231-244
 |  Abstract »  |  Full Text »  |  PDF »

Wortmannin induces homotypic fusion of plant prevacuolar compartments.

J. Wang, Y. Cai, Y. Miao, S. K. Lam, and L. Jiang (2009)
J. Exp. Bot. 60, 3075-3083
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease.

H. J. McCrea and P. De Camilli (2009)
Physiology 24, 8-16
 |  Abstract »  |  Full Text »  |  PDF »

A C-terminal Sequence in the Guanine Nucleotide Exchange Factor Sec7 Mediates Golgi Association and Interaction with the Rsp5 Ubiquitin Ligase.

D. A. K. Dehring, A. S. Adler, A. Hosseini, and L. Hicke (2008)
J. Biol. Chem. 283, 34188-34196
 |  Abstract »  |  Full Text »  |  PDF »

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG.

E. Itakura, C. Kishi, K. Inoue, and N. Mizushima (2008)
Mol. Biol. Cell 19, 5360-5372
 |  Abstract »  |  Full Text »  |  PDF »

A Trypanosoma cruzi Phosphatidylinositol 3-Kinase (TcVps34) Is Involved in Osmoregulation and Receptor-mediated Endocytosis.

A. C. Schoijet, K. Miranda, W. Girard-Dias, W. de Souza, M. M. Flawia, H. N. Torres, R. Docampo, and G. D. Alonso (2008)
J. Biol. Chem. 283, 31541-31550
 |  Abstract »  |  Full Text »  |  PDF »

The Arabidopsis Phosphatidylinositol 3-Kinase Is Important for Pollen Development.

Y. Lee, E.-S. Kim, Y. Choi, I. Hwang, C. J. Staiger, Y.-Y. Chung, and Y. Lee (2008)
Plant Physiology 147, 1886-1897
 |  Abstract »  |  Full Text »  |  PDF »

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae..

K. Obara, T. Noda, K. Niimi, and Y. Ohsumi (2008)
Genes Cells 13, 537-547
 |  Abstract »  |  Full Text »  |  PDF »

SHIP-1 Increases Early Oxidative Burst and Regulates Phagosome Maturation in Macrophages.

L. A. Kamen, J. Levinsohn, A. Cadwallader, S. Tridandapani, and J. A. Swanson (2008)
J. Immunol. 180, 7497-7505
 |  Abstract »  |  Full Text »  |  PDF »

The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit.

L. Demmel, M. Gravert, E. Ercan, B. Habermann, T. Muller-Reichert, V. Kukhtina, V. Haucke, T. Baust, M. Sohrmann, Y. Kalaidzidis, et al. (2008)
Mol. Biol. Cell 19, 1991-2002
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis in the Shiitake Mushroom Lentinula edodes and Involvement of GTPase LeRAB7.

M. T. Lee, C. Y. Y. Szeto, T. P. Ng, and H. S. Kwan (2007)
Eukaryot. Cell 6, 2406-2418
 |  Abstract »  |  Full Text »  |  PDF »

Schizosaccharomyces pombe Sst4p, a Conserved Vps27/Hrs Homolog, Functions Downstream of Phosphatidylinositol 3-Kinase Pik3p To Mediate Proper Spore Formation.

M. Onishi, M. Iida, T. Koga, S. Yamada, A. Hirata, T. Iwaki, K. Takegawa, Y. Fukui, and H. Tachikawa (2007)
Eukaryot. Cell 6, 2343-2353
 |  Abstract »  |  Full Text »  |  PDF »

Atg18 Regulates Organelle Morphology and Fab1 Kinase Activity Independent of Its Membrane Recruitment by Phosphatidylinositol 3,5-Bisphosphate.

J. A. Efe, R. J. Botelho, and S. D. Emr (2007)
Mol. Biol. Cell 18, 4232-4244
 |  Abstract »  |  Full Text »  |  PDF »

Imaging and manipulating phosphoinositides in living cells.

T. Balla (2007)
J. Physiol. 582, 927-937
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that a wortmannin-sensitive signal transduction pathway regulates aflatoxin biosynthesis.

J.-W. Lee, L. V. Roze, and J. E. Linz (2007)
Mycologia 99, 562-568
 |  Abstract »  |  Full Text »  |  PDF »

Traffic to the Malaria Parasite Food Vacuole: A NOVEL PATHWAY INVOLVING A PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING PROTEIN.

M. T. McIntosh, A. Vaid, H. D. Hosgood, J. Vijay, A. Bhattacharya, M. H. Sahani, P. Baevova, K. A. Joiner, and P. Sharma (2007)
J. Biol. Chem. 282, 11499-11508
 |  Abstract »  |  Full Text »  |  PDF »

Rice SCAMP1 Defines Clathrin-Coated, trans-Golgi-Located Tubular-Vesicular Structures as an Early Endosome in Tobacco BY-2 Cells.

S. K. Lam, C. L. Siu, S. Hillmer, S. Jang, G. An, D. G. Robinson, and L. Jiang (2007)
PLANT CELL 19, 296-319
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 4-Phosphate Is Required for Translation Initiation in Saccharomyces cerevisiae.

E. Cameroni, C. De Virgilio, and O. Deloche (2006)
J. Biol. Chem. 281, 38139-38149
 |  Abstract »  |  Full Text »  |  PDF »

Rabs and their effectors: Achieving specificity in membrane traffic.

B. L. Grosshans, D. Ortiz, and P. Novick (2006)
PNAS 103, 11821-11827
 |  Abstract »  |  Full Text »  |  PDF »

Arf6-independent GPI-anchored Protein-enriched Early Endosomal Compartments Fuse with Sorting Endosomes via a Rab5/Phosphatidylinositol-3'-Kinase-dependent Machinery.

M. Kalia, S. Kumari, R. Chadda, M. M. Hill, R. G. Parton, and S. Mayor (2006)
Mol. Biol. Cell 17, 3689-3704
 |  Abstract »  |  Full Text »  |  PDF »

Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes.

E. E. Johnson, J. H. Overmeyer, W. T. Gunning, and W. A. Maltese (2006)
J. Cell Sci. 119, 1219-1232
 |  Abstract »  |  Full Text »  |  PDF »

Assortment of Phosphatidylinositol 3-Kinase Complexes--Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure in Saccharomyces cerevisiae.

K. Obara, T. Sekito, and Y. Ohsumi (2006)
Mol. Biol. Cell 17, 1527-1539
 |  Abstract »  |  Full Text »  |  PDF »

The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase.

P. M. Kane (2006)
Microbiol. Mol. Biol. Rev. 70, 177-191
 |  Abstract »  |  Full Text »  |  PDF »

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

A. Yamamoto, M. L. Cremona, and J. E. Rothman (2006)
J. Cell Biol. 172, 719-731
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of membrane traffic by phosphoinositide 3-kinases.

K. Lindmo and H. Stenmark (2006)
J. Cell Sci. 119, 605-614
 |  Abstract »  |  Full Text »  |  PDF »

PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway.

W. R. Parrish, C. J. Stefan, and S. D. Emr (2005)
J. Cell Sci. 118, 5589-5601
 |  Abstract »  |  Full Text »  |  PDF »

The Phosphoinositide-3-phosphatase MTMR2 Associates with MTMR13, a Membrane-associated Pseudophosphatase Also Mutated in Type 4B Charcot-Marie-Tooth Disease.

F. L. Robinson and J. E. Dixon (2005)
J. Biol. Chem. 280, 31699-31707
 |  Abstract »  |  Full Text »  |  PDF »

A Genomic Screen for Yeast Vacuolar Membrane ATPase Mutants.

M. Sambade, M. Alba, A. M. Smardon, R. W. West, and P. M. Kane (2005)
Genetics 170, 1539-1551
 |  Abstract »  |  Full Text »  |  PDF »

A Sorting Nexin PpAtg24 Regulates Vacuolar Membrane Dynamics during Pexophagy via Binding to Phosphatidylinositol-3-Phosphate.

Y. Ano, T. Hattori, M. Oku, H. Mukaiyama, M. Baba, Y. Ohsumi, N. Kato, and Y. Sakai (2005)
Mol. Biol. Cell 16, 446-457
 |  Abstract »  |  Full Text »  |  PDF »

Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans.

J. Gunther, M. Nguyen, A. Hartl, W. Kunkel, P. F. Zipfel, and R. Eck (2005)
Microbiology 151, 81-89
 |  Abstract »  |  Full Text »  |  PDF »

The 15-Amino Acid Motif of the C Terminus of the {beta}2-Adrenergic Receptor Is Sufficient to Confer Insulin-Stimulated Counterregulation to the {beta}1-Adrenergic Receptor.

S. Gavi, D. Yin, E. Shumay, H.-y. Wang, and C. C. Malbon (2005)
Endocrinology 146, 450-457
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Salvage from the Prevacuolar Compartment Is Essential for Efficient Vacuolar Protein Targeting.

L. L.P. daSilva, J. P. Taylor, J. L. Hadlington, S. L. Hanton, C. J. Snowden, S. J. Fox, O. Foresti, F. Brandizzi, and J. Denecke (2005)
PLANT CELL 17, 132-148
 |  Abstract »  |  Full Text »  |  PDF »

Atg21 Is Required for Effective Recruitment of Atg8 to the Preautophagosomal Structure during the Cvt Pathway.

K. Meiling-Wesse, H. Barth, C. Voss, E.-L. Eskelinen, U. D. Epple, and M. Thumm (2004)
J. Biol. Chem. 279, 37741-37750
 |  Abstract »  |  Full Text »  |  PDF »

SMG-1 Is a Phosphatidylinositol Kinase-Related Protein Kinase Required for Nonsense-Mediated mRNA Decay in Caenorhabditis elegans.

A. Grimson, S. O'Connor, C. L. Newman, and P. Anderson (2004)
Mol. Cell. Biol. 24, 7483-7490
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for the Myotubularin-related Phosphatase Ymr1p and the Synaptojanin-like Phosphatases Sjl2p and Sjl3p in Regulation of Phosphatidylinositol 3-Phosphate in Yeast.

W. R. Parrish, C. J. Stefan, and S. D. Emr (2004)
Mol. Biol. Cell 15, 3567-3579
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositides in Constitutive Membrane Traffic.

M. G. Roth (2004)
Physiol Rev 84, 699-730
 |  Abstract »  |  Full Text »  |  PDF »

Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.

T. Koga, M. Onishi, Y. Nakamura, A. Hirata, T. Nakamura, C. Shimoda, T. Iwaki, K. Takegawa, and Y. Fukui (2004)
Genes Cells 9, 561-574
 |  Abstract »  |  Full Text »  |  PDF »

PtdIns-specific MPR Pathway Association of a Novel WD40 Repeat Protein, WIPI49.

T. R. Jeffries, S. K. Dove, R. H. Michell, and P. J. Parker (2004)
Mol. Biol. Cell 15, 2652-2663
 |  Abstract »  |  Full Text »  |  PDF »

Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly in Saccharomyces cerevisiae.

F. Reggiori, C.-W. Wang, U. Nair, T. Shintani, H. Abeliovich, and D. J. Klionsky (2004)
Mol. Biol. Cell 15, 2189-2204
 |  Abstract »  |  Full Text »  |  PDF »

The p21-activated Protein Kinase-related Kinase Cla4 Is a Coincidence Detector of Signaling by Cdc42 and Phosphatidylinositol 4-Phosphate.

A. C. Wild, J. W. Yu, M. A. Lemmon, and K. J. Blumer (2004)
J. Biol. Chem. 279, 17101-17110
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Multivesicular Bodies as Prevacuolar Compartments in Nicotiana tabacum BY-2 Cells.

Y. C. Tse, B. Mo, S. Hillmer, M. Zhao, S. W. Lo, D. G. Robinson, and L. Jiang (2004)
PLANT CELL 16, 672-693
 |  Abstract »  |  Full Text »  |  PDF »

Autophagy regulates the processing of amino terminal huntingtin fragments.

Z.-H. Qin, Y. Wang, K. B. Kegel, A. Kazantsev, B. L. Apostol, L. M. Thompson, J. Yoder, N. Aronin, and M. DiFiglia (2003)
Hum. Mol. Genet. 12, 3231-3244
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Phosphatase in Muscle Cell Lines: Involvement of PtdIns(3)P in Insulin-Stimulated Glucose Transport.

C. Chaussade, L. Pirola, S. Bonnafous, F. Blondeau, S. Brenz-Verca, H. Tronchere, F. Portis, S. Rusconi, B. Payrastre, J. Laporte, et al. (2003)
Mol. Endocrinol. 17, 2448-2460
 |  Abstract »  |  Full Text »  |  PDF »

Ephrin-B2 Induces Migration of Endothelial Cells Through the Phosphatidylinositol-3 Kinase Pathway and Promotes Angiogenesis in Adult Vasculature.

H. Maekawa, Y. Oike, S. Kanda, Y. Ito, Y. Yamada, H. Kurihara, R. Nagai, and T. Suda (2003)
Arterioscler Thromb Vasc Biol 23, 2008-2014
 |  Abstract »  |  Full Text »  |  PDF »

PIKfyve Controls Fluid Phase Endocytosis but Not Recycling/Degradation of Endocytosed Receptors or Sorting of Procathepsin D by Regulating Multivesicular Body Morphogenesis.

O. C. Ikonomov, D. Sbrissa, M. Foti, J.-L. Carpentier, and A. Shisheva (2003)
Mol. Biol. Cell 14, 4581-4591
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Analysis of the Myotubularin Family of Phosphatases in Caenorhabditis elegans.

Y. Xue, H. Fares, B. Grant, Z. Li, A. M. Rose, S. G. Clark, and E. Y. Skolnik (2003)
J. Biol. Chem. 278, 34380-34386
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a Role of SNX16 in Regulating Traffic between the Early and Later Endosomal Compartments.

B. J. Hanson and W. Hong (2003)
J. Biol. Chem. 278, 34617-34630
 |  Abstract »  |  Full Text »  |  PDF »

Vps27 recruits ESCRT machinery to endosomes during MVB sorting.

D. J. Katzmann, C. J. Stefan, M. Babst, and S. D. Emr (2003)
J. Cell Biol. 162, 413-423
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial movement and positioning in axons: the role of growth factor signaling.

S. R. Chada and P. J. Hollenbeck (2003)
J. Exp. Biol. 206, 1985-1992
 |  Abstract »  |  Full Text »  |  PDF »

The Saccharomyces cerevisiae LSB6 Gene Encodes Phosphatidylinositol 4-Kinase Activity.

G.-S. Han, A. Audhya, D. J. Markley, S. D. Emr, and G. M. Carman (2002)
J. Biol. Chem. 277, 47709-47718
 |  Abstract »  |  Full Text »  |  PDF »

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.

P. Burda, S. M. Padilla, S. Sarkar, and S. D. Emr (2002)
J. Cell Sci. 115, 3889-3900
 |  Abstract »  |  Full Text »  |  PDF »

Inositol Phospholipid Metabolism in Arabidopsis. Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C.

B. Mueller-Roeber and C. Pical (2002)
Plant Physiology 130, 22-46
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein.

S. Hayashi, T. Okada, N. Igarashi, T. Fujita, S. Jahangeer, and S.-i. Nakamura (2002)
J. Biol. Chem. 277, 33319-33324
 |  Abstract »  |  Full Text »  |  PDF »

Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy.

A. E. Wurmser and S. D. Emr (2002)
J. Cell Biol. 158, 761-772
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Binding of the Cytoplasm to Vacuole Targeting Pathway Proteins, Cvt13 and Cvt20, to Phosphatidylinositol 3-Phosphate at the Pre-autophagosomal Structure Is Required for Selective Autophagy.

D. C. Nice, T. K. Sato, P. E. Stromhaug, S. D. Emr, and D. J. Klionsky (2002)
J. Biol. Chem. 277, 30198-30207
 |  Abstract »  |  Full Text »  |  PDF »

Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor.

L. Hunyady, A. J. Baukal, Z. Gaborik, J. A. Olivares-Reyes, M. Bor, M. Szaszak, R. Lodge, K. J. Catt, and T. Balla (2002)
J. Cell Biol. 157, 1211-1222
 |  Abstract »  |  Full Text »  |  PDF »

Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.

P. Berger, S. Bonneick, S. Willi, M. Wymann, and U. Suter (2002)
Hum. Mol. Genet. 11, 1569-1579
 |  Abstract »  |  Full Text »  |  PDF »

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

C. J. Bonangelino, J. J. Nau, J. E. Duex, M. Brinkman, A. E. Wurmser, J. D. Gary, S. D. Emr, and L. S. Weisman (2002)
J. Cell Biol. 156, 1015-1028
 |  Abstract »  |  Full Text »  |  PDF »

Functional Dissection of Lipid and Protein Kinase Signals of PIKfyve Reveals the Role of PtdIns 3,5-P2 Production for Endomembrane Integrity.

O. C. Ikonomov, D. Sbrissa, K. Mlak, M. Kanzaki, J. Pessin, and A. Shisheva (2002)
J. Biol. Chem. 277, 9206-9211
 |  Abstract »  |  Full Text »  |  PDF »

The C Terminus of the Vps34p Phosphoinositide 3-Kinase Is Necessary and Sufficient for the Interaction with the Vps15p Protein Kinase.

Y. V. Budovskaya, H. Hama, D. B. DeWald, and P. K. Herman (2002)
J. Biol. Chem. 277, 287-294
 |  Abstract »  |  Full Text »

Location, Location, Location: Membrane Targeting Directed by PX Domains.

T. K. Sato, M. Overduin, and S. D. Emr (2001)
Science 294, 1881-1885
 |  Abstract »  |  Full Text »  |  PDF »

Autophagy in Yeast: Mechanistic Insights and Physiological Function.

H. Abeliovich and D. J. Klionsky (2001)
Microbiol. Mol. Biol. Rev. 65, 463-479
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Phosphoinositide Metabolism, Akt Phosphorylation, and Glucose Transport by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) in 3T3-L1 Adipocytes.

H. Ono, H. Katagiri, M. Funaki, M. Anai, K. Inukai, Y. Fukushima, H. Sakoda, T. Ogihara, Y. Onishi, M. Fujishiro, et al. (2001)
Mol. Endocrinol. 15, 1411-1422
 |  Abstract »  |  Full Text »  |  PDF »

Sac1 Lipid Phosphatase and Stt4 Phosphatidylinositol 4-Kinase Regulate a Pool of Phosphatidylinositol 4-Phosphate That Functions in the Control of the Actin Cytoskeleton and Vacuole Morphology.

M. Foti, A. Audhya, and S. D. Emr (2001)
Mol. Biol. Cell 12, 2396-2411
 |  Abstract »  |  Full Text »  |  PDF »

A New Dynamin-Like Protein, ADL6, Is Involved in Trafficking from the trans-Golgi Network to the Central Vacuole in Arabidopsis.

J. B. Jin, Y. A Kim, S. J. Kim, S. H. Lee, D. H. Kim, G.-W. Cheong, and I. Hwang (2001)
PLANT CELL 13, 1511-1526
 |  Abstract »  |  Full Text »  |  PDF »

Ras Regulates the Polarity of the Yeast Actin Cytoskeleton through the Stress Response Pathway.

J. Ho and A. Bretscher (2001)
Mol. Biol. Cell 12, 1541-1555
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Vps34 Phosphatidylinositol 3-Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae.

A. Kihara, T. Noda, N. Ishihara, and Y. Ohsumi (2001)
J. Cell Biol. 152, 519-530
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of Phosphatidylinositol 3-Phosphate from the trans-Golgi Network to the Lumen of the Central Vacuole in Plant Cells.

D. H. Kim, Y.-J. Eu, C. M. Yoo, Y.-W. Kim, K. T. Pih, J. B. Jin, S. J. Kim, H. Stenmark, and I. Hwang (2001)
PLANT CELL 13, 287-301
 |  Abstract »  |  Full Text »

Vps10p Transport from the trans-Golgi Network to the Endosome Is Mediated by Clathrin-coated Vesicles.

O. Deloche, B. G. Yeung, G. S. Payne, and R. Schekman (2001)
Mol. Biol. Cell 12, 475-485
 |  Abstract »  |  Full Text »

Phosphoinositides in membrane traffic at the synapse.

O Cremona and P De Camilli (2001)
J. Cell Sci. 114, 1041-1052
 |  Abstract »  |  PDF »

Patterns within protein/polyphosphoinositide interactions provide specific targets for therapeutic intervention.

C. P. BERRIE and M. FALASCA (2000)
FASEB J 14, 2618-2622
 |  Abstract »  |  Full Text »

A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence.

A. Bruckmann, W. Künkel, A. Härtl, R. Wetzker, and R. Eck (2000)
Microbiology 146, 2755-2764
 |  Abstract »  |  Full Text »

Glut-1 Translocation in FRTL-5 Thyroid Cells: Role of Phosphatidylinositol 3-Kinase and N-Glycosylation.

N. Samih, S. Hovsepian, A. Aouani, D. Lombardo, and G. Fayet (2000)
Endocrinology 141, 4146-4155
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles for the Yeast Phosphatidylinositol 4-Kinases, Stt4p and Pik1p, in Secretion, Cell Growth, and Organelle Membrane Dynamics.

A. Audhya, M. Foti, and S. D. Emr (2000)
Mol. Biol. Cell 11, 2673-2689
 |  Abstract »  |  Full Text »

The Heat Shock Protein Ssa2p Is Required for Import of Fructose-1,6-Bisphosphatase into Vid Vesicles.

C. R. Brown, J. A. McCann, and H.-L. Chiang (2000)
J. Cell Biol. 150, 65-76
 |  Abstract »  |  Full Text »  |  PDF »

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors.

A. Arcaro, M. J. Zvelebil, C. Wallasch, A. Ullrich, M. D. Waterfield, and J. Domin (2000)
Mol. Cell. Biol. 20, 3817-3830
 |  Abstract »  |  Full Text »

Distinct Membrane Domains on Endosomes in the Recycling Pathway Visualized by Multicolor Imaging of Rab4, Rab5, and Rab11.

B. Sonnichsen, S. De Renzis, E. Nielsen, J. Rietdorf, and M. Zerial (2000)
J. Cell Biol. 149, 901-914
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Endothelial Growth Factor-Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt.

M. Morales-Ruiz, D. Fulton, G. Sowa, L. R. Languino, Y. Fujio, K. Walsh, and W. C. Sessa (2000)
Circ. Res. 86, 892-896
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells.

A. Siddhanta, J. M. Backer, and D. Shields (2000)
J. Biol. Chem. 275, 12023-12031
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 4,5-Bisphosphate Regulates Two Steps of Homotypic Vacuole Fusion.

A. Mayer, D. Scheglmann, S. Dove, A. Glatz, W. Wickner, and A. Haas (2000)
Mol. Biol. Cell 11, 807-817
 |  Abstract »  |  Full Text »

Association of Impaired Phosphatidylinositol 3-Kinase Activity in GLUT1-Containing Vesicles with Malinsertion of Glucose Transporters into the Plasma Membrane of Fibroblasts from a Patient with Severe Insulin Resistance and Clinical Features of Werner Syndrome.

C. Kausch, A. Hamann, I. Uphues, A. Niendorf, D. Müller-Wieland, H.-G. Joost, P. Algenstaedt, M. Dreyer, H. W. Rüdiger, H.-U. Häring, et al. (2000)
J. Clin. Endocrinol. Metab. 85, 905-918
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Distinct Classes of Phosphatidylinositol 3'-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells.

A. Petiot, E. Ogier-Denis, E. F. C. Blommaart, A. J. Meijer, and P. Codogno (2000)
J. Biol. Chem. 275, 992-998
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Regulation of protein sorting at the TGN by plasma membrane receptor activation.

M Baldassarre, A Dragonetti, P Marra, A Luini, C Isidoro, and R Buccione (2000)
J. Cell Sci. 113, 741-748
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Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor.

J Murray, L Wilson, and S Kellie (2000)
J. Cell Sci. 113, 337-348
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Complementation Analysis in PtdInsP Kinase-deficient Yeast Mutants Demonstrates That Schizosaccharomyces pombe and Murine Fab1p Homologues Are Phosphatidylinositol 3-Phosphate 5-Kinases.

R. K. McEwen, S. K. Dove, F. T. Cooke, G. F. Painter, A. B. Holmes, A. Shisheva, Y. Ohya, P. J. Parker, and R. H. Michell (1999)
J. Biol. Chem. 274, 33905-33912
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Direct Involvement of Phosphatidylinositol 4-Phosphate in Secretion in the Yeast Saccharomyces cerevisiae.

H. Hama, E. A. Schnieders, J. Thorner, J. Y. Takemoto, and D. B. DeWald (1999)
J. Biol. Chem. 274, 34294-34300
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SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling.

L. O. Beitz, D. A. Fruman, T. Kurosaki, L. C. Cantley, and A. M. Scharenberg (1999)
J. Biol. Chem. 274, 32662-32666
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Vasopressin stimulates sodium transport in A6 cells via a phosphatidylinositide 3-kinase-dependent pathway.

R. S. Edinger, M. D. Rokaw, and J. P. Johnson (1999)
Am J Physiol Renal Physiol 277, F575-F579
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Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.

S. Oki, T. Kohsaka, and M. Azuma (1999)
Int. Immunol. 11, 1563-1571
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Phosphoinositide-Ap-2 Interactions Required for Targeting to Plasma Membrane Clathrin-Coated Pits.

I. Gaidarov and J. H. Keen (1999)
J. Cell Biol. 146, 755-764
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Synergistic Role of the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Cascade in the Regulation of Insulin Receptor Trafficking.

T. Sasaoka, T. Wada, H. Ishihara, Y. Takata, T. Haruta, I. Usui, M. Ishiki, and M. Kobayashi (1999)
Endocrinology 140, 3826-3834
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Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast.

C. M. Alarcon, J. Heitman, and M. E. Cardenas (1999)
Mol. Biol. Cell 10, 2531-2546
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Vacuole Fusion Regulated by Protein Phosphatase 2C in Fission Yeast.

F. Gaits and P. Russell (1999)
Mol. Biol. Cell 10, 2647-2654
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The Phosphatidylinositol 3-Phosphate Binding Protein Vac1p Interacts with a Rab GTPase and a Sec1p Homologue to Facilitate Vesicle-mediated Vacuolar Protein Sorting.

G. G. Tall, H. Hama, D. B. DeWald, and B. F. Horazdovsky (1999)
Mol. Biol. Cell 10, 1873-1889
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SAC1-like Domains of Yeast SAC1, INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases.

S. Guo, L. E. Stolz, S. M. Lemrow, and J. D. York (1999)
J. Biol. Chem. 274, 12990-12995
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Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways.

A. E. Wurmser, J. D. Gary, and S. D. Emr (1999)
J. Biol. Chem. 274, 9129-9132
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